Research Topics
Genomes and Genes | Lluis EspinosaSummaryAffiliation: Hospital del Mar Country: Spain Publications
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Detail Information
Publications
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemiaLluis Espinosa
Cancer Research Program, Institut Municipal d Investigacions Mediques, IMIM, Hospital del Mar, 08003 Barcelona, Spain
Cancer Cell 18:268-81. 2010....
Hematopoietic stem cell development requires transient Wnt/β-catenin activityCristina Ruiz-Herguido
Program in Cancer Research, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
J Exp Med 209:1457-68. 2012..Together, those findings indicate that Wnt/β-catenin activity is needed for the emergence but not the maintenance of HSCs in mouse embryos...
The Notch pathway in the developing hematopoietic systemAnna Bigas
Program in Cancer Research, IMIM Hospital del Mar, Barcelona, Spain
Int J Dev Biol 54:1175-88. 2010..Here, we will review the work from recent years showing how Notch participates in the embryonic development of hematopoiesis in the mouse, but also in other organisms such as chick, zebrafish and flies...
The Notch pathway in hematopoietic stem cellsAnna Bigas
Program in Cancer Research Institut Mar Investigacions Mèdiques IMIM, Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, 08003, Barcelona, Spain
Curr Top Microbiol Immunol 360:1-18. 2012..In the following sections, we will review what is known about the role of Notch in HSC establishment and hematopoietic cell lineage specification...
Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancerJulia Inglés-Esteve
Cancer Research Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain
PLoS ONE 7:e38347. 2012..Our findings identify a genetic signature that is important for breast cancer prognosis and for future personalized treatments based on NF-κB targeting...
