F Guarner

Summary

Affiliation: Hospital Universitario
Country: Spain

Publications

  1. ncbi request reprint Should yoghurt cultures be considered probiotic?
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Br J Nutr 93:783-6. 2005
  2. ncbi request reprint Role of microecology in chronic inflammatory bowel diseases
    F Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Eur J Clin Nutr 56:S34-8. 2002
  3. ncbi request reprint The intestinal flora in inflammatory bowel disease: normal or abnormal?
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Curr Opin Gastroenterol 21:414-8. 2005
  4. ncbi request reprint Enteric flora in health and disease
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Digestion 73:5-12. 2006
  5. ncbi request reprint Role of bacteria in experimental colitis
    Francisco Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona 08035, Spain
    Best Pract Res Clin Gastroenterol 17:793-804. 2003
  6. ncbi request reprint Inulin and oligofructose: impact on intestinal diseases and disorders
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona 08035, Spain
    Br J Nutr 93:S61-5. 2005
  7. ncbi request reprint Mechanisms of disease: the hygiene hypothesis revisited
    Francisco Guarner
    University Hospital Vall d Hebron, Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 3:275-84. 2006
  8. ncbi request reprint Microecology as a target for therapeutic intervention in inflammatory bowel disease
    Francisco Guarner
    University Hospital Vall d Hebron, Digestive System Research Unit, Passeig Vall d Hebron, 119 129, E 08035 Barcelona, Spain
    IDrugs 6:868-73. 2003
  9. ncbi request reprint Gut flora in health and disease
    Francisco Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Lancet 361:512-9. 2003
  10. ncbi request reprint Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis
    S Videla
    Digestive System Research Unit, Hospital Vall d Hebron, Barcelona, Spain
    J Pharmacol Exp Ther 316:940-5. 2006

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Should yoghurt cultures be considered probiotic?
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Br J Nutr 93:783-6. 2005
    ..bulgaricus) improves lactose digestion and eliminates symptoms of lactose intolerance. Thus, these cultures clearly fulfil the current concept of probiotics...
  2. ncbi request reprint Role of microecology in chronic inflammatory bowel diseases
    F Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Eur J Clin Nutr 56:S34-8. 2002
    ..Preliminary clinical trials with probiotics in IBD are encouraging. Probiotics offer a valuable tool for the prevention and control of inflammatory bowel diseases...
  3. ncbi request reprint The intestinal flora in inflammatory bowel disease: normal or abnormal?
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Curr Opin Gastroenterol 21:414-8. 2005
    ..This review discusses the possible role of a microbial imbalance in the pathophysiology of inflammatory bowel disease...
  4. ncbi request reprint Enteric flora in health and disease
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Barcelona, Spain
    Digestion 73:5-12. 2006
    ..On the other hand, there is evidence implicating the gut flora in certain pathological conditions, including multisystem organ failure, colon cancer and inflammatory bowel diseases...
  5. ncbi request reprint Role of bacteria in experimental colitis
    Francisco Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona 08035, Spain
    Best Pract Res Clin Gastroenterol 17:793-804. 2003
    ..Prebiotics may increase colonization by lactobacilli and can prevent mucosal inflammation. Modulation of the gut flora with probiotics may prove useful in the prevention and control of inflammatory bowel diseases...
  6. ncbi request reprint Inulin and oligofructose: impact on intestinal diseases and disorders
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona 08035, Spain
    Br J Nutr 93:S61-5. 2005
    ..Inulin and oligofructose may offer an opportunity to prevent chronic inflammatory intestinal disorders, and this potential should be tested in further clinical studies...
  7. ncbi request reprint Mechanisms of disease: the hygiene hypothesis revisited
    Francisco Guarner
    University Hospital Vall d Hebron, Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 3:275-84. 2006
    ..The use of probiotics, prebiotics, helminths or microbe-derived immunoregulatory vaccines might, therefore, become a valuable approach to disease prevention...
  8. ncbi request reprint Microecology as a target for therapeutic intervention in inflammatory bowel disease
    Francisco Guarner
    University Hospital Vall d Hebron, Digestive System Research Unit, Passeig Vall d Hebron, 119 129, E 08035 Barcelona, Spain
    IDrugs 6:868-73. 2003
    ..However, certain probiotic strains are able to downregulate inflammatory pathways. Restoring the microbial balance with prebiotics and probiotics offers promise for the control of IBD...
  9. ncbi request reprint Gut flora in health and disease
    Francisco Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Lancet 361:512-9. 2003
    ..Nevertheless, bacteria are also useful in promotion of human health. Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases...
  10. ncbi request reprint Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis
    S Videla
    Digestive System Research Unit, Hospital Vall d Hebron, Barcelona, Spain
    J Pharmacol Exp Ther 316:940-5. 2006
    ..In conclusion, PDE4 inhibition by rolipram markedly ameliorates the course of chronic colitis and it is superior to methylprednisolone in preventing late collagen deposition...
  11. ncbi request reprint Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat
    S Videla
    Department of Microbiology, Hospital General Vall d'Hebron, Barcelona, Spain
    Am J Gastroenterol 96:1486-93. 2001
    ..05). However, inulin or butyrate enemas had no effect. CONCLUSIONS: Oral inulin reduces the severity of dextran sodium sulfate colitis. The effect seems to be mediated by modification of the intracolonic milieu...
  12. ncbi request reprint Therapeutic effect of phenantroline in two rat models of inflammatory bowel disease
    C Medina
    Digestive Disease Research Unit, Hospital Vall d'Hebron, Barcelona, Spain
    Scand J Gastroenterol 36:1314-9. 2001
    ..CONCLUSIONS: Although phenantroline did not modify the activity of inflammatory mediators, this compound substantially reduced intestinal injury associated with tissue remodelling...
  13. ncbi request reprint Oral oligofructose-enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin
    F Casellas
    Digestive System Research Unit, Unitat d Atenció Crohn Colitis, University Hospital Vall d Hebron, CIBERehd, Barcelona, Spain
    Aliment Pharmacol Ther 25:1061-7. 2007
    ..Inulin and oligofructose promote selective growth of saccharolytic bacteria with low inflammatory potential...
  14. pmc Increased mucosal tumour necrosis factor alpha production in Crohn's disease can be downregulated ex vivo by probiotic bacteria
    N Borruel
    Digestive System Research Unit, Hospitals Vall d Hebron, Autonomous University, Barcelona, Spain
    Gut 51:659-64. 2002
    ..Tumour necrosis factor alpha (TNF-alpha) plays a key role in the pathogenesis of intestinal inflammation in Crohn's disease. The effect of bacteria on TNF-alpha release by intestinal mucosa was investigated...
  15. pmc Modulation of colonic barrier function by the composition of the commensal flora in the rat
    A Garcia-Lafuente
    Digestive System Research Unit, Hospital General Universitari Vall d Hebron, Barcelona 08035, Spain
    Gut 48:503-7. 2001
    ..Altered intestinal permeability is a key pathogenetic factor of idiopathic bowel inflammation. We investigated in the rat if changes in the composition of the bowel flora can alter colonic permeability...
  16. doi request reprint Cutoff values of the Inflammatory Bowel Disease Questionnaire to predict a normal health related quality of life
    J W Huamán
    Digestive System Research Unit, Unitat Atenció Crohn Colitis, Hospital Universitari Vall d Hebron, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Spain
    J Crohns Colitis 4:637-41. 2010
    ..However, we do not dispose of validated criteria to determine the questionnaire's scoring threshold that has to be reached in order to be able to assert that the patients' quality of life has normalized...
  17. pmc Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid
    M Llopis
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona 08035, Spain
    Gut 54:955-9. 2005
    ..Injury is facilitated by barrier disruption and invasion of commensal bacteria. However, certain bacteria have shown anti-inflammatory properties in in vitro models...
  18. doi request reprint Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis
    E Varela
    Department of Gastroenterology, Digestive System Research Unit, Institut de Recerca Vall d Hebron, University Hospital Vall d Hebron, Universitat Autonoma de Barcelona, CIBERehd, Barcelona, Spain
    Aliment Pharmacol Ther 38:151-61. 2013
    ..Potentially, Faecalibacterium prausnitzii, bacteria with anti-inflammatory properties, might be deficient in ulcerative colitis (UC)...
  19. doi request reprint Faecal DNA and calprotectin as biomarkers of acute intestinal toxicity in patients undergoing pelvic radiotherapy
    E Varela
    Digestive System Research Unit, University Hospital Vall d Hebron, Autonomous University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Aliment Pharmacol Ther 30:175-85. 2009
    ..Acute intestinal toxicity is a frequent complication that may lead to interruption of treatment in patients undergoing pelvic radiotherapy. Reliable, non-invasive biological markers to evidence their severity are not yet available...
  20. ncbi request reprint Epidermal growth factor increases surface hydrophobicity and resistance to acid in the rat duodenum
    A Lugea
    Digestive System Research Unit, Hospital General Vall d'Hebron, Barcelona 08035, Spain
    Am J Physiol Gastrointest Liver Physiol 280:G774-9. 2001
    ..These data suggest that EGF increases duodenal resistance to luminal acid via stimulation of mucosal zwitterionic phospholipids...
  21. doi request reprint Influence of colectomy on hydrogen excretion in breath
    Francesc Casellas
    Digestive System Research Unit, Hospital Universitari Vall d Hebron, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona 08035, Spain
    Int J Colorectal Dis 25:485-9. 2010
    ..A scarcely studied variable is the effect of colonic anatomical integrity on H(2) excretion in breath...
  22. pmc Regulation of gall bladder motility by the arginine-nitric oxide pathway in guinea pigs
    M Mourelle
    Digestive System Research Unit, Hospital General Vall d Hebron, Autonomous University of Barcelona, Spain
    Gut 34:911-5. 1993
    ..These findings support the existence of a key L-arginine-nitric oxide pathway regulating gall bladder contraction...
  23. ncbi request reprint Consensus statements from the Workshop "Probiotics and Health: Scientific evidence"
    F Guarner
    Hospital Vall d Hebron, Barcelona, Spain
    Nutr Hosp 25:700-4. 2010
    ..Each statement has been sustained with the most relevant scientific aspects that were discussed during the Workshop and the following evaluation of the report by all experts who approved and signed it...
  24. ncbi request reprint Prebiotics in inflammatory bowel diseases
    Francisco Guarner
    Digestive System Research Unit Ciberehd University Hospital Vall d Hebron Passeig Vall d Hebron, 119 129 08035 Barcelona, Spain
    Br J Nutr 98:S85-9. 2007
    ..Encouraging results have been obtained in preliminary clinical trials...
  25. ncbi request reprint Studies with inulin-type fructans on intestinal infections, permeability, and inflammation
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, CIBERehd, Barcelona, Spain
    J Nutr 137:2568S-2571S. 2007
    ..Finally, inulin and oligofructose have proven useful to prevent mucosal inflammatory disorders in animal models and in patients with inflammatory bowel disease...
  26. ncbi request reprint Prebiotics and mucosal barrier function
    Francisco Guarner
    J Nutr 136:2269; author reply 2270-1. 2006
  27. ncbi request reprint Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa
    Natalia Borruel
    Digestive System Research Unit, Hospitals Vall d Hebron, Universidad Autonoma de Barcelona, Barcelona, Spain
    Am J Gastroenterol 98:865-70. 2003
    ..The aim of this study was to elucidate whether host-bacteria interactions influence mucosal cytokine production...
  28. ncbi request reprint Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease
    Monica Carol
    Digestive System Research Unit, University Hospital Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    J Leukoc Biol 79:917-22. 2006
    ..coli strain had no significant effect. In conclusion, L. casei reduces the number of activated T lymphocytes in the lamina propria of Crohn's disease mucosa. A balanced, local microecology may restore immune homeostasis...
  29. ncbi request reprint Selected topics in probiotics and prebiotics: meeting report for the 2004 international scientific association for probiotics and prebiotics
    Mary Ellen Sanders
    Dairy and Food Culture Technologies, 7119 S Glencoe Ct, Centennial, CO 80122 2526, USA
    Curr Issues Intest Microbiol 6:55-68. 2005
    ..Brief conclusions from these discussion groups are summarized in this paper...
  30. ncbi request reprint Induction of colonic transmural inflammation by Bacteroides fragilis: implication of matrix metalloproteinases
    Carlos Medina
    Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
    Inflamm Bowel Dis 11:99-105. 2005
    ..We hypothesized that Bacteroides fragilis-produced metalloproteinases (MMPs) are responsible for bacterial migration through the intestinal wall and transmural inflammation...
  31. ncbi request reprint PASSCLAIM--gut health and immunity
    John H Cummings
    Pathology and Neuroscience, University of Dundee Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Eur J Nutr 43:II118-II173. 2004
    ..The digestive tract is most frequently the object of functional and health claims and a large market already exists for gut-functional foods worldwide...
  32. ncbi request reprint Discussion on toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    Gregor Reid
    Gastroenterology 127:366-7; author reply 367. 2004
  33. ncbi request reprint Lactobacillus casei prevents the upregulation of ICAM-1 expression and leukocyte recruitment in experimental colitis
    Sandra Angulo
    Department of Gastroenterology, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 291:G1155-62. 2006
    ..casei administration did not modify VCAM-1 upregulation in colitic animals. L. casei attenuates leukocyte recruitment observed in experimental colitis induced by TNBS. This effect is possibly related to abrogation of ICAM-1 upregulation...
  34. ncbi request reprint The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium "The Intelligent Intestine," held in Paris, June 14, 2002
    Pierre Bourlioux
    Microbiology Department, Paris Sud XI University, Chatenay Malabry, France
    Am J Clin Nutr 78:675-83. 2003
    ..In cooperation with these endogenous barriers, some in-transit bacteria, such as probiotics, can act as partners of the defense system of the intestine...
  35. doi request reprint Probiotic prophylaxis in predicted severe acute pancreatitis
    Gregor Reid
    Lancet 372:112-3; author reply 114. 2008
  36. doi request reprint The gut microbiota predispose to the pathophysiology of acute postradiotherapy diarrhea
    Chaysavanh Manichanh
    Unité d Ecologie et de Physiologie du Système Digestif, INRA, Jouy en Josas, France
    Am J Gastroenterol 103:1754-61. 2008
    ..As there is no current clinical or experimental information on the role of the gut microbiota in this pathogenesis, we conducted a pilot observational study on the fecal microbiota in patients receiving pelvic radiotherapy...
  37. doi request reprint Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial
    Jordi Giralt
    Department of Radiation Oncology, Vall d Hebron University Hospital, Barcelona, Spain
    Int J Radiat Oncol Biol Phys 71:1213-9. 2008
    ..To determine whether a probiotic drink containing Lactobacillus casei DN-114 001 reduces the incidence of radiation-induced diarrhea in patients with gynecologic cancer...
  38. ncbi request reprint Fecal excretion of human deoxyribonucleic acid as an index of inflammatory activity in ulcerative colitis
    Francesc Casellas
    Digestive System Research Unit, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    Clin Gastroenterol Hepatol 2:683-9. 2004
    ..The aim of our study was to determine whether excretion of human DNA is useful in the evaluation of disease activity in ulcerative colitis...
  39. ncbi request reprint Modulatory effect of nitric oxide on mast cells during induction of dextran sulfate sodium colitis
    Sebastian Videla
    Digestive System Research Unit, Hospital Vall d Hebron, Barcelona, Spain
    Dig Dis Sci 52:45-51. 2007
    ..Our results suggest that constitutive isoforms of NOS prevent mast cell activation...
  40. ncbi request reprint Polyethylene glycol enhances colonic barrier function and ameliorates experimental colitis in rats
    Sebastian Videla
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Int J Colorectal Dis 22:571-80. 2007
    ..We aimed to establish whether PEG 4000 affects colonic barrier function and the development of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in rats...
  41. ncbi request reprint Hygiene, microbial diversity and immune regulation
    Francisco Guarner
    Digestive System Research Unit, CIBERehd, University Hospital Vall d Hebron, Barcelona, Spain
    Curr Opin Gastroenterol 23:667-72. 2007
    ..Sanitation, antibiotics and vaccines have done more to extend life expectancy than any other medical innovation. Concern exists, however, about the link between hygiene and increased incidence of immune-mediated disorders...