A Aventin

Summary

Affiliation: Hospital de la Santa Creu i Sant Pau
Country: Spain

Publications

  1. ncbi request reprint Typical CBFbeta/MYH11 fusion due to insertion of the 3'-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22
    A Aventin
    Department of Hematology, University Hospital Sant Pau, Barcelona, Spain
    Cancer Genet Cytogenet 123:137-9. 2000
  2. ncbi request reprint MLL tandem duplication in two cases of acute myelocytic leukemia with unbalanced translocations: der(16)t(11;16)(q23;p13) and der(18)t(11;18)(q22;p11.2)
    A Aventin
    Department of Hematology, University Hospital Sant Pau, Avenida Sant Antoni Ma Claret 167, UAB, 08025 Barcelona, Spain
    Cancer Genet Cytogenet 142:8-12. 2003
  3. pmc Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14
    A Aventin
    Department of Haematology, Hospital Sant Pau, 08025 Barcelona, Spain
    J Clin Pathol 56:798-800. 2003
  4. ncbi request reprint Chromosome 16 inversion-associated translocations in acute myeloid leukemia elucidated using a dual-color CBFB DNA probe
    Anna Aventin
    Department of Hematology, University Hospital Sant Pau, Barcelona, Spain
    Cancer Genet Cytogenet 134:142-4. 2002
  5. doi request reprint Bone marrow WT1 levels at diagnosis, post-induction and post-intensification in adult de novo AML
    J F Nomdedeu
    Laboratori dacute Hematologia, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Leukemia 27:2157-64. 2013
  6. ncbi request reprint Clinical utility of bone marrow flow cytometry in B-cell non-Hodgkin lymphomas (B-NHL)
    G Perea
    Department of Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Histopathology 45:268-74. 2004
  7. ncbi request reprint Prognostic value of minimal residual disease (MRD) in acute myeloid leukemia (AML) with favorable cytogenetics [t(8;21) and inv(16)]
    G Perea
    Hematology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Leukemia 20:87-94. 2006
  8. ncbi request reprint Prognostic factors influencing feasibility of cytogenetic and molecular analysis in leukapheresis products in chronic myelogenous leukemia patients
    M Carrasco
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, St Antoni Maria i Claret, 167, Autonomous University of Barcelona, Spain
    Ann Hematol 81:710-6. 2002
  9. ncbi request reprint Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies
    L Munoz
    Hematology Department, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    Haematologica 86:1261-9. 2001
  10. ncbi request reprint FLT3 mutations are associated with other molecular lesions in AML
    Maria J Carnicer
    Laboratori d Hematologia, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    Leuk Res 28:19-23. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Typical CBFbeta/MYH11 fusion due to insertion of the 3'-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22
    A Aventin
    Department of Hematology, University Hospital Sant Pau, Barcelona, Spain
    Cancer Genet Cytogenet 123:137-9. 2000
    ....
  2. ncbi request reprint MLL tandem duplication in two cases of acute myelocytic leukemia with unbalanced translocations: der(16)t(11;16)(q23;p13) and der(18)t(11;18)(q22;p11.2)
    A Aventin
    Department of Hematology, University Hospital Sant Pau, Avenida Sant Antoni Ma Claret 167, UAB, 08025 Barcelona, Spain
    Cancer Genet Cytogenet 142:8-12. 2003
    ..Thus, systematic screening of this molecular defect should be performed in patients with unbalanced translocations involving 11q22 approximately q23-->qter...
  3. pmc Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14
    A Aventin
    Department of Haematology, Hospital Sant Pau, 08025 Barcelona, Spain
    J Clin Pathol 56:798-800. 2003
    ..Overexpression of the cyclin D1 protein was demonstrated on bone marrow trephine by immunohistochemical staining...
  4. ncbi request reprint Chromosome 16 inversion-associated translocations in acute myeloid leukemia elucidated using a dual-color CBFB DNA probe
    Anna Aventin
    Department of Hematology, University Hospital Sant Pau, Barcelona, Spain
    Cancer Genet Cytogenet 134:142-4. 2002
    ..We suggest that all cases with inv(16)(p13q22) should be investigated by FISH with appropriate probes for a possible translocation of 16q22-->qter to another chromosome...
  5. doi request reprint Bone marrow WT1 levels at diagnosis, post-induction and post-intensification in adult de novo AML
    J F Nomdedeu
    Laboratori dacute Hematologia, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Leukemia 27:2157-64. 2013
    ..001. WT1 levels in bone marrow assayed using the standardized ELN method provide relevant prognostic information in de novo AML...
  6. ncbi request reprint Clinical utility of bone marrow flow cytometry in B-cell non-Hodgkin lymphomas (B-NHL)
    G Perea
    Department of Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Histopathology 45:268-74. 2004
    ..To determine the efficacy of flow cytometry (FC) in the assessment of bone marrow (BM) in B-cell non-Hodgkin lymphoma (B-NHL). FC is a common practice, but is far from being validated...
  7. ncbi request reprint Prognostic value of minimal residual disease (MRD) in acute myeloid leukemia (AML) with favorable cytogenetics [t(8;21) and inv(16)]
    G Perea
    Hematology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Leukemia 20:87-94. 2006
    ..04). Combined use of FC and RQ-PCR may improve MRD detection, and provide useful clinical information on relapse kinetics in AML patients...
  8. ncbi request reprint Prognostic factors influencing feasibility of cytogenetic and molecular analysis in leukapheresis products in chronic myelogenous leukemia patients
    M Carrasco
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, St Antoni Maria i Claret, 167, Autonomous University of Barcelona, Spain
    Ann Hematol 81:710-6. 2002
    ....
  9. ncbi request reprint Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies
    L Munoz
    Hematology Department, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    Haematologica 86:1261-9. 2001
    ..The study of cytokine receptor expression by flow cytometry could allow us to differentiate between normal and tumoral cells...
  10. ncbi request reprint FLT3 mutations are associated with other molecular lesions in AML
    Maria J Carnicer
    Laboratori d Hematologia, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    Leuk Res 28:19-23. 2004
    ..4% of patients showed Class I + Class II mutations. Our findings could be consistent with the cooperative model. The search for new tyrosine kinases which can be the target of molecular lesions in AML warrants further investigation...
  11. ncbi request reprint Intensive salvage chemotherapy for primary refractory or first relapsed adult acute lymphoblastic leukemia: results of a prospective trial
    R Martino
    Servei d Hematologia Clinica, Hospital de Sant Pau, Av Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Haematologica 84:505-10. 1999
    ..In this protocol, chemotherapy was to be followed by an allogeneic or autologous stem cell transplant (SCT) within three months from CR...
  12. ncbi request reprint Genetic diagnosis by comparative genomic hybridization in adult de novo acute myelocytic leukemia
    Silvia Casas
    Department of Hematology, Hospital Sant Pau Autonomous University of Barcelona, Avda Sant Antoni Ma Claret 167, Barcelona 08025, Spain
    Cancer Genet Cytogenet 153:16-25. 2004
    ..Application of the CGH technique is thus a useful complementary diagnostic tool for CCA in de novo AML cases with abnormal karyotypes or with unsuccessful cytogenetics...
  13. doi request reprint Immunophenotype of acute myeloid leukemia with NPM mutations: prognostic impact of the leukemic compartment size
    J Nomdedeu
    Department of Hematology and Laboratory, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret 167, 08025 Barcelona, Spain
    Leuk Res 35:163-8. 2011
    ..Further studies are required to determine whether the degree of leukemic stem cell expansion (CD45+CD123+cells) increases the risk of acquisition of FLT3-ITD and/or provides selective advantages...
  14. doi request reprint Adverse impact of IDH1 and IDH2 mutations in primary AML: experience of the Spanish CETLAM group
    J Nomdedeu
    Hematology Department, Hosptial de Santa Creu i Sant Pau, Barcelona, Spain
    Leuk Res 36:990-7. 2012
    ..IDH1 and IDH2 mutations are common genetic alterations in normal karyotype AML. Favourable genotype NPM or CEBPA mutated/FLT3 wt can be further categorized according to the IDH1 and IDH2 mutational status...
  15. ncbi request reprint Interstitial deletions at the long arm of chromosome 13 may be as common as monosomies in multiple myeloma. A genotypic study
    Josep F Nomdedeu
    Laboratori d Hematologia, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret 167, 08025 Barcelona, Spain
    Haematologica 87:828-35. 2002
    ..Deletions of 13q14 are rare in monoclonal gammopathy of undetermined significance (MGUS) and are thus believed to be associated with the development of the full myeloma phenotype...
  16. ncbi request reprint Microsatellite instability is not an uncommon finding in adult de novo acute myeloid leukemia
    Josep F Nomdedeu
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Ann Hematol 84:368-75. 2005
    ..hMLH1 promoter was hypermethylated in five MSI+ cases. Overall survival analysis revealed no adverse effect of MSI positivity. These results suggest that MSI may be a common biologic finding in de novo AML...
  17. ncbi request reprint MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias
    A Lasa
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Leukemia 18:1231-7. 2004
    ..It remains to be investigated when this methylation process is acquired and which are the basic mechanisms underlying these molecular events in AML1-ETO and CEBPalpha-mutated AML...
  18. ncbi request reprint Acute myeloid leukemia subgroups identified by pathway-restricted gene expression signatures
    Elena Serrano
    Laboratori d Hematologia, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Acta Haematol 116:77-89. 2006
    ..In accordance with previous results, Meis1 downregulation is a useful surrogate marker indicating a good prognosis in AML patients. Simple qPCR platforms may help to identify different biologic subgroups in AML...
  19. doi request reprint Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias
    Elena Serrano
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Leuk Res 32:944-53. 2008
    ..Furthermore, some of the genes deregulated by the leukemogenic process reverted to their normal expression with demethylating and HDAC inhibitor treatment, highlighting the role of chromatin remodeling processes in AML...
  20. ncbi request reprint Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia
    Mar Bellido
    Laboratori d Hematologia, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret 167, 08025 Barcelona, Spain
    Haematologica 88:994-1001. 2003
    ....
  21. ncbi request reprint Clonal heterogeneity assessed by flow cytometry in B-cell lymphomas arising from germinal centers
    Mar Bellido
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Am J Clin Pathol 117:864-70. 2002
    ..The 3 flow cytometric patterns were observed, respectively, in de novo DLBCL and BL, transformation into BL, and transformation into DLBCL. Flow cytometric data can provide valuable information about the natural history of NHL...
  22. ncbi request reprint High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias
    Adriana Lasa
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Ann Hematol 87:205-11. 2008
    ..It remains to be investigated whether these CEACAM disturbances provide growth advantages to tumoral cells by inhibiting the anoikis process...
  23. ncbi request reprint Detection of chromosomal abnormalities in chronic lymphocytic leukemia increased by interphase fluorescence in situ hybridization in tetradecanoylphorbol acetate-stimulated peripheral blood cells
    Jana Sanchez
    Department of Hematology, Hospital Sant Pau, Autonomous University of Barcelona, Avda Sant Antoni M a Claret 167, 08025 Barcelona, Spain
    Cancer Genet Cytogenet 175:57-60. 2007
    ..I-FISH-TPA is thus a reliable technique for clinical diagnostics in CLL...