Lluis Espinosa

Summary

Affiliation: Hospital del Mar
Country: Spain

Publications

  1. pmc The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia
    Lluis Espinosa
    Cancer Research Program, Institut Municipal d Investigacions Mediques, IMIM, Hospital del Mar, 08003 Barcelona, Spain
    Cancer Cell 18:268-81. 2010
  2. pmc Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling
    Jordi Guiu
    Program in Cancer Research, Hospital del Mar Medical Research Institute, IMIM, Barcelona Biomedical Research Park, 08003 Barcelona, Spain
    J Exp Med 210:71-84. 2013
  3. doi request reprint The Notch pathway in hematopoietic stem cells
    Anna Bigas
    Program in Cancer Research Institut Mar Investigacions Mèdiques IMIM, Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, 08003, Barcelona, Spain
    Curr Top Microbiol Immunol 360:1-18. 2012
  4. pmc Hematopoietic stem cell development requires transient Wnt/β-catenin activity
    Cristina Ruiz-Herguido
    Program in Cancer Research, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    J Exp Med 209:1457-68. 2012
  5. doi request reprint The Notch pathway in the developing hematopoietic system
    Anna Bigas
    Program in Cancer Research, IMIM Hospital del Mar, Barcelona, Spain
    Int J Dev Biol 54:1175-88. 2010
  6. pmc Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer
    Alba Dalmases
    Cancer Research Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain
    Oncotarget 5:196-210. 2014
  7. doi request reprint A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
    Pol Margalef
    Institut Municipal d Investigacions Mediques, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, Barcelona 08003, Spain
    Cell Rep 2:840-54. 2012
  8. pmc Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer
    Julia Inglés-Esteve
    Cancer Research Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain
    PLoS ONE 7:e38347. 2012

Collaborators

Detail Information

Publications9

  1. pmc The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia
    Lluis Espinosa
    Cancer Research Program, Institut Municipal d Investigacions Mediques, IMIM, Hospital del Mar, 08003 Barcelona, Spain
    Cancer Cell 18:268-81. 2010
    ....
  2. pmc Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling
    Jordi Guiu
    Program in Cancer Research, Hospital del Mar Medical Research Institute, IMIM, Barcelona Biomedical Research Park, 08003 Barcelona, Spain
    J Exp Med 210:71-84. 2013
    ....
  3. doi request reprint The Notch pathway in hematopoietic stem cells
    Anna Bigas
    Program in Cancer Research Institut Mar Investigacions Mèdiques IMIM, Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, 08003, Barcelona, Spain
    Curr Top Microbiol Immunol 360:1-18. 2012
    ..In the following sections, we will review what is known about the role of Notch in HSC establishment and hematopoietic cell lineage specification...
  4. pmc Hematopoietic stem cell development requires transient Wnt/β-catenin activity
    Cristina Ruiz-Herguido
    Program in Cancer Research, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    J Exp Med 209:1457-68. 2012
    ..Together, those findings indicate that Wnt/β-catenin activity is needed for the emergence but not the maintenance of HSCs in mouse embryos...
  5. doi request reprint The Notch pathway in the developing hematopoietic system
    Anna Bigas
    Program in Cancer Research, IMIM Hospital del Mar, Barcelona, Spain
    Int J Dev Biol 54:1175-88. 2010
    ..Here, we will review the work from recent years showing how Notch participates in the embryonic development of hematopoiesis in the mouse, but also in other organisms such as chick, zebrafish and flies...
  6. pmc Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer
    Alba Dalmases
    Cancer Research Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain
    Oncotarget 5:196-210. 2014
    ..This study supports that p53 deficiency is necessary for a doxorubicin driven NF-кB-response that limits doxorubicin cytotoxicity in breast cancer and is linked to an aggressive clinical behavior...
  7. doi request reprint A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
    Pol Margalef
    Institut Municipal d Investigacions Mediques, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, Barcelona 08003, Spain
    Cell Rep 2:840-54. 2012
    ..Our findings identify a potentially druggable target for treating patients with advance refractory CRC...
  8. pmc Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer
    Julia Inglés-Esteve
    Cancer Research Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain
    PLoS ONE 7:e38347. 2012
    ..Our findings identify a genetic signature that is important for breast cancer prognosis and for future personalized treatments based on NF-κB targeting...