Tomas Alvaro

Summary

Affiliation: Hospital Universitari Germans Trias i Pujol
Country: Spain

Publications

  1. ncbi Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells
    Tomas Alvaro
    Department of Pathology, Hospital Verge de la Cinta, C Esplanetes n degree 14, 43500 Tortosa, Spain
    Clin Cancer Res 11:1467-73. 2005
  2. ncbi Tumor-infiltrating cells as a prognostic factor in Hodgkin's lymphoma: a quantitative tissue microarray study in a large retrospective cohort of 267 patients
    Tomás Alvaro-Naranjo
    Department of Pathology, Hospital Verge de la Cinta, Tortosa, Spain
    Leuk Lymphoma 46:1581-91. 2005
  3. ncbi Immunohistochemical patterns of reactive microenvironment are associated with clinicobiologic behavior in follicular lymphoma patients
    Tomas Alvaro
    Department of Pathology, Hospital Verge de la Cinta, Tortosa, Spain
    J Clin Oncol 24:5350-7. 2006
  4. ncbi The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, C Esplanetes n 14, 43500 Tortosa, Spain
    Haematologica 91:1605-12. 2006
  5. doi Tumor-infiltrated immune response correlates with alterations in the apoptotic and cell cycle pathways in Hodgkin and Reed-Sternberg cells
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    Clin Cancer Res 14:685-91. 2008
  6. doi Appraisal of immune response in lymphoproliferative syndromes: a systematic review
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    Crit Rev Oncol Hematol 70:103-13. 2009
  7. ncbi Automated quantification of nuclear immunohistochemical markers with different complexity
    Carlos Lopez
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tarragona, Spain
    Histochem Cell Biol 129:379-87. 2008
  8. doi Roundness variation in JPEG images affects the automated process of nuclear immunohistochemical quantification: correction with a linear regression model
    Carlos Lopez
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, IISPV, C Esplanetes no 14, Tortosa 43500, Spain
    Histochem Cell Biol 132:469-77. 2009
  9. pmc Effects of image compression on automatic count of immunohistochemically stained nuclei in digital images
    Carlos Lopez
    Correspondence Joaquín Jaén Martínez, Department of Pathology, Hospital de Tortosa Verge de la Cinta, C Esplanetes no 14, 43500 Tortosa, Spain Email
    J Am Med Inform Assoc 15:794-8. 2008
  10. doi Is it necessary to evaluate nuclei in HER2 FISH evaluation?
    Carlos Lopez
    Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta, IISPV, URV, Tortosa, Spain
    Am J Clin Pathol 139:47-54. 2013

Collaborators

Detail Information

Publications15

  1. ncbi Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells
    Tomas Alvaro
    Department of Pathology, Hospital Verge de la Cinta, C Esplanetes n degree 14, 43500 Tortosa, Spain
    Clin Cancer Res 11:1467-73. 2005
    ..This study aimed to assess the relevance of regulatory T cells and CTLs present in the background of HL samples in the prognosis of a series of classic HL (cHL) patients...
  2. ncbi Tumor-infiltrating cells as a prognostic factor in Hodgkin's lymphoma: a quantitative tissue microarray study in a large retrospective cohort of 267 patients
    Tomás Alvaro-Naranjo
    Department of Pathology, Hospital Verge de la Cinta, Tortosa, Spain
    Leuk Lymphoma 46:1581-91. 2005
    ..Independently of the classical clinical and pathological features, these cells appear to be an unfavourable prognostic factor in HL and, more particularly, the presence of cytotoxic TIA-1+cells...
  3. ncbi Immunohistochemical patterns of reactive microenvironment are associated with clinicobiologic behavior in follicular lymphoma patients
    Tomas Alvaro
    Department of Pathology, Hospital Verge de la Cinta, Tortosa, Spain
    J Clin Oncol 24:5350-7. 2006
    ..Recent molecular data have suggested that non-neoplastic cells are powerful modulators that may confer a selective advantage or disadvantage on the outcome of follicular lymphoma (FL) patients...
  4. ncbi The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, C Esplanetes n 14, 43500 Tortosa, Spain
    Haematologica 91:1605-12. 2006
    ..The aim of this study was to determine the extent to which macrophages are present in FL and to investigate the expression of STAT1 in these cells...
  5. doi Tumor-infiltrated immune response correlates with alterations in the apoptotic and cell cycle pathways in Hodgkin and Reed-Sternberg cells
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    Clin Cancer Res 14:685-91. 2008
    ..To analyze tumor-microenvironment relationships in Hodgkin lymphoma (HL) as potential determinants in the decision-making process related to the alterations in cell cycle and apoptotic pathways of Hodgkin/Reed-Sternberg (H/RS) cells...
  6. doi Appraisal of immune response in lymphoproliferative syndromes: a systematic review
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    Crit Rev Oncol Hematol 70:103-13. 2009
    ....
  7. ncbi Automated quantification of nuclear immunohistochemical markers with different complexity
    Carlos Lopez
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tarragona, Spain
    Histochem Cell Biol 129:379-87. 2008
    ..In conclusion, this new automated procedure is an objective, faster and reproducible method that has an excellent level of accuracy, even with digital images with a high complexity...
  8. doi Roundness variation in JPEG images affects the automated process of nuclear immunohistochemical quantification: correction with a linear regression model
    Carlos Lopez
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, IISPV, C Esplanetes no 14, Tortosa 43500, Spain
    Histochem Cell Biol 132:469-77. 2009
    ..Our results demonstrate that it is possible to carry out unbiased automated immunohistochemical nuclear quantification in compressed DIs with a methodology that could be easily incorporated in different systems of digital image analysis...
  9. pmc Effects of image compression on automatic count of immunohistochemically stained nuclei in digital images
    Carlos Lopez
    Correspondence Joaquín Jaén Martínez, Department of Pathology, Hospital de Tortosa Verge de la Cinta, C Esplanetes no 14, 43500 Tortosa, Spain Email
    J Am Med Inform Assoc 15:794-8. 2008
    ..Compression does not compromise the accuracy of immunohistochemical nuclear marker counts obtained by computer-assisted analysis systems for digital images with low complexity and could be an efficient method for storing these images...
  10. doi Is it necessary to evaluate nuclei in HER2 FISH evaluation?
    Carlos Lopez
    Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta, IISPV, URV, Tortosa, Spain
    Am J Clin Pathol 139:47-54. 2013
    ..The proposed enhanced method substantially improves HER2 FISH assessment in breast cancer biopsy specimens because the evaluation of HER2/CEP17 copy numbers is more representative, easier, and faster than the conventional method...
  11. ncbi Digital image analysis in breast cancer: an example of an automated methodology and the effects of image compression
    Carlos Lopez
    Unitat de Suport a la Recerca de la Gerencia Territorial Terres de l Ebre, IDIAP, Tortosa, Spain
    Stud Health Technol Inform 179:155-71. 2012
    ..Moreover, the results demonstrate that with correction factors, it is possible to carry out unbiased automated quantifications on IHC nuclear markers in compressed DIs...
  12. ncbi Development of automated quantification methodologies of immunohistochemical markers to determine patterns of immune response in breast cancer: a retrospective cohort study
    Carlos Lopez
    Unitat de Suport a la Recerca Terres de l Ebre, IISPV, Institut Universitari d Investigació en Atenció Primària IDIAP Jordi Gol, URV, UAB, Tortosa, Spain
    BMJ Open 4:e005643. 2014
    ..It is expected that these differences will be able to explain differences in survival, relapse and clinicopathological variables between the two groups...
  13. pmc Quantification of diverse subcellular immunohistochemical markers with clinicobiological relevancies: validation of a new computer-assisted image analysis procedure
    Marylène Lejeune
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    J Anat 212:868-78. 2008
    ..Our semi-automated computerized method eliminates the major causes of observer variability and may be considered a valid alternative to manual microscopic quantification for diagnostic, prognostic and therapeutic purposes...
  14. doi Improved demonstration of immunohistochemical prognostic markers for survival in follicular lymphoma cells
    Francisca I Camacho
    Department of Pathology, Hospital Universitario de Getafe, Carretera de Toledo, Getafe, Madrid, Spain
    Mod Pathol 24:698-707. 2011
    ..This not only confirms that a group of FL cases may have a very good clinical course, but also indicates that this group can be identified using this integrated clinical and immunohistochemical approach...
  15. pmc Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
    Adriana Garcia-Herrera
    Department of Pathology, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Am J Surg Pathol 35:1214-25. 2011
    ..However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study...