Research Topics
Species | A AventinSummaryAffiliation: Hospital de la Santa Creu i Sant Pau Country: Spain Publications
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Detail Information
Publications
Typical CBFbeta/MYH11 fusion due to insertion of the 3'-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22A Aventin
Department of Hematology, University Hospital Sant Pau, Barcelona, Spain
Cancer Genet Cytogenet 123:137-9. 2000....- Chromosome 16 inversion-associated translocations in acute myeloid leukemia elucidated using a dual-color CBFB DNA probeAnna Aventin
Department of Hematology, University Hospital Sant Pau, Barcelona, Spain
Cancer Genet Cytogenet 134:142-4. 2002..We suggest that all cases with inv(16)(p13q22) should be investigated by FISH with appropriate probes for a possible translocation of 16q22-->qter to another chromosome... 
Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14A Aventin
Department of Haematology, Hospital Sant Pau, 08025 Barcelona, Spain
J Clin Pathol 56:798-800. 2003..Overexpression of the cyclin D1 protein was demonstrated on bone marrow trephine by immunohistochemical staining...- MLL tandem duplication in two cases of acute myelocytic leukemia with unbalanced translocations: der(16)t(11;16)(q23;p13) and der(18)t(11;18)(q22;p11.2)A Aventin
Department of Hematology, University Hospital Sant Pau, Avenida Sant Antoni Ma Claret 167, UAB, 08025 Barcelona, Spain
Cancer Genet Cytogenet 142:8-12. 2003..Thus, systematic screening of this molecular defect should be performed in patients with unbalanced translocations involving 11q22 approximately q23-->qter... - Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignanciesL Munoz
Hematology Department, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret, 167, 08025 Barcelona, Spain
Haematologica 86:1261-9. 2001..The study of cytokine receptor expression by flow cytometry could allow us to differentiate between normal and tumoral cells... - FLT3 mutations are associated with other molecular lesions in AMLMaria J Carnicer
Laboratori d Hematologia, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret, 167, 08025 Barcelona, Spain
Leuk Res 28:19-23. 2004..4% of patients showed Class I + Class II mutations. Our findings could be consistent with the cooperative model. The search for new tyrosine kinases which can be the target of molecular lesions in AML warrants further investigation... - Intensive salvage chemotherapy for primary refractory or first relapsed adult acute lymphoblastic leukemia: results of a prospective trialR Martino
Servei d Hematologia Clinica, Hospital de Sant Pau, Av Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Haematologica 84:505-10. 1999..In this protocol, chemotherapy was to be followed by an allogeneic or autologous stem cell transplant (SCT) within three months from CR... - Genetic diagnosis by comparative genomic hybridization in adult de novo acute myelocytic leukemiaSilvia Casas
Department of Hematology, Hospital Sant Pau Autonomous University of Barcelona, Avda Sant Antoni Ma Claret 167, Barcelona 08025, Spain
Cancer Genet Cytogenet 153:16-25. 2004..Application of the CGH technique is thus a useful complementary diagnostic tool for CCA in de novo AML cases with abnormal karyotypes or with unsuccessful cytogenetics... 
Immunophenotype of acute myeloid leukemia with NPM mutations: prognostic impact of the leukemic compartment sizeJ Nomdedeu
Department of Hematology and Laboratory, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret 167, 08025 Barcelona, Spain
Leuk Res 35:163-8. 2011..Further studies are required to determine whether the degree of leukemic stem cell expansion (CD45+CD123+cells) increases the risk of acquisition of FLT3-ITD and/or provides selective advantages...- Adverse impact of IDH1 and IDH2 mutations in primary AML: experience of the Spanish CETLAM groupJ Nomdedeu
Hematology Department, Hosptial de Santa Creu i Sant Pau, Barcelona, Spain
Leuk Res 36:990-7. 2012..IDH1 and IDH2 mutations are common genetic alterations in normal karyotype AML. Favourable genotype NPM or CEBPA mutated/FLT3 wt can be further categorized according to the IDH1 and IDH2 mutational status... - Interstitial deletions at the long arm of chromosome 13 may be as common as monosomies in multiple myeloma. A genotypic studyJosep F Nomdedeu
Laboratori d Hematologia, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret 167, 08025 Barcelona, Spain
Haematologica 87:828-35. 2002..Deletions of 13q14 are rare in monoclonal gammopathy of undetermined significance (MGUS) and are thus believed to be associated with the development of the full myeloma phenotype... - Microsatellite instability is not an uncommon finding in adult de novo acute myeloid leukemiaJosep F Nomdedeu
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Ann Hematol 84:368-75. 2005..hMLH1 promoter was hypermethylated in five MSI+ cases. Overall survival analysis revealed no adverse effect of MSI positivity. These results suggest that MSI may be a common biologic finding in de novo AML... - MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemiasA Lasa
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Leukemia 18:1231-7. 2004..It remains to be investigated when this methylation process is acquired and which are the basic mechanisms underlying these molecular events in AML1-ETO and CEBPalpha-mutated AML... - Acute myeloid leukemia subgroups identified by pathway-restricted gene expression signaturesElena Serrano
Laboratori d'Hematologia, Hospital de la Santa Creu i Sant Pau, , Barcelona, Spain
Acta Haematol 116:77-89. 2006..In accordance with previous results, Meis1 downregulation is a useful surrogate marker indicating a good prognosis in AML patients. Simple qPCR platforms may help to identify different biologic subgroups in AML... - Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemiasElena Serrano
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
Leuk Res 32:944-53. 2008..Furthermore, some of the genes deregulated by the leukemogenic process reverted to their normal expression with demethylating and HDAC inhibitor treatment, highlighting the role of chromatin remodeling processes in AML... - Clonal heterogeneity assessed by flow cytometry in B-cell lymphomas arising from germinal centersMar Bellido
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Am J Clin Pathol 117:864-70. 2002..The 3 flow cytometric patterns were observed, respectively, in de novo DLBCL and BL, transformation into BL, and transformation into DLBCL. Flow cytometric data can provide valuable information about the natural history of NHL... - Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemiaMar Bellido
Laboratori d Hematologia, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret 167, 08025 Barcelona, Spain
Haematologica 88:994-1001. 2003.... - Detection of chromosomal abnormalities in chronic lymphocytic leukemia increased by interphase fluorescence in situ hybridization in tetradecanoylphorbol acetate-stimulated peripheral blood cellsJana Sanchez
Department of Hematology, Hospital Sant Pau, Autonomous University of Barcelona, Avda Sant Antoni M a Claret 167, 08025 Barcelona, Spain
Cancer Genet Cytogenet 175:57-60. 2007..I-FISH-TPA is thus a reliable technique for clinical diagnostics in CLL... - High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemiasAdriana Lasa
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Ann Hematol 87:205-11. 2008..It remains to be investigated whether these CEACAM disturbances provide growth advantages to tumoral cells by inhibiting the anoikis process...