Research Topics
| Juan CordobaSummaryAffiliation: Hospital Universitari Vall d'Hebron Country: Spain Publications
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Detail Information
Publications
Hepatic encephalopathyJuan Cordoba
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Departament de Medicina, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
Semin Liver Dis 28:70-80. 2008..Liver transplant should be considered in selected patients with hepatic encephalopathy. Future prospects include new drugs that decrease plasma ammonia, measures to reduce brain edema, and liver-support devices...- Hyponatremic and hepatic encephalopathies: similarities, differences and coexistenceJuan Cordoba
Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119, Barcelona, 08035, Spain
Metab Brain Dis 25:73-80. 2010..Recognition of these abnormalities is important to plan therapy. New drugs that affect brain hydration may be useful for both encephalopathies... - New assessment of hepatic encephalopathyJuan Cordoba
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Paseo Vall d Hebron 119, Barcelona 08035, Spain
J Hepatol 54:1030-40. 2011..The new methods presented are also valuable for investigating the neurological manifestations occurring after liver transplantation... 
T2 hyperintensity along the cortico-spinal tract in cirrhosis relates to functional abnormalitiesJuan Cordoba
Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119, Barcelona 08035, Spain
Hepatology 38:1026-33. 2003..These findings suggest that mild cerebral edema along the cortico-spinal pathway may cause neuronal dysfunction. These results support the participation of astrocytic edema in the pathogenesis of hepatic encephalopathy...- Normal protein diet for episodic hepatic encephalopathy: results of a randomized studyJuan Cordoba
Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain
J Hepatol 41:38-43. 2004..We designed a study to assess the effects of the amount of protein in the diet on the evolution of episodic hepatic encephalopathy... - Hepatic encephalopathy is associated with posttransplant cognitive function and brain volumeRita Garcia-Martinez
Internal Medicine Hepatology Service, Hospital Universitari Vall d Hebron, Barcelona, Spain
Liver Transpl 17:38-46. 2011..41, P = 0.049). In conclusion, the association of HE with cognitive function and brain volume suggests that having experienced HE before liver transplantation impairs the posttransplantation neurological outcome... - Quality of life in cirrhosis is related to potentially treatable factorsIñigo Les
Servei de Medicina Interna Hepatologia, Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain
Eur J Gastroenterol Hepatol 22:221-7. 2010..The aim of this study was to identify factors that influence HRQOL and may be potentially treatable in patients with cirrhosis... - Effects of branched-chain amino acids supplementation in patients with cirrhosis and a previous episode of hepatic encephalopathy: a randomized studyIñigo Les
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
Am J Gastroenterol 106:1081-8. 2011..We performed a study to investigate the long-term effects of supplementing a protein-controlled diet with BCAA... 
Brain magnetic resonance spectroscopy in episodic hepatic encephalopathyLaia Chavarria
1 Liver Unit, Hospital Vall d Hebron, Barcelona, Spain 2 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Ciberehd, Instituto de Salud Carlos III, Madrid, Spain 3 Departament de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
J Cereb Blood Flow Metab 33:272-7. 2013..Although astrocytes have a major role in this condition, brain edema during episodic HE may be extracellular and does not appear to be directly responsible for the development of neurologic manifestations...- Neuropsychological abnormalities in cirrhosis include learning impairmentMARIA ORTIZ
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
J Hepatol 44:104-10. 2006..We designed a study to assess the presence of memory abnormalities in cirrhotic patients and the effects of liver transplantation... - Oral glutamine challenge and magnetic resonance spectroscopy in three patients with congenital portosystemic shuntsMARIA ORTIZ
Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119, Barcelona 08035, Spain
J Hepatol 40:552-7. 2004..Our aim was to investigate the relationship between capillary blood ammonia after oral glutamine challenge and magnetic resonance spectroscopy in three patients with congenital portosystemic shunts... - A long-term study of changes in the volume of brain ventricles and white matter lesions after successful liver transplantationRita Garcia Martinez
Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
Transplantation 89:589-94. 2010..A prolonged survival in liver transplant recipients due to a better management exposes them to multiple factors that can impair neurologic function in the long term... - Falls and cognitive dysfunction impair health-related quality of life in patients with cirrhosisEva Roman
University School of Nursing Sant Pau, Universitat Autonoma de Barcelona, Instituto de Salud Carlos III, Barcelona, Spain
Eur J Gastroenterol Hepatol 25:77-84. 2013..Falls are frequent in patients with cirrhosis and cognitive dysfunction and can deteriorate health-related quality of life (HRQoL)... - Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathyBeatriz Minguez
Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
Hepatology 43:707-14. 2006..These disturbances, which include signs of increase in brain water and a compensatory osmotic response (decrease in brain myo-inositol), appear to be secondary to brain exposure to ammonia induced by portal-systemic shunting... - Prognostic assessment in patients with hepatic encephalopathyRita Garcia-Martinez
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
Dis Markers 31:171-9. 2011..The recurrence of HE is more common in patients that develop progressive deterioration of liver function and hyponatremia. The bouts of HE may cause sequels that have been shown to persist after liver transplant... - Decreased white matter lesion volume and improved cognitive function after liver transplantationAlex Rovira
Unitat de Ressonància Magnètica I D I, Departament de Radiologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
Hepatology 46:1485-90. 2007..The associated improvement of cognitive function supports a relationship between brain edema and minimal hepatic encephalopathy... - Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosisMarc Oria
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
J Hepatol 56:109-14. 2012..Ornithine phenylacetate (OP) is a new drug that has been proposed for the treatment of hepatic encephalopathy (HE) because it decreases plasma ammonia. We performed a study to assess if OP would impact on neuronal function... - Quality of life and cognitive function in hepatitis C at different stages of liver diseaseJuan Cordoba
Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Hospital Universitari Vall d Hebron, Paseo Vall d Hebron 119, Barcelona 08035, Spain
J Hepatol 39:231-8. 2003..Hepatitis C has been associated with a decrease in quality of life and with neurological abnormalities. The aim of our study was to investigate the relationship between quality of life and cognitive function... - Motor-evoked potentials in awake rats are a valid method of assessing hepatic encephalopathy and of studying its pathogenesisMarc Oria
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
Hepatology 52:2077-85. 2010..This method shows the lack of efficacy of mannitol, a therapy that decreases brain edema, and relates disturbances of the function of the motor tract to ammonia and its metabolites... - Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendationsMARIA ORTIZ
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119, Barcelona 08035, Spain
J Hepatol 42:S45-53. 2005 - Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failureLaia Chavarria
Liver Unit, Hospital Vall Hebron, Barcelona, Spain
Gastroenterology 138:1566-73. 2010..Two mechanisms have been proposed in the pathogenesis: vasogenic edema that is secondary to the breakdown of the blood-brain barrier and cytotoxic edema caused by ammonia metabolites in astrocytes... - Brain magnetic resonance in experimental acute-on-chronic liver failureLaia Chavarria
Liver Unit, Hospital Vall Hebron, Barcelona, Spain
Liver Int 33:294-300. 2013..The aim of this study was to perform magnetic resonance (MR) study of the brain in a rat model combining bile duct ligation (BDL) and lipopolysaccharide (LPS) administration to investigate brain oedema in liver failure... - Neuroimaging in acute liver failureLaia Chavarria
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Vall d Hebron Institut of Research, Barcelona, Spain
Neurochem Int 59:1175-80. 2011..Neuroimaging methods, which are rapidly evolving, will undoubtedly lead to future diagnostic and therapeutic progress that could be very helpful for patients with ALF... - Validity of the Spanish version of the Chronic Liver Disease Questionnaire (CLDQ) as a standard outcome for quality of life assessmentMontserrat Ferrer
Health Services Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
Liver Transpl 12:95-104. 2006..These findings support its use as a standard outcome for patients with chronic liver diseases within the whole severity range, from "no cirrhosis" to transplant recipients, both in Spanish and international studies... - Magnetic resonance imaging measurement of brain edema in patients with liver disease: resolution after transplantationAlex Rovira
Magnetic Resonance Unit, Department of Radiology, Hospital Universitari Vall d Hebron, Barcelona, Spain
Curr Opin Neurol 15:731-7. 2002.... - Understanding the mechanisms of cerebral complications in fulminant hepatic failure: fluxes better than levelsJuan Cordoba
Liver Unit, Hospital Universitari Vall d Hebron, Paseo Vall d Hebron 119, Barcelona 08035, Spain
J Hepatol 37:878-9. 2002 - 1H magnetic resonance in the study of hepatic encephalopathy in humansJuan Cordoba
Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
Metab Brain Dis 17:415-29. 2002..These abnormalities appear to participate in some of the neurological manifestations of hepatic encephalopathy... - Reprint of: Neuroimaging in acute liver failureLaia Chavarria
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Vall d Hebron Institut of Research, Barcelona, Spain
Neurochem Int 60:684-9. 2012..Neuroimaging methods, which are rapidly evolving, will undoubtedly lead to future diagnostic and therapeutic progress that could be very helpful for patients with ALF... - Acute-on-chronic liver failure: the brainRita Garcia-Martinez
Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Madrid, Spain
Curr Opin Crit Care 17:177-83. 2011..Brain disturbances, which are considered a form of hepatic encephalopathy, are common in acute-on-chronic liver failure... - A 1H nuclear magnetic resonance-based metabonomic approach for grading hepatic encephalopathy and monitoring the effects of therapeutic hypothermia in ratsIgnasi Barba
Plataforma Metabonomica, RECAVA, Servei de Cardiologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
Liver Int 28:1141-8. 2008..There are no good biomarkers for grading hepatic encephalopathy (HE) and monitoring the effectiveness of therapeutic measures... - A new method for measuring motor evoked potentials in the awake rat: effects of anestheticsMarc Oria
Servicio de Medicina Interna Hepatología, Hospital Vall d Hebron, Barcelona, Spain
J Neurotrauma 25:266-75. 2008..This model may prove useful in the investigation of various diseases that affect the motor pathways without the confounding effects of anesthesia... - Current trends in chronic hepatitis B management: results of a questionnaireIñigo Les
Liver Unit, Hospital General Universitario Vall d Hebron and CIBER EHD, Barcelona, Spain
Eur J Gastroenterol Hepatol 21:1177-83. 2009..Aim of this study was to analyze general knowledge, therapeutic and diagnostic trends of physicians treating CHB in Spain... - Encephalopathy and liver transplantationLaia Chavarria
Liver Unit, Hospital Vall Hebron, Barcelona, Spain
Metab Brain Dis 28:285-92. 2013..Other factors present before LT that contribute to a worse neuropsychological outcome after LT are diabetes mellitus and alcohol consumption. Long-term after LT, cognitive function may worsen in relation to vascular risk factors... - Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trialPere Gines
Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
Hepatology 48:204-13. 2008..CONCLUSION: The V(2) receptor antagonist satavaptan improves the control of ascites and increases serum sodium in patients with cirrhosis, ascites, and hyponatremia under diuretic treatment...