R de la Torre

Summary

Affiliation: Hospital del Mar
Country: Spain

Publications

  1. ncbi request reprint Changes in androgenic steroid profile due to urine contamination by microorganisms: a prospective study in the context of doping control
    R de la Torre
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Doctor Aiguader 80, E 08003 Barcelona, Spain
    Anal Biochem 289:116-23. 2001
  2. ncbi request reprint Pathogenicity of Cryptococcus neoformans var. gattii in an immunocompetent mouse model
    J M Torres-Rodriguez
    Clinical and Experimental Mycology Research Group, IMIM, Institut Municipal d Assistència Sanitària, Barcelona, Spain
    Med Mycol 41:59-63. 2003
  3. ncbi request reprint Platelet SERT as a peripheral biomarker of serotonergic neurotransmission in the central nervous system
    S Yubero-Lahoz
    Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM Hospital del Mar Medical Research Institute, Parc de Recerca Biomedica de Barcelona, Doctor Aiguader, 88, 08003 Barcelona, Spain
    Curr Med Chem 20:1382-96. 2013
  4. doi request reprint Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future
    Rafael de la Torre
    Neurosciences Research Programme, IMIM Hospital del Mar Research Institute and CIBEROBN, Barcelona, Spain
    Prog Brain Res 197:1-14. 2012
  5. pmc Acute heroin intoxication in a baby chronically exposed to cocaine and heroin: a case report
    Xavier Joya
    Unitat de Recerca Infància i Entorn URIE, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
    J Med Case Reports 5:288. 2011
  6. ncbi request reprint Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans
    Rafael de la Torre
    Institut Municipal d Investigacio Medica, Pharmacology Unit IMIM, Dr Aiguader 80, 08003 Barcelona, Spain
    Trends Pharmacol Sci 25:505-8. 2004
  7. ncbi request reprint Is dopamine behind the health benefits of red wine?
    Rafael de la Torre
    Pharmacology Unit IMIM, Institut Municipal d Investigacio Medica, Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Nutr 45:307-10. 2006
  8. ncbi request reprint Pharmacology of MDMA in humans
    - de la Torre R
    Pharmacology Unit, Institut Municipal d Investigacio Medica, Universitat Autonoma de Barcelona, Spain
    Ann N Y Acad Sci 914:225-37. 2000
  9. ncbi request reprint Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition
    Rafael de la Torre
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Ther Drug Monit 26:137-44. 2004
  10. pmc Non-linear pharmacokinetics of MDMA ('ecstasy') in humans
    R de la Torre
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Universitat Pompeu Fabra and Universitat Autònoma de Barcelona, Spain
    Br J Clin Pharmacol 49:104-9. 2000

Research Grants

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Changes in androgenic steroid profile due to urine contamination by microorganisms: a prospective study in the context of doping control
    R de la Torre
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Doctor Aiguader 80, E 08003 Barcelona, Spain
    Anal Biochem 289:116-23. 2001
    ..In contrast, a few organisms were able to synthesize 5alpha-androstanedione, 5beta-androstanedione, and androstenedione using endogenous steroids as substrates...
  2. ncbi request reprint Pathogenicity of Cryptococcus neoformans var. gattii in an immunocompetent mouse model
    J M Torres-Rodriguez
    Clinical and Experimental Mycology Research Group, IMIM, Institut Municipal d Assistència Sanitària, Barcelona, Spain
    Med Mycol 41:59-63. 2003
    ..Strain GR52 was highest in pathogenicity and had marked lung tropism. In contrast, the serotype C reference strain showed the lowest pathogenicity and seemed not to spread outside the abdominal viscera...
  3. ncbi request reprint Platelet SERT as a peripheral biomarker of serotonergic neurotransmission in the central nervous system
    S Yubero-Lahoz
    Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM Hospital del Mar Medical Research Institute, Parc de Recerca Biomedica de Barcelona, Doctor Aiguader, 88, 08003 Barcelona, Spain
    Curr Med Chem 20:1382-96. 2013
    ..This review summarizes recent clinical and preclinical data relevant to the use of blood platelets asa peripheral marker for the central 5-HT system, and outlines future directions in this field...
  4. doi request reprint Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future
    Rafael de la Torre
    Neurosciences Research Programme, IMIM Hospital del Mar Research Institute and CIBEROBN, Barcelona, Spain
    Prog Brain Res 197:1-14. 2012
    ..Epigallocatechin gallate, a green tea polyphenol, that modulates DYRK1A functioning has already shown preliminarily that this approach may prove useful in therapeutics...
  5. pmc Acute heroin intoxication in a baby chronically exposed to cocaine and heroin: a case report
    Xavier Joya
    Unitat de Recerca Infància i Entorn URIE, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
    J Med Case Reports 5:288. 2011
    ..abstract:..
  6. ncbi request reprint Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans
    Rafael de la Torre
    Institut Municipal d Investigacio Medica, Pharmacology Unit IMIM, Dr Aiguader 80, 08003 Barcelona, Spain
    Trends Pharmacol Sci 25:505-8. 2004
    ..Such features limit allometric scaling across animal models...
  7. ncbi request reprint Is dopamine behind the health benefits of red wine?
    Rafael de la Torre
    Pharmacology Unit IMIM, Institut Municipal d Investigacio Medica, Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Nutr 45:307-10. 2006
    ..Hydroxytyrosol is a dopamine metabolite, and also a very active naturally occurring phenol compound in olive oil...
  8. ncbi request reprint Pharmacology of MDMA in humans
    - de la Torre R
    Pharmacology Unit, Institut Municipal d Investigacio Medica, Universitat Autonoma de Barcelona, Spain
    Ann N Y Acad Sci 914:225-37. 2000
    ..Both peak concentrations and peak effects were obtained between 1 and 2 h and decreased to baseline values 4-6 h after drug administration...
  9. ncbi request reprint Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition
    Rafael de la Torre
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Ther Drug Monit 26:137-44. 2004
    ..One of the interesting features of MDMA metabolism is its potential involvement in the development of mid- to long-term neurotoxic effects as a result of progressive neurodegeneration of the serotonergic neurotransmission system...
  10. pmc Non-linear pharmacokinetics of MDMA ('ecstasy') in humans
    R de la Torre
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Universitat Pompeu Fabra and Universitat Autònoma de Barcelona, Spain
    Br J Clin Pharmacol 49:104-9. 2000
    ..A clinical trial was designed for the evaluation of MDMA pharmacological effects and pharmacokinetics in healthy volunteers...
  11. doi request reprint Bioavailability of olive oil phenolic compounds in humans
    R de la Torre
    Human Pharmacology and Clinical Neurosciences Research Group, Neuropsychopharmacology Programme Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, CEXS Universitat Pompeu Fabra, Barcelona, Spain
    Inflammopharmacology 16:245-7. 2008
    ..The picture is further compounded by the fact that hydroxytyrosol is also a dopamine metabolite and body fluids concentrations combine exogenous and endogenous sources...
  12. doi request reprint High throughput analysis of drugs of abuse in hair by combining purposely designed sample extraction compatible with immunometric methods used for drug testing in urine
    R de la Torre
    Institut Municipal d Investigatiò Mèdica IMIM Hospital del Mar, Neuropsychopharmacology Program, Barcelona, Spain
    Forensic Sci Int 196:18-21. 2010
    ..The main advantage of VMA-T method is the possibility to simultaneously extract from hair main drug classes, in a period of time lower than 2h and its compatibility with immunological methods applied in urine drug testing...
  13. doi request reprint Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip
    Elisabet Cuyàs
    Human Pharmacology and Clinical Neurosciences Research Group of the Neuropsychopharmacology Program, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Parc de Recerca Biomedica de Barcelona, c Dr Aiguader 88 08003 Barcelona, Spain
    Pharmacogenomics 11:257-66. 2010
    ..The aim of this study was to assess the suitability of PHARMAchip for the genotyping of polymorphisms of genes associated with drug metabolism and response as an alternative to Jurilab Ltd's DrugMEt Test...
  14. ncbi request reprint MDMA (ecstasy) pharmacokinetics in a CYP2D6 poor metaboliser and in nine CYP2D6 extensive metabolisers
    Rafael de la Torre
    Pharmacology Unit, Institut Municipal d Investigacio Medica IMIM, Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Clin Pharmacol 61:551-4. 2005
  15. ncbi request reprint HAIRVEQ 2006: evolution of laboratories' performance after different educational actions
    M Ventura
    Unitat de Recerca en Farmacologia, IMIM Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    Forensic Sci Int 176:2-8. 2008
    ..More educational actions should be addressed to a group of laboratories, which did not yet show satisfying qualitative and quantitative results...
  16. doi request reprint ORALVEQ: external quality assessment scheme of drugs of abuse in oral fluid: results obtained in the first round performed in 2007
    M Ventura
    Grup de Recerca en Bioanàlisi i Serveis Analítics, Programa de Recerca en Neuropsicofarmacologia, IMIM Hospital del Mar, Barcelona, Spain
    Forensic Sci Int 182:35-40. 2008
    ....
  17. ncbi request reprint Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial
    M Fito
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Eur J Clin Nutr 62:570-4. 2008
    ..To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients...
  18. ncbi request reprint Clinical evaluation of the Triage analytic device for drugs-of-abuse testing
    R de la Torre
    Departamento de Farmacologia y Toxicologia, Institut Municipal d Investigacio Medica, Barcelona
    Clin Chem 42:1433-8. 1996
    ..Globally, the Triage device, in a clinical situation, demonstrated performance comparable with that of an instrument-based immunoassay and, in some cases (e.g., for benzodiazepines), the Triage performance was even better...
  19. ncbi request reprint 3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans
    M Segura
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Chem Res Toxicol 14:1203-8. 2001
    ..Its validation showed appropriate accuracy and precision for its use in pharmacokinetic studies...
  20. ncbi request reprint Bioavailability of tyrosol, an antioxidant phenolic compound present in wine and olive oil, in humans
    M I Covas
    Lipids and Cardiovascular Epidemiology Unit, Municipal Institute of Medical Research, Barcelona, Spain
    Drugs Exp Clin Res 29:203-6. 2003
    ..In summary, our results suggest that tyrosol from wine or virgin olive oil could exert beneficial effects on human health in vivo if its biological properties are confirmed in in vivo studies...
  21. ncbi request reprint Bioavailability of phenolic compounds from olive oil and oxidative/antioxidant status at postprandial state in healthy humans
    T Weinbrenner
    Lipids and Cardiovascular Epidemiology Unit, Institute of Medical Investigation, Barcelona, Spain
    Drugs Exp Clin Res 30:207-12. 2004
    ..The phenolic content of the olive oils administered may account for the protection of the endogenous antioxidant defenses at postprandial state after ingestion of moderate and high phenolic content olive oils...
  22. ncbi request reprint Capillary gas chromatography-mass spectrometry quantitative determination of hydroxytyrosol and tyrosol in human urine after olive oil intake
    E Miro-Casas
    Unitat de Farmacologia, Universitat Autonoma de Barcelona, Barcelona, 08003, Spain
    Anal Biochem 294:63-72. 2001
    ..Our results further indicate that hydroxytyrosol and tyrosol are mainly excreted in conjugated form, since only 5.9 +/- 1.4% (hydroxytyrosol) and 13.8 +/- 5.4% (tyrosol) of the total amounts excreted in urine were in free form...
  23. ncbi request reprint [Coronary disease protective factors: antioxidant effect of olive oil]
    M I Covas
    , , Carrer Dr. Aiguader, 80, 08003 Barcelona, Espagne
    Therapie 56:607-11. 2001
    ..PC from diet could bind human LDL in non-supplemented volunteers. PC from virgin olive oil could bind LDL and tyrosol is bioavailable in humans from ingestion of virgin olive oil in its natural form...
  24. ncbi request reprint Human pharmacology of 3,4-methylenedioxymethamphetamine ("ecstasy"): psychomotor performance and subjective effects
    J Cami
    Pharmacology Unit, Institut Muncipal d Investigació Mèdica, Barcelona, Spain
    J Clin Psychopharmacol 20:455-66. 2000
    ..These data support the abuse liability of MDMA...
  25. ncbi request reprint Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics
    M Farre
    Pharmacology Unit, Institut Municipal d Investigacio Medica, Doctor Aiguader 80, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 173:364-75. 2004
    ..MDMA presents non-linear pharmacokinetics, probably by inhibition of cytochrome P450 isoform 2D6. Users are known to often take more than one dose per session. This practice could have serious implications for the toxicity of MDMA...
  26. ncbi request reprint Modulation of rate of onset and intensity of drug effects reduces abuse potential in healthy males
    P N Roset
    Pharmacology Research Unit, , Carrer Doctor Aiguader 80, , Universitat Pompeu Fabra, E-08003 Barcelona, Spain
    Drug Alcohol Depend 64:285-98. 2001
    ..At the medium dose, the balance between pleasurable and unpleasant feelings resulted in euphorigenic effects, which were evident in the fast condition but were blunted in the slow condition...
  27. ncbi request reprint Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program
    M Torrens
    Servei de Psiquiatria, Hospital del Mar, Universitat Autonoma de Barcelona, Spain
    Drug Alcohol Depend 52:193-200. 1998
    ..02, P = NS) and EDDP (r = -0.14, P = NS) was found. Therapeutic drug monitoring during methadone maintenance seems to be useful for assessing compliance with treatment but not for predicting heroin use and subjective withdrawal symptoms...
  28. ncbi request reprint Stability studies of amphetamine and ephedrine derivatives in urine
    C Jimenez
    Unitat de Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Chromatogr B Analyt Technol Biomed Life Sci 843:84-93. 2006
    ..These results show the feasibility of preparing reference materials containing ephedrine and amphetamine derivatives to be used for quality control purposes...
  29. doi request reprint Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2 h apart
    A M Peiró
    Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Programme, IMIM Hospital del Mar Medical Research Institute, Doctor Aiguader 88, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 225:883-93. 2013
    ..3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most abused recreational drugs. Its usual pattern of misuse includes repeated doses taken over a short time period that could influence MDMA pharmacology and toxicity...
  30. ncbi request reprint Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression
    M G Ladona
    Department of Pharmacology and Toxicology, Municipal Institute of Medical Investigation, Autonomous University, Barcelona, Spain
    Life Sci 68:431-43. 2000
    ....
  31. ncbi request reprint Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial
    M Fito
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica IMIM, Carrer Doctor Aiguader, Barcelona, Spain
    Atherosclerosis 181:149-58. 2005
    ..Consumption of VOO, rich in PC, could provide beneficial effects in CHD patients as an additional and complementary intervention to the pharmacological treatment...
  32. ncbi request reprint Four years' experience in external proficiency testing programs for hair testing of drugs of abuse in Italy (HAIRVEQ) and comparison with the Society of Hair Testing program in 2005
    M Ventura
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Ther Drug Monit 29:11-9. 2007
    ..Considering the few number of laboratories showing a satisfying performance, guidelines have to be provided focused on method validation and qualitative and quantitative data evaluation...
  33. ncbi request reprint Characterization of human gene expression changes after olive oil ingestion: an exploratory approach
    V Konstantinidou
    Cardiovascular Risk and Nutrition Research Group, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Folia Biol (Praha) 55:85-91. 2009
    ..Our results support the hypothesis that postprandial protective changes related to olive oil consumption could be mediated through gene expression changes...
  34. ncbi request reprint Analytical methodology for the detection of benzodiazepine consumption in opioid-dependent subjects
    M Segura
    Unitat de Farmacologia, , Barcelona, Spain
    J Anal Toxicol 25:130-6. 2001
    ..Oxazepam and nordiazepam were the benzodiazepines most frequently recoved in urine samples. The prevalence of alprazolam use (40%) was higher than that of flunitrazepam (10%)...
  35. ncbi request reprint Stability studies of testosterone and epitestosterone glucuronides in urine
    C Jimenez
    Unitat de Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Rapid Commun Mass Spectrom 20:858-64. 2006
    ..These results show the feasibility of preparing reference materials containing TG and EG to be used for quality control purposes...
  36. ncbi request reprint Reference materials for analytical toxicology including doping control: freeze-dried urine samples
    C Jimenez
    Unitat de Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Analyst 129:449-55. 2004
    ..The loss of analytes in freeze-dried samples was due to their volatility. Furthermore, an increase in pH by 1 unit was observed following reconstitution of samples prepared from drug-free urine of commercial origin...
  37. pmc Pharmacogenetic profile of xenobiotic enzyme metabolism in survivors of the Spanish toxic oil syndrome
    M G Ladona
    Department of Pharmacology, Municipal Institute of Medical Investigation, Barcelona, Spain
    Environ Health Perspect 109:369-75. 2001
    ..These findings suggest a possible role of impaired acetylation mediating susceptibility in TOS...
  38. doi request reprint Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study
    S de Sola Llopis
    Behavioral Neurology and Dementia Research Group, Neuropsychopharmacology Program, IMIM Hospital del Mar, Barcelona, Spain
    J Psychopharmacol 22:498-510. 2008
    ....
  39. ncbi request reprint Postprandial effects of wine consumption on lipids and oxidative stress biomarkers
    M I Covas
    Lipids and Cardiovascular Epidemiology Unit, Institut d Investigaciò Médica, Barcelona, Spain
    Drugs Exp Clin Res 29:217-23. 2003
    ..Daily consumption of moderate doses of red wine can improve postprandial lipid profile and oxidative status when wine is ingested outside meals...
  40. ncbi request reprint Effect of quinolones on caffeine disposition
    M Carbo
    Department of Pharmacology and Toxicology, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Clin Pharmacol Ther 45:234-40. 1989
    ..In two additional healthy volunteers under a controlled multiple-dose regimen of caffeine ingestion, administration of pipemidic acid for 2 days caused a fourfold increase in the plasma concentrations of caffeine...
  41. ncbi request reprint High-performance liquid chromatography with electrochemical detection applied to the analysis of 3,4-dihydroxymethamphetamine in human plasma and urine
    M Segura
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Chromatogr B Analyt Technol Biomed Life Sci 769:313-21. 2002
    ..Intermediate precision and inter-day accuracy were within 3.9-6.5% and 7.4-15.3% for urine and 5.0-10.8% and 9.2-13.4% for plasma...
  42. pmc In vitro susceptibilities of clinical yeast isolates to the new antifungal eberconazole compared with their susceptibilities to clotrimazole and ketoconazole
    J M Torres-Rodriguez
    Experimental and Clinical Mycology Research Group GREMEC, IMIM, Autonomous University of Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 43:1258-9. 1999
    ....
  43. ncbi request reprint Immunochemical characterization of somatic and metabolic antigens of 4 species of Aphanoascus: preliminary results
    J M Torres-Rodriguez
    GREMEC, Autonomous University of Barcelona, Spain
    Mycopathologia 142:51-5. 1998
    ..However, some differences were noted between the species of Aphanoascus. These results suggest the existence of species-specific antigens...
  44. ncbi request reprint In vitro susceptibility of Cryptococcus neoformans serotypes to GM 237354 derivative of the sordarin class
    J M Torres-Rodriguez
    Clinical and Experimental Mycology Group GREMEC, Institut Municipal d Investigacio Medica IMIM, Autonomous University of Barcelona, Barcelona, Spain
    Mycoses 45:313-6. 2002
    ..0 microg ml(-1) to GM 237354 (MIC90% 1.0 microg ml(-1), MIC50% 0.5 microg ml(-1)). Cryptococcus neoformans var. gattii serotype B, was significantly less susceptible than A and AD serotypes (P = 0.047 and P = 0.022, respectively)...
  45. ncbi request reprint Antigens of Fusarium solani: types and criteria for immunochemical characterization
    O López Jodra
    Grup de Recerca en Micologia Experimental i Clinica, Universitat Autonoma, Barcelona, Spain
    Allergol Immunopathol (Madr) 28:261-6. 2000
    ..There are no established methods for the preparation and standardization of Fusarium solani antigens. This lack of standardization makes it difficult to use these antigens in allergenic diagnostic tests...
  46. ncbi request reprint Detection of non-steroidal anti-inflammatory drugs in equine plasma and urine by gas chromatography-mass spectrometry
    G Gonzalez
    Departament de Farmacologia i Toxicologia, Institut Municipal d Investigacio Medica IMIM, Universitat Autonoma de Barcelona, Spain
    J Chromatogr A 719:251-64. 1996
    ..The procedure was applied to the screening and confirmation of NSAIDs in routine doping control of equine samples...
  47. ncbi request reprint Stability studies of selected doping agents in urine: caffeine
    R Ventura
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica IMIM, Doctor Aiguader 80, 08003 Barcelona, Spain
    J Chromatogr B Analyt Technol Biomed Life Sci 795:167-77. 2003
    ..The stability of caffeine was also evaluated in non-sterile samples stored at -20 degrees C for 18 months. No significant loss of the compound was observed at any of the investigated conditions...
  48. ncbi request reprint Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans
    E Miro-Casas
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Eur J Clin Nutr 57:186-90. 2003
    ..The study also aimed to investigate whether these phenolic compounds could be used as biomarkers of virgin olive oil intake...
  49. doi request reprint Laparoscopic sleeve gastrectomy and laparoscopic gastric bypass are equally effective for reduction of cardiovascular risk in severely obese patients at one year of follow-up
    David Benaiges
    Department of Endocrinology and Nutrition, Hospital Universitari del Mar, Barcelona, Spain
    Surg Obes Relat Dis 7:575-80. 2011
    ..The secondary objectives were to compare the techniques in terms of weight loss and co-morbidity improvement. The study was performed at a university hospital in Barcelona, Spain...
  50. ncbi request reprint Datura stramonium poisoning. Identification of tropane alkaloids in urine by gas chromatography-mass spectrometry
    S Nogue
    Clinical Toxicology Unit, Hospital Clinic i Provincial, Barcelona, Spain
    J Int Med Res 23:132-7. 1995
    ..The presence of tropane belladona alkaloids in a urine sample was demonstrated by gas chromatography-mass spectrometry...
  51. ncbi request reprint Efficacy of antidepressants in substance use disorders with and without comorbid depression. A systematic review and meta-analysis
    Marta Torrens
    Psychiatric and Drug Abuse Department, Hospital del Mar IAPs, Passeig Maritim 25 29, E 08003 Barcelona, Spain
    Drug Alcohol Depend 78:1-22. 2005
    ..Differences both related to individual characteristics and specific antidepressant drugs need to be clarified in future studies...
  52. doi request reprint Impact of substance dependence and dual diagnosis on the quality of life of heroin users seeking treatment
    Mònica Astals
    Department of Psychiatry and Drug Abuse and Psychiatric Research Group, Hospital del Mar IAPS and Institut Municipal d Investigació Mèdica IMIM, and Departament de Psiquiatria i Medicina Legal, Universitat Autonoma de Barcelona, Barcelona, Spain
    Subst Use Misuse 43:612-32. 2008
    ..Mean scores for PCS-12 and MCS-12 were 44.1+/-10.1 and 39.9+/-11.7, without differences by presence or absence of dual diagnosis. Heroin users on methadone treatment showed a high prevalence of dual diagnosis and a very impaired HRQoL...
  53. ncbi request reprint Retention rate and illicit opioid use during methadone maintenance interventions: a meta-analysis
    Magi Farre
    Pharmacology Unit Institut Municipal d Investigacio Mèdica IMIM, Carrer Doctor Aiguador 80, E 08003, Barcelona, Spain
    Drug Alcohol Depend 65:283-90. 2002
    ..92, 95% CI 1.32--2.78). It is proposed that in agonist-maintenance programmes, oral methadone at doses of 50 mg/day or higher is the drug of choice for opioid dependence...
  54. ncbi request reprint Relative abuse liability of gamma-hydroxybutyric acid, flunitrazepam, and ethanol in club drug users
    Sergio Abanades
    Pharmacology Research Unit, Human Pharmacology and Clinical Neurosciences Research Group, Institut Municipal d Investigacio Medica, c Doctor Aiguader 80, Barcelona, Spain
    J Clin Psychopharmacol 27:625-38. 2007
    ..To evaluate GHB-induced subjective and physiological effects, its relative abuse liability and its impact on psychomotor performance in club drug users...
  55. ncbi request reprint 3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics
    Cándido Hernández-López
    Unit of Pharmacology, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    J Pharmacol Exp Ther 300:236-44. 2002
    ..Confirmation of these findings in further studies will be highly relevant in terms of road safety...
  56. ncbi request reprint Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics
    Magi Farre
    Pharmacology Research Unit, Institut Municipal d Investigació Mèdica Hospital del Mar, Doctor Aiguader 88, E 08003 Barcelona, Spain
    J Pharmacol Exp Ther 323:954-62. 2007
    ..Marked decrease in the effects of MDMA could lead users to take higher doses of MDMA and to produce potential life-threatening toxic effects...
  57. ncbi request reprint Importance of clinical diagnoses for comorbidity studies in substance use disorders
    Marta Torrens
    Drug Abuse Unit, Institut d Atenció Psiquiátrica IAPS, Hospital del Mar, Universitat Autonoma Barcelona, Passeig Maritim 25 29, E 08003 Barcelona, Spain
    Neurotox Res 10:253-61. 2006
    ....
  58. ncbi request reprint Characteristics of heroin addicts entering methadone maintenance treatment: quality of life and gender
    Elisabet Puigdollers
    Institut Municipal d Investigacio Medica, Barcelona, Spain
    Subst Use Misuse 39:1353-68. 2004
    ..To provide information on MMP patient's characteristics, particularly those related with Health Related Quality of Life (HRQoL) and gender...
  59. ncbi request reprint Diagnosing comorbid psychiatric disorders in substance abusers: validity of the Spanish versions of the Psychiatric Research Interview for Substance and Mental Disorders and the Structured Clinical Interview for DSM-IV
    Marta Torrens
    Departmernt of Psychiatry and Drug Abuse, Hospital del Mar, Institut Municipal d Investigacio Medica, Passeig Marítimo 25 29, E 08003 Barcelona, Spain
    Am J Psychiatry 161:1231-7. 2004
    ....
  60. doi request reprint Psychiatric comorbidity in young cocaine users: induced versus independent disorders
    M Jesús Herrero
    Health Services Research Unit IMIM Hospital del Mar, Barcelona, Spain
    Addiction 103:284-93. 2008
    ..To examine the psychiatric status of young cocaine users using a validated instrument for the evaluation of psychiatric comorbidity, emphasizing the distinction between independent and induced psychiatric conditions...
  61. ncbi request reprint Measuring the core features of personality disorders in substance abusers using the Temperament and Character Inventory (TCI)
    Fernando Gutierrez
    Institut Clínic de Psiquiatria i Psicologia, Hospital Clinic de Barcelona, Villarroel, 170, 08036 Barcelona, Spain
    J Pers Disord 16:344-59. 2002
    ..Character dimensions are a reliable, valid and low-cost tool for detecting PDs in drug abusers and may help to provide an operational definition of the common core features underlying all PDs...
  62. ncbi request reprint Maintenance buprenorphine for opioid users
    Magi Farre
    Lancet 361:1906-7; author reply 1907-8. 2003
  63. ncbi request reprint Medical assessment in drug addicts: reliability and validity of the Cumulative Illness Rating Scale (Substance Abuse version)
    Claudio Castillo
    Unitat de Recerca Psiquiàtrica, Institut d Atenció Psiquiátrica Salut Mental i Toxicomanies, Hospital del Mar, Passeig Maritim 25 29, ES 08003 Barcelona, Spain
    Eur Addict Res 10:112-7. 2004
    ..To adapt the Cumulative Illness Rating Scale for its use in substance abuse patients (CIRS-SA) and to assess the reliability, internal consistency, and validity of the instrument...
  64. ncbi request reprint Diagnostic Interview for Genetic Studies (DIGS): inter-rater and test-retest reliability and validity in a Spanish population
    Miguel Roca
    Hospital Joan March, University of Balearic Islands, Institut Universitari d Investigacio en Ciencies de la Salut, Edifici Guillem Cifre, Carretera de Valldemossa km 7, 5, 07122 Palma de Mallorca, Baleares, Spain
    Eur Psychiatry 22:44-8. 2007
    ..To test the reliability and validity of the DIGS in Spanish population...
  65. ncbi request reprint Dual diagnosis in an inpatient drug-abuse detoxification unit
    Agnes Nocon
    Department of Psychiatry, Hospital del Mar, Barcelona, Spain
    Eur Addict Res 13:192-200. 2007
    ..A total of 80% of the patients successfully completed the detoxification process. The present results enhance the value of detoxification in a general hospital as a first step of the overall treatment strategy...

Research Grants5

  1. Metabolism and Pharmacogenetics in MDMA-Induced Toxicity
    Rafael de la Torre; Fiscal Year: 2009
    ..A study will compare MDMA toxicity when co-adminsitered with the MRP1 inhibitor probenecid. ..