Rafael Arroyo

Summary

Affiliation: Hospital Universitario
Country: Spain

Publications

  1. pmc Interleukin-10 haplotypes in Celiac Disease in the Spanish population
    Concepcion Nunez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    BMC Med Genet 7:32. 2006
  2. pmc Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population
    Jose Luis Santiago
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Med Genet 8:54. 2007
  3. pmc A functional PTPN22 polymorphism associated with several autoimmune diseases is not associated with IgA deficiency in the Spanish population
    Concepcion Nunez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    BMC Med Genet 7:25. 2006
  4. pmc Interleukin-10 polymorphisms in Spanish IgA deficiency patients: a case-control and family study
    Javier Ortiz
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid
    BMC Med Genet 7:56. 2006
  5. pmc Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study
    Jose Luis Santiago
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Med Genet 7:54. 2006
  6. pmc Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4
    Elena Urcelay
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Genomics 6:56. 2005
  7. pmc Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases
    Alfonso Martinez
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Genomics 9:329. 2008
  8. ncbi Interleukin-10 polymorphisms in Spanish multiple sclerosis patients
    Alfonso Martinez Doncel
    Immunology Department, Hospital Universitario San Carlos, 28040, Madrid, Spain
    J Neuroimmunol 131:168-72. 2002
  9. pmc Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis
    A Martinez
    Immunology Department, Hospital Clinico San Carlos, C Martín Lagos, S N, 28040 Madrid, Spain
    Ann Rheum Dis 65:1188-91. 2006
  10. ncbi An IFNG polymorphism is associated with interferon-beta response in Spanish MS patients
    A Martinez
    Clinical Immunology Department, Hospital Clinico San Carlos, c Martin Lagos s n 28040 Madrid, Spain
    J Neuroimmunol 173:196-9. 2006

Collaborators

Detail Information

Publications76

  1. pmc Interleukin-10 haplotypes in Celiac Disease in the Spanish population
    Concepcion Nunez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    BMC Med Genet 7:32. 2006
    ..Our aim was to study the role of those polymorphisms in susceptibility to CD in our population...
  2. pmc Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population
    Jose Luis Santiago
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Med Genet 8:54. 2007
    ..A PTPN22 polymorphism, C1858T, was found associated with type 1 diabetes (T1D) in different Caucasian populations. In this study, we aimed at confirming the role of this variant in T1D predisposition in the Spanish population...
  3. pmc A functional PTPN22 polymorphism associated with several autoimmune diseases is not associated with IgA deficiency in the Spanish population
    Concepcion Nunez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    BMC Med Genet 7:25. 2006
    ..We studied the association of that polymorphism with immunoglobulin A deficiency (IgAD) following a double approach: a case-control and a TDT study...
  4. pmc Interleukin-10 polymorphisms in Spanish IgA deficiency patients: a case-control and family study
    Javier Ortiz
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid
    BMC Med Genet 7:56. 2006
    ..Our aim was to ascertain if any of these polymorphic markers are associated or linked to IgAD in Spanish patients...
  5. pmc Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study
    Jose Luis Santiago
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Med Genet 7:54. 2006
    ..For these reasons, we investigated for the first time the association with T1D of six single nucleotide polymorphisms (SNPs) mapping to these candidate genes: slc2F2, slc2F11, T306I, L503F, OCTN2-promoter and OCTN2-intron...
  6. pmc Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4
    Elena Urcelay
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Genomics 6:56. 2005
    ..We aimed to corroborate whether this haplotype increases the susceptibility conferred by the DQ2-DR3 alleles in a Mediterranean population. We also searched for additional susceptibility factors to the classic DQ2-DR3 and DQ8-DR4...
  7. pmc Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases
    Alfonso Martinez
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Genomics 9:329. 2008
    ....
  8. ncbi Interleukin-10 polymorphisms in Spanish multiple sclerosis patients
    Alfonso Martinez Doncel
    Immunology Department, Hospital Universitario San Carlos, 28040, Madrid, Spain
    J Neuroimmunol 131:168-72. 2002
    ..The data indicate that IL-10 is not a major susceptibility locus in MS, but in our population it might, however, have a minor role...
  9. pmc Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis
    A Martinez
    Immunology Department, Hospital Clinico San Carlos, C Martín Lagos, S N, 28040 Madrid, Spain
    Ann Rheum Dis 65:1188-91. 2006
    ..A Japanese study has described a strong association between rheumatoid arthritis and several polymorphisms located in the Fc receptor-like 3 (FCRL3) gene, a member of a family of genes related to Fc receptors located on chromosome 1q21-23...
  10. ncbi An IFNG polymorphism is associated with interferon-beta response in Spanish MS patients
    A Martinez
    Clinical Immunology Department, Hospital Clinico San Carlos, c Martin Lagos s n 28040 Madrid, Spain
    J Neuroimmunol 173:196-9. 2006
    ..Our results show a very different allelic distribution when patients with relapses were compared with relapse-free patients...
  11. ncbi Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD
    A Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 69:313-7. 2007
    ..4-2.9), when HLA-DRB1*0103 carrier patients were compared with HLA-DRB1*0103 noncarriers. Our data suggest an epistatic interaction between genes in chromosomes 6p21 and 1q21-22, marked, respectively, by HLA-DRB1*0103 and FCRL3-169 AG...
  12. ncbi Association of the major histocompatibility complex with response to infliximab therapy in rheumatoid arthritis patients
    Alfonso Martinez
    Hospital Clinico San Carlos, Madrid, Spain
    Arthritis Rheum 50:1077-82. 2004
    ..To determine whether major histocompatibility complex (MHC) polymorphisms are associated with a good or poor response to infliximab therapy in patients with rheumatoid arthritis (RA)...
  13. pmc Early B-cell Factor gene association with multiple sclerosis in the Spanish population
    Alfonso Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    BMC Neurol 5:19. 2005
    ..Failure of B-cell differentiation was found in EBF-deficient mice and involvement of B-lymphocytes in MS has been suggested from their presence in cerebrospinal fluid and lesions of patients...
  14. ncbi Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA
    Alfonso Martinez
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:685-9. 2007
    ..Besides, this report indicates that when patients are grouped based upon a well-defined molecular event, complex diseases may reveal themselves as being constituted by distinct entities in which some genes may have a strong influence...
  15. ncbi Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study
    A Martinez
    Servico de Immunologiá Clinica, Hospital Universitario San Carlos, Madrid, Spain
    Genes Immun 4:117-21. 2003
    ..No other allele in the present study is found to be associated to RA. Our data suggest that most of the loci studied play no major role in the susceptibility to RA, the IL-10 gene being the sole exception...
  16. ncbi PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population
    A Martinez
    Immunology Department, Hospital Clinico San Carlos, C Martín Lagos, S N, 28040 Madrid, Spain
    Rheumatology (Oxford) 44:1263-6. 2005
    ..Given this discrepancy and the importance of antibodies against citrullinated peptides in the early course of the disease, we performed a replication study...
  17. pmc Role of the MHC2TA gene in autoimmune diseases
    Alfonso Martinez
    Immunology Department, Hospital Universitario San Carlos, Martin Lagos s n, 28040 Madrid, Spain
    Ann Rheum Dis 66:325-9. 2007
    ..However, no evidence of association of this MHC2TA variant with the two autoimmune diseases could be subsequently detected in independent cohorts...
  18. ncbi FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?
    Alfonso Martinez
    Department of Immunology, Hospital Clinico San Carlos, Madrid, Spain
    J Neuroimmunol 189:132-6. 2007
    ..We aimed at testing for the first time whether this gene was involved in multiple sclerosis (MS) pathogenesis...
  19. pmc MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up
    Maria Inmaculada Dominguez-Mozo
    Servicio de Neurologia, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    BMC Neurol 12:107. 2012
    ..2. To study MHC2TA expression in MS patients with and without minor allele C. 3. To analyze the relation between MHC2TA mRNA levels and HHV-6 active infection in MS patients...
  20. pmc DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands
    Emilio G De la Concha
    Department of Clinical Immunology, Hospital Clinico San Carlos, Instituto de Investigacíon Sanitaria San Carlos IdISSC, Madrid, Spain
    PLoS ONE 7:e31018. 2012
    ..We also evaluated the association with the presence of oligoclonal IgM bands against myelin lipids (OCMB) in cerebrospinal fluid...
  21. ncbi Role of interleukin 4 in Spanish multiple sclerosis patients
    Elena Urcelay
    Immunology Department, Hospital Universitario San Carlos, Martin Lagos s n, 28040 Madrid, Spain
    J Neuroimmunol 168:164-7. 2005
    ..003, OR [CI]=0.57 [0.38-0.84]), probably indicative of an MS protection haplotype at 5q31 locus. No difference among MS clinical forms or age at onset was detected...
  22. doi CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Ciudad Universitaria, Madrid, Spain
    Mult Scler 17:513-20. 2011
    ..In a prior study of our group we found an up-regulation of CD46 expression in a cohort of Spanish multiple sclerosis (MS) patients...
  23. pmc Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk
    María L Cavanillas
    Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Hum Genet 18:794-9. 2010
    ..The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation...
  24. ncbi IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk
    Alfonso Martinez
    Department of Immunology, Hospital Universitario San Carlos, Madrid, Spain
    Eur J Hum Genet 16:861-4. 2008
    ....
  25. doi Herpesvirus active replication in multiple sclerosis: a genetic control?
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    J Neurol Sci 311:98-102. 2011
    ..The results show that MS patients without HHV-6 active replication are better responders to interferon beta treatment than those with HHV-6 active replication...
  26. ncbi TLR4 haplotypes in multiple sclerosis: a case-control study in the Spanish population
    Elena Urcelay
    Clinical Immunology Department, Hospital Clinico San Carlos, Spain
    J Neuroimmunol 192:215-8. 2007
    ..In conclusion, TLR4 does not play a major role in the predisposition to suffer from multiple sclerosis in our population...
  27. ncbi Human herpesvirus-6 and multiple sclerosis: relapsing-remitting versus secondary progressive
    Roverto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    Mult Scler 13:578-83. 2007
    ..iii) We did not find any difference in HHV-6 viral loads. These results suggest that HHV-6A does not play an active role in SPMS, while this virus may contribute to the pathogenesis of RRMS triggering MS attacks in a subset of patients...
  28. doi Immunological mechanisms that associate with oligoclonal IgM band synthesis in multiple sclerosis
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Immunol 137:51-9. 2010
    ..These results help to elucidate the B lymphocytes responsible for intrathecal IgM secretion in MS and the origin of this abnormal B-cell response in patients with aggressive MS...
  29. pmc CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility
    Fiona Blanco-Kelly
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    PLoS ONE 5:e11520. 2010
    ....
  30. doi IFNbeta-1a therapy for multiple sclerosis expands regulatory CD8+ T cells and decreases memory CD8+ subset: a longitudinal 1-year study
    Carol Aristimuño
    Department of Neurology, Gregorio Marañón University General Hospital, Madrid, Spain
    Clin Immunol 134:148-57. 2010
    ..After 1 year of IFNbeta-1a, a direct correlation was observed between plasmacytoid dendritic cells and effector CD8(+) T cells...
  31. ncbi Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Brain Pathol 16:20-7. 2006
    ..This study was undertaken in order to investigate the possible relation of HHV-6 and EBV in relapsing-remitting MS (RRMS)...
  32. ncbi Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, 28040, Spain
    J Clin Virol 37:S24-6. 2006
    ..Although the etiology of multiple sclerosis (MS) remains uncertain, clinical, epidemiological, and laboratory findings suggest that environmental factors may be involved in the disease...
  33. ncbi Interferon beta treatment: bioavailability and antiviral activity in multiple sclerosis patients
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    J Neurovirol 13:504-12. 2007
    ..5% to 12.2% in sera; furthermore, a good correlation with the bioavailability of interferon beta was found, because patients with a decrease in HHV-6 prevalence had higher levels of MxA (P = .046, at the third month)...
  34. ncbi MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients
    Elena Urcelay
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Inflamm Bowel Dis 12:33-7. 2006
    ..We studied the association of both polymorphisms in an independent population to reveal the impact of the MDR1 gene on predisposition to inflammatory bowel disease...
  35. pmc HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV
    Marta Garcia-Montojo
    Multiple Sclerosis Unit, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Profesor Martín Lagos s n, 28240, Madrid, Spain
    Retrovirology 11:2. 2014
    ..A possible link between the HERV-W copy on chromosome Xq22.3, that contains an almost complete open reading frame, and the gender differential prevalence in MS has been suggested...
  36. pmc Role of the human endogenous retrovirus HERV-K18 in autoimmune disease susceptibility: study in the Spanish population and meta-analysis
    Belén de la Hera
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    PLoS ONE 8:e62090. 2013
    ..We aimed at evaluating the role of HERV-K18 in chromosome 1 on autoimmune disease susceptibility...
  37. ncbi JC virus in cerebrospinal fluid samples of multiple sclerosis patients at the first demyelinating event
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    Mult Scler 13:590-5. 2007
    ....
  38. ncbi Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, 28040 Madrid, Spain
    Arch Neurol 61:1523-7. 2004
    ..Recent studies have focused on the relationship between human herpesvirus 6 (HHV-6) and multiple sclerosis (MS)...
  39. pmc Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis
    Belén de la Hera
    Immunology Dept, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    PLoS ONE 9:e90182. 2014
    ..Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts...
  40. doi Anti-JCV antibodies detection and JCV DNA levels in PBMC, serum and urine in a cohort of Spanish Multiple Sclerosis patients treated with natalizumab
    Maria Inmaculada Dominguez-Mozo
    Unidad de Esclerosis Multiple, Hospital Clínico San Carlos Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, 28040, Madrid, Spain
    J Neuroimmune Pharmacol 8:1277-86. 2013
    ..Further research would be necessary to understand the different JCV excretion profiles in urine. ..
  41. ncbi HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-β therapy in multiple sclerosis
    Concepcion Nunez
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    J Med Genet 51:395-400. 2014
    ..We investigated the contribution conferred by HLA alleles on the development of NAbs in independent cohorts of Southern Europe...
  42. doi Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
    Jezabel Varadé
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Spain
    Mult Scler 18:959-65. 2012
    ..Ten genes previously showing different evidence of association with multiple sclerosis have been selected to validate...
  43. pmc The DNA copy number of human endogenous retrovirus-W (MSRV-type) is increased in multiple sclerosis patients and is influenced by gender and disease severity
    Marta Garcia-Montojo
    Multiple Sclerosis Unit, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    PLoS ONE 8:e53623. 2013
    ..The present study addresses MSRV-type DNA load in relation with the gender differences and clinical status in MS and healthy controls...
  44. doi Clinical response to interferon-beta-1a may be linked to low baseline circulating BDCA1 myeloid dendritic cells Differential role of circulating dendritic cells and CD4+ regulatory T-cells in relapsing-remitting multiple sclerosis: a 1-year longitudinal s
    Clara de Andrés
    Department of Neurology, Gregorio Marañón University General Hospital, Madrid, Spain
    J Neuroimmunol 212:112-20. 2009
    ..01). A better understanding of the rules that govern the T(Reg)-DC relationship will enable scientists to better manage the immune response in MS patients...
  45. ncbi Beta-interferon treatment reduces human herpesvirus-6 viral load in multiple sclerosis relapses but not in remission
    Roberto Alvarez-Lafuente
    Unidad de Investigacion, Hospital Clinico San Carlos, Madrid, Espana
    Eur Neurol 52:87-91. 2004
    ....
  46. ncbi Role of the PXR gene locus in inflammatory bowel diseases
    Alfonso Martinez
    Department of Immunology, Hospital Universitario San Carlos, Madrid, Spain
    Inflamm Bowel Dis 13:1484-7. 2007
    ..Considering previous results, we aimed at investigating the impact of this locus on IBD predisposition in the Spanish population...
  47. ncbi A recombined haplotype in the major histocompatibility region contains a cluster of genes conferring high susceptibility to ulcerative colitis in the Spanish population
    Laura Fernandez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Inflamm Bowel Dis 11:785-91. 2005
    ..Our aim was to look for associations among distinct genetic polymorphisms in the major histocompatibility complex (MHC) that might play a role in determining the susceptibility to UC and especially to the extensive form of the disease...
  48. ncbi Correlation between spasticity and quality of life in patients with multiple sclerosis: the CANDLE study
    Rafael Arroyo
    1Department of Neurology, Hospital Clinico San Carlos, Madrid, Spain
    Int J Neurosci 123:850-8. 2013
    ..Spasticity is a common symptom in multiple sclerosis (MS) that increases the burden of disease. This study investigated the relationship between the degree of spasticity and patients' health-related quality of life (QoL)...
  49. ncbi May intracranial hypotension be a cause of venous sinus thrombosis?
    D Sopelana
    Department of Neurology, San Carlos Clinical Hospital, ES 28013 Madrid, Spain
    Eur Neurol 51:113-5. 2004
  50. ncbi MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease
    Juan L Mendoza
    Department of Gastroenterology, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain
    Inflamm Bowel Dis 13:585-90. 2007
    ..To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD)...
  51. ncbi Association of the organic cation transporter OCTN genes with Crohn's disease in the Spanish population
    Alfonso Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Hum Genet 14:222-6. 2006
    ..Our data support the interpretation of the 1672C>T SLC22A4 and -207G>C SLC22A5 polymorphisms as genetic markers of susceptibility/protection haplotypes...
  52. ncbi Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility
    M Carmen Martin
    Servicio de Inmunología Clínica, Hospital Clinico San Carlos, 1a planta Sur, C Profesor Martin Lagos s n, 28040 Madrid, Spain
    Immunogenetics 59:833-7. 2007
    ..Concordantly, one out of the three haplotypes carrying both exonic risk alleles was found to increase CD susceptibility (p = 0.007; OR [95%CI] = 1.74 [1.13-2.67]). Therefore, the NOS2A gene seems to be involved in IBD aetiology...
  53. ncbi Genetic markers linked to rheumatoid arthritis are also strongly associated with articular manifestations in ulcerative colitis patients
    Concepcion Nunez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 67:324-30. 2006
    ..Thus, it seems that the development of articular manifestations in ulcerative colitis patients appears to be influenced by some genetic factor(s) present in some major histocompatibility complex haplotypes...
  54. ncbi Single nucleotide polymorphisms and microsatellite alleles of tumor necrosis factor alpha and interleukin-10 genes and the risk of advanced chronic alcoholic liver disease
    Jose M Ladero
    Department of Gastroenterology, Hospital Clinico San Carlos, Medical School, Complutense University, Madrid, Spain
    Liver 22:245-51. 2002
    ..In CALD there is a imbalance between TNF alpha and IL-10, which may be modulated by several polymorphisms at both genetic loci. Our aim has been to elucidate the possible relation between these polymorphisms and the risk of CALD...
  55. pmc Polymorphisms in interleukin-10 gene according to mutations of NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn's disease
    Juan L Mendoza
    Department of Gastroenterology, Hospital Clinico San Carlos de Madrid, Universidad Complutense, Madrid, Spain
    World J Gastroenterol 12:443-8. 2006
    ..To examine the contribution of interleukin-10 (IL-10) gene polymorphisms to Crohnos disease (CD) phenotype, and the possible genetic epistasis between IL-10 gene polymorphisms and CARD15/NOD2 gene mutations...
  56. doi MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Neurol 17:129-35. 2010
    ....
  57. doi Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases
    A Martinez
    Hospital Clinico San Carlos, Madrid, Spain
    Arthritis Rheum 58:2598-602. 2008
    ..The aim of this study was to investigate the role of this STAT4 tagging polymorphism in other immune-mediated diseases...
  58. ncbi TNF-376A marks susceptibility to MS in the Spanish population: A replication study
    A Martinez
    Immunology Department, Urcelay, Multiple Sclerosis Unit, Neurology Department, Hospital Clinico San Carlos, Madrid, Spain
    Neurology 62:809-10. 2004
    ....
  59. ncbi Glutathione S-transferase M1 and T1 genetic polymorphisms are not related to the risk of hepatocellular carcinoma: a study in the Spanish population
    Jose M Ladero
    Department of Gastroenterology, Hospital Clinico San Carlos, Complutense University, Madrid, Spain
    Eur J Cancer 42:73-7. 2006
    ..In conclusion, polymorphisms in GSTM1 and GSTT1 genes are not related to the incidence of HCC in a high-risk Spanish population...
  60. doi Cost-effectiveness analysis of disease modifiying drugs (interferons and glatiramer acetate) as first line treatments in remitting-relapsing multiple sclerosis patients
    Rainel Sánchez-de la Rosa
    Medical Department, TEVA Pharmaceutical, Madrid, Spain
    J Med Econ 15:424-33. 2012
    ..However, IM IFNβ-1a is not a cost-effective strategy vs GA, because incremental cost per QALY gained with IM IFNβ-1a exceeds the €30,000 per QALY threshold commonly used in Spain...
  61. doi Retrospective observational study of the management of multiple sclerosis patients with resistant spasticity in Spain: the '5E' study
    Rafael Arroyo
    Neurology Service, Hospital Clinico San Carlos, C Martin Lago s n 28040 Madrid, Spain
    Expert Rev Pharmacoecon Outcomes Res 11:205-13. 2011
    ..Multiple sclerosis spasticity (MSS) is a common and disabling symptom for which a number of antispastic agents are available; however, evidence-based guidelines for optimal management are lacking...
  62. doi STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility
    M C Cenit
    Immunology Department, Hospital Clínico S Carlos, Madrid, Spain
    Genes Immun 11:264-8. 2010
    ..The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population. A major role of this gene in MS seems unlikely...
  63. ncbi Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility
    A Marquez
    Department of Immunology, Hospital Universitario Clinico San Carlos, Madrid, Spain
    Genes Immun 10:631-5. 2009
    ..This susceptibility locus seems to affect mainly to the ileal CD subphenotype, although this point awaits further corroboration in independent cohorts...
  64. doi Glypican 5 is an interferon-beta response gene: a replication study
    M D C Cénit
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Mult Scler 15:913-7. 2009
    ..Our aim is to replicate the results obtained at the two loci most strongly implicated in the response to interferon-beta treatment, HAPLN1 and GPC5...
  65. ncbi Prevalence of herpesvirus DNA in MS patients and healthy blood donors
    R Alvarez-Lafuente
    Clinical Microbiology Service, Hospital Clinico San Carlos, Madrid, Spain
    Acta Neurol Scand 105:95-9. 2002
    ..The aim of this study is to determine the DNA prevalence of different members of Herpesviridae in multiple sclerosis (MS) patients and to describe the possible effect of beta-interferon treatment on such prevalence...
  66. ncbi The 795CT polymorphism in osteopontin gene is not associated with multiple sclerosis in a Spanish population
    A Mas
    Department of Immunology, Hospital Clinico San Carlos, c Prof Martin Lagos, s n 28040, Madrid, Spain
    Mult Scler 13:250-2. 2007
    ..In conclusion, our data suggest that the 795 polymorphism does not play an etiological role per se and the haplotype structure may differ from one population to another...
  67. ncbi [Extraintestinal manifestations in inflammatory bowel disease: differences between Crohn's disease and ulcerative colitis]
    Juan Luis Mendoza
    Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Aparato Digestivo, Hospital Clinico San Carlos, Madrid, Spain
    Med Clin (Barc) 125:297-300. 2005
    ..The aim of this study was determine the prevalence of the major EM of IBD and their differences between Crohn's disease (CD) and ulcerative colitis (UC)...
  68. ncbi Interferon-beta treatment and active replication of the JC virus in relapsing-remitting multiple sclerosis patients
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Neurol 14:233-6. 2007
    ..6 +/- 7.2 and 32.3 +/- 8.4 copies/microg of DNA, respectively. These results lead us to conclude that beta-IFN treatment in monotherapy has not any effect on JCV active replication...
  69. doi IL23R: a susceptibility locus for celiac disease and multiple sclerosis?
    C Nunez
    Servicio de Inmunología Clínica, Hospital Clinico San Carlos, Madrid, Spain
    Genes Immun 9:289-93. 2008
    ....
  70. ncbi Herpesviruses and human endogenous retroviral sequences in the cerebrospinal fluid of multiple sclerosis patients
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Mult Scler 14:595-601. 2008
    ..To analyze the possible role of human herpesvirus (HHVs) and human endogenous retroviruses (HERVs) infection in multiple sclerosis (MS) pathogenesis...
  71. doi Chromosomal region 16p13: further evidence of increased predisposition to immune diseases
    A Martinez
    Immunology Department, Hospital Universitario Clinico San Carlos, Martin Lagos s n, 28040 Madrid, Spain
    Ann Rheum Dis 69:309-11. 2010
    ..The role of CLEC16A polymorphisms in the pathogenesis of T1D, MS and RA and its relationship with the association reported with a MHC2TA haplotype were investigated...
  72. doi CD46 expression and HHV-6 infection in patients with multiple sclerosis
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Acta Neurol Scand 120:246-50. 2009
    ..The aim of this study was to investigate the possible association between the levels of the CD46 expression, and the presence and viral load of HHV-6 in patients with multiple sclerosis (MS)...
  73. doi Neutralizing antibodies, MxA expression and MMP-9/TIMP-1 ratio as markers of bioavailability of interferon-beta treatment in multiple sclerosis patients: a two-year follow-up study
    M Garcia-Montojo
    Unidad de Esclerosis Multiple, Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Neurol 17:470-8. 2010
    ....
  74. ncbi Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain
    Enrique Rey
    Digestive Disease Service, Hospital Clinico San Carlos, Complutense University, Madrid, Spain
    Eur J Gastroenterol Hepatol 18:969-75. 2006
    ..This study therefore sought to examine the prevalence of atypical symptoms, and their association with typical GER symptoms in Spain...
  75. ncbi Myenteric antiplexus antibodies and class II HLA in achalasia
    Antonio Ruiz-de-León
    Department of Gastroenterology, Hospital Universitario San Carlos, Universidad Complutense, Madrid, Spain
    Dig Dis Sci 47:15-9. 2002
    ..17 and OR = 5.82, respectively). All of the women and 66.7% of the men with achalasia and the DQB1*0603 allele or the DQA1*0103-DQB1*0603 heterodimer were positive for antibodies...
  76. ncbi A computer-assisted morphometric quantitative analysis of iron overload in liver biopsies. A comparison with histological and biochemical methods
    Luis Ortega
    Department of Gastroenterology, Hospital Clinico San Carlos, Universidad Complutense de Madrid Medical School, Madrid, Spain
    Pathol Res Pract 201:673-7. 2005
    ....