R Blesa

Summary

Affiliation: Hospital de la Santa Creu i Sant Pau
Country: Spain

Publications

  1. ncbi request reprint [Observational study on safety, tolerability and effectiveness of galantamine in patients with mild to moderately severe Alzheimer's disease]
    R Blesa
    Hospital de la Santa Creu i Sant Pau, Barcelona, and Hospital Clinicao Universitario San Carlos, Madrid, Spain
    Neurologia 21:289-96. 2006
  2. ncbi request reprint Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease
    Rafael Blesa
    Hospital Sta Creu i Sant Pau, Barcelona, Spain
    Pharmacogenet Genomics 16:771-4. 2006
  3. ncbi request reprint Noncognitive symptoms and long-term treatment expectations for Alzheimer disease
    Rafael Blesa
    Neurology Department, Hospital Sta Creu i Sant Pau, Barcelona, Spain
    Alzheimer Dis Assoc Disord 18:S9-16. 2004
  4. ncbi request reprint Caregiver preference for rivastigmine patches versus capsules for the treatment of Alzheimer disease
    Rafael Blesa
    Hospital de la Sta Creu i Sant Pau, Barcelona, Spain
    Neurology 69:S23-8. 2007
  5. ncbi request reprint Relationship between the efficacy of rivastigmine and apolipoprotein E (epsilon4) in patients with mild to moderately severe Alzheimer disease
    Rafael Blesa
    Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Alzheimer Dis Assoc Disord 20:248-54. 2006
  6. ncbi request reprint Detection of the presenilin 1 gene mutation (M139T) in early-onset familial Alzheimer disease in Spain
    R Queralt
    Genetics Service, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS, , Villarroel 170, 08036, Barcelona, Spain
    Neurosci Lett 299:239-41. 2001
  7. doi request reprint PICOGEN: five years experience with a genetic counselling program for dementia
    J Fortea
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Hospital Clinic de Barcelona, Barcelona, Spain
    Neurologia 26:143-9. 2011
  8. ncbi request reprint Clinical validity of the 'mini-mental state' for Spanish speaking communities
    R Blesa
    Institut Clinic de Malalties del Sistema Nervios, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, Facultat de Medicina, Universitat de Barcelona, Villarroel, 170, 08036, Barcelona, Spain
    Neuropsychologia 39:1150-7. 2001
  9. doi request reprint Problem-solving abilities and frontal lobe cortical thickness in healthy aging and mild cognitive impairment
    G Sánchez-Benavides
    Group of Behavioral Neurology, Neuropsychopharmacology Program, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Int Neuropsychol Soc 16:836-45. 2010
  10. ncbi request reprint Whole genome analysis in a consanguineous family with early onset Alzheimer's disease
    J Clarimon
    Memory Unit, Alzheimer s Laboratory, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Neurobiol Aging 30:1986-91. 2009

Collaborators

Detail Information

Publications44

  1. ncbi request reprint [Observational study on safety, tolerability and effectiveness of galantamine in patients with mild to moderately severe Alzheimer's disease]
    R Blesa
    Hospital de la Santa Creu i Sant Pau, Barcelona, and Hospital Clinicao Universitario San Carlos, Madrid, Spain
    Neurologia 21:289-96. 2006
    ..Its main objective was the assessment of the safety and tolerability of galantamine in the treatment of mild to moderately severe dementia of the Alzheimer type under real clinical conditions...
  2. ncbi request reprint Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease
    Rafael Blesa
    Hospital Sta Creu i Sant Pau, Barcelona, Spain
    Pharmacogenet Genomics 16:771-4. 2006
    ..These differences may reflect rivastigmine's ability to inhibit BuChE and AChE...
  3. ncbi request reprint Noncognitive symptoms and long-term treatment expectations for Alzheimer disease
    Rafael Blesa
    Neurology Department, Hospital Sta Creu i Sant Pau, Barcelona, Spain
    Alzheimer Dis Assoc Disord 18:S9-16. 2004
    ..They also have been shown to improve or delay the onset of neuropsychiatric and behavioral symptoms. These noncognitive benefits can impact greatly the lives of patients with AD as well as the persons who care for them...
  4. ncbi request reprint Caregiver preference for rivastigmine patches versus capsules for the treatment of Alzheimer disease
    Rafael Blesa
    Hospital de la Sta Creu i Sant Pau, Barcelona, Spain
    Neurology 69:S23-8. 2007
    ..Preference for the patch may indicate reduced caregiver stress, substantiated by greater satisfaction and less interference with daily life. These benefits may lead to improved compliance...
  5. ncbi request reprint Relationship between the efficacy of rivastigmine and apolipoprotein E (epsilon4) in patients with mild to moderately severe Alzheimer disease
    Rafael Blesa
    Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Alzheimer Dis Assoc Disord 20:248-54. 2006
    ..It would be interesting in the future to analyze the interaction between these 2 factors using other available anticholinesterase drugs...
  6. ncbi request reprint Detection of the presenilin 1 gene mutation (M139T) in early-onset familial Alzheimer disease in Spain
    R Queralt
    Genetics Service, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS, , Villarroel 170, 08036, Barcelona, Spain
    Neurosci Lett 299:239-41. 2001
    ..The detection of the M139T mutation in an independent EOAD family strongly supports the pathogenicity of this mutation in familial Alzheimer disease (AD)...
  7. doi request reprint PICOGEN: five years experience with a genetic counselling program for dementia
    J Fortea
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Hospital Clinic de Barcelona, Barcelona, Spain
    Neurologia 26:143-9. 2011
    ..We describe the 5 year experience of a genetic counselling program for familial dementias (the PICOGEN program)...
  8. ncbi request reprint Clinical validity of the 'mini-mental state' for Spanish speaking communities
    R Blesa
    Institut Clinic de Malalties del Sistema Nervios, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, Facultat de Medicina, Universitat de Barcelona, Villarroel, 170, 08036, Barcelona, Spain
    Neuropsychologia 39:1150-7. 2001
    ..The recommended cut-off in our study was 24/25 (non-demented above 24). The adaptation and normalisation of MMS provides the Spanish population with a highly valuable screening tool...
  9. doi request reprint Problem-solving abilities and frontal lobe cortical thickness in healthy aging and mild cognitive impairment
    G Sánchez-Benavides
    Group of Behavioral Neurology, Neuropsychopharmacology Program, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Int Neuropsychol Soc 16:836-45. 2010
    ....
  10. ncbi request reprint Whole genome analysis in a consanguineous family with early onset Alzheimer's disease
    J Clarimon
    Memory Unit, Alzheimer s Laboratory, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Neurobiol Aging 30:1986-91. 2009
    ..We provide here the first catalog of autozygosity in EOAD and suggest that the regions identified are excellent candidate loci for a recessive genetic lesion causing this disease...
  11. ncbi request reprint Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease
    J Casademont
    Muscle Research Group, Internal Medicine Department, Hospital Clinic, IDIBAPS, Faculty of Medicine, University of Barcelona, Villarroel 170 08036, Barcelona, Catalonia, Spain
    J Neurol Sci 206:23-6. 2003
    ..Increased enzymatic activities of diverse complexes and oxidative capacity of the ETC were found. Enhanced mitochondrial ETC function may contribute to the beneficial effects of rivastigmine on clinical manifestations of AD...
  12. doi request reprint A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study
    Teresa Gomez-Isla
    Neurology Department, Hospital Santa Cruz y San Pablo and Centro de Investigación Biomédica en Red CIBERNED, Lisboa, Spain
    Alzheimer Dis Assoc Disord 22:21-9. 2008
    ..In vivo studies have shown that Triflusal and its active metabolite 2-hydroxy-4-trifluoromethyl-benzoic acid have potent anti-inflammatory actions in the central nervous system...
  13. doi request reprint Sustained response to Rituximab in anti-AChR and anti-MuSK positive Myasthenia Gravis patients
    Isabel Illa
    Department of Neurology, Neuromuscular Unit, Hospital Santa Creu i Sant Pau, Universitat Autonoma Barcelona, Barcelona, Spain
    J Neuroimmunol 201:90-4. 2008
    ..046) and correlated with a more sustained clinical improvement. We did not find any significant changes in IgG4 that could explain the different outcome observed between these two groups...
  14. ncbi request reprint A novel antiganglioside specificity against terminal NeuNAc(alfa 2-3)Gal in acute bulbar palsy
    Ricard Rojas-Garcia
    Department of Neurology, Hospital de la Sta Creu i St Pau and Institut de Recerca HSCSP, Universitat Autonoma de Barcelona, Barcelona, Sant Antoni Maria Claret 167 08025, Spain
    J Neuroimmunol 176:219-22. 2006
    ..These data are supportive for extending the panel of antiganglioside specificities with anti-GM3...
  15. ncbi request reprint Diagnostic validity of the Alzheimer's disease functional assessment and change scale in mild cognitive impairment and mild to moderate Alzheimer's disease
    R M Manero
    Service of Neurology and Section of Behavioral Neurology and Dementias, Hospital del Mar, Barcelona, Spain
    Dement Geriatr Cogn Disord 37:366-75. 2014
    ..Conclusion: The ADFACS is a reliable, valid, and sensitive instrument to assess functional abilities; it is useful in dementia assessment for elderly populations. © 2013 S. Karger AG, Basel. ..
  16. ncbi request reprint [Rapid Disability Rating Scale-2 in Alzheimer's disease: NORMACODEM project data]
    A Monllau
    Sección de Neurología de la Conducta y Demencias, Servicio de Neurologia, Hospital del Mar, Barcelona, Spain
    Neurologia 21:282-8. 2006
    ..Test retest reliability, internal consistency, data of discriminant validity of the scale, correlations with other functional and cognitive measures were analyzed...
  17. ncbi request reprint Galantamine provides sustained benefits in patients with 'advanced moderate' Alzheimer's disease for at least 12 months
    Rafael Blesa
    Hospital Clinic Universitari, Barcelona, Spain
    Dement Geriatr Cogn Disord 15:79-87. 2003
    ..This drug has potential for broader use in clinical practice...
  18. ncbi request reprint Mild cognitive impairment: a risk indicator of later dementia, or a preclinical phase of the disease?
    J Guarch
    Clinical Psychology Department, Clinical Institute of Neurosciences, Hospital Clinic, Barcelona, Spain
    Int J Geriatr Psychiatry 23:257-65. 2008
    ....
  19. doi request reprint Medial temporal lobe correlates of memory screening measures in normal aging, MCI, and AD
    Gonzalo Sánchez-Benavides
    Institut Municipal d Investigacio Medica, Neuropsychopharmacology Program, Barcelona, Spain
    J Geriatr Psychiatry Neurol 23:100-8. 2010
    ....
  20. ncbi request reprint A megalin polymorphism associated with promoter activity and Alzheimer's disease risk
    Teo Vargas
    Neuroscience Laboratory, Research Center, Hospital 12 de Octubre, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:895-902. 2010
    ..This study provides strong evidence that this megalin polymorphism confers a greater risk for AD, and supports a biological role for megalin in the neurodegenerative processes involved in AD...
  21. doi request reprint Homocysteine and cognitive impairment. Relation with diagnosis and neuropsychological performance
    Isabel Sala
    Memory Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Dement Geriatr Cogn Disord 26:506-12. 2008
    ..Its relationship with cognitive impairment, however, remains unclear. We aimed to determine the relationship of tHcy levels with clinical diagnoses and cognitive performance in a sample of outpatients with cognitive impairment...
  22. doi request reprint Clinicopathological and genetic correlates of frontotemporal lobar degeneration and corticobasal degeneration
    Albert Lladó
    Service of Neurology, Hospital Clínic and Institut d Investigació, Biomedica August Pi i Sunyer, Barcelona, Spain
    J Neurol 255:488-94. 2008
    ..To correlate clinical diagnosis and genetic features with different pathological substrates in patients with frontotemporal lobar degeneration (FTLD) and corticobasal degeneration (CBD)...
  23. ncbi request reprint Galantamine: therapeutic effects beyond cognition
    R Blesa
    Neurology Department, Hospital Clinic, University of Barcelona, Spain
    Dement Geriatr Cogn Disord 11:28-34. 2000
    ..These clinical benefits are not offset by disruption of patients' sleep, as has been reported with other cholinergic treatments...
  24. ncbi request reprint A novel presenilin 2 gene mutation (D439A) in a patient with early-onset Alzheimer's disease
    A Lleo
    Neurology Service, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Neurology 57:1926-8. 2001
    ..Haplotype analysis indicated that his affected mother was the most probable mutation carrier. The D439A mutation is located near the C-terminal end of the PS2 protein, a region critical for endoproteolytic processing...
  25. ncbi request reprint [Alzheimer's disease and brain evolution: is Alzheimer's disease an example of antagonistic pleiotropy?]
    E Bufill
    Unidad de Neurologia, Servicio de Medicina Interna, Hospital General de Vic, Vic, Barcelona, Spain
    Rev Neurol 42:25-33. 2006
    ..Alzheimer's disease (AD) appears to be exclusive to our species. This suggests a relationship between the disease and genetic, functional and structural changes that have taken place throughout the evolution of the human brain...
  26. doi request reprint Spanish Multicenter Normative Studies (NEURONORMA Project): norms for verbal fluency tests
    Jordi Peña-Casanova
    Section of Behavioral Neurology and Dementias, Hospital del Mar, Institut Municipal d Assistència Sanitària, Barcelona, Spain
    Arch Clin Neuropsychol 24:395-411. 2009
    ..These data may also be of considerable use for comparisons with other international normative studies. Finally, these norms should help improve the interpretation of verbal fluency tasks and allow for greater diagnostic accuracy...
  27. doi request reprint Spanish Multicenter Normative Studies (NEURONORMA Project): norms for the visual object and space perception battery-abbreviated, and judgment of line orientation
    Jordi Peña-Casanova
    Section of Behavioral Neurology and Dementias, Hospital del Mar, Institut Municipal d Assistència Sanitària, Barcelona, Spain
    Arch Clin Neuropsychol 24:355-70. 2009
    ..The normative information provided here should prove useful for characterizing and interpreting individual test performances as well as comparing the scores from these tests with any other test using NEURONORMA norms...
  28. doi request reprint Spanish Multicenter Normative Studies (NEURONORMA Project): norms for the Stroop color-word interference test and the Tower of London-Drexel
    Jordi Peña-Casanova
    Section of Behavioral Neurology and Dementias, Hospital del Mar, Institut Municipal d Assistència Sanitària, Barcelona, Spain
    Arch Clin Neuropsychol 24:413-29. 2009
    ..In addition, the same statistical procedures for data analyses were applied. These co-normed data allow clinicians to compare scores from one test with all tests...
  29. doi request reprint Spanish Multicenter Normative Studies (NEURONORMA Project): norms for Boston naming test and token test
    Jordi Peña-Casanova
    Section of Behavioral Neurology and Dementias, Hospital del Mar, Institut Municipal d Assistència Sanitària, Barcelona, Spain
    Arch Clin Neuropsychol 24:343-54. 2009
    ..These co-normed data allow clinicians to compare scores from one test with all tests...
  30. doi request reprint Spanish Multicenter Normative Studies (NEURONORMA Project): methods and sample characteristics
    Jordi Peña-Casanova
    Section of Behavioral Neurology and Dementias, Hospital del Mar, Barcelona, Spain
    Arch Clin Neuropsychol 24:307-19. 2009
    ..These data may also be of considerable use for comparisons with other normative studies. Limitations of these normative data are also commented on...
  31. doi request reprint Spanish Multicenter Normative Studies (NEURONORMA Project): norms for verbal span, visuospatial span, letter and number sequencing, trail making test, and symbol digit modalities test
    Jordi Peña-Casanova
    Section of Behavioral Neurology and Dementias, Hospital del Mar, Institut Municipal d Assistència Sanitària, Barcelona, Spain
    Arch Clin Neuropsychol 24:321-41. 2009
    ..These data may be of considerable use for comparisons with other normative studies. Limitations of these normative data are mainly related to the techniques of recruitment and stratification employed...
  32. doi request reprint Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation
    Cristina Guardia-Laguarta
    Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    J Neuropathol Exp Neurol 69:53-9. 2010
    ..The mutation leads to a protein that is poorly processed by gamma-secretase. This loss of function may be an additional mechanism by which some mutations around the gamma-secretase cleavage site lead to familial Alzheimer disease...
  33. ncbi request reprint Emotional reactions to predictive testing in Alzheimer's disease and other inherited dementias
    Jose L Molinuevo
    Unidad Memoria Alzheimer, Institut Clínic de Neurociències, Hospital Clinic i Universitari, Barcelona, Spain
    Am J Alzheimers Dis Other Demen 20:233-8. 2005
    ..The emotional reactions were similar, although the diseases, their phenotype, and mutation characteristics were different...
  34. doi request reprint Spanish Multicenter Normative Studies (NEURONORMA Project): norms for the Rey-Osterrieth complex figure (copy and memory), and free and cued selective reminding test
    Jordi Peña-Casanova
    Section of Behavioral Neurology and Dementias, Hospital del Mar, Institut Municipal d Assistència Sanitària, Barcelona, Spain
    Arch Clin Neuropsychol 24:371-93. 2009
    ..These co-normed data will allow clinicians to compare scores from one test with all the tests included in the project...
  35. ncbi request reprint Frequency of mutations in the presenilin and amyloid precursor protein genes in early-onset Alzheimer disease in Spain
    Alberto Lleo
    Neurology Service, Hospital Clinic, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer, Barcelona, Spain
    Arch Neurol 59:1759-63. 2002
    ..The relative contribution of mutations in the presenilin (PSEN) and amyloid precursor protein genes to autosomal dominant and other early-onset Alzheimer disease (AD) cases is not well established...
  36. ncbi request reprint Uncommon polymorphism in the presenilin genes in human familial Alzheimer's disease: not to be mistaken with a pathogenic mutation
    Alberto Lleo
    Neurology Service, Institut d Investigacions Biomediques August Pi i Suyner IDIBAPS, Hospital Clinic, Barcelona, Spain
    Neurosci Lett 318:166-8. 2002
    ..These uncommon single-nucleotide polymorphisms should be always taken into account in the genetic testing of AD. They may well have important implications for genetic counselling in AD...
  37. ncbi request reprint [Clinical characteristics of a family with early-onset Alzheimer's disease associated with a presenilin 1 mutation (M139T)]
    Alberto Lleo
    Neurologia, Hospital Clinic, Barcelona, Spain
    Med Clin (Barc) 118:698-700. 2002
    ..The objective of this study was to describe the clinical features and the genetic analysis of a family with autosomal-dominant familial Alzheimer's disease...
  38. pmc Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface
    Cristina Guardia-Laguarta
    Alzheimer Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neurochem 110:220-30. 2009
    ..Taken together, our results suggest that mild membrane cholesterol reduction impacts the cleavage of APP upstream of gamma-secretase and appears to be mediated by changes in APP trafficking and partitioning into lipid rafts...
  39. ncbi request reprint Regulatory issues
    Jose L Molinuevo
    Unitat Memoria Alzheimer, Institut Clínic Malalties Sistema Nerviós, Hospital Clinic i Universitari, Barcelona, Spain
    Int Psychogeriatr 15:283-6. 2003
    ..Clinical research, as part of medical practice, should be ruled by the same ethical principles...
  40. doi request reprint Clinical and pathological heterogeneity of neuronal intermediate filament inclusion disease
    Laura Molina-Porcel
    Service of Neurology, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, Barcelona, Spain
    Arch Neurol 65:272-5. 2008
    ..To report new cases of neuronal intermediate filament inclusion disease (NIFID)...
  41. ncbi request reprint Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease
    Bengt Winblad
    Karolinska Institutet Alzheimer Research Center, Huddinge, Sweden
    Int J Geriatr Psychiatry 22:485-91. 2007
    ..Transdermal patches may offer advantages over conventional oral formulations...
  42. ncbi request reprint Reduced KIAA0471 mRNA expression in Alzheimer's patients: a new candidate gene product linked to the disease?
    Lluïsa de Yebra
    Unitat de Bioquimica, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Hum Mol Genet 13:2607-12. 2004
    ..In addition, they may open a new area of research for diagnostic and therapeutic tools, the relevance of which is also considered...
  43. ncbi request reprint A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease
    Mario Ezquerra
    Genetics Service, Department of Ciencias Fisiologicas I, University of Barcelona, Institut de Investigacions Biomédiques Agustí Pi i Sunyer, Hospital Clinic, Villaroel 170, 08036 Barcelona, Spain
    Arch Neurol 60:1149-51. 2003
    ..Most cases are due to mutations in the PSEN1 gene, whereas mutations in the APP and PSEN2 genes are rare...
  44. pmc Reelin expression and glycosylation patterns are altered in Alzheimer's disease
    Arancha Botella-Lopez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, E 03550 Sant Joan d Alacant, Spain
    Proc Natl Acad Sci U S A 103:5573-8. 2006
    ....