Andres Esteban

..This review emphasizes clinical aspects in the evaluation and management of ARDS in the ICUs and updates the latest advances in these therapies...

..We aimed to identify risk factors for a combined end-point of death and/or prolonged ventilator dependence and developed an ALI-specific prediction model...

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..The American-European Consensus Conference definition for the acute respiratory distress syndrome (ARDS) has never been validated...

..To determine the threshold of age that best discriminates the survival of mechanically ventilated patients and to estimate the outcome of mechanically ventilated older patients...

..We conducted a multicenter, randomized trial to evaluate the effect of noninvasive positive-pressure ventilation on mortality in this clinical setting...

..To describe the outcome of patients with sepsis according to location on a ward or in an intensive care unit...

..Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice...

..A new classification of patients based on the duration of liberation of mechanical ventilation has been proposed...

..To assess the factors associated with reintubation in patients who had successfully passed a spontaneous breathing trial...

..To determine whether mechanical ventilation using high tidal volume is associated with nonpulmonary organ dysfunction that can be attenuated by dexamethasone...

..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...

..Peroxynitrite scavenging protects from vascular dysfunction in sepsis...

..Our study suggests that SCr0 greater than 1.40 mg/dL and, in patients with low baseline SCr, a DeltaSCr greater than 0.31 are predictors of in-hospital mortality in mechanically ventilated patients...

..To describe the time course of the changes in pulmonary and vascular function, and systemic inflammation induced by injurious mechanical ventilation...

..Nitro-oxidative stress is involved in sepsis-induced AKI, and protein nitration seems to be one mechanism involved...

..Experimental studies have shown that mechanical ventilation using high tidal volumes (V(T)) damages the lungs, causing pulmonary edema. We tested the hypothesis that high V(T) ventilation in rats induces major vascular dysfunction...

..Admission of older patients to intensive care units is a controversial issue...

..To determine the proportion of clinical errors by comparing clinical and pathological diagnoses, and to evaluate changes of errors over time...

..The main objective of study was to evaluate the outcome of patients who require reintubation after elective extubation...

..Dexamethasone averts mechanical ventilation-induced changes under conditions of bacterial sepsis...

..To test the hypothesis that aging increases the susceptibility to organ dysfunction and systemic inflammation induced by injurious mechanical ventilation...

..To demonstrate that increased formation of reactive oxygen (ROS) and nitrogen species (RNS) is involved in VILI-induced vascular dysfunction...

..This and other management strategies have been evaluated in patients who, fulfilling the clinical criteria of acute respiratory distress syndrome, could not have diffuse alveolar damage...

..The possibility to use autopsy tissue samples, which contain nucleic acids of very poor quality, would open new possibilities for genetic studies...

..The purpose of the study was to describe the clinical characteristics and outcomes of critically ill patients with 2009 influenza A(H1N1)...

..Using clinical criteria the revised Berlin definition for ARDS allowed the identification of severe ARDS of more than 72 hours as a homogeneous group of patients characterized by a high proportion of DAD...

..Treatment with levosimendan in this animal model of sepsis attenuated pulmonary vasoconstriction and improved portal blood flow, intestinal mucosal oxygenation, pulmonary function, and vascular reactivity...

..The best results (decreased need for intubation and decreased mortality) have been reported among patients with exacerbations of chronic obstructive pulmonary disease and cardiogenic pulmonary edema...

..The objective of this study was to analyze the association between candidate gene polymorphisms and susceptibility to acute respiratory distress syndrome (ARDS) in patients with severe sepsis...

..Sensitivity, specificity, and likelihood ratios were calculated by using pathology pattern as criterion standard...

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..The SOFA score is useful to assess organ dysfunction in burn patients. Burn-induced organ dysfunction (early and late), as well as the change in organ dysfunction, is independently associated with mortality...

..Therefore, though in clinical practice this position may improve refractory hypoxemia in patients with ARDS, there is no evidence to support its systematic use...

..Also, this complication (unplanned extubation and reintubation rates) may be used as a marker of quality of weaning care in intensive care units...

..To evaluate the effect of the implementation of a nursing-driven protocol of sedation on duration of intubation...

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..More study is needed to improve the criteria to predict successful spontaneous breathing and extubation, and to clarify the role of non-invasive ventilation to avoid reintubation...

..There is little information regarding the pathophysiology of this illness. Important questions remain regarding this disease, including predisposing factors and management. Patients who require mechanical ventilation have poor outcomes...

..The main determinants of patient outcome were initial severity of illness and the development of shock and/or acute renal failure...

..Also discussed are the myriad causes of ARDS, incidence, epidemiology, mortality, and factors that influence outcome...

..Ventilator-associated pneumonia was associated with a significant increase in ICU length of stay but no increase in mortality...

..Future research must to include study of genetic polymorphisms of the mediators involve in the development of ALI/ARDS. Studies to define better the population at risk are necessary to estimate better their true incidence...