Blanca Espinet

Summary

Affiliation: Hospital del Mar
Country: Spain

Publications

  1. ncbi request reprint Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Cancer Genet Cytogenet 143:172-3. 2003
  2. ncbi request reprint Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma?
    Blanca Espinet
    Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Laboratori de Citologia Hematologica, Laboratori de Patologia, Hospital del Mar, IMAS, URNHE, PRBB, Barcelona 08003, Spain
    Hum Pathol 36:1232-7. 2005
  3. ncbi request reprint Genetic characterization of Sézary's syndrome by conventional cytogenetics and cross-species color banding fluorescent in situhybridization
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, E 08003 Barcelona, Spain
    Haematologica 89:165-73. 2004
  4. ncbi request reprint FISH is better than BIOMED-2 PCR to detect IgH/BCL2 translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sections
    Blanca Espinet
    Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Hospital del Mar, IMAS, URNHE, PRBB, Escola de Citologia Hematològica Soledad Woessner IMAS, Barcelona, Spain
    Leuk Res 32:737-42. 2008
  5. doi request reprint Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma
    Blanca Espinet
    Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Servei d Hematologia Clinica, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
    Genes Chromosomes Cancer 49:439-51. 2010
  6. doi request reprint Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemia
    Olaya Villa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia Hospital del Mar, URNHE, URTTS, PRBB IMIM, Pg Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 185:32-6. 2008
  7. doi request reprint 3q26 (hTERC) gain studied by fluorescence in situ hybridization as a persistence-progression indicator in low-grade squamous intraepithelial lesion cases
    Francesc Alameda
    Department of Pathology and Laboratory of Molecular Cytogenetics, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
    Hum Pathol 40:1474-8. 2009
  8. ncbi request reprint FOXP1 status in splenic marginal zone lymphoma: a fluorescence in situ hybridization and immunohistochemistry approach
    Cristina Baro
    Dept Biologia Animal, Vegetal i Ecologia Unitat d Antropologia Biològica Facultat de Biociències Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
    Histol Histopathol 24:1399-404. 2009
  9. ncbi request reprint Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarrays
    Carlota Costa
    Pathology Department, Cytogenetic and Molecular Biology Laboratory, Citology Section, Mar Hospital, IMAS, Barcelona, Spain
    Histol Histopathol 24:821-9. 2009
  10. ncbi request reprint Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma
    Marta Salido
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, Barcelona 08003, Spain
    Cancer Genet Cytogenet 163:160-3. 2005

Detail Information

Publications76

  1. ncbi request reprint Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Cancer Genet Cytogenet 143:172-3. 2003
    ....
  2. ncbi request reprint Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma?
    Blanca Espinet
    Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Laboratori de Citologia Hematologica, Laboratori de Patologia, Hospital del Mar, IMAS, URNHE, PRBB, Barcelona 08003, Spain
    Hum Pathol 36:1232-7. 2005
    ..The existence of such asymptomatic patients with an indolent clinical course should induce a strict clinical judgment in terms of therapeutic decisions...
  3. ncbi request reprint Genetic characterization of Sézary's syndrome by conventional cytogenetics and cross-species color banding fluorescent in situhybridization
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, E 08003 Barcelona, Spain
    Haematologica 89:165-73. 2004
    ..Cytogenetic studies are scarce. This study was designed to increase cytogenetic information on this disorder...
  4. ncbi request reprint FISH is better than BIOMED-2 PCR to detect IgH/BCL2 translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sections
    Blanca Espinet
    Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Hospital del Mar, IMAS, URNHE, PRBB, Escola de Citologia Hematològica Soledad Woessner IMAS, Barcelona, Spain
    Leuk Res 32:737-42. 2008
    ..In 4% of cases, the IgH/BCL2 translocation was not detected by any of the two techniques tested. Our results show that FISH represents the best technique to detect t(14;18) at diagnosis...
  5. doi request reprint Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma
    Blanca Espinet
    Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Servei d Hematologia Clinica, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
    Genes Chromosomes Cancer 49:439-51. 2010
    ..Additionally, we observed that 3q gains and 17p losses detected by conventional cytogenetics are proliferation-independent prognostic markers indicating poor outcome...
  6. doi request reprint Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemia
    Olaya Villa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia Hospital del Mar, URNHE, URTTS, PRBB IMIM, Pg Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 185:32-6. 2008
    ..The appearance of chromatin extrusion in cytological analysis should draw attention of the presence of dmin aggregation and possible MYC amplification...
  7. doi request reprint 3q26 (hTERC) gain studied by fluorescence in situ hybridization as a persistence-progression indicator in low-grade squamous intraepithelial lesion cases
    Francesc Alameda
    Department of Pathology and Laboratory of Molecular Cytogenetics, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
    Hum Pathol 40:1474-8. 2009
    ....
  8. ncbi request reprint FOXP1 status in splenic marginal zone lymphoma: a fluorescence in situ hybridization and immunohistochemistry approach
    Cristina Baro
    Dept Biologia Animal, Vegetal i Ecologia Unitat d Antropologia Biològica Facultat de Biociències Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
    Histol Histopathol 24:1399-404. 2009
    ..FOXP1 protein expression seemed to be not related to any aberration and IHC studies are not conclusive...
  9. ncbi request reprint Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarrays
    Carlota Costa
    Pathology Department, Cytogenetic and Molecular Biology Laboratory, Citology Section, Mar Hospital, IMAS, Barcelona, Spain
    Histol Histopathol 24:821-9. 2009
    ..With regards to proteins, the expression of MYC and CCND1 in the initial stages of the illness would help in the acquisition of the altered cellular phenotype...
  10. ncbi request reprint Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma
    Marta Salido
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, Barcelona 08003, Spain
    Cancer Genet Cytogenet 163:160-3. 2005
    ..FISH techniques on paraffin tissue sections may help to identify genetic aberrations such as CCND1 rearrangement in order to establish a diagnosis of oncocytoma...
  11. doi request reprint Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques
    Itziar Salaverria
    Department of Pathology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Genes Chromosomes Cancer 47:1086-97. 2008
    ..Furthermore, most MCL harbor complex karyotypes with a high number of both structural and numerical alterations affecting several common breakpoints, leading to various balanced and unbalanced translocations...
  12. ncbi request reprint Aberrant nuclear BCL10 expression and lack of t(11;18)(q21;q21) in primary cutaneous marginal zone B-cell lymphoma
    Fernando Gallardo
    Department of Dermatology, Hospital del Mar, IMAS, Barcelona, Spain Catalonian Cutaneous Lymphoma Network, Barcelona, Spain
    Hum Pathol 37:867-73. 2006
    ..t(11;18)(q21;q21), strongly linked to extracutaneous MALT lymphomas, does not seem to play a role in PCMZL. The participation of other MALT1 gene translocations in PCMZL pathogenesis seems also unlikely...
  13. doi request reprint CKS1B amplification is a frequent event in cutaneous squamous cell carcinoma with aggressive clinical behaviour
    Rocio Salgado
    Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
    Genes Chromosomes Cancer 49:1054-61. 2010
    ..cSCC [3/39]) (P < 0.001). Several drugs targeting CKS1B have been reported and may be useful for treating patients with cSCC and CKS1B amplifications...
  14. doi request reprint Absence of TCR loci chromosomal translocations in cutaneous T-cell lymphomas
    Rocio Salgado
    Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Hospital del Mar Parc de Salut Mar, IMIM Institut de Recerca de l Hospital del Mar, Programa de Recerca en Càncer, GRETNHE, Barcelona, Spain
    Cancer Genet 204:405-9. 2011
    ..TCR loci rearrangements are not frequent in CTCLs; however, we cannot exclude a pathogenic role in these malignancies...
  15. ncbi request reprint Comparative genomic hybridization analysis of cutaneous large B-cell lymphomas
    Sonia Giménez
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Unitat de Recerca en Neoplàsies Hematològiques, PRBB, Barcelona, Spain
    Exp Dermatol 14:883-90. 2005
    ..Our study seems to confirm clear-cut differences between primary cutaneous LBCL and nodal diffuse LBCL, and it suggests the presence of genotypic differences between cases of PCLBCL leg type and cases of PCFCL...
  16. ncbi request reprint Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemia
    Elisabet Lloveras
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 148:71-6. 2004
    ..Although these results do not confirm our previous hypothesis, further observations of this group of patients (with monosomy 18) regarding malignant transformation is warranted...
  17. doi request reprint Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?
    Ana Belén Galván
    Laboratori de Citogenètica Molecular Servei de Patologia, Parc Salut Mar GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
    Leuk Res 34:1242-5. 2010
    ..7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification...
  18. ncbi request reprint FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type
    Blanca Espinet
    Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, IMIM Hospital del Mar, GRETNHE, IMIM Barcelona, Spain
    Histol Histopathol 26:213-21. 2011
    ..Mechanisms not related to translocation seem to be responsible for this overexpression...
  19. ncbi request reprint Pentasomy 21 with two isochromosomes 21 in a case of acute myeloid leukemia without maturation
    Marta Salido
    Laboratori de Citologia Hematologica, Escola de Citologia Hematològica S Woessner IMAS, Hospital del Mar, IMAS, IMIM, Barcelona, Spain
    Cancer Genet Cytogenet 132:71-3. 2002
    ..To our knowledge, this is the first report of pentasomy 21q in AML without Down syndrome...
  20. ncbi request reprint Genetic characterization of the paraimmunoblastic variant of small lymphocytic lymphoma/chronic lymphocytic leukemia: A case report and review of the literature
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Escola de Citologia Hematològica Soledad Woessner IMAS, Barcelona, Spain
    Hum Pathol 33:1145-8. 2002
    ..A literature review shows only 20 previously reported cases, 6 of which involve genetic studies...
  21. ncbi request reprint Gain of multiple copies of the CBFB gene: a new genetic aberration in a case of granulocytic sarcoma
    Mar Mallo
    Laboratory of Cytogenetics and Molecular Biology and Laboratory of Hematological Cytology URNHE IMAS IMIM and URTTS IMAS IMIM, Pathology Service, Hospital del Mar, Passeig Maritim, 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 179:62-5. 2007
    ..To our knowledge, no cases with this rare genetic anomaly have been previously described...
  22. doi request reprint Are ER+PR+ and ER+PR- breast tumors genetically different? A CGH array study
    Alma Carracedo
    Pathology Service, Molecular Cytogenetics Laboratory, Hospital del Mar, IMIM, Barcelona, Spain
    Cancer Genet 205:138-46. 2012
    ..Amplification of these genes could contribute to resistance to apoptosis, increased activation of the PI3K/Akt/mTOR pathway, and the loss of PR in at least some ER+PR- tumors...
  23. doi request reprint Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma
    Cristina Baro
    Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Parc de Salut Mar, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
    Leuk Res 35:256-9. 2011
    ..According to our results, FISH is the best technique to define variant rearrangements of IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL...
  24. doi request reprint Cytogenetic characterization of NCI-H69 and NCI-H69AR small cell lung cancer cell lines by spectral karyotyping
    Marta Salido
    Pathology Department, Molecular Cytogenetic Laboratory, IMAS, GRETNHE Escola de Citologia Hematologica S Woessner IMAS, Barcelona, Spain
    Cancer Genet Cytogenet 191:97-101. 2009
    ..In conclusion, SKY provides a useful complementary technique to routine cytogenetics for the accurate characterization of SCLC cell lines and could provide some relevant information concerning regions involved in chemoresistance...
  25. ncbi request reprint Contribution of cytogenetics and in situ hybridization to the study of monoclonal gammopathies of undetermined significance
    Elisabet Lloveras
    Laboratori de Citologia Hematologica, Laboratori de Referència de Catalunya, Departament de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Cancer Genet Cytogenet 132:25-9. 2002
    ..Prospective follow-up is needed to evaluate the clinical value of monosomy 18 as a predictive factor for defining a high risk of malignant transformation in MGUS patients...
  26. doi request reprint A multicolor fluorescence in situ hybridization assay: A monitoring tool in the surveillance of patients with a history of non-muscle-invasive urothelial cell carcinoma: A prospective study
    Ana B Galván
    Molecular Cytogenetics Laboratory, Department of Pathology, Hospital del Mar Research Institute, Barcelona, Spain
    Cancer Cytopathol 119:395-403. 2011
    ..The aim of the current study was to compare a multicolor fluorescence in situ hybridization (FISH) assay (UroVysion) with routine follow-up (cystoscopy and cytology) in the monitoring of patients with a previous history of NMIUCC...
  27. ncbi request reprint Is fluorescence in situ hybridization a useful method in diagnosis of polycythemia vera patients?
    Lurdes Zamora
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, Barcelona 08003, Spain
    Cancer Genet Cytogenet 151:139-45. 2004
    ..3%. We conclude that, probably, the application of FISH with the mentioned probes, is not very useful to detect cytogenetic aberrations in untreated PV patients...
  28. ncbi request reprint Comparative analysis of TCR-gamma gene rearrangements by Genescan and polyacrylamide gel-electrophoresis in cutaneous T-cell lymphoma
    Carlota Costa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Acta Derm Venereol 84:6-11. 2004
    ..On sequencing the PCR products we demonstrated non-clonality of these five samples. Our results confirm that PCR-Genescan is a useful, reliable and specific screening method for detecting dominant clones in patients with T-cell lymphoma...
  29. doi request reprint Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-
    Mar Mallo
    Laboratori de, Citogenètica i Biologia Molecular, Servei de Patologia, IMAS, GRETNHE, IMIM Hospital del Mar, Barcelona
    Haematologica 93:1001-8. 2008
    ....
  30. ncbi request reprint Monosomy 15 in chronic myelomonocytic leukemia. description of a case and review of the literature
    Lourdes Zamora
    Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, Pg Marítim, 25 29, 08003, Barcelona, Spain
    Cancer Genet Cytogenet 134:165-7. 2002
    ..On the other hand, monosomy 15 in complex karyotypes is a frequent chromosome aberration in myelodysplastic syndromes, particularly in refractory anemia with excess of blasts...
  31. ncbi request reprint Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia
    Eulàlia Puigdecanet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
    Cancer Genet Cytogenet 167:39-42. 2006
    ..Our results suggest a lack of structural and numerical rearrangements (deletions, translocations, or amplifications) of PRV-1, TPO, and c-MPL genes in ET patients...
  32. doi request reprint Mycosis fungoides and Sézary syndrome
    Blanca Espinet
    Molecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar, Barcelona, Spain
    Methods Mol Biol 973:175-88. 2013
    ..Moreover, two MF genomic subgroups have been described, distinguishing a stable group (0-5 DNA aberrations) and an unstable group (>5 DNA aberrations), showing that the genomic unstable group had a shorter overall survival (P = 0.05)...
  33. doi request reprint Identification of t(17;22)(q22;q13) (COL1A1/PDGFB) in dermatofibrosarcoma protuberans by fluorescence in situ hybridization in paraffin-embedded tissue microarrays
    Sonia Segura
    Department of Dermatology, Hospital del Mar, Universitat Autonoma de Barcelona, E 08003 Barcelona, Spain
    Hum Pathol 42:176-84. 2011
    ..The detection of the translocation may be an additional diagnostic tool in cases of dermatofibrosarcoma protuberans showing nonconclusive histologic features...
  34. ncbi request reprint A new case of acute nonlymphocytic leukemia (French-American-British subtype M1) with double minutes and c-MYC amplification
    Natalia Rodon
    Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Cancer Genet Cytogenet 132:161-4. 2002
    ..A review of dmins in ANLL is presented...
  35. doi request reprint Molecular diagnosis of dermatofibrosarcoma protuberans: a comparison between reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization methodologies
    Rocio Salgado
    Laboratori de Citogenètica Molecular, Servei de Patologia, GRETNHE, Programa de Recerca en Càncer, IMIM Institut de Recerca del Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
    Genes Chromosomes Cancer 50:510-7. 2011
    ....
  36. doi request reprint Oligonucleotide array-CGH identifies genomic subgroups and prognostic markers for tumor stage mycosis fungoides
    Rocio Salgado
    Laboratori de Citogenètica Molecular, Servei de Patologia, IMIM Hospital del Mar, Barcelona, Spain
    J Invest Dermatol 130:1126-35. 2010
    ..3 (CDKN2A, CDKN2B, and MTAP) and 10q26qter (MGMT and EBF3) may have an important role in prognosis. In addition, we describe the MFt genomic instability profile, which, to our knowledge, has not been reported earlier...
  37. ncbi request reprint Chimeric BCR/ABL gene detected by fluorescence in situ hybridization in three new cases of Philadelphia chromosome-negative chronic myelocytic leukemia
    Dolors Costa
    Unitat Hematopatologia, Hospital del Mar, Barcelona, Spain
    Cancer Genet Cytogenet 141:114-9. 2003
    ..In conclusion, in cases of Ph- CML, FISH studies are of paramount importance since they can detect chromosomal reorganization and its location, and can also provide quantitative follow-up of these patients...
  38. pmc Polysomy of chromosome 17 in breast cancer tumors showing an overexpression of ERBB2: a study of 175 cases using fluorescence in situ hybridization and immunohistochemistry
    Marta Salido
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Breast Cancer Res 7:R267-73. 2005
    ....
  39. ncbi request reprint Study of chromosomal abnormalities in 11 cases of cervical dysplasia using comparative genomic hybridization on cotton-lint cervical samples
    Carlota Costa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
    Cancer Genet Cytogenet 164:61-5. 2006
    ..In the laboratory, the manipulation of this type of sample obtained by a noninvasive system is much simpler, easier, and faster than the obtained with a conventional biopsy...
  40. doi request reprint Prospective study of clinical and biological prognostic factors at diagnosis in patients with early stage B-cell chronic lymphocytic leukemia
    Ana C Oliveira
    Servei d Hematologia Clinica, Institut Catala d Oncologia, Hospital Duran i Reynals, IDIBELL, Hospitalet, Barcelona, Spain
    Leuk Lymphoma 52:429-35. 2011
    ..2, 95% CI 1.1-9.3, p = 0.03) and 17p- (OR 3.5, 95% CI 0.95-13.1, p = 0.05) correlated with worse PFS. A longer follow-up is necessary to analyze the prognostic value of these variables regarding overall survival...
  41. ncbi request reprint Correlation between histologic findings and cytogenetic abnormalities in bladder carcinoma: a FISH study
    Jose Placer
    Department of Urology, Laboratory of Cytogenetics and Molecular Biology, Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain
    Urology 65:913-8. 2005
    ..To investigate the chromosomal abnormalities present in bladder carcinoma using a fluorescence in situ hybridization assay and to correlate the genetic findings with the pathologic grade and stage...
  42. doi request reprint Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group
    Marta Salido
    Hospital del Mar, IMAS, Barcelona, Spain
    Blood 116:1479-88. 2010
    ..Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL...
  43. ncbi request reprint Gastrointestinal involvement in mantle cell lymphoma: a prospective clinic, endoscopic, and pathologic study
    Antonio Salar
    Department of Clinical Hematology, Hospital del Mar, Barcelona, Spain
    Am J Surg Pathol 30:1274-80. 2006
    ..IHC for cyclin D1 was significantly more sensitive than FISH t(11;14) or PCR for immunoglobulin heavy chain gene to confirm MCL in this setting...
  44. doi request reprint Genomic arrays in chronic lymphocytic leukemia routine clinical practice: are we ready to substitute conventional cytogenetics and fluorescence in situ hybridization techniques?
    Anna Puiggros
    Programa de Recerca en Càncer, Grup de Recerca Translacional en Neoplàsies Hematològiques GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
    Leuk Lymphoma 54:986-95. 2013
    ..In conclusion, genomic arrays are valid to detect known and novel genomic imbalances in CLL, but should be maintained as a complementary tool to the current techniques...
  45. doi request reprint MYC Copy Number Gains are Associated with Poor Outcome in Penile Squamous Cell Carcinoma
    Emili Masferrer
    Servei de Dermatologia, Facultat de Medicina, Universitat de Barcelona, Hospital del Mar, Parc de Salut Mar, Institut Hospital del Mar d Investigacions Mèdiques, Barcelona, Spain Universitat Autònoma de Barcelona, Barcelona, Spain Electronic address
    J Urol 188:1965-71. 2012
    ..We determined MYC gene numerical aberrations and protein expression at different stages of penile squamous cell carcinoma carcinogenesis. We correlated these findings with clinicopathological parameters and HPV infection...
  46. ncbi request reprint Identification of male cardiomyocytes of extracardiac origin in the hearts of women with male progeny: male fetal cell microchimerism of the heart
    Antoni Bayes-Genis
    Servei de Cardiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Heart Lung Transplant 24:2179-83. 2005
    ..Whether extracardiac fetal progenitors are present in the heart of women with male issue is unknown...
  47. doi request reprint [Persistent polyclonal B-cell lymphocytosis: study of 35 cases]
    Lourdes Florensa
    Laboratori de Citologia Hematologica, Servei de Patologia, Hospital del Mar, Barcelona, Espana
    Med Clin (Barc) 136:565-73. 2011
    ..To date, it has not been elucidated whether this is a benign or premalignant disorder. We analyzed the PPBL characteristics with especial attention to its evolution...
  48. ncbi request reprint Methotrexate resistance in vitro is achieved by a dynamic selectionprocess of tumor cell variants emerging during treatment
    Josep M de Anta
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Int J Cancer 119:1607-15. 2006
    ..Therefore, this model provides a mechanism by which a tumor cell population lacking resistant subpopulations before treatment is able to acquire the genetic changes required for stable drug resistance...
  49. ncbi request reprint Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromes
    Francesc Sole
    Laboratori de Citogenètica i Biologia Molecular, Hospital del Mar IMAS, 08003 Barcelona, Spain
    Haematologica 90:1168-78. 2005
    ..The main aim of the present study was to identify chromosomal abnormalities with a previously unrecognized good or poor prognosis in order to find new cytogenetic markers with predictive value...
  50. doi request reprint Increased MLL gene rearrangements in amniocytes from fetuses of mothers who smoke
    Rosa Ana de la Chica
    Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Leuk Res 35:1066-9. 2011
    ..Epidemiologic studies, including a large series of patients, will be needed to determine whether the offspring of parents who smoke have an increased lifetime risk of leukemia...
  51. ncbi request reprint CDC28 protein kinase regulatory subunit 1B (CKS1B) expression and genetic status analysis in oral squamous cell carcinoma
    Gemma Martin-Ezquerra
    Department of Medicine and Dermatology, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    Histol Histopathol 26:71-7. 2011
    ..This phenotypical and cytogenetic profile is not observed in premalignant or inflammatory oral mucosal lesions...
  52. ncbi request reprint Is the gain of 9p involved in the pathogenesis of polycythemia vera? A purpose of a case
    Lurdes Zamora
    Departament de Citogenètica, General Lab, Laboratoris d Anàlisis, C Londres, 45, 08036 Barcelona, Spain
    Haematologica 87:ECR05. 2002
  53. ncbi request reprint New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)
    Cristina Baro
    Department Biologia Animal, Vegetal i Ecologia, Unitat d Antropologia Biològica, Facultat de Biociencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Leuk Res 32:727-36. 2008
    ..Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected...
  54. doi request reprint Biallelic losses of 13q do not confer a poorer outcome in chronic lymphocytic leukaemia: analysis of 627 patients with isolated 13q deletion
    Anna Puiggros
    Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Hospital del Mar, Barcelona, Spain Grup de Recerca Translacional en Neoplàsies Hematològiques, Cancer Research Program, IMIM Hospital del Mar, Barcelona, Spain
    Br J Haematol 163:47-54. 2013
    ..In conclusion, loss of the remaining 13q allele is not enough to entail a worse prognosis in CLL. The presence of isolated 13q deletion can be risk-stratified according to the percentage of altered cells. ..
  55. doi request reprint Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: does -7/7q- detection by FISH have prognostic value?
    Vera Ademà
    Institut de Recerca Contra la Leucèmia Josep Carreras, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
    Leuk Res 37:416-21. 2013
    ..Our results suggest that FISH 7q could be beneficial in patients with intermediate WHO morphologic risk stratification and no evidence of -7/7q- by CC...
  56. doi request reprint Chronic lymphocytic leukaemia with 17p deletion: a retrospective analysis of prognostic factors and therapy results
    Julio Delgado
    Hospital Clinic, IDIBAPSHospital Sant PauHospital del MarHospital Duran i ReynalsHospital Vall d Hebron, BarcelonaHospital 12 de Octubre, MadridHospital General, ValenciaHospital La PrincesaHospital Principe de AsturiasHospital Infanta Leonor, MadridHospital Germans Trias i Pujol, BadalonaHospital Central de Asturias, OviedoHospital Josep Trueta, GironaHospital Clinico, Salamanca, Spain
    Br J Haematol 157:67-74. 2012
    ....
  57. ncbi request reprint Clinical utility of a multiprobe FISH assay in voided urine specimens for the detection of bladder cancer and its recurrences, compared with urinary cytology
    Jose Placer
    Department of Urology, Hospital del Mar, IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
    Eur Urol 42:547-52. 2002
    ....
  58. ncbi request reprint Collection of Philadelphia-negative stem cells using recombinant human granulocyte colony-stimulating factor in chronic myeloid leukemia patients treated with alpha-interferon
    Juan Carlos Hernández-Boluda
    BMT Unit, Institute of Hematology and Oncology, Department of Hematology, Hospital del Mar, Villaroel 170, 08036 Barcelona, Spain
    Haematologica 87:17-22. 2002
    ..The results of using recombinant human granulocyte colony-stimulating factor (rHuG-CSF) for harvesting hematopoietic progenitors in CML patients treated with interferon-a (IFN) are reported...
  59. doi request reprint Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-hodgkin lymphomas
    Antonio Martinez
    Hematopathology and Hematology Department, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 36:296-304. 2012
    ..8 years. In conclusion, PBML is a very uncommon lymphoma with particular clinical features and heterogenous histology. Its recognition is important to establish accurate diagnosis and adequate therapy...
  60. ncbi request reprint Epidermal growth factor receptor gene numerical aberrations are frequent events in actinic keratoses and invasive cutaneous squamous cell carcinomas
    Agusti Toll
    Exp Dermatol 19:151-3. 2010
    ..Our results suggest that EGFR numerical aberrations occur in the early stages of epithelial carcinogenesis in skin, not playing a role in the progression from low-grade SCCs into more aggressive phenotypes...
  61. ncbi request reprint RxFISH karyotype and MYC amplification in the HT-29 colon adenocarcinoma cell line
    Cristina Corzo
    Genes Chromosomes Cancer 36:425-6. 2003
  62. ncbi request reprint Absence of MALT1 translocations in primary cutaneous marginal zone B-cell lymphoma
    Blanca Espinet
    Haematologica 89:ELT14. 2004
    ..We examined the presence of MALT1 translocations in a series of 23 PCMZL. FISH assay with a MALT1 dual color break apart translocation probe revealed the absence of MALT1 translocations in all cases...
  63. ncbi request reprint Translocation (5;17)(q13;q21) in a case with precursor T-lymphoblastic lymphoma/leukemia
    Lourdes Zamora
    Cancer Genet Cytogenet 132:81-2. 2002
  64. ncbi request reprint Incidence of trisomy 8 and 9, deletion of D13S319 and D20S108 loci and BCR/ABL translocation in non-treated essential thrombocythemia patients: an analysis of bone marrow cells using interphase fluorescence in situ hybridization
    Lurdes Zamora
    Haematologica 88:110-1. 2003
  65. ncbi request reprint Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes
    Ana Ferrer
    Department of Hematology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Oncogene 23:8941-9. 2004
    ..These results support that mitoxantrone can be effective in the treatment of MCL but that this activity requires the integrity of functional DNA-damage response genes...
  66. ncbi request reprint MLL intrachromosomal amplification in a pre-B acute lymphoblastic leukemia
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular Servei de Patologia Hospital del Mar IMAS Barcelona, Spain
    Haematologica 88:EIM03. 2003
  67. ncbi request reprint Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL)
    Marta Salido
    Haematologica 88:ELT33. 2003
    ..No deletions were detected in any of the 16 cases. ATM deletions could be considered a rare event in SMZBCL...
  68. ncbi request reprint Analysis of T-cell receptor gamma gene rearrangements by PCR-Genescan and PCR-polyacrylamide gel electrophoresis in early-stage mycosis fungoides/large-plaque parapsoriasis
    Carlota Costa
    Dermatology 207:418-9. 2003
  69. ncbi request reprint Could ATRA/Idarubicin treatment of acute promyelocytic leukemia induce the appearance of new clonal cytogenetic abnormalities in patients in complete remission?
    Mar Mallo
    Leuk Res 31:1315-7. 2007
  70. ncbi request reprint A new translocation t(11;13)(q13;q14) in a mature B-cell neoplasm
    Francesc Sole
    Haematologica 87:777-8. 2002
    ..To our knowledge, this is the first reported case with this novel cytogenetic aberration...
  71. ncbi request reprint Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia-positive chronic myeloid leukemia: two cases with a different outcome
    José Tomás Navarro
    Servei d Hematologia, Institut Catala d Oncologia, Hospital Germans Trias i Pujol, Badalona, Barcelona
    Am J Hematol 82:849-51. 2007
    ....
  72. ncbi request reprint Endogenous erythroid and megakaryocytic circulating progenitors, HUMARA clonality assay, and PRV-1 expression are useful tools for diagnosis of polycythemia vera and essential thrombocythemia
    Lourdes Florensa
    Blood 103:2427-8. 2004
  73. ncbi request reprint Additional i(1)(q10) in a primitive neuroectodermal tumor type Merkel cell carcinoma as a primary cytogenetic change
    Cristina Corzo
    Cancer Genet Cytogenet 142:165-7. 2003
  74. ncbi request reprint Clonal cytogenetic abnormalities in patients with chronic myeloid leukemia in complete cytogenetic response to imatinib mesylate
    Blanca Espinet
    Haematologica 90:556-8. 2005
    ..We add information to this issue presenting a series of 29 patients in complete cytogenetic response after imatinib treatment, three of whom developed clonal aberrations...
  75. ncbi request reprint Report of 46,XX/46,XY/47,XXY/48,XXYY mosaicism in an adult phenotypic male
    Lurdes Zamora
    Am J Med Genet 111:215-7. 2002
  76. ncbi request reprint Clonality analysis by HUMARA assay in Spanish females with essential thrombocythemia and polycythemia vera
    Lurdes Zamora
    Haematologica 90:259-61. 2005
    ..The X-chromosome inactivation pattern was analyzed by HUMARA-polymerase chain reaction on DNA from purified granulocytes, T lymphocytes and the CD3- fraction of mononuclear cells...