Research Topics
Genomes and GenesSpecies | Blanca EspinetSummaryAffiliation: Hospital del Mar Country: Spain Publications
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Publications
Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a familyBlanca Espinet
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Cancer Genet Cytogenet 143:172-3. 2003....
Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphomaBlanca Espinet
Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Servei d Hematologia Clinica, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
Genes Chromosomes Cancer 49:439-51. 2010..Additionally, we observed that 3q gains and 17p losses detected by conventional cytogenetics are proliferation-independent prognostic markers indicating poor outcome...- Genetic characterization of Sézary's syndrome by conventional cytogenetics and cross-species color banding fluorescent in situhybridizationBlanca Espinet
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, E 08003 Barcelona, Spain
Haematologica 89:165-73. 2004..Cytogenetic studies are scarce. This study was designed to increase cytogenetic information on this disorder... - FISH is better than BIOMED-2 PCR to detect IgH/BCL2 translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sectionsBlanca Espinet
Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Hospital del Mar, IMAS, URNHE, PRBB, Escola de Citologia Hematològica Soledad Woessner IMAS, Barcelona, Spain
Leuk Res 32:737-42. 2008..In 4% of cases, the IgH/BCL2 translocation was not detected by any of the two techniques tested. Our results show that FISH represents the best technique to detect t(14;18) at diagnosis... - Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma?Blanca Espinet
Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Laboratori de Citologia Hematologica, Laboratori de Patologia, Hospital del Mar, IMAS, URNHE, PRBB, Barcelona 08003, Spain
Hum Pathol 36:1232-7. 2005..The existence of such asymptomatic patients with an indolent clinical course should induce a strict clinical judgment in terms of therapeutic decisions... - Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemiaOlaya Villa
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia Hospital del Mar, URNHE, URTTS, PRBB IMIM, Pg Maritim 25 29, 08003 Barcelona, Spain
Cancer Genet Cytogenet 185:32-6. 2008..The appearance of chromatin extrusion in cytological analysis should draw attention of the presence of dmin aggregation and possible MYC amplification... - 3q26 (hTERC) gain studied by fluorescence in situ hybridization as a persistence-progression indicator in low-grade squamous intraepithelial lesion casesFrancesc Alameda
Department of Pathology and Laboratory of Molecular Cytogenetics, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
Hum Pathol 40:1474-8. 2009.... - FOXP1 status in splenic marginal zone lymphoma: a fluorescence in situ hybridization and immunohistochemistry approachCristina Baro
Dept Biologia Animal, Vegetal i Ecologia Unitat d Antropologia Biològica Facultat de Biociències Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Histol Histopathol 24:1399-404. 2009..FOXP1 protein expression seemed to be not related to any aberration and IHC studies are not conclusive... - Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinomaMarta Salido
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, Barcelona 08003, Spain
Cancer Genet Cytogenet 163:160-3. 2005..FISH techniques on paraffin tissue sections may help to identify genetic aberrations such as CCND1 rearrangement in order to establish a diagnosis of oncocytoma... - Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniquesItziar Salaverria
Department of Pathology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Genes Chromosomes Cancer 47:1086-97. 2008..Furthermore, most MCL harbor complex karyotypes with a high number of both structural and numerical alterations affecting several common breakpoints, leading to various balanced and unbalanced translocations... - Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarraysCarlota Costa
Pathology Department, Cytogenetic and Molecular Biology Laboratory, Citology Section, Mar Hospital, IMAS, Barcelona, Spain
Histol Histopathol 24:821-9. 2009..With regards to proteins, the expression of MYC and CCND1 in the initial stages of the illness would help in the acquisition of the altered cellular phenotype... - CKS1B amplification is a frequent event in cutaneous squamous cell carcinoma with aggressive clinical behaviourRocio Salgado
Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
Genes Chromosomes Cancer 49:1054-61. 2010..cSCC [3/39]) (P < 0.001). Several drugs targeting CKS1B have been reported and may be useful for treating patients with cSCC and CKS1B amplifications... - Absence of TCR loci chromosomal translocations in cutaneous T-cell lymphomasRocio Salgado
Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Hospital del Mar Parc de Salut Mar, IMIM Institut de Recerca de l Hospital del Mar, Programa de Recerca en Càncer, GRETNHE, Barcelona, Spain
Cancer Genet 204:405-9. 2011..TCR loci rearrangements are not frequent in CTCLs; however, we cannot exclude a pathogenic role in these malignancies... - Aberrant nuclear BCL10 expression and lack of t(11;18)(q21;q21) in primary cutaneous marginal zone B-cell lymphomaFernando Gallardo
Department of Dermatology, Hospital del Mar, IMAS, Barcelona, Spain Catalonian Cutaneous Lymphoma Network, Barcelona, Spain
Hum Pathol 37:867-73. 2006..t(11;18)(q21;q21), strongly linked to extracutaneous MALT lymphomas, does not seem to play a role in PCMZL. The participation of other MALT1 gene translocations in PCMZL pathogenesis seems also unlikely... - FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-typeBlanca Espinet
Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, IMIM Hospital del Mar, GRETNHE, IMIM Barcelona, Spain
Histol Histopathol 26:213-21. 2011..Mechanisms not related to translocation seem to be responsible for this overexpression... - Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?Ana Belén Galván
Laboratori de Citogenètica Molecular Servei de Patologia, Parc Salut Mar GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
Leuk Res 34:1242-5. 2010..7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification... - Are ER+PR+ and ER+PR- breast tumors genetically different? A CGH array studyAlma Carracedo
Pathology Service, Molecular Cytogenetics Laboratory, Hospital del Mar, IMIM, Barcelona, Spain
Cancer Genet 205:138-46. 2012..Amplification of these genes could contribute to resistance to apoptosis, increased activation of the PI3K/Akt/mTOR pathway, and the loss of PR in at least some ER+PR- tumors... - Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemiaElisabet Lloveras
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
Cancer Genet Cytogenet 148:71-6. 2004..Although these results do not confirm our previous hypothesis, further observations of this group of patients (with monosomy 18) regarding malignant transformation is warranted... - Cytogenetic characterization of NCI-H69 and NCI-H69AR small cell lung cancer cell lines by spectral karyotypingMarta Salido
Pathology Department, Molecular Cytogenetic Laboratory, IMAS, GRETNHE Escola de Citologia Hematologica S Woessner IMAS, Barcelona, Spain
Cancer Genet Cytogenet 191:97-101. 2009..In conclusion, SKY provides a useful complementary technique to routine cytogenetics for the accurate characterization of SCLC cell lines and could provide some relevant information concerning regions involved in chemoresistance... - Contribution of cytogenetics and in situ hybridization to the study of monoclonal gammopathies of undetermined significanceElisabet Lloveras
Laboratori de Citologia Hematologica, Laboratori de Referència de Catalunya, Departament de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Cancer Genet Cytogenet 132:25-9. 2002..Prospective follow-up is needed to evaluate the clinical value of monosomy 18 as a predictive factor for defining a high risk of malignant transformation in MGUS patients... - Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphomaCristina Baro
Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Parc de Salut Mar, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
Leuk Res 35:256-9. 2011..According to our results, FISH is the best technique to define variant rearrangements of IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL... - A multicolor fluorescence in situ hybridization assay: A monitoring tool in the surveillance of patients with a history of non-muscle-invasive urothelial cell carcinoma: A prospective studyAna B Galván
Molecular Cytogenetics Laboratory, Department of Pathology, Hospital del Mar Research Institute, Barcelona, Spain
Cancer Cytopathol 119:395-403. 2011..The aim of the current study was to compare a multicolor fluorescence in situ hybridization (FISH) assay (UroVysion) with routine follow-up (cystoscopy and cytology) in the monitoring of patients with a previous history of NMIUCC... - Comparative analysis of TCR-gamma gene rearrangements by Genescan and polyacrylamide gel-electrophoresis in cutaneous T-cell lymphomaCarlota Costa
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Acta Derm Venereol 84:6-11. 2004..On sequencing the PCR products we demonstrated non-clonality of these five samples. Our results confirm that PCR-Genescan is a useful, reliable and specific screening method for detecting dominant clones in patients with T-cell lymphoma... - Is fluorescence in situ hybridization a useful method in diagnosis of polycythemia vera patients?Lurdes Zamora
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, Barcelona 08003, Spain
Cancer Genet Cytogenet 151:139-45. 2004..3%. We conclude that, probably, the application of FISH with the mentioned probes, is not very useful to detect cytogenetic aberrations in untreated PV patients... - Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-Mar Mallo
Laboratori de, Citogenètica i Biologia Molecular, Servei de Patologia, IMAS, GRETNHE, IMIM Hospital del Mar, Barcelona
Haematologica 93:1001-8. 2008.... - Gain of multiple copies of the CBFB gene: a new genetic aberration in a case of granulocytic sarcomaMar Mallo
Laboratory of Cytogenetics and Molecular Biology and Laboratory of Hematological Cytology URNHE IMAS IMIM and URTTS IMAS IMIM, Pathology Service, Hospital del Mar, Passeig Maritim, 25 29, 08003 Barcelona, Spain
Cancer Genet Cytogenet 179:62-5. 2007..To our knowledge, no cases with this rare genetic anomaly have been previously described... - Pentasomy 21 with two isochromosomes 21 in a case of acute myeloid leukemia without maturationMarta Salido
Laboratori de Citologia Hematologica, Escola de Citologia Hematològica S Woessner IMAS, Hospital del Mar, IMAS, IMIM, Barcelona, Spain
Cancer Genet Cytogenet 132:71-3. 2002..To our knowledge, this is the first report of pentasomy 21q in AML without Down syndrome... - Monosomy 15 in chronic myelomonocytic leukemia. description of a case and review of the literatureLourdes Zamora
Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, Pg Marítim, 25 29, 08003, Barcelona, Spain
Cancer Genet Cytogenet 134:165-7. 2002..On the other hand, monosomy 15 in complex karyotypes is a frequent chromosome aberration in myelodysplastic syndromes, particularly in refractory anemia with excess of blasts... - Genetic characterization of the paraimmunoblastic variant of small lymphocytic lymphoma/chronic lymphocytic leukemia: A case report and review of the literatureBlanca Espinet
, Departament de Patologia, , Barcelona, Spain
Hum Pathol 33:1145-8. 2002..A literature review shows only 20 previously reported cases, 6 of which involve genetic studies... - Comparative genomic hybridization analysis of cutaneous large B-cell lymphomasSonia Giménez
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Unitat de Recerca en Neoplàsies Hematològiques, PRBB, Barcelona, Spain
Exp Dermatol 14:883-90. 2005..Our study seems to confirm clear-cut differences between primary cutaneous LBCL and nodal diffuse LBCL, and it suggests the presence of genotypic differences between cases of PCLBCL leg type and cases of PCFCL... - Molecular diagnosis of dermatofibrosarcoma protuberans: a comparison between reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization methodologiesRocio Salgado
Laboratori de Citogenètica Molecular, Servei de Patologia, GRETNHE, Programa de Recerca en Càncer, IMIM Institut de Recerca del Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
Genes Chromosomes Cancer 50:510-7. 2011.... - Oligonucleotide array-CGH identifies genomic subgroups and prognostic markers for tumor stage mycosis fungoidesRocio Salgado
Laboratori de Citogenètica Molecular, Servei de Patologia, IMIM Hospital del Mar, Barcelona, Spain
J Invest Dermatol 130:1126-35. 2010..3 (CDKN2A, CDKN2B, and MTAP) and 10q26qter (MGMT and EBF3) may have an important role in prognosis. In addition, we describe the MFt genomic instability profile, which, to our knowledge, has not been reported earlier... - Identification of t(17;22)(q22;q13) (COL1A1/PDGFB) in dermatofibrosarcoma protuberans by fluorescence in situ hybridization in paraffin-embedded tissue microarraysSonia Segura
Department of Dermatology, Hospital del Mar, Universitat Autonoma de Barcelona, E 08003 Barcelona, Spain
Hum Pathol 42:176-84. 2011..The detection of the translocation may be an additional diagnostic tool in cases of dermatofibrosarcoma protuberans showing nonconclusive histologic features... - A new case of acute nonlymphocytic leukemia (French-American-British subtype M1) with double minutes and c-MYC amplificationNatalia Rodon
Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Cancer Genet Cytogenet 132:161-4. 2002..A review of dmins in ANLL is presented... 
Polysomy of chromosome 17 in breast cancer tumors showing an overexpression of ERBB2: a study of 175 cases using fluorescence in situ hybridization and immunohistochemistryMarta Salido
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Breast Cancer Res 7:R267-73. 2005....- Study of chromosomal abnormalities in 11 cases of cervical dysplasia using comparative genomic hybridization on cotton-lint cervical samplesCarlota Costa
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
Cancer Genet Cytogenet 164:61-5. 2006..In the laboratory, the manipulation of this type of sample obtained by a noninvasive system is much simpler, easier, and faster than the obtained with a conventional biopsy... - Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma GroupMarta Salido
Hospital del Mar, IMAS, Barcelona, Spain
Blood 116:1479-88. 2010..Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL... - Correlation between histologic findings and cytogenetic abnormalities in bladder carcinoma: a FISH studyJose Placer
Department of Urology, Laboratory of Cytogenetics and Molecular Biology, Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain
Urology 65:913-8. 2005..To investigate the chromosomal abnormalities present in bladder carcinoma using a fluorescence in situ hybridization assay and to correlate the genetic findings with the pathologic grade and stage... - Prospective study of clinical and biological prognostic factors at diagnosis in patients with early stage B-cell chronic lymphocytic leukemiaAna C Oliveira
Servei d Hematologia Clinica, Institut Catala d Oncologia, Hospital Duran i Reynals, IDIBELL, Hospitalet, Barcelona, Spain
Leuk Lymphoma 52:429-35. 2011..2, 95% CI 1.1-9.3, p = 0.03) and 17p- (OR 3.5, 95% CI 0.95-13.1, p = 0.05) correlated with worse PFS. A longer follow-up is necessary to analyze the prognostic value of these variables regarding overall survival... - Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemiaEulàlia Puigdecanet
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
Cancer Genet Cytogenet 167:39-42. 2006..Our results suggest a lack of structural and numerical rearrangements (deletions, translocations, or amplifications) of PRV-1, TPO, and c-MPL genes in ET patients... - MYC Copy Number Gains are Associated with Poor Outcome in Penile Squamous Cell CarcinomaEmili Masferrer
Servei de Dermatologia, Facultat de Medicina, Universitat de Barcelona, Hospital del Mar, Parc de Salut Mar, Institut Hospital del Mar d Investigacions Mèdiques, Barcelona, Spain Universitat Autònoma de Barcelona, Barcelona, Spain Electronic address
J Urol 188:1965-71. 2012..We determined MYC gene numerical aberrations and protein expression at different stages of penile squamous cell carcinoma carcinogenesis. We correlated these findings with clinicopathological parameters and HPV infection... - Chimeric BCR/ABL gene detected by fluorescence in situ hybridization in three new cases of Philadelphia chromosome-negative chronic myelocytic leukemiaDolors Costa
Unitat Hematopatologia, Hospital del Mar, Barcelona, Spain
Cancer Genet Cytogenet 141:114-9. 2003..In conclusion, in cases of Ph- CML, FISH studies are of paramount importance since they can detect chromosomal reorganization and its location, and can also provide quantitative follow-up of these patients... - Identification of male cardiomyocytes of extracardiac origin in the hearts of women with male progeny: male fetal cell microchimerism of the heartAntoni Bayes-Genis
Servei de Cardiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
J Heart Lung Transplant 24:2179-83. 2005..Whether extracardiac fetal progenitors are present in the heart of women with male issue is unknown... - Methotrexate resistance in vitro is achieved by a dynamic selectionprocess of tumor cell variants emerging during treatmentJosep M de Anta
Unitat de Biologia Cellular i Molecular, , Barcelona, Spain
Int J Cancer 119:1607-15. 2006..Therefore, this model provides a mechanism by which a tumor cell population lacking resistant subpopulations before treatment is able to acquire the genetic changes required for stable drug resistance... - [Persistent polyclonal B-cell lymphocytosis: study of 35 cases]Lourdes Florensa
Laboratori de Citologia Hematologica, Servei de Patologia, Hospital del Mar, Barcelona, Espana
Med Clin (Barc) 136:565-73. 2011..To date, it has not been elucidated whether this is a benign or premalignant disorder. We analyzed the PPBL characteristics with especial attention to its evolution... - Increased MLL gene rearrangements in amniocytes from fetuses of mothers who smokeRosa Ana de la Chica
Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Leuk Res 35:1066-9. 2011..Epidemiologic studies, including a large series of patients, will be needed to determine whether the offspring of parents who smoke have an increased lifetime risk of leukemia... - CDC28 protein kinase regulatory subunit 1B (CKS1B) expression and genetic status analysis in oral squamous cell carcinomaGemma Martin-Ezquerra
Department of Medicine and Dermatology, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
Histol Histopathol 26:71-7. 2011..This phenotypical and cytogenetic profile is not observed in premalignant or inflammatory oral mucosal lesions... - Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromesFrancesc Sole
Laboratori de Citogenètica i Biologia Molecular, Hospital del Mar IMAS, 08003 Barcelona, Spain
Haematologica 90:1168-78. 2005..The main aim of the present study was to identify chromosomal abnormalities with a previously unrecognized good or poor prognosis in order to find new cytogenetic markers with predictive value... - Gastrointestinal involvement in mantle cell lymphoma: a prospective clinic, endoscopic, and pathologic studyAntonio Salar
Department of Clinical Hematology, Hospital del Mar, Barcelona, Spain
Am J Surg Pathol 30:1274-80. 2006..IHC for cyclin D1 was significantly more sensitive than FISH t(11;14) or PCR for immunoglobulin heavy chain gene to confirm MCL in this setting... - New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)Cristina Baro
Department Biologia Animal, Vegetal i Ecologia, Unitat d Antropologia Biològica, Facultat de Biociencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
Leuk Res 32:727-36. 2008..Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected... - Is the gain of 9p involved in the pathogenesis of polycythemia vera? A purpose of a caseLurdes Zamora
Departament de Citogenètica, General Lab, Laboratoris d Anàlisis, C Londres, 45, 08036 Barcelona, Spain
Haematologica 87:ECR05. 2002 - Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: does -7/7q- detection by FISH have prognostic value?Vera Ademà
Institut de Recerca Contra la Leucèmia Josep Carreras, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
Leuk Res 37:416-21. 2013..Our results suggest that FISH 7q could be beneficial in patients with intermediate WHO morphologic risk stratification and no evidence of -7/7q- by CC... - Chronic lymphocytic leukaemia with 17p deletion: a retrospective analysis of prognostic factors and therapy resultsJulio Delgado
Hospital Clinic, IDIBAPSHospital Sant PauHospital del MarHospital Duran i ReynalsHospital Vall d Hebron, BarcelonaHospital 12 de Octubre, MadridHospital General, ValenciaHospital La PrincesaHospital Principe de AsturiasHospital Infanta Leonor, MadridHospital Germans Trias i Pujol, BadalonaHospital Central de Asturias, OviedoHospital Josep Trueta, GironaHospital Clinico, Salamanca, Spain
Br J Haematol 157:67-74. 2012.... - Clinical utility of a multiprobe FISH assay in voided urine specimens for the detection of bladder cancer and its recurrences, compared with urinary cytologyJose Placer
Department of Urology, Hospital del Mar, IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
Eur Urol 42:547-52. 2002.... - Mycosis fungoides and Sézary syndromeBlanca Espinet
Molecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar, Barcelona, Spain
Methods Mol Biol 973:175-88. 2013..Moreover, two MF genomic subgroups have been described, distinguishing a stable group (0-5 DNA aberrations) and an unstable group (>5 DNA aberrations), showing that the genomic unstable group had a shorter overall survival (P = 0.05)... - Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-hodgkin lymphomasAntonio Martinez
Hematopathology and Hematology Department, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
Am J Surg Pathol 36:296-304. 2012..8 years. In conclusion, PBML is a very uncommon lymphoma with particular clinical features and heterogenous histology. Its recognition is important to establish accurate diagnosis and adequate therapy... - Epidermal growth factor receptor gene numerical aberrations are frequent events in actinic keratoses and invasive cutaneous squamous cell carcinomasAgusti Toll
Exp Dermatol 19:151-3. 2010..Our results suggest that EGFR numerical aberrations occur in the early stages of epithelial carcinogenesis in skin, not playing a role in the progression from low-grade SCCs into more aggressive phenotypes... - Collection of Philadelphia-negative stem cells using recombinant human granulocyte colony-stimulating factor in chronic myeloid leukemia patients treated with alpha-interferonJuan Carlos Hernández-Boluda
BMT Unit, Institute of Hematology and Oncology, Department of Hematology, Hospital del Mar, Villaroel 170, 08036 Barcelona, Spain
Haematologica 87:17-22. 2002..The results of using recombinant human granulocyte colony-stimulating factor (rHuG-CSF) for harvesting hematopoietic progenitors in CML patients treated with interferon-a (IFN) are reported... - Absence of MALT1 translocations in primary cutaneous marginal zone B-cell lymphomaBlanca Espinet
Haematologica 89:ELT14. 2004..We examined the presence of MALT1 translocations in a series of 23 PCMZL. FISH assay with a MALT1 dual color break apart translocation probe revealed the absence of MALT1 translocations in all cases... - Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genesAna Ferrer
Department of Hematology, Hematopathology Unit, , , University of Barcelona, Spain
Oncogene 23:8941-9. 2004..These results support that mitoxantrone can be effective in the treatment of MCL but that this activity requires the integrity of functional DNA-damage response genes... - MLL intrachromosomal amplification in a pre-B acute lymphoblastic leukemiaBlanca Espinet
, Spain
Haematologica 88:EIM03. 2003 - Translocation (5;17)(q13;q21) in a case with precursor T-lymphoblastic lymphoma/leukemiaLourdes Zamora
Cancer Genet Cytogenet 132:81-2. 2002 - RxFISH karyotype and MYC amplification in the HT-29 colon adenocarcinoma cell lineCristina Corzo
Genes Chromosomes Cancer 36:425-6. 2003 - Analysis of T-cell receptor gamma gene rearrangements by PCR-Genescan and PCR-polyacrylamide gel electrophoresis in early-stage mycosis fungoides/large-plaque parapsoriasisCarlota Costa
Dermatology 207:418-9. 2003 - Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL)Marta Salido
Haematologica 88:ELT33. 2003..No deletions were detected in any of the 16 cases. ATM deletions could be considered a rare event in SMZBCL... - Incidence of trisomy 8 and 9, deletion of D13S319 and D20S108 loci and BCR/ABL translocation in non-treated essential thrombocythemia patients: an analysis of bone marrow cells using interphase fluorescence in situ hybridizationLurdes Zamora
Haematologica 88:110-1. 2003 - Endogenous erythroid and megakaryocytic circulating progenitors, HUMARA clonality assay, and PRV-1 expression are useful tools for diagnosis of polycythemia vera and essential thrombocythemiaLourdes Florensa
Blood 103:2427-8. 2004 - Could ATRA/Idarubicin treatment of acute promyelocytic leukemia induce the appearance of new clonal cytogenetic abnormalities in patients in complete remission?Mar Mallo
Leuk Res 31:1315-7. 2007 - Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia-positive chronic myeloid leukemia: two cases with a different outcomeJosé Tomás Navarro
Servei d Hematologia, Institut Catala d Oncologia, Hospital Germans Trias i Pujol, Badalona, Barcelona
Am J Hematol 82:849-51. 2007.... - Additional i(1)(q10) in a primitive neuroectodermal tumor type Merkel cell carcinoma as a primary cytogenetic changeCristina Corzo
Cancer Genet Cytogenet 142:165-7. 2003 - Report of 46,XX/46,XY/47,XXY/48,XXYY mosaicism in an adult phenotypic maleLurdes Zamora
Am J Med Genet 111:215-7. 2002 - A new translocation t(11;13)(q13;q14) in a mature B-cell neoplasmFrancesc Sole
Haematologica 87:777-8. 2002..To our knowledge, this is the first reported case with this novel cytogenetic aberration... - Clonality analysis by HUMARA assay in Spanish females with essential thrombocythemia and polycythemia veraLurdes Zamora
Haematologica 90:259-61. 2005..The X-chromosome inactivation pattern was analyzed by HUMARA-polymerase chain reaction on DNA from purified granulocytes, T lymphocytes and the CD3- fraction of mononuclear cells... - Clonal cytogenetic abnormalities in patients with chronic myeloid leukemia in complete cytogenetic response to imatinib mesylateBlanca Espinet
Haematologica 90:556-8. 2005..We add information to this issue presenting a series of 29 patients in complete cytogenetic response after imatinib treatment, three of whom developed clonal aberrations...