Francisco Guarner

Summary

Affiliation: Hospital Universitari Vall d'Hebron
Country: Spain

Publications

  1. ncbi request reprint Hygiene, microbial diversity and immune regulation
    Francisco Guarner
    Digestive System Research Unit, CIBERehd, University Hospital Vall d Hebron, Barcelona, Spain
    Curr Opin Gastroenterol 23:667-72. 2007
  2. doi request reprint [The intestinal microbiota and inflammatory bowel disease]
    Francisco Guarner
    Unidad de Investigación de Aparato Digestivo, Hospital Universitari Vall d Hebron, Barcelona, Espana
    Gastroenterol Hepatol 34:147-54. 2011
  3. ncbi request reprint Studies with inulin-type fructans on intestinal infections, permeability, and inflammation
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, CIBERehd, Barcelona, Spain
    J Nutr 137:2568S-2571S. 2007
  4. ncbi request reprint [Role of intestinal flora in health and disease]
    F Guamer
    Unidad de Investigación de Aparato Digestivo, Hospital Universitari Vall d Hebron, Barcelona, Espana
    Nutr Hosp 22:14-9. 2007
  5. ncbi request reprint Prebiotics in inflammatory bowel diseases
    Francisco Guarner
    Digestive System Research Unit Ciberehd University Hospital Vall d Hebron Passeig Vall d Hebron, 119 129 08035 Barcelona, Spain
    Br J Nutr 98:S85-9. 2007
  6. doi request reprint Prebiotics, probiotics and helminths: the 'natural' solution?
    Francisco Guarner
    Digestive System Research Unit, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, University Hospital Vall d Hebron, ES 08035 Barcelona, Spain
    Dig Dis 27:412-7. 2009
  7. doi request reprint Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa
    Marta Llopis
    Digestive System Research Unit, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Spain
    Inflamm Bowel Dis 15:275-83. 2009
  8. ncbi request reprint Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease
    Monica Carol
    Digestive System Research Unit, University Hospital Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    J Leukoc Biol 79:917-22. 2006
  9. ncbi request reprint Fecal excretion of deoxyribonucleic acid in long-term follow-up of patients with inactive ulcerative colitis
    Francesc Casellas
    Digestive System Research Unit, Unitat d Atenció Crohn Colitis, Barcelona, Spain
    Inflamm Bowel Dis 13:386-90. 2007
  10. doi request reprint The gut microbiota in IBD
    Chaysavanh Manichanh
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Nat Rev Gastroenterol Hepatol 9:599-608. 2012

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Hygiene, microbial diversity and immune regulation
    Francisco Guarner
    Digestive System Research Unit, CIBERehd, University Hospital Vall d Hebron, Barcelona, Spain
    Curr Opin Gastroenterol 23:667-72. 2007
    ..Sanitation, antibiotics and vaccines have done more to extend life expectancy than any other medical innovation. Concern exists, however, about the link between hygiene and increased incidence of immune-mediated disorders...
  2. doi request reprint [The intestinal microbiota and inflammatory bowel disease]
    Francisco Guarner
    Unidad de Investigación de Aparato Digestivo, Hospital Universitari Vall d Hebron, Barcelona, Espana
    Gastroenterol Hepatol 34:147-54. 2011
    ..In the next few years, the results of international projects designed to determine the precise impact of the microbiota in various physiological and pathological processes will hopefully lead to major advances...
  3. ncbi request reprint Studies with inulin-type fructans on intestinal infections, permeability, and inflammation
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, CIBERehd, Barcelona, Spain
    J Nutr 137:2568S-2571S. 2007
    ..Finally, inulin and oligofructose have proven useful to prevent mucosal inflammatory disorders in animal models and in patients with inflammatory bowel disease...
  4. ncbi request reprint [Role of intestinal flora in health and disease]
    F Guamer
    Unidad de Investigación de Aparato Digestivo, Hospital Universitari Vall d Hebron, Barcelona, Espana
    Nutr Hosp 22:14-9. 2007
    ..On the other hand, there is evidence implicating intestinal microbiota in certain pathological processes including multi-organ failure, colon cancer, and inflammatory bowel disease...
  5. ncbi request reprint Prebiotics in inflammatory bowel diseases
    Francisco Guarner
    Digestive System Research Unit Ciberehd University Hospital Vall d Hebron Passeig Vall d Hebron, 119 129 08035 Barcelona, Spain
    Br J Nutr 98:S85-9. 2007
    ..Encouraging results have been obtained in preliminary clinical trials...
  6. doi request reprint Prebiotics, probiotics and helminths: the 'natural' solution?
    Francisco Guarner
    Digestive System Research Unit, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, University Hospital Vall d Hebron, ES 08035 Barcelona, Spain
    Dig Dis 27:412-7. 2009
    ..The therapeutic manipulation of gut microecology has attracted high expectation as a strategic area for the control and prevention of IBD...
  7. doi request reprint Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa
    Marta Llopis
    Digestive System Research Unit, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Spain
    Inflamm Bowel Dis 15:275-83. 2009
    ..The study of isolated commensal bacteria's effects on the mucosal immune response might be relevant for a better understanding of pathophysiological mechanisms in IBD...
  8. ncbi request reprint Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease
    Monica Carol
    Digestive System Research Unit, University Hospital Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    J Leukoc Biol 79:917-22. 2006
    ..coli strain had no significant effect. In conclusion, L. casei reduces the number of activated T lymphocytes in the lamina propria of Crohn's disease mucosa. A balanced, local microecology may restore immune homeostasis...
  9. ncbi request reprint Fecal excretion of deoxyribonucleic acid in long-term follow-up of patients with inactive ulcerative colitis
    Francesc Casellas
    Digestive System Research Unit, Unitat d Atenció Crohn Colitis, Barcelona, Spain
    Inflamm Bowel Dis 13:386-90. 2007
    ..The aim of this study was to determine the stability of fecal DNA in inactive ulcerative colitis and its potential value as an indicator of relapse...
  10. doi request reprint The gut microbiota in IBD
    Chaysavanh Manichanh
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Nat Rev Gastroenterol Hepatol 9:599-608. 2012
    ..Whether such changes are a cause or a consequence of the disease remains to be elucidated...
  11. pmc Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
    Chaysavanh Manichanh
    Digestive System Research Unit, Departament de Medicina, University Hospital Vall d Hebron, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gut 63:401-8. 2014
    ..To characterise the influence of diet on abdominal symptoms, anal gas evacuation, intestinal gas distribution and colonic microbiota in patients complaining of flatulence...
  12. doi request reprint Unstable composition of the fecal microbiota in ulcerative colitis during clinical remission
    Cristina Martinez
    Digestive Disease Research Unit, University Hospital Vall d Hebron, CIBERehd, Barcelona, Spain
    Am J Gastroenterol 103:643-8. 2008
    ..We investigated dynamics of fecal microbiota in ulcerative colitis (UC) during remission by genomic technology...
  13. ncbi request reprint Lactobacillus casei prevents the upregulation of ICAM-1 expression and leukocyte recruitment in experimental colitis
    Sandra Angulo
    Department of Gastroenterology, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 291:G1155-62. 2006
    ..casei administration did not modify VCAM-1 upregulation in colitic animals. L. casei attenuates leukocyte recruitment observed in experimental colitis induced by TNBS. This effect is possibly related to abrogation of ICAM-1 upregulation...
  14. ncbi request reprint Mechanisms of disease: the hygiene hypothesis revisited
    Francisco Guarner
    University Hospital Vall d Hebron, Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 3:275-84. 2006
    ..The use of probiotics, prebiotics, helminths or microbe-derived immunoregulatory vaccines might, therefore, become a valuable approach to disease prevention...
  15. ncbi request reprint Fecal excretion of human deoxyribonucleic acid as an index of inflammatory activity in ulcerative colitis
    Francesc Casellas
    Digestive System Research Unit, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    Clin Gastroenterol Hepatol 2:683-9. 2004
    ..The aim of our study was to determine whether excretion of human DNA is useful in the evaluation of disease activity in ulcerative colitis...
  16. ncbi request reprint Restoration of quality of life of patients with inflammatory bowel disease after one year with antiTNFα treatment
    Francesc Casellas
    Unitat Atenció Crohn Colitis, Hospital Universitari Vall d Hebron, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Spain
    J Crohns Colitis 6:881-6. 2012
    ..This can be assessed by using a cut-off scoring threshold of the IBDQ-36 questionnaire. It has not been established if antiTNFα treatment is able to restore to normal patients' HRQOL...
  17. ncbi request reprint The intestinal flora in inflammatory bowel disease: normal or abnormal?
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Curr Opin Gastroenterol 21:414-8. 2005
    ..This review discusses the possible role of a microbial imbalance in the pathophysiology of inflammatory bowel disease...
  18. ncbi request reprint Modulatory effect of nitric oxide on mast cells during induction of dextran sulfate sodium colitis
    Sebastian Videla
    Digestive System Research Unit, Hospital Vall d Hebron, Barcelona, Spain
    Dig Dis Sci 52:45-51. 2007
    ..Our results suggest that constitutive isoforms of NOS prevent mast cell activation...
  19. pmc Processing faecal samples: a step forward for standards in microbial community analysis
    Alba Santiago
    Vall d Hebron Research Institute, Digestive System Research Unit, Passeig de la Vall d Hebron 119 129, Barcelona 08035, Spain
    BMC Microbiol 14:112. 2014
    ..We also studied the effect of stool water content, which typically increases in diarrhoeic samples, and of a microbial disruption method on DNA integrity and, therefore, on providing an unbiased microbial composition analysis...
  20. ncbi request reprint Role of bacteria in experimental colitis
    Francisco Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona 08035, Spain
    Best Pract Res Clin Gastroenterol 17:793-804. 2003
    ..Prebiotics may increase colonization by lactobacilli and can prevent mucosal inflammation. Modulation of the gut flora with probiotics may prove useful in the prevention and control of inflammatory bowel diseases...
  21. pmc Reshaping the gut microbiome with bacterial transplantation and antibiotic intake
    Chaysavanh Manichanh
    Digestive System Research Unit, University Hospital Vall d Hebron, CIBERehd, 08035 Barcelona, Spain
    Genome Res 20:1411-9. 2010
    ....
  22. ncbi request reprint Inulin and oligofructose: impact on intestinal diseases and disorders
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona 08035, Spain
    Br J Nutr 93:S61-5. 2005
    ..Inulin and oligofructose may offer an opportunity to prevent chronic inflammatory intestinal disorders, and this potential should be tested in further clinical studies...
  23. ncbi request reprint Polyethylene glycol enhances colonic barrier function and ameliorates experimental colitis in rats
    Sebastian Videla
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Int J Colorectal Dis 22:571-80. 2007
    ..We aimed to establish whether PEG 4000 affects colonic barrier function and the development of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in rats...
  24. ncbi request reprint Enteric flora in health and disease
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Digestion 73:5-12. 2006
    ..On the other hand, there is evidence implicating the gut flora in certain pathological conditions, including multisystem organ failure, colon cancer and inflammatory bowel diseases...
  25. pmc Storage conditions of intestinal microbiota matter in metagenomic analysis
    Silvia Cardona
    Digestive System Research Unit, Vall d Hebron Institut de Recerca, CIBERehd, Barcelona, Spain
    BMC Microbiol 12:158. 2012
    ..Here, we evaluated how different storage conditions of fecal samples affect the quality of extracted nucleic acids and the stability of their microbial communities...
  26. ncbi request reprint Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa
    Natalia Borruel
    Digestive System Research Unit, Hospitals Vall d Hebron, Universidad Autonoma de Barcelona, Barcelona, Spain
    Am J Gastroenterol 98:865-70. 2003
    ..The aim of this study was to elucidate whether host-bacteria interactions influence mucosal cytokine production...
  27. ncbi request reprint Gut flora in health and disease
    Francisco Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Lancet 361:512-9. 2003
    ..Nevertheless, bacteria are also useful in promotion of human health. Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases...
  28. pmc Short-term effect of antibiotics on human gut microbiota
    Suchita Panda
    Digestive System Research Unit, Vall d Hebron Research Institute, Barcelona, Spain
    PLoS ONE 9:e95476. 2014
    ..04). The maintenance of or possible increase detected in microbial load and the selection of Gram-negative over Gram-positive bacteria breaks the idea generally held about the effect of broad-spectrum antibiotics on gut microbiota. ..
  29. ncbi request reprint [Progress in the knowledge of the intestinal human microbiota]
    Virginia Robles-Alonso
    Servicio de Aparato Digestivo, Hospital Universitario Vall d Hebron, Barcelona, Espana
    Nutr Hosp 28:553-7. 2013
    ..A better knowledge of the contributions of microbial symbionts to host health will help in the design of interventions to improve symbiosis and combat disease...
  30. doi request reprint Linking the gut microbiota to human health
    Virginia Robles Alonso
    Digestive System Research Unit, University Hospital Vall d Hebron, CIBERehd, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Br J Nutr 109:S21-6. 2013
    ..Probiotics and prebiotics are used to improve symbiosis between enteric microbiota and the host or restore states of dysbiosis...
  31. ncbi request reprint Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial
    Jordi Giralt
    Department of Radiation Oncology, Vall d Hebron University Hospital, Barcelona, Spain
    Int J Radiat Oncol Biol Phys 71:1213-9. 2008
    ..To determine whether a probiotic drink containing Lactobacillus casei DN-114 001 reduces the incidence of radiation-induced diarrhea in patients with gynecologic cancer...
  32. ncbi request reprint Microecology as a target for therapeutic intervention in inflammatory bowel disease
    Francisco Guarner
    University Hospital Vall d Hebron, Digestive System Research Unit, Passeig Vall d Hebron, 119 129, E 08035 Barcelona, Spain
    IDrugs 6:868-73. 2003
    ..However, certain probiotic strains are able to downregulate inflammatory pathways. Restoring the microbial balance with prebiotics and probiotics offers promise for the control of IBD...
  33. doi request reprint Understanding the microbiota in the midst of Renaissance architecture and olive groves
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Centro de Investigación Biomédica en Red en Área temática de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Nat Immunol 14:101-5. 2013
    ..Leading scientists working on the microbiome gathered in an October 2012 meeting in Baeza, Spain, to discuss recent advances in the understanding of the role of the microbiota in immunity, pathogen colonization, metabolism and disease...
  34. ncbi request reprint Should yoghurt cultures be considered probiotic?
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Br J Nutr 93:783-6. 2005
    ..bulgaricus) improves lactose digestion and eliminates symptoms of lactose intolerance. Thus, these cultures clearly fulfil the current concept of probiotics...
  35. ncbi request reprint PASSCLAIM--gut health and immunity
    John H Cummings
    Pathology and Neuroscience, University of Dundee Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Eur J Nutr 43:II118-II173. 2004
    ..The digestive tract is most frequently the object of functional and health claims and a large market already exists for gut-functional foods worldwide...
  36. ncbi request reprint Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis
    Carlos Medina
    Digestive Disease Research Unit, Hospital Vall d Hebron, 08035 Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 284:G116-22. 2003
    ..We conclude that increased activity of matrix metalloproteinases may contribute to epithelial damage in this model of colitis...
  37. ncbi request reprint The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium "The Intelligent Intestine," held in Paris, June 14, 2002
    Pierre Bourlioux
    Microbiology Department, Paris Sud XI University, Chatenay Malabry, France
    Am J Clin Nutr 78:675-83. 2003
    ..In cooperation with these endogenous barriers, some in-transit bacteria, such as probiotics, can act as partners of the defense system of the intestine...
  38. doi request reprint The gut microbiota predispose to the pathophysiology of acute postradiotherapy diarrhea
    Chaysavanh Manichanh
    Unité d Ecologie et de Physiologie du Système Digestif, INRA, Jouy en Josas, France
    Am J Gastroenterol 103:1754-61. 2008
    ..As there is no current clinical or experimental information on the role of the gut microbiota in this pathogenesis, we conducted a pilot observational study on the fecal microbiota in patients receiving pelvic radiotherapy...
  39. doi request reprint Probiotic prophylaxis in predicted severe acute pancreatitis
    Gregor Reid
    Lancet 372:112-3; author reply 114. 2008
  40. ncbi request reprint Induction of colonic transmural inflammation by Bacteroides fragilis: implication of matrix metalloproteinases
    Carlos Medina
    Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
    Inflamm Bowel Dis 11:99-105. 2005
    ..We hypothesized that Bacteroides fragilis-produced metalloproteinases (MMPs) are responsible for bacterial migration through the intestinal wall and transmural inflammation...
  41. ncbi request reprint Selected topics in probiotics and prebiotics: meeting report for the 2004 international scientific association for probiotics and prebiotics
    Mary Ellen Sanders
    Dairy and Food Culture Technologies, 7119 S Glencoe Ct, Centennial, CO 80122 2526, USA
    Curr Issues Intest Microbiol 6:55-68. 2005
    ..Brief conclusions from these discussion groups are summarized in this paper...
  42. ncbi request reprint Prebiotics and mucosal barrier function
    Francisco Guarner
    J Nutr 136:2269; author reply 2270-1. 2006
  43. ncbi request reprint Discussion on toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    Gregor Reid
    Gastroenterology 127:366-7; author reply 367. 2004