Javier Cortes

Summary

Affiliation: Hospital Universitari Vall d'Hebron
Country: Spain

Publications

  1. ncbi request reprint Targeting the microtubules in breast cancer beyond taxanes: the epothilones
    Javier Cortes
    Department of Oncology, Vall d Hebron University Hospital, Barcelona, Spain
    Oncologist 12:271-80. 2007
  2. doi request reprint Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine
    Javier Cortes
    Vall d Hebron University Hospital, Barcelona, Spain
    J Clin Oncol 28:3922-8. 2010
  3. doi request reprint Safety of bevacizumab in metastatic breast cancer patients undergoing surgery
    Javier Cortes
    Department of Oncology, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur J Cancer 48:475-81. 2012
  4. doi request reprint HER2 and hormone receptor-positive breast cancer--blocking the right target
    Javier Cortes
    Vall d Hebron University Hospital, Oncology Department, Breast Cancer Unit, Paseo Vall d Hebron 119 129, 08035 Barcelona, Spain
    Nat Rev Clin Oncol 8:307-11. 2011
  5. doi request reprint Eribulin mesylate: a promising new antineoplastic agent for locally advanced or metastatic breast cancer
    Javier Cortes
    Department of Medical Oncology, Breast Cancer Unit, Vall d Hebron University Hospital, 08035 Barcelona, Spain
    Future Oncol 7:355-64. 2011
  6. ncbi request reprint Prognostic factors for disease-free survival in patients with T3-4 or N+ rectal cancer treated with preoperative chemoradiation therapy, surgery, and intraoperative irradiation
    Juan A Diaz-Gonzalez
    Department of Oncology, Clinica Universitaria, University of Navarra, Navarra, Spain
    Int J Radiat Oncol Biol Phys 64:1122-8. 2006
  7. doi request reprint Pregnancy after treatment of breast cancer in young women does not adversely affect the prognosis
    Octavi Córdoba
    Breast Cancer Unit, Service of Gynecology, Hospital Vall d Hebron, Barcelona, Spain
    Breast 21:272-5. 2012
  8. doi request reprint Outcome of patients following hepatic resection for metastatic cutaneous and ocular melanoma
    Mireia Caralt
    Department of Hepatobiliopancreatic Surgery and Transplants, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Hepatobiliary Pancreat Sci 18:268-75. 2011
  9. doi request reprint Implication of breast cancer phenotype for patients with leptomeningeal carcinomatosis
    Davis Torrejón
    Breast Cancer Center, Vall d Hebron University Hospital, Passeig de la Vall d Hebron 119 129, 08035 Barcelona, Spain
    Breast 22:19-23. 2013
  10. pmc Beyond taxanes: the next generation of microtubule-targeting agents
    Javier Cortes
    Breast Cancer Program, Department of Oncology, Vall d Hebron University Hospital, Vall d Hebron 119 129, Barcelona, Spain
    Breast Cancer Res Treat 133:821-30. 2012

Detail Information

Publications41

  1. ncbi request reprint Targeting the microtubules in breast cancer beyond taxanes: the epothilones
    Javier Cortes
    Department of Oncology, Vall d Hebron University Hospital, Barcelona, Spain
    Oncologist 12:271-80. 2007
    ..The results of these studies are eagerly awaited and it is anticipated that epothilones may become an important treatment option in patients with breast cancer...
  2. doi request reprint Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine
    Javier Cortes
    Vall d Hebron University Hospital, Barcelona, Spain
    J Clin Oncol 28:3922-8. 2010
    ....
  3. doi request reprint Safety of bevacizumab in metastatic breast cancer patients undergoing surgery
    Javier Cortes
    Department of Oncology, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur J Cancer 48:475-81. 2012
    ..Evaluate the safety of surgery in relation to bevacizumab in the first-line treatment of metastatic breast cancer (mBC) in two international trials...
  4. doi request reprint HER2 and hormone receptor-positive breast cancer--blocking the right target
    Javier Cortes
    Vall d Hebron University Hospital, Oncology Department, Breast Cancer Unit, Paseo Vall d Hebron 119 129, 08035 Barcelona, Spain
    Nat Rev Clin Oncol 8:307-11. 2011
    ..In this article, we highlight the importance of considering chemotherapy and anti-HER2 therapy as the standard of care in HER2-positive and hormone receptor-positive tumors...
  5. doi request reprint Eribulin mesylate: a promising new antineoplastic agent for locally advanced or metastatic breast cancer
    Javier Cortes
    Department of Medical Oncology, Breast Cancer Unit, Vall d Hebron University Hospital, 08035 Barcelona, Spain
    Future Oncol 7:355-64. 2011
    ..In addition, eribulin has a manageable tolerability profile, requires no premedication and has shorter infusion times than most other microtubule-targeted agents...
  6. ncbi request reprint Prognostic factors for disease-free survival in patients with T3-4 or N+ rectal cancer treated with preoperative chemoradiation therapy, surgery, and intraoperative irradiation
    Juan A Diaz-Gonzalez
    Department of Oncology, Clinica Universitaria, University of Navarra, Navarra, Spain
    Int J Radiat Oncol Biol Phys 64:1122-8. 2006
    ..Potential predictive factors for response and disease-free survival, with intense local multidisciplinary approach, are analyzed...
  7. doi request reprint Pregnancy after treatment of breast cancer in young women does not adversely affect the prognosis
    Octavi Córdoba
    Breast Cancer Unit, Service of Gynecology, Hospital Vall d Hebron, Barcelona, Spain
    Breast 21:272-5. 2012
    ..009). Breast cancer patients presented a high number of unwanted pregnancies. Pregnancy after breast cancer not only did not adversely affect prognosis of the neoplasm but also may have a protective effect...
  8. doi request reprint Outcome of patients following hepatic resection for metastatic cutaneous and ocular melanoma
    Mireia Caralt
    Department of Hepatobiliopancreatic Surgery and Transplants, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Hepatobiliary Pancreat Sci 18:268-75. 2011
    ..The aim of this study was to analyze the outcome of patients undergoing hepatic resection for melanoma liver metastases...
  9. doi request reprint Implication of breast cancer phenotype for patients with leptomeningeal carcinomatosis
    Davis Torrejón
    Breast Cancer Center, Vall d Hebron University Hospital, Passeig de la Vall d Hebron 119 129, 08035 Barcelona, Spain
    Breast 22:19-23. 2013
    ..We aimed to study the implications of breast cancer (BC) subtypes for the development and prognosis of leptomeningeal carcinomatosis (LC)...
  10. pmc Beyond taxanes: the next generation of microtubule-targeting agents
    Javier Cortes
    Breast Cancer Program, Department of Oncology, Vall d Hebron University Hospital, Vall d Hebron 119 129, Barcelona, Spain
    Breast Cancer Res Treat 133:821-30. 2012
    ..The development of new microtubule-targeting agents helps to address the need for additional effective regimens for patients progressing after standard treatment with anthracycline- and taxane-containing regimens...
  11. doi request reprint Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study
    Javier Cortes
    Vall d Hebron University Hospital, Vall d Hebron Institute of Oncology, Barcelona, Spain
    Lancet 377:914-23. 2011
    ..Eribulin mesilate is a non-taxane microtubule dynamics inhibitor with a novel mode of action. We aimed to compare overall survival of heavily pretreated patients receiving eribulin versus currently available treatments...
  12. ncbi request reprint Complete pathological remission in a patient with hormone-receptor positive and c-erbB-2 expression-negative breast cancer treated with FAC chemotherapy during pregnancy
    Octavi Córdoba
    Breast Unit, Service of Obstetrics and Gynecology, Hospital Vail d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    Tumori 96:629-32. 2010
    ..This case illustrates how the integrated work of different specialists can obtain excellent oncological and obstetrical results in the care of pregnant women with breast cancer...
  13. doi request reprint Nonpegylated liposomal doxorubicin (TLC-D99), paclitaxel, and trastuzumab in HER-2-overexpressing breast cancer: a multicenter phase I/II study
    Javier Cortes
    Vall d Hebron University Hospital, Barcelona, Spain
    Clin Cancer Res 15:307-14. 2009
    ....
  14. doi request reprint Multidisciplinary approach to breast cancer diagnosed during pregnancy: maternal and neonatal outcomes
    Octavi Córdoba
    Vall d Hebron Breast Cancer Center, Service of Gynecology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Breast 22:515-9. 2013
    ..We assessed maternal and neonatal outcome in women diagnosed with breast cancer during pregnancy...
  15. doi request reprint Docetaxel combined with targeted therapies in metastatic breast cancer
    Javier Cortes
    Department of Oncology, Vall d Hebron University Hospital, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Cancer Treat Rev 38:387-96. 2012
    ..Overall, docetaxel in combination with novel targeted agents in MBC appears to be highly active in patients with MBC, and such combinations represent promising treatment regimens for clinical investigation...
  16. doi request reprint Cost-effectiveness analyses of docetaxel versus paclitaxel once weekly in patients with metastatic breast cancer in progression following anthracycline chemotherapy, in Spain
    Carmen Frias
    Corporacio Sanitaria Parc Tauli, Barcelona, Spain
    Clin Transl Oncol 12:692-700. 2010
    ..Our aim was to evaluate the cost-effectiveness of docetaxel versus weekly paclitaxel regimen in patients with metastatic breast cancer previously treated with anthracycline from the Spanish National Health Service (NHS) perspective...
  17. doi request reprint Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    Jose Baselga
    Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Paseo Vall d Hebron 119 129, Barcelona, Spain E 08035
    J Clin Oncol 28:1138-44. 2010
    ..This phase II trial assessed the efficacy and safety profile of the combination in patients with HER2-positive breast cancer whose disease had progressed during prior trastuzumab-based therapy...
  18. doi request reprint PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition
    Yasir H Ibrahim
    Experimental Therapeutics Laboratory, Vall d Hebron Institute of Oncology VHIO, Pg Vall d Hebron, Barcelona, Spain
    Cancer Discov 2:1036-47. 2012
    ....
  19. pmc Advances in first-line treatment for patients with HER-2+ metastatic breast cancer
    Leticia De Mattos-Arruda
    Medical Oncology Department, Vall d Hebron University Hospital, Barcelona, Spain
    Oncologist 17:631-44. 2012
    ..Although anti-HER-2 therapy with trastuzumab and chemotherapy is the standard first-line treatment, the best therapeutic regimen has yet to be defined, and new strategies are evolving...
  20. ncbi request reprint Chemotherapy and role of the proliferation marker Ki-67 in digestive neuroendocrine tumors
    Eduardo Vilar
    Department of Medical Oncology, Vall d Hebron University Hospital, Barcelona 08035, Spain
    Endocr Relat Cancer 14:221-32. 2007
    ..Also a comprehensive review of the literature about chemotherapy in NETs is presented...
  21. doi request reprint New approach to cancer therapy based on a molecularly defined cancer classification
    Javier Cortes
    Head of the Breast Cancer and Melanoma Programs, Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Barcelona, Spain Medical Oncologist, Medica Scientia Innovation Research MedSIR, Barcelona, Spain
    CA Cancer J Clin 64:70-4. 2014
    ..CA Cancer J Clin 2014;64:70-74. (©) 2013 American Cancer Society. ..
  22. doi request reprint Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
    Aleix Prat
    1 Translational Genomics Group, Vall d Hebron Institute of Oncology VHIO, Barcelona, Spain 2 Breast Cancer Unit, Vall d Hebron Institute of Oncology VHIO, Barcelona, Spain 3 Medical Oncology Department, Vall d Hebron Institute of Oncology VHIO, Barcelona, Spain
    Sci Rep 3:3544. 2013
    ....
  23. doi request reprint Breast cancer and HSP90 inhibitors: is there a role beyond the HER2-positive subtype?
    Leticia De Mattos-Arruda
    Medical Oncology Department, Vall d Hebron University Hospital, Paseo Vall d Hebron 119 129, 08035 Barcelona, Spain
    Breast 21:604-7. 2012
    ..In this article, we revisit HSP90 inhibitors in the context of breast cancer and discuss some notable preclinical data that reveal potential roles in both hormonal receptor-positive and triple negative breast tumor subtypes...
  24. doi request reprint Eribulin mesylate, a novel microtubule inhibitor in the treatment of breast cancer
    Javier Cortes
    Department of Oncology, Vall d Hebron University Hospital, Barcelona, Spain
    Cancer Treat Rev 38:143-51. 2012
    ....
  25. doi request reprint Circulating tumour cells and cell-free DNA as tools for managing breast cancer
    Leticia De Mattos-Arruda
    Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Paseo Vall d Hebron 119 129, 08035 Barcelona, Spain
    Nat Rev Clin Oncol 10:377-89. 2013
    ..In this Review, we discuss the current status of blood-born biomarkers as surrogates for tissue-based biomarkers, and their burgeoning impact on the management of patients with breast cancer. ..
  26. doi request reprint The effect of biology in the treatment of small breast tumors
    Jose Perez-Garcia
    From the Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Medica Scientia Innovation Research MedSIR, Passeig Vall d Hebron, Barcelona, Spain
    Am Soc Clin Oncol Educ Book 33:25-31. 2013
    ..Although a chemotherapy-based strategy might be useful for triple-negative or HER2-positive T1b tumors, more information is urgently needed in order to optimize the treatment of our patients. ..
  27. ncbi request reprint Preoperative chemoradiation with oral tegafur within a multidisciplinary therapeutic approach in patients with T3-4 rectal cancer
    Juan A Diaz-Gonzalez
    Department of Oncology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Int J Radiat Oncol Biol Phys 61:1378-84. 2005
    ..The aim of this study was to evaluate the activity in terms of downstaging histologic patterns of residual tumor and clinical tolerance of a neoadjuvant chemoradiation program with oral tegafur for rectal cancer...
  28. ncbi request reprint Epidermal growth factor receptor pathway inhibitors
    Jose Baselga
    Medical Oncology Service, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Spain
    Cancer Chemother Biol Response Modif 22:205-23. 2005
  29. pmc Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients
    Maurizio Scaltriti
    Departments of Medical Oncology and Molecular Pathology, Vall d Hebron Institute of Oncology, 08035 Barcelona, Spain
    Proc Natl Acad Sci U S A 108:3761-6. 2011
    ....
  30. doi request reprint Hepatic resection for liver metastases as part of the "oncosurgical" treatment of metastatic breast cancer
    Mireia Caralt
    Department of Hepatobiliopancreatic Surgery and Transplants, Hospital Universitari Vall d Hebron, Paseo Vall d Hebron119 129, Barcelona, 08035, Spain
    Ann Surg Oncol 15:2804-10. 2008
    ..Metastatic breast cancer is considered an incurable disease despite new therapies. Recent studies suggest that liver resection associated with systemic treatment may improve patient survival...
  31. ncbi request reprint Prognostic and predictive factors and genetic analysis of early breast cancer
    Miguel Martin
    Department of Medical Oncology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin Transl Oncol 11:634-42. 2009
    ....
  32. ncbi request reprint Combined irinotecan, oxaliplatin and 5-fluorouracil in patients with advanced colorectal cancer. a feasibility pilot study
    Emiliano Calvo
    Department of Oncology, Division of Medical Oncology, Clinica Universitaria de Navarra, University of Navarra, Navarra, Spain
    Oncology 63:254-65. 2002
    ..To evaluate the feasibility and a possible activity range of combination irinotecan (CPT-11), oxaliplatin, and 5-FU in advanced colorectal cancer (ACC)...
  33. doi request reprint Use of pertuzumab for the treatment of HER2-positive metastatic breast cancer
    Leticia De Mattos-Arruda
    Medical Oncology Department, Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Barcelona, Spain
    Adv Ther 30:645-58. 2013
    ..Pertuzumab, a HER2-targeted monoclonal antibody that prevents HER2 dimerisation, is the first of a class of promising targeted agents for the treatment of HER2-positive breast cancer...
  34. doi request reprint Dasatinib plus capecitabine for advanced breast cancer: safety and efficacy in phase I study CA180004
    George Somlo
    City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Clin Cancer Res 19:1884-93. 2013
    ..We aimed to assess toxicity and maximum tolerated dose (MTD) for dasatinib plus capecitabine, estimate efficacy, and explore effects on angiogenesis...
  35. doi request reprint Current situation: lower genital tract pathology and colposcopy training in spanish gynecology and obstetrics residents
    Núria Laia Rodríguez-Mias
    Department of Obstetrics and Gynecology, Hospital Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain
    J Low Genit Tract Dis 17:12-6. 2013
    ..This didactic change was carried out under the auspices of the Asociación Española de Patología Cervical y Colposcopia and the Sociedad Española Ginecología y Obstetricia and its Resident Section...
  36. pmc Do we need biomarkers to predict the benefit of adding adjuvant taxanes for treatment of breast cancer?
    Jose Perez-Garcia
    Breast Cancer Unit, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Breast Cancer Res 14:104. 2012
    ..For this reason, the Ki67 index might help to better define the group of patients who could have the optimal benefit...
  37. doi request reprint Molecular pathways: targeting hsp90--who benefits and who does not
    Maurizio Scaltriti
    Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Clin Cancer Res 18:4508-13. 2012
    ..Several ongoing studies testing different combinations of Hsp90 inhibitors with other targeted agents will confirm whether Hsp90 inhibition can potentiate the efficacy of targeted therapy and/or prevent the emergence of drug resistance...
  38. ncbi request reprint New approaches in angiogenic targeting for colorectal cancer
    Aleix Prat
    Department of Medical Oncology, Vall d Hebron University Hospital, Paseo Vall d Hebron, 119 129, Barcelona 08035, Spain
    World J Gastroenterol 13:5857-66. 2007
    ..In this review we discuss and highlight current and future approaches in angiogenic targeting for CRC...
  39. pmc Eribulin mesylate as a microtubule inhibitor for treatment of patients with metastatic breast cancer
    Eva Muñoz-Couselo
    Breast Cancer Unit, Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Onco Targets Ther 4:185-92. 2011
    ..This review will focus on eribulin as a new active agent for MBC and its role in the management of breast disease...
  40. ncbi request reprint Paclitaxel, cisplatin, and vinorelbine combination chemotherapy in metastatic non-small-cell lung cancer
    Javier Cortes
    Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain
    Am J Clin Oncol 27:299-303. 2004
    ..3 weeks and the median overall survival was 31.3 weeks. This three-drug chemotherapy combination is feasible, well tolerated, and shows activity in metastatic NSCLC...
  41. ncbi request reprint Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    Maurizio Scaltriti
    Medical Oncology Program, Medical Oncology Department, Vall d Hebron University Hospital and Research Institute, Barcelona 08035, Spain
    J Natl Cancer Inst 99:628-38. 2007
    ....