Maria Isabel Covas

Summary

Affiliation: Hospital del Mar
Country: Spain

Publications

  1. ncbi request reprint Olive oil and the cardiovascular system
    Maria Isabel Covas
    Institut Municipal dInvestigació Mèdica IMIM Hospital del Mar, Parc de Recerca Biomédica de Barcelona PRBB, Carrer Dr Aiguader, 80 08003 Barcelona, Spain
    Pharmacol Res 55:175-86. 2007
  2. pmc Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
    Carolina Ortega-Azorín
    Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain
    Cardiovasc Diabetol 11:137. 2012
  3. ncbi request reprint Scientific aspects that justify the benefits of the Mediterranean diet: mild-to-moderate versus heavy drinking
    M I Covas
    Lipids and Cardiovascular Research Unit, Municipal Institute for Medical Research IMIM, 08003 Barcelona, Spain
    Ann N Y Acad Sci 957:162-73. 2002
  4. ncbi request reprint The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial
    Maria Isabel Covas
    Municipal Institute for Medical Research, Barcelona, Spain
    Ann Intern Med 145:333-41. 2006
  5. doi request reprint Bioactive effects of olive oil phenolic compounds in humans: reduction of heart disease factors and oxidative damage
    M I Covas
    Cardiovascular Risk and Nutrition Group, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, CIBER de Fisiopatología de la Obesidad y Nutrición, Parc de Recerca Biomédica de Barcelona PRBB, Barcelona, Spain
    Inflammopharmacology 16:216-8. 2008
  6. ncbi request reprint Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans
    Maria Isabel Covas
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica IMIM, 08003 Barcelona, Spain
    Free Radic Biol Med 40:608-16. 2006
  7. ncbi request reprint Postprandial effects of wine consumption on lipids and oxidative stress biomarkers
    M I Covas
    Lipids and Cardiovascular Epidemiology Unit, Institut d Investigaciò Médica, Barcelona, Spain
    Drugs Exp Clin Res 29:217-23. 2003
  8. doi request reprint Wine and oxidative stress: up-to-date evidence of the effects of moderate wine consumption on oxidative damage in humans
    Maria Isabel Covas
    Cardiovascular Risk and Nutrition Research Group URLEC CARIN, Institut Municipal d Investigacio Medica, CIBER de Fisiopatología de la Obesidad y Nutrición, Barcelona Biomedical Research Park, Carrer Doctor Aiguader, 88, 08003 Barcelona, Spain
    Atherosclerosis 208:297-304. 2010
  9. doi request reprint Olive oil and cardiovascular health
    Maria Isabel Covas
    Cardiovascular Risk and Nutrition Research Group, Institut Municipal d Investigacio Medica IMIM, CIBER de Fisiopatologia de la Obesidad y Nutricion CIBEROBN, Barcelona, Spain
    J Cardiovasc Pharmacol 54:477-82. 2009
  10. ncbi request reprint Relationship between physical activity and oxidative stress biomarkers in women
    Maria Isabel Covas
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal de Investigació Mèdica, IMIM, Barcelona, Spain
    Med Sci Sports Exerc 34:814-9. 2002

Detail Information

Publications72

  1. ncbi request reprint Olive oil and the cardiovascular system
    Maria Isabel Covas
    Institut Municipal dInvestigació Mèdica IMIM Hospital del Mar, Parc de Recerca Biomédica de Barcelona PRBB, Carrer Dr Aiguader, 80 08003 Barcelona, Spain
    Pharmacol Res 55:175-86. 2007
    ....
  2. pmc Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
    Carolina Ortega-Azorín
    Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain
    Cardiovasc Diabetol 11:137. 2012
    ..However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet)...
  3. ncbi request reprint Scientific aspects that justify the benefits of the Mediterranean diet: mild-to-moderate versus heavy drinking
    M I Covas
    Lipids and Cardiovascular Research Unit, Municipal Institute for Medical Research IMIM, 08003 Barcelona, Spain
    Ann N Y Acad Sci 957:162-73. 2002
    ..Efficacy versus effectiveness, the role of basic and animal research, and bioavailability studies providing evidence is also discussed...
  4. ncbi request reprint The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial
    Maria Isabel Covas
    Municipal Institute for Medical Research, Barcelona, Spain
    Ann Intern Med 145:333-41. 2006
    ..Little information is available on the effect of the phenolic compounds of olive oil on plasma lipid levels. No international study with a large sample size has been done...
  5. doi request reprint Bioactive effects of olive oil phenolic compounds in humans: reduction of heart disease factors and oxidative damage
    M I Covas
    Cardiovascular Risk and Nutrition Group, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, CIBER de Fisiopatología de la Obesidad y Nutrición, Parc de Recerca Biomédica de Barcelona PRBB, Barcelona, Spain
    Inflammopharmacology 16:216-8. 2008
    ..Here, we update the state of the art, and degree of evidence, of the body of knowledge concerning the protective role on lipids and lipid oxidative damage in humans of the olive oil phenolic compounds...
  6. ncbi request reprint Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans
    Maria Isabel Covas
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica IMIM, 08003 Barcelona, Spain
    Free Radic Biol Med 40:608-16. 2006
    ..In conclusion, olive oil phenolic content seems to modulate the LDL phenolic content and the postprandial oxidative stress promoted by 40 mL olive oil ingestion in humans...
  7. ncbi request reprint Postprandial effects of wine consumption on lipids and oxidative stress biomarkers
    M I Covas
    Lipids and Cardiovascular Epidemiology Unit, Institut d Investigaciò Médica, Barcelona, Spain
    Drugs Exp Clin Res 29:217-23. 2003
    ..Daily consumption of moderate doses of red wine can improve postprandial lipid profile and oxidative status when wine is ingested outside meals...
  8. doi request reprint Wine and oxidative stress: up-to-date evidence of the effects of moderate wine consumption on oxidative damage in humans
    Maria Isabel Covas
    Cardiovascular Risk and Nutrition Research Group URLEC CARIN, Institut Municipal d Investigacio Medica, CIBER de Fisiopatología de la Obesidad y Nutrición, Barcelona Biomedical Research Park, Carrer Doctor Aiguader, 88, 08003 Barcelona, Spain
    Atherosclerosis 208:297-304. 2010
    ..In this way, the postprandial oxidative stress after a meal, despite the diversity of biomarkers used for its evaluation, is counteracted by the ingestion of wine. Further studies are warranted...
  9. doi request reprint Olive oil and cardiovascular health
    Maria Isabel Covas
    Cardiovascular Risk and Nutrition Research Group, Institut Municipal d Investigacio Medica IMIM, CIBER de Fisiopatologia de la Obesidad y Nutricion CIBEROBN, Barcelona, Spain
    J Cardiovasc Pharmacol 54:477-82. 2009
    ....
  10. ncbi request reprint Relationship between physical activity and oxidative stress biomarkers in women
    Maria Isabel Covas
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal de Investigació Mèdica, IMIM, Barcelona, Spain
    Med Sci Sports Exerc 34:814-9. 2002
    ..To examine the relationship between physical activity and levels of plasma lipid peroxides, superoxide dismutase in erythrocytes (SOD), and glutathione peroxidase (GSH-Px) in whole blood activities...
  11. ncbi request reprint Virgin olive oil phenolic compounds: binding to human low density lipoprotein (LDL) and effect on LDL oxidation
    M I Covas
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica IMIM, Carrer Doctor Aiguader, 80, 08003 Barcelona, Spain
    Int J Clin Pharmacol Res 20:49-54. 2000
    ..These results provide further evidence that phenolic compounds bound to LDL are likely to protect LDL from oxidation...
  12. ncbi request reprint Why should population attributable fractions be periodically recalculated? An example from cardiovascular risk estimation in southern Europe
    Maria Grau
    Epidemiology and Cardiovascular Genetics, Program of Research on Inflammatory and Cardiovascular Disorders, Institut Municipal d Investigacio Medica, 08003 Barcelona, Spain
    Prev Med 51:78-84. 2010
    ..To determine the effect of age and study period on coronary heart disease (CHD) risk attributable to cardiovascular risk factors...
  13. doi request reprint Time course of changes in the expression of insulin sensitivity-related genes after an acute load of virgin olive oil
    Valentini Konstantinidou
    Cardiovascular Risk and Nutrition Research Group, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, CIBER de Fisiopatologia de la Obesidad y Nutricion CIBEROBN, Barcelona, Spain
    OMICS 13:431-8. 2009
    ....
  14. doi request reprint Hypertensive status and lipoprotein oxidation in an elderly population at high cardiovascular risk
    Monica Guxens
    Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Am J Hypertens 22:68-73. 2009
    ..Our aim was to assess the relationship between the degree of in vivo low-density lipoprotein (oxLDL) oxidation and the hypertensive status in a elderly population at high cardiovascular risk...
  15. ncbi request reprint Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial
    Montserrat Fito
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica, IMIM Hospital del Mar, Barcelona, Spain
    Arch Intern Med 167:1195-203. 2007
    ..Despite the richness in antioxidants of the Mediterranean diet, to our knowledge, no randomized controlled trials have assessed its effect on in vivo lipoprotein oxidation...
  16. ncbi request reprint Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men
    Tanja Weinbrenner
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Nutr 134:2314-21. 2004
    ..01). In conclusion, the olive oil phenolic content modulated the oxidative/antioxidative status of healthy men who consumed a very low-antioxidant diet...
  17. ncbi request reprint Antioxidant paraoxonase 1 activity in the metabolic syndrome
    Mariano Senti
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica, E 08003 Barcelona, Spain
    J Clin Endocrinol Metab 88:5422-6. 2003
    ....
  18. ncbi request reprint Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation--a randomized controlled trial
    Jaume Marrugat
    Lipids and Cardiovascular Epidemiology, Research Unit, Institut Municipal d Investigacio Medica, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Nutr 43:140-7. 2004
    ..Evidence from in vitro studies suggests that antioxidant olive oil phenolic compounds can prevent LDL oxidation. However, in vivo evidence in support of this hypothesis is sparse...
  19. doi request reprint In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial
    Valentini Konstantinidou
    Cardiovascular Risk and Nutrition Research Group, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Centro de Investigación Biomédica Eu Red CIBER de Fisiopatología de la Obesidad y Nutrición, Barcelona, Spain
    FASEB J 24:2546-57. 2010
    ..In addition, the benefits associated with a TMD and olive oil polyphenol consumption on cardiovascular risk can be mediated through nutrigenomic effects...
  20. ncbi request reprint Postprandial and short-term effects of dietary virgin olive oil on oxidant/antioxidant status
    Montserrat Fito
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Lipids 37:245-51. 2002
    ..Virgin olive oil consumption could provide short-term benefits for LDL resistance to oxidation and in glutathione-related enzyme activities...
  21. doi request reprint trans Fatty acid consumption, lifestyle and type 2 diabetes prevalence in a Spanish population
    Kyriaki Papantoniou
    Environmental Epidemiology Research Centre, Biomedical Research Park, 08003 Barcelona, Spain
    Eur J Nutr 49:357-64. 2010
    ..To analyse the association of trans fatty acid (TFA) consumption with the risk of type 2 diabetes and lifestyle in a South European population...
  22. ncbi request reprint Adherence to the Mediterranean diet is associated with better mental and physical health
    Miguel Angel Munoz
    Cardiovascular Risk and Nutrition Research Group CARIN ULEC, IMIM Hospital del Mar Barcelona, Biomedical Research Park Parc de Recerca Biomèdica de Barcelona PRBB, c Doctor Aiguader 88, 08003 Barcelona, Spain
    Br J Nutr 101:1821-7. 2009
    ..Adherence to the Mediterranean diet was associated with higher scoring for self-perceived health...
  23. doi request reprint In vivo transcriptomic profile after a Mediterranean diet in high-cardiovascular risk patients: a randomized controlled trial
    Olga Castañer
    Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Research Institute, Barcelona, Spain
    Am J Clin Nutr 98:845-53. 2013
    ..Nutrients can exert healthy effects through nutrigenomic modulation. Data are scarce concerning the in vivo effect of a sustained traditional Mediterranean diet (TMD) pattern on the whole transcriptomic response...
  24. ncbi request reprint Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review
    Montserrat Fito
    Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Ann Ist Super Sanita 43:375-81. 2007
    ..Here, we summarize the state of the art of the body of knowledge, and to which extent we have evidence, of the bioavailability and of the antioxidant benefits of olive oil phenolic compounds in humans...
  25. doi request reprint The Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease
    Mireia Urpi-Sarda
    Department of Internal Medicine, University of Barcelona, Barcelona, Spain
    J Nutr 142:1019-25. 2012
    ..01). This study suggests that a MD reduces TNFR concentrations in patients at high cardiovascular risk...
  26. doi request reprint Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans
    Olga Castañer
    Cardiovascular Risk and Nutrition, Research Groups of Institut Mar d Investigacions Mèdiques Research Institute Hospital del Mar, Barcelona, Spain
    Am J Clin Nutr 95:1238-44. 2012
    ..Polyphenols could exert health benefits not only by scavenging free radicals but also by modulating gene expression...
  27. doi request reprint A short screener is valid for assessing Mediterranean diet adherence among older Spanish men and women
    Helmut Schroder
    Cardiovascular Risk and Nutrition Research Group, IMIM Institut de Recerca del Hospital del Mar, Barcelona 08003, Spain
    J Nutr 141:1140-5. 2011
    ..The 10-y estimated coronary artery disease risk decreased as the PREDIMED score increased (P < 0.001). The MEDAS is a valid instrument for rapid estimation of adherence to the Mediterranean diet and may be useful in clinical practice...
  28. ncbi request reprint Prevalence in the eligibility for weight loss treatment in a Mediterranean population
    Helmut Schroder
    Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d Investigacio Medica, Parc de Recerca Biomedica de Barcelona, Spain
    Br J Nutr 99:442-6. 2008
    ..This trend is more pronounced in older age groups and among the population with a basic educational level...
  29. ncbi request reprint South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe
    Maria Grau
    Lipids and Cardiovascular Epidemiology Unit, Municipal Institute Medical Research IMIM Barcelona, Carrer Dr Aiguader, 88, E 08003 Barcelona, Spain
    Eur Heart J 28:2841-9. 2007
    ..The aim of our study was to determine whether differences exist in the degree of LDL oxidation in stable CAD patients from different regions of Europe...
  30. pmc Glycemic load, glycemic index, and body mass index in Spanish adults
    Michelle A Mendez
    Center for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Biomedical Research Park, Barcelona, Spain
    Am J Clin Nutr 89:316-22. 2009
    ..Studies on obesity and glycemic index (GI) or glycemic load (GL) have had inconsistent results, perhaps in part because of underreporting or to heterogeneous dietary patterns across food cultures...
  31. ncbi request reprint Alcohol consumption is directly associated with circulating oxidized low-density lipoprotein
    Helmut Schroder
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica, IMIM, Barcelona, Spain
    Free Radic Biol Med 40:1474-81. 2006
    ..No significant relationship of ox-LDL with alcohol-independent consumption of wine, beer, and spirits was observed. Alcohol consumption was independently and directly associated with circulating ox-LDL in the present population...
  32. pmc The effects of the mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial
    Rosa Casas
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain CIBER 06 03 Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 9:e100084. 2014
    ..Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known...
  33. ncbi request reprint Hydroxytyrosol disposition in humans
    Elisabet Miro-Casas
    Unitat de Farmacologia de l Institut Municipal d Investigació Mèdica URAF IMIM, Doctor Aiguader No 80, 08003 Barcelona, Spain
    Clin Chem 49:945-52. 2003
    ..In animal and in vitro studies, hydroxytyrosol and its metabolites have been shown to be strong antioxidants. One of the prerequisites to assess their in vivo physiologic significance is to determine their presence in human plasma...
  34. doi request reprint Antioxidant activities of hydroxytyrosol main metabolites do not contribute to beneficial health effects after olive oil ingestion
    Olha Khymenets
    Human Pharmacology and Clinical Neurosciences Research Group, IMIM Hospital del Mar Research Institute, C Dr Aiguader 88, Barcelona, Spain
    Drug Metab Dispos 38:1417-21. 2010
    ..01-10 muM) after dietary olive oil consumption. None of the glucuronides displayed significant antioxidant activities at the concentrations tested...
  35. ncbi request reprint Low energy density diets are associated with favorable nutrient intake profile and adequacy in free-living elderly men and women
    Helmut Schroder
    Cardiovascular Risk and Nutrition Research Group CARIN ULEC, IMIM Hospital del Mar, Biomedical Research Park Parc de Recerca Biomèdica de Barcelona PRBB, 08003 Barcelona, Spain
    J Nutr 138:1476-81. 2008
    ..A low energy density diet has a higher capacity to prevent nutrient deficiency, despite lower energy content, than a high energy density diet in the elderly population studied...
  36. doi request reprint Validity of two short screeners for diet quality in time-limited settings
    Helmut Schroder
    Cardiovascular Risk and Nutrition Research Group CARIN ULEC, Program of Research in Inflammatory and Cardiovascular Disorders RICAD, IMIM Hospital del Mar, Biomedical Research Park, c Doctor Aiguader 88, 08003 Barcelona, Spain
    Public Health Nutr 15:618-26. 2012
    ..The present study assessed concurrent and construct validity of the short Diet Quality Screener (sDQS) and brief Mediterranean Diet Screener (bMDSC) questionnaires...
  37. doi request reprint Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study
    Olha Khymenets
    Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    OMICS 13:7-19. 2009
    ..Our data support the hypothesis that 3 weeks of nutritional intervention with VOO supplementation, at doses common in the Mediterranean diet, can alter the expression of genes related to atherosclerosis development and progression...
  38. ncbi request reprint Secular trends of obesity and cardiovascular risk factors in a Mediterranean population
    Helmut Schroder
    Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d Investigacio Medica, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Obesity (Silver Spring) 15:557-62. 2007
    ..To evaluate time trends of obesity, abdominal obesity, and cardiovascular risk factors (CRFs) according to BMI and waist circumference (WC) categories in a Mediterranean population...
  39. ncbi request reprint Relationship of classical and non-classical risk factors with genetic variants relevant to coronary heart disease
    Josep Maria Manresa
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Eur J Cardiovasc Prev Rehabil 13:738-44. 2006
    ..We aimed to determine the relationship of classical and non-classical cardiovascular risk factors with candidate gene polymorphisms potentially involved in cardiovascular risk in the general Mediterranean population...
  40. ncbi request reprint Association of fast food consumption with energy intake, diet quality, body mass index and the risk of obesity in a representative Mediterranean population
    Helmut Schroder
    Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d Investigacio Medica, IMIM Hospital de Mar, Biomedical Research Park Parc de Recerca Biomèdica de Barcelona PRBB, c Doctor Aiguader 88, 08003 Barcelona, Spain
    Br J Nutr 98:1274-80. 2007
    ..046). Fast food consumption was associated with higher energy intakes, poor diet quality and higher BMI. The likelihood of not meeting the DRI for energy, and of being obese, increased with the frequency of fast food consumption...
  41. ncbi request reprint Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
    Ramon Estruch
    Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
    Ann Intern Med 145:1-11. 2006
    ..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...
  42. ncbi request reprint [Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction]
    Monica Guxens
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica, Barcelona, Espana
    Rev Esp Cardiol 61:269-75. 2008
    ..However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and PON2-311 polymorphisms and their interaction on AMI risk...
  43. ncbi request reprint Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity
    Marta Tomas
    Lipids and Cardiovascular Epidemiology Unit, Departament de Ciencies Experimentals i de la Salut, Institut Municipal d Investigacio Medica IMIM, Dr Aiguader 80, E 08003 Barcelona, Spain
    J Lipid Res 43:713-20. 2002
    ..These results suggest that the effects of regular and acute exercise on PON1 activity levels are modulated by PON1-192 polymorphism. Changes were less evident for the PON1-55 polymorphism...
  44. ncbi request reprint Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial
    M Fito
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica IMIM, Carrer Doctor Aiguader, Barcelona, Spain
    Atherosclerosis 181:149-58. 2005
    ..Consumption of VOO, rich in PC, could provide beneficial effects in CHD patients as an additional and complementary intervention to the pharmacological treatment...
  45. doi request reprint Olive oil polyphenols enhance the expression of cholesterol efflux related genes in vivo in humans. A randomized controlled trial
    Marta Farras
    Cardiovascular Risk and Nutrition Research Group, CIBER de Fisiopatología de la Obesidad y la Nutrición, IMIM Research Institut Hospital del Mar, Barcelona, Spain
    J Nutr Biochem 24:1334-9. 2013
    ..These results are in agreement with previous ones concerning the fact that benefits associated with polyphenol-rich olive oil consumption on cardiovascular risk could be mediated through an in vivo nutrigenomic effect in humans...
  46. doi request reprint Dietary supplement use and health-related behaviors in a Mediterranean population
    Maria Asunción Rovira
    Cardiovascular Risk and Nutrition Research Group, Research Program in Inflammatory and Cardiovascular Disorders, Institut de Recerca Hospital del Mar, Barcelona, Spain CIBER Epidemiology and Public Health, Instituto de Salud Carlos III, Madrid, Spain
    J Nutr Educ Behav 45:386-91. 2013
    ..To determine predictors and health-related motivation for supplement use...
  47. doi request reprint Relationship of lipid oxidation with subclinical atherosclerosis and 10-year coronary events in general population
    Miquel Gomez
    Cardiology Department, Parc de Salut Mar, Barcelona, Spain Medicine Department, Autonomous University of Barcelona, Barcelona, Spain Inflammatory and Cardiovascular Disease Programme RICAD, IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain
    Atherosclerosis 232:134-40. 2014
    ....
  48. doi request reprint Health effects of olive oil polyphenols: recent advances and possibilities for the use of health claims
    Sandra Martín-Peláez
    Cardiovascular Risk and Nutrition Research Group CARIN, Research in Inflammatory and Cardiovascular Disorders RICAD, Barcelona, Spain
    Mol Nutr Food Res 57:760-71. 2013
    ..This review discusses the health effects of olive oil phenols along with the possibilities of communicating these effects on food labels...
  49. doi request reprint Concurrent and construct validity of Mediterranean diet scores as assessed by an FFQ
    Alejandra A Benítez-Arciniega
    Cardiovascular Risk and Nutrition Research Group CARIN ULEC, IMIM Hospital del Mar Barcelona, Biomedical Research Park Parc de Recerca Biomèdica de Barcelona PRBB, c Doctor Aiguader 88, 08003 Barcelona, Spain
    Public Health Nutr 14:2015-21. 2011
    ....
  50. ncbi request reprint Is dopamine behind the health benefits of red wine?
    Rafael de la Torre
    Pharmacology Unit IMIM, Institut Municipal d Investigacio Medica, Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Nutr 45:307-10. 2006
    ..Hydroxytyrosol is a dopamine metabolite, and also a very active naturally occurring phenol compound in olive oil...
  51. ncbi request reprint Bioavailability of phenolic compounds from olive oil and oxidative/antioxidant status at postprandial state in healthy humans
    T Weinbrenner
    Lipids and Cardiovascular Epidemiology Unit, Institute of Medical Investigation, Barcelona, Spain
    Drugs Exp Clin Res 30:207-12. 2004
    ..The phenolic content of the olive oils administered may account for the protection of the endogenous antioxidant defenses at postprandial state after ingestion of moderate and high phenolic content olive oils...
  52. pmc Effects of 1-year intervention with a mediterranean diet on plasma Fatty acid composition and metabolic syndrome in a population at high cardiovascular risk
    Jordi Mayneris-Perxachs
    Department of Nutrition and Food Science XARTA INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    PLoS ONE 9:e85202. 2014
    ..The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention...
  53. ncbi request reprint Olive oil and oxidative stress
    Montserrat Fito
    Lipids and Cardiovascular Epidemiology Unit and Pharmacology Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Mol Nutr Food Res 51:1215-24. 2007
    ..In this review, we summarize the state of the art, and degree of evidence, of the body of knowledge concerning the protective role of the major and minor components of olive oil on oxidative stress...
  54. ncbi request reprint HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans
    Mireia Urpi-Sarda
    Nutrition and Food Science Department, CeRTA, Pharmacy School, University of Barcelona, Barcelona, Spain
    Clin Chem 53:292-9. 2007
    ..We sought to develop a method for nutritional analysis of resveratrol, a phenolic compound with purported health-promoting properties, and to determine all resveratrol metabolites...
  55. doi request reprint Role of sex and time of blood sampling in SOD1 and SOD2 expression variability
    Olha Khymenets
    Human Pharmacology and Clinical Neurosciences Research Group, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
    Clin Biochem 41:1348-54. 2008
    ..This study investigates how some of human physiological parameters, in particular sex and daytime, can contribute to the normal variation in blood gene expression...
  56. doi request reprint Antioxidant enzyme activity and coronary heart disease: meta-analyses of observational studies
    Gemma Flores-Mateo
    Primary Care Centres Research Institut Jordi Gol, Barcelona, Spain
    Am J Epidemiol 170:135-47. 2009
    ....
  57. ncbi request reprint Use of a three-day estimated food record, a 72-hour recall and a food-frequency questionnaire for dietary assessment in a Mediterranean Spanish population
    H Schroder
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica, IMIM, Barcelona, Spain
    Clin Nutr 20:429-37. 2001
    ..To assess the validity and the short-term reproducibility of a semi-quantitative, self-administrated food frequency questionnaire and a structured 72-hour recall in a Mediterranean Spanish population...
  58. doi request reprint Exocrine pancreatic cancer clinical factors were related to timing of blood extraction and influenced serum concentrations of lipids
    Miquel Porta
    Institut Municipal d Investigació Mèdica Hospital del Mar, Barcelona, Spain
    J Clin Epidemiol 61:695-704. 2008
    ..We analyzed the influence of clinical factors and timing of blood extraction on serum concentrations of cholesterol and triglycerides in exocrine pancreatic cancer (EPC)...
  59. doi request reprint Mediterranean diet and waist circumference in a representative national sample of young Spaniards
    Helmut Schroder
    Cardiovascular Risk and Nutrition Research Group CARIN ULEC, Municipal Institute of Medical Research IMIM Hospital del Mar, Biomedical Research Park Parc de Recerca Biomèdica de Barcelona PRBB, Spain
    Int J Pediatr Obes 5:516-9. 2010
    ..54 cm in sex-, age- and height-adjusted WC. These results suggest that following Mediterranean dietary principles may be important in reducing the risk of high waist circumference in young people...
  60. ncbi request reprint Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial
    M Fito
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Eur J Clin Nutr 62:570-4. 2008
    ..To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients...
  61. ncbi request reprint Validation of the Minnesota Leisure Time Physical Activity Questionnaire In Spanish Women. Investigators of the MARATDON Group
    R Elosua
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica, IMIM, Barcelona, Spain
    Med Sci Sports Exerc 32:1431-7. 2000
    ..It is important to validate PA measurement instruments in different populations. The objective was to validate the Minnesota leisure time PA questionnaire among Spanish women...
  62. ncbi request reprint High monetary costs of dietary patterns associated with lower body mass index: a population-based study
    H Schroder
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica, IMIM, Barcelona, Spain
    Int J Obes (Lond) 30:1574-9. 2006
    ..The purpose of this study was to determine the cost differences between low and high adherence to two dietary patterns which have been inversely associated with body mass index (BMI) and obesity...
  63. ncbi request reprint Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women
    R Elosua
    Unitat de Lipids i Epidemiologia Cardiovascular, Institut Municipal d Investigacio Medica, Dr Aiguader 80, Barcelona 08003, Spain
    Atherosclerosis 167:327-34. 2003
    ..Regular PA increases endogenous antioxidant activity and LDL resistance to oxidation, and decreases oxidized LDL concentration; 30 min of aerobic PA decreases P-GR and B-GSH-Px activity in the first 30-60 min with a posterior recovery...
  64. ncbi request reprint Decreased endogenous antioxidant enzymatic status in essential hypertension
    J Pedro-Botet
    Hospital del Mar, Barcelona, Spain
    J Hum Hypertens 14:343-5. 2000
    ..64, P < 0.0001, respectively). The low endogenous antioxidant enzyme activities observed may in turn result in decreased superoxide anion removal leading to nitric oxide inactivation. Journal of Human Hypertension (2000) 14, 343-345..
  65. doi request reprint Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
    Rafael de la Torre
    Human Pharmacology and Clinical Neurosciences Research Group Neurosciences Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain Cardiovascular Risk and Nutrition Research Group Inflammatory and Cardiovascular Disorders Program, IMIM Hospital del Mar Research Institute, and CIBER of Physiopathology of Obesity and Nutrition CIBEROBN, Barcelona, Spain University Pompeu Fabra, CEXS UPF, Barcelona, Spain
    Mol Nutr Food Res 58:278-88. 2014
    ..Accumulating data suggest that overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), is a critical pathogenic mechanisms in the intellectual deficit...
  66. ncbi request reprint Trends in cardiovascular risk factor prevalence (1995-2000-2005) in northeastern Spain
    Maria Grau
    Lipids and Cardiovascular Epidemiology Unit, Municipal Institute for Medical Research IMIM, Carrer Dr Aiguader 88, Barcelona, Spain
    Eur J Cardiovasc Prev Rehabil 14:653-9. 2007
    ..Our objective was to determine the trends of cardiovascular risk factor prevalence between 1995 and 2005 in the 35-74-year-old population of Gerona, Spain...
  67. ncbi request reprint [Prevalence of hepatitis B and hepatitis C viruses in different counties of Catalonia, Spain: cross-sectional study]
    Ricard Sola
    Societat Catalana de Digestologia, Acadèmia de Ciències Mèdiques de Catalunya i Balears, Barcelona, Spain
    Med Clin (Barc) 119:90-5. 2002
    ..There are few data available in our community regarding the prevalence of hepatitis B (HBV) and hepatitis C (HCV) virus infection in the general population...
  68. ncbi request reprint [Coronary disease protective factors: antioxidant effect of olive oil]
    M I Covas
    , , Carrer Dr. Aiguader, 80, 08003 Barcelona, Espagne
    Therapie 56:607-11. 2001
    ..PC from diet could bind human LDL in non-supplemented volunteers. PC from virgin olive oil could bind LDL and tyrosol is bioavailable in humans from ingestion of virgin olive oil in its natural form...
  69. ncbi request reprint Bioavailability of tyrosol, an antioxidant phenolic compound present in wine and olive oil, in humans
    M I Covas
    Lipids and Cardiovascular Epidemiology Unit, Municipal Institute of Medical Research, Barcelona, Spain
    Drugs Exp Clin Res 29:203-6. 2003
    ..In summary, our results suggest that tyrosol from wine or virgin olive oil could exert beneficial effects on human health in vivo if its biological properties are confirmed in in vivo studies...
  70. ncbi request reprint Capillary gas chromatography-mass spectrometry quantitative determination of hydroxytyrosol and tyrosol in human urine after olive oil intake
    E Miro-Casas
    Unitat de Farmacologia, Universitat Autonoma de Barcelona, Barcelona, 08003, Spain
    Anal Biochem 294:63-72. 2001
    ..Our results further indicate that hydroxytyrosol and tyrosol are mainly excreted in conjugated form, since only 5.9 +/- 1.4% (hydroxytyrosol) and 13.8 +/- 5.4% (tyrosol) of the total amounts excreted in urine were in free form...
  71. ncbi request reprint Characterization of human gene expression changes after olive oil ingestion: an exploratory approach
    V Konstantinidou
    Cardiovascular Risk and Nutrition Research Group, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Folia Biol (Praha) 55:85-91. 2009
    ..Our results support the hypothesis that postprandial protective changes related to olive oil consumption could be mediated through gene expression changes...
  72. doi request reprint Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
    R Estruch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain
    J Epidemiol Community Health 63:582-8. 2009
    ..Thus, the effects of changes in dietary fibre intake on cardiovascular risk factors were assessed over 3 months in free-living high-risk subjects...