A Fernandez-Flores

..Fine-needle aspiration of one of the hepatic lesions showed a pleomorphic plasmacytoid tumor. Immunocytochemistry using p63 and kappa-chain antibodies was useful in determining the plasmacytic nature of the cells...

..It also examines the current conception of the existence of at least two types of cutaneous MALT-lymphomas and their relation to the duality immunocytoma/pseudolymphoma from the old literature...

..66% of the metastases. We found SMA as a very useful tool in diagnosing an invasion in CAC. Regarding the expression of c-erbB-2, all of our cases had a value of either 0 or 1...

..The sarcomatoid component of the tumor expressed several types of cytokeratins, such as AE1/AE3, CK 5/6, 34betaE12, and CAM 5.2. It was also positive for p63 and for D2-40 in a diffuse pattern...

..Hundreds of prognostic factors have been described in literature and it is not possible to mention all of them in a report. Therefore, in the current report, we summarize some of them...

..We concluded that these findings supported the hypothesis that the embryologic differences of these areas of head and neck might play a role in the morphology of Unna and Miescher nevi...

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..Since some involve the skin, either primarily or as part of their systemic manifestations, we have tried to briefly examine some of the cutaneous conditions related to IgG4...

..Cyclin D-1 was expressed in the parabasal layer. Immunohistochemistry of the squamous proliferation was negative for human papillomavirus...

..It also reviews some advances on many of these lymphomas published in the last 2 years...

..It did not stain with anti-amyloid A, or with antibodies against either kappa light or lambda light chains. Therefore the amyloid deposit was keratinic in nature...

..We have found no other reported case of areolar sebaceous hyperplasia either in cases of breast carcinoma or in cases of leprechaunism...

..It also presents an additional case emphasizing the current approach to the differential diagnosis...

..The internalized cells frequently appeared apoptotic. Immunohistochemical analysis revealed that the internalized cells as well as the cannibal cells expressed CD68...

..CD56+ cells represented 80 to 90% of the infiltrate, showing atypical morphologic features, and clusters of CD56 positive cells were also observed...

..We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis...

..The lesion spontaneously improved and eventually disappeared. It was thought to be secondary to a chronic trauma to the area due to a prolonged stance in bed in the emergency room...

..We therefore tried to investigate the use of p53 in such a conundrum. This marker has rarely been reported in cutaneous leiomyomas and even in more rare occasions, in cutaneous leiomyomas...

..This would be similar to the morphologic relation, already described, between fibrous papules of the face and oral fibromas of phakomatoses...

..They were highlighted on immunohistochemical study with CD79a, CD138 and EMA, and showed polyclonal immunoexpression of kappa and lambda immunoglobulin light chains...

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..41%). We concluded that vascular invasion is a common feature in cutaneous metastases, especially in nonhematologic neoplasms, and because sometimes is focal, it should be carefully searched...

..We decided to investigate the presence of coarse keratohyalin granules in cases of irritated SK...

..Although most of the vessels were identified as blood vessels (venules and capillaries), some were demonstrated to be dilated lymphatic vessels...

..Cutaneous granular cell tumors have only rarely been examined for Bcl-2, a marker that is expressed by granular cell tumors from other parts of the body...

..Concerning the current association, as well as many of those described in the literature, we also discuss whether they might be more than mere coincidences, maybe explained by some molecular alterations...

..Foreign bodies typical of steroids were found, together with areas of calcification and ossification with lamellar bone. Multivacuolated macrophages were found in the fibrous tissue close to these areas of calcification and ossification...

..the morphologic changes in specimens from people who have committed suicide by hanging have mainly centered on macroscopic findings. Pour purpose is to inestigate the microscopis changes in the ligature marks...

..Taking these into account, we introduce a possible morphological classification of calcinosis cutis, based on the pattern of the cutaneous deposits...

..In the current report, we review many morphologic, clinical, ultrastructural, molecular and genetic aspects that support the hypothesis of an origin of PEComas from the neural crest...

..Even with the few clinical details provided by the literary description, the current report examines the possibility of Hodgkin lymphoma as a diagnosis, concluding that the option is not an unwise one...

..We intend to examine cases of amyloidosis stained with Congo red with ultraviolet light and to see if such method offers advantages with respect to Congo red only and to immunohistochemistry...

..Nevertheless, we have not found any studies on HER2/neu status, estrogen receptors, or progesterone receptors in nipple adenoma of male patients...

..Therefore, evidence of those particles does not exclude sarcoidosis (Tab. 1, Fig. 4, Ref. 23)...

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..It also showed apple-green birefringence when observed under polarized light. Nevertheless, it failed to express any of the markers investigated in the immunohistochemical study...

..This study tested the proliferation rate of the cell population underneath the cornoid lamella...

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..Although our results are not incompatible with a main role of dendritic cells in FD, at least such a role would be plaid without an increase in the number of dendritic cells...

..The pattern of cytokeratins expressed by our case was positive for AE1-AE3, CAM 5.2, and CK7, without any expression for CK20. Other markers expressed by the tumor were EMA, ER, c-erbB-2, p53, and S-100...

..We also discuss several alternatives that have been given in literature to explain the mechanism of how Imatinib works in DFSP...

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..We present a case of a 72-year-old woman, who had cutaneous vulvar involvement by Langerhans-cell histiocytosis, diagnosed by biopsy. An immunohistochemical study is also described...

..We suggest that imprints of lipomatous tumors may play a complementary role in such a search, and report a case of a 74-yr-old woman with an atypical lipomatous tumor of the left thigh, in which imprints helped to make the diagnosis....

..Biopsies showed chronic inflammation and a non-necrotizing granuloma. An adult pinworm was found in the lumen from an uninvolved segment. The patient responded to mebendazole...

..It also describes Spain in the second half of the nineteenth century. Thus Thomas Hodgkin was a witness to one of the most vivid periods of the history of the country. The paper considers both aspects of Hodgkin's commentaries on Spain...

..Lastly, we see this CD30+ infiltrate as a source of investigation to understand why keratoacanthomas spontaneously regress, instead of progressing to a metastasizing squamous cell carcinoma...

..The biopsy showed the characteristics of a typical HH with moderate iron deposits. Immunohistochemical staining failed to demonstrate either estrogen or progesterone receptors (Fig. 1, Ref. 15). Full Text (Free, PDF) www.bmj.sk...

..Thermalgic information is mainly dependent on small fibres, either myelinated or unmyelinated, and S100 protein is expressed by Schwann cells...

..The ability of BCC to infiltrate would have more to do with the acquisition by the tumour of such a property, rather than with a stage of indifferentiation...

..Both findings strongly support the hypothesis that the inflammatory infiltrate might play a primary role, and that the hyperkeratosis might be a secondary event...

..The lesion was surgically removed and due to the disproportionate post-surgery bleeding, the patient was studied by the Hematology Service, and she was diagnosed as an inhibitor of Factor VIII carrier...

..We conclude that CD30 positive cells might play a role in KA regression (Tab. 2, Fig. 4, Ref. 24)...

..On the other hand, granuloma annulare (GA) has been recently closely associated with infection by Borrelia. We investigated how frequently pseudorosettes can be detected in common GA cases confirmed for Borrelia by PCR...

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..Since the latter has recently been atributted to C5b-9 deposit in the vessel wall, we discuss if both conditions are pathogentically connected or just coincidental (Fig. 3, Ref. 32). Full Text (Free, PDF) www.bmj.sk...

..The cells expressing both markers were mostly found in the top part of the dermis. The multinucleate cells expressed only CD68, but not CD1a...

..Nevertheless, the vessels of the MHs were positive for CD34, CD31, and von Willebrand Factor. This study adds MH to the list of vascular lesions that fail to express the allegedly lymphatic marker podoplanin...

..Since Toker cell (TC) was first described in 1970, many interpretations concerning their origin have been offered in literature. We tried to investigate the histology of Toker cells in horizontal sections of the nipple...

..We conclude that the main point of this study is not to trust the presence of plasma cells as a solid criterion on its own, when evaluating a melanocytic lesion...

..The role of the pathologist has progressed through history from the basic detection of amyloid as a substance to immunophenotypical classification of the particular amyloid present...