Juan Cordoba

Summary

Affiliation: Hospital Universitari Vall d'Hebron
Country: Spain

Publications

  1. ncbi request reprint Normal protein diet for episodic hepatic encephalopathy: results of a randomized study
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Hepatol 41:38-43. 2004
  2. ncbi request reprint Hepatic encephalopathy
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Departament de Medicina, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Semin Liver Dis 28:70-80. 2008
  3. pmc Prognostic assessment in patients with hepatic encephalopathy
    Rita Garcia-Martinez
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
    Dis Markers 31:171-9. 2011
  4. doi request reprint Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF)
    Juan Cordoba
    Hospital Vall d Hebron, Department of Medicine, Liver Unit, Universitat Autonoma de Barcelona, Spain Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas CIBERehd, Instituto de Salud Carlos III, Madrid, Spain Electronic address
    J Hepatol 60:275-81. 2014
  5. ncbi request reprint T2 hyperintensity along the cortico-spinal tract in cirrhosis relates to functional abnormalities
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119, Barcelona 08035, Spain
    Hepatology 38:1026-33. 2003
  6. ncbi request reprint Hyponatremic and hepatic encephalopathies: similarities, differences and coexistence
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119, Barcelona, 08035, Spain
    Metab Brain Dis 25:73-80. 2010
  7. doi request reprint New assessment of hepatic encephalopathy
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Paseo Vall d Hebron 119, Barcelona 08035, Spain
    J Hepatol 54:1030-40. 2011
  8. doi request reprint Hepatic encephalopathy is associated with posttransplant cognitive function and brain volume
    Rita Garcia-Martinez
    Internal Medicine Hepatology Service, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Liver Transpl 17:38-46. 2011
  9. ncbi request reprint Quality of life in cirrhosis is related to potentially treatable factors
    Iñigo Les
    Servei de Medicina Interna Hepatologia, Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur J Gastroenterol Hepatol 22:221-7. 2010
  10. pmc Brain magnetic resonance spectroscopy in episodic hepatic encephalopathy
    Laia Chavarria
    Liver Unit, Hospital Vall d Hebron, Barcelona, Spain
    J Cereb Blood Flow Metab 33:272-7. 2013

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Normal protein diet for episodic hepatic encephalopathy: results of a randomized study
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Hepatol 41:38-43. 2004
    ..We designed a study to assess the effects of the amount of protein in the diet on the evolution of episodic hepatic encephalopathy...
  2. ncbi request reprint Hepatic encephalopathy
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Departament de Medicina, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Semin Liver Dis 28:70-80. 2008
    ..Liver transplant should be considered in selected patients with hepatic encephalopathy. Future prospects include new drugs that decrease plasma ammonia, measures to reduce brain edema, and liver-support devices...
  3. pmc Prognostic assessment in patients with hepatic encephalopathy
    Rita Garcia-Martinez
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
    Dis Markers 31:171-9. 2011
    ..The recurrence of HE is more common in patients that develop progressive deterioration of liver function and hyponatremia. The bouts of HE may cause sequels that have been shown to persist after liver transplant...
  4. doi request reprint Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF)
    Juan Cordoba
    Hospital Vall d Hebron, Department of Medicine, Liver Unit, Universitat Autonoma de Barcelona, Spain Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas CIBERehd, Instituto de Salud Carlos III, Madrid, Spain Electronic address
    J Hepatol 60:275-81. 2014
    ..In spite of the high incidence of hepatic encephalopathy (HE) in cirrhosis, there are few observational studies...
  5. ncbi request reprint T2 hyperintensity along the cortico-spinal tract in cirrhosis relates to functional abnormalities
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119, Barcelona 08035, Spain
    Hepatology 38:1026-33. 2003
    ..These findings suggest that mild cerebral edema along the cortico-spinal pathway may cause neuronal dysfunction. These results support the participation of astrocytic edema in the pathogenesis of hepatic encephalopathy...
  6. ncbi request reprint Hyponatremic and hepatic encephalopathies: similarities, differences and coexistence
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119, Barcelona, 08035, Spain
    Metab Brain Dis 25:73-80. 2010
    ..Recognition of these abnormalities is important to plan therapy. New drugs that affect brain hydration may be useful for both encephalopathies...
  7. doi request reprint New assessment of hepatic encephalopathy
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Paseo Vall d Hebron 119, Barcelona 08035, Spain
    J Hepatol 54:1030-40. 2011
    ..The new methods presented are also valuable for investigating the neurological manifestations occurring after liver transplantation...
  8. doi request reprint Hepatic encephalopathy is associated with posttransplant cognitive function and brain volume
    Rita Garcia-Martinez
    Internal Medicine Hepatology Service, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Liver Transpl 17:38-46. 2011
    ..41, P = 0.049). In conclusion, the association of HE with cognitive function and brain volume suggests that having experienced HE before liver transplantation impairs the posttransplantation neurological outcome...
  9. ncbi request reprint Quality of life in cirrhosis is related to potentially treatable factors
    Iñigo Les
    Servei de Medicina Interna Hepatologia, Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur J Gastroenterol Hepatol 22:221-7. 2010
    ..The aim of this study was to identify factors that influence HRQOL and may be potentially treatable in patients with cirrhosis...
  10. pmc Brain magnetic resonance spectroscopy in episodic hepatic encephalopathy
    Laia Chavarria
    Liver Unit, Hospital Vall d Hebron, Barcelona, Spain
    J Cereb Blood Flow Metab 33:272-7. 2013
    ..Although astrocytes have a major role in this condition, brain edema during episodic HE may be extracellular and does not appear to be directly responsible for the development of neurologic manifestations...
  11. doi request reprint Effects of branched-chain amino acids supplementation in patients with cirrhosis and a previous episode of hepatic encephalopathy: a randomized study
    Iñigo Les
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
    Am J Gastroenterol 106:1081-8. 2011
    ..We performed a study to investigate the long-term effects of supplementing a protein-controlled diet with BCAA...
  12. ncbi request reprint Oral glutamine challenge and magnetic resonance spectroscopy in three patients with congenital portosystemic shunts
    MARIA ORTIZ
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119, Barcelona 08035, Spain
    J Hepatol 40:552-7. 2004
    ..Our aim was to investigate the relationship between capillary blood ammonia after oral glutamine challenge and magnetic resonance spectroscopy in three patients with congenital portosystemic shunts...
  13. doi request reprint A long-term study of changes in the volume of brain ventricles and white matter lesions after successful liver transplantation
    Rita Garcia Martinez
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Transplantation 89:589-94. 2010
    ..A prolonged survival in liver transplant recipients due to a better management exposes them to multiple factors that can impair neurologic function in the long term...
  14. ncbi request reprint Safety of ornithine phenylacetate in cirrhotic decompensated patients: an open-label, dose-escalating, single-cohort study
    Meritxell Ventura-Cots
    Liver Unit, Hospital Vall d Hebron Department of Medicine, Universitat Autònoma de Barcelona Laboratori de Metabolopaties, Hospital Universitari Vall d Hebron UCICAC, Vall Hebron Institut of Research Pharmacy, Hospital Vall Hebron Liver Unit, Hospital Sant Pau, Barcelona CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain
    J Clin Gastroenterol 47:881-7. 2013
    ..Confirm in patients with cirrhosis and gastrointestinal bleeding the safety of ornithine phenylacetate (OP) and assess the pharmacokinetic profile of OP and its effects on plasma ammonia...
  15. doi request reprint Falls and cognitive dysfunction impair health-related quality of life in patients with cirrhosis
    Eva Roman
    University School of Nursing Sant Pau, Universitat Autonoma de Barcelona, Instituto de Salud Carlos III, Barcelona, Spain
    Eur J Gastroenterol Hepatol 25:77-84. 2013
    ..Falls are frequent in patients with cirrhosis and cognitive dysfunction and can deteriorate health-related quality of life (HRQoL)...
  16. ncbi request reprint Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy
    Beatriz Minguez
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Hepatology 43:707-14. 2006
    ..These disturbances, which include signs of increase in brain water and a compensatory osmotic response (decrease in brain myo-inositol), appear to be secondary to brain exposure to ammonia induced by portal-systemic shunting...
  17. ncbi request reprint Neuropsychological abnormalities in cirrhosis include learning impairment
    MARIA ORTIZ
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Hepatol 44:104-10. 2006
    ..We designed a study to assess the presence of memory abnormalities in cirrhotic patients and the effects of liver transplantation...
  18. ncbi request reprint Decreased white matter lesion volume and improved cognitive function after liver transplantation
    Alex Rovira
    Unitat de Ressonància Magnètica I D I, Departament de Radiologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Hepatology 46:1485-90. 2007
    ..663; P < 0.001). This evolution indicates that lesion volume is partially related to a reversible type of tissue damage, which is compatible with brain edema...
  19. ncbi request reprint Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis
    Marc Oria
    Liver Unit, Hospital Universitari Vall d Hebron, Department of Medicine, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119 129, 08035, Barcelona, Spain
    Metab Brain Dis 21:297-308. 2006
    ..Impairment in the function of the first neuron of the motor tract (corticospinal tract) has been demonstrated in patients with cirrhosis and minimal hepatic encephalopathy...
  20. doi request reprint Brain magnetic resonance in experimental acute-on-chronic liver failure
    Laia Chavarria
    Liver Unit, Hospital Vall Hebron, Barcelona, Spain
    Liver Int 33:294-300. 2013
    ..The aim of this study was to perform magnetic resonance (MR) study of the brain in a rat model combining bile duct ligation (BDL) and lipopolysaccharide (LPS) administration to investigate brain oedema in liver failure...
  21. doi request reprint Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis
    Marc Oria
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
    J Hepatol 56:109-14. 2012
    ..Ornithine phenylacetate (OP) is a new drug that has been proposed for the treatment of hepatic encephalopathy (HE) because it decreases plasma ammonia. We performed a study to assess if OP would impact on neuronal function...
  22. ncbi request reprint Quality of life and cognitive function in hepatitis C at different stages of liver disease
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Hospital Universitari Vall d Hebron, Paseo Vall d Hebron 119, Barcelona 08035, Spain
    J Hepatol 39:231-8. 2003
    ..Hepatitis C has been associated with a decrease in quality of life and with neurological abnormalities. The aim of our study was to investigate the relationship between quality of life and cognitive function...
  23. ncbi request reprint Motor-evoked potentials in awake rats are a valid method of assessing hepatic encephalopathy and of studying its pathogenesis
    Marc Oria
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Barcelona, Spain
    Hepatology 52:2077-85. 2010
    ..Disturbances of MEP caused by the administration of blood into the gastrointestinal tract in rats with portocaval anastomosis were associated with an increase in ammonia, glutamine, and glutamate in brain microdialysate...
  24. ncbi request reprint Validity of the Spanish version of the Chronic Liver Disease Questionnaire (CLDQ) as a standard outcome for quality of life assessment
    Montserrat Ferrer
    Health Services Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Liver Transpl 12:95-104. 2006
    ..These findings support its use as a standard outcome for patients with chronic liver diseases within the whole severity range, from "no cirrhosis" to transplant recipients, both in Spanish and international studies...
  25. ncbi request reprint Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure
    Laia Chavarria
    Liver Unit, Hospital Vall Hebron, Barcelona, Spain
    Gastroenterology 138:1566-73. 2010
    ..Two mechanisms have been proposed in the pathogenesis: vasogenic edema that is secondary to the breakdown of the blood-brain barrier and cytotoxic edema caused by ammonia metabolites in astrocytes...
  26. ncbi request reprint Effects of intravenous albumin in patients with cirrhosis and episodic hepatic encephalopathy: a randomized double-blind study
    Macarena Simón-Talero
    Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d Hebron, Institut de Recerca VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Hepatol 59:1184-92. 2013
    ..The aim of this study is to assess the efficacy of albumin in a multicenter, prospective, double-blind, controlled trial (ClinicalTrials.gov number, NCT00886925)...
  27. doi request reprint Neuroimaging in acute liver failure
    Laia Chavarria
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Vall d Hebron Institut of Research, Barcelona, Spain
    Neurochem Int 59:1175-80. 2011
    ..Neuroimaging methods, which are rapidly evolving, will undoubtedly lead to future diagnostic and therapeutic progress that could be very helpful for patients with ALF...
  28. ncbi request reprint Magnetic resonance imaging measurement of brain edema in patients with liver disease: resolution after transplantation
    Alex Rovira
    Magnetic Resonance Unit, Department of Radiology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Curr Opin Neurol 15:731-7. 2002
    ....
  29. doi request reprint Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial
    Pere Gines
    Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
    Hepatology 48:204-13. 2008
    ..01 for all compared to placebo). Thirst was significantly more common in patients treated with satavaptan compared to those treated with placebo, whereas the frequency of other adverse events was similar among groups...
  30. doi request reprint Encephalopathy and liver transplantation
    Laia Chavarria
    Liver Unit, Hospital Vall Hebron, Barcelona, Spain
    Metab Brain Dis 28:285-92. 2013
    ..Other factors present before LT that contribute to a worse neuropsychological outcome after LT are diabetes mellitus and alcohol consumption. Long-term after LT, cognitive function may worsen in relation to vascular risk factors...
  31. ncbi request reprint Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations
    MARIA ORTIZ
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119, Barcelona 08035, Spain
    J Hepatol 42:S45-53. 2005
  32. ncbi request reprint 1H magnetic resonance in the study of hepatic encephalopathy in humans
    Juan Cordoba
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Metab Brain Dis 17:415-29. 2002
    ..These abnormalities appear to participate in some of the neurological manifestations of hepatic encephalopathy...
  33. doi request reprint Current trends in chronic hepatitis B management: results of a questionnaire
    Iñigo Les
    Liver Unit, Hospital General Universitario Vall d Hebron and CIBER EHD, Barcelona, Spain
    Eur J Gastroenterol Hepatol 21:1177-83. 2009
    ..Aim of this study was to analyze general knowledge, therapeutic and diagnostic trends of physicians treating CHB in Spain...
  34. ncbi request reprint Understanding the mechanisms of cerebral complications in fulminant hepatic failure: fluxes better than levels
    Juan Cordoba
    Liver Unit, Hospital Universitari Vall d Hebron, Paseo Vall d Hebron 119, Barcelona 08035, Spain
    J Hepatol 37:878-9. 2002
  35. ncbi request reprint Reprint of: Neuroimaging in acute liver failure
    Laia Chavarria
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Vall d Hebron Institut of Research, Barcelona, Spain
    Neurochem Int 60:684-9. 2012
    ..Neuroimaging methods, which are rapidly evolving, will undoubtedly lead to future diagnostic and therapeutic progress that could be very helpful for patients with ALF...
  36. doi request reprint Acute-on-chronic liver failure: the brain
    Rita Garcia-Martinez
    Servei de Medicina Interna Hepatologia, Hospital Vall d Hebron, Madrid, Spain
    Curr Opin Crit Care 17:177-83. 2011
    ..Brain disturbances, which are considered a form of hepatic encephalopathy, are common in acute-on-chronic liver failure...
  37. ncbi request reprint A 1H nuclear magnetic resonance-based metabonomic approach for grading hepatic encephalopathy and monitoring the effects of therapeutic hypothermia in rats
    Ignasi Barba
    Plataforma Metabonomica, RECAVA, Servei de Cardiologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Liver Int 28:1141-8. 2008
    ..There are no good biomarkers for grading hepatic encephalopathy (HE) and monitoring the effectiveness of therapeutic measures...
  38. ncbi request reprint Randomized pilot study: effects of an exercise programme and leucine supplementation in patients with cirrhosis
    Eva Roman
    Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, 08041, Barcelona, Spain
    Dig Dis Sci 59:1966-75. 2014
    ..Physical exercise could improve functional limitations, muscle mass, and health-related quality of life (HRQoL) in patients with cirrhosis...
  39. ncbi request reprint Brain magnetic resonance in hepatic encephalopathy
    Juli Alonso
    Departament de Radiologia, Unitat de Ressonància Magnètica IDI, Hospital Vall d Hebron, Vall d Hebron Institut of Research VHIR, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Barcelona, Spain
    Semin Ultrasound CT MR 35:136-52. 2014
    ....
  40. doi request reprint A new method for measuring motor evoked potentials in the awake rat: effects of anesthetics
    Marc Oria
    Servicio de Medicina Interna Hepatología, Hospital Vall d Hebron, Barcelona, Spain
    J Neurotrauma 25:266-75. 2008
    ..This model may prove useful in the investigation of various diseases that affect the motor pathways without the confounding effects of anesthesia...