Roberto Alvarez-Lafuente

Summary

Affiliation: Hospital Universitario
Country: Spain

Publications

  1. doi request reprint CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Ciudad Universitaria, Madrid, Spain
    Mult Scler 17:513-20. 2011
  2. doi request reprint CD46 expression and HHV-6 infection in patients with multiple sclerosis
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Acta Neurol Scand 120:246-50. 2009
  3. doi request reprint MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Neurol 17:129-35. 2010
  4. pmc MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up
    Maria Inmaculada Dominguez-Mozo
    Servicio de Neurologia, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    BMC Neurol 12:107. 2012
  5. ncbi request reprint Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA
    Alfonso Martinez
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:685-9. 2007
  6. ncbi request reprint Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Brain Pathol 16:20-7. 2006
  7. ncbi request reprint Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, 28040, Spain
    J Clin Virol 37:S24-6. 2006
  8. ncbi request reprint Beta-interferon treatment reduces human herpesvirus-6 viral load in multiple sclerosis relapses but not in remission
    Roberto Alvarez-Lafuente
    Unidad de Investigacion, Hospital Clinico San Carlos, Madrid, Espana
    Eur Neurol 52:87-91. 2004
  9. doi request reprint Anti-JCV antibodies detection and JCV DNA levels in PBMC, serum and urine in a cohort of Spanish Multiple Sclerosis patients treated with natalizumab
    Maria Inmaculada Dominguez-Mozo
    Unidad de Esclerosis Multiple, Hospital Clínico San Carlos Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, 28040, Madrid, Spain
    J Neuroimmune Pharmacol 8:1277-86. 2013
  10. doi request reprint Herpesvirus active replication in multiple sclerosis: a genetic control?
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    J Neurol Sci 311:98-102. 2011

Collaborators

Detail Information

Publications27

  1. doi request reprint CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Ciudad Universitaria, Madrid, Spain
    Mult Scler 17:513-20. 2011
    ..In a prior study of our group we found an up-regulation of CD46 expression in a cohort of Spanish multiple sclerosis (MS) patients...
  2. doi request reprint CD46 expression and HHV-6 infection in patients with multiple sclerosis
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Acta Neurol Scand 120:246-50. 2009
    ..The aim of this study was to investigate the possible association between the levels of the CD46 expression, and the presence and viral load of HHV-6 in patients with multiple sclerosis (MS)...
  3. doi request reprint MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Neurol 17:129-35. 2010
    ....
  4. pmc MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up
    Maria Inmaculada Dominguez-Mozo
    Servicio de Neurologia, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    BMC Neurol 12:107. 2012
    ..2. To study MHC2TA expression in MS patients with and without minor allele C. 3. To analyze the relation between MHC2TA mRNA levels and HHV-6 active infection in MS patients...
  5. ncbi request reprint Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA
    Alfonso Martinez
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:685-9. 2007
    ..Besides, this report indicates that when patients are grouped based upon a well-defined molecular event, complex diseases may reveal themselves as being constituted by distinct entities in which some genes may have a strong influence...
  6. ncbi request reprint Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Brain Pathol 16:20-7. 2006
    ..This study was undertaken in order to investigate the possible relation of HHV-6 and EBV in relapsing-remitting MS (RRMS)...
  7. ncbi request reprint Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, 28040, Spain
    J Clin Virol 37:S24-6. 2006
    ..Although the etiology of multiple sclerosis (MS) remains uncertain, clinical, epidemiological, and laboratory findings suggest that environmental factors may be involved in the disease...
  8. ncbi request reprint Beta-interferon treatment reduces human herpesvirus-6 viral load in multiple sclerosis relapses but not in remission
    Roberto Alvarez-Lafuente
    Unidad de Investigacion, Hospital Clinico San Carlos, Madrid, Espana
    Eur Neurol 52:87-91. 2004
    ....
  9. doi request reprint Anti-JCV antibodies detection and JCV DNA levels in PBMC, serum and urine in a cohort of Spanish Multiple Sclerosis patients treated with natalizumab
    Maria Inmaculada Dominguez-Mozo
    Unidad de Esclerosis Multiple, Hospital Clínico San Carlos Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, 28040, Madrid, Spain
    J Neuroimmune Pharmacol 8:1277-86. 2013
    ..Further research would be necessary to understand the different JCV excretion profiles in urine. ..
  10. doi request reprint Herpesvirus active replication in multiple sclerosis: a genetic control?
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    J Neurol Sci 311:98-102. 2011
    ..The results show that MS patients without HHV-6 active replication are better responders to interferon beta treatment than those with HHV-6 active replication...
  11. ncbi request reprint Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, 28040 Madrid, Spain
    Arch Neurol 61:1523-7. 2004
    ..Recent studies have focused on the relationship between human herpesvirus 6 (HHV-6) and multiple sclerosis (MS)...
  12. ncbi request reprint JC virus in cerebrospinal fluid samples of multiple sclerosis patients at the first demyelinating event
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    Mult Scler 13:590-5. 2007
    ....
  13. pmc HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV
    Marta Garcia-Montojo
    Multiple Sclerosis Unit, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Profesor Martín Lagos s n, 28240, Madrid, Spain
    Retrovirology 11:2. 2014
    ..A possible link between the HERV-W copy on chromosome Xq22.3, that contains an almost complete open reading frame, and the gender differential prevalence in MS has been suggested...
  14. pmc Role of the human endogenous retrovirus HERV-K18 in autoimmune disease susceptibility: study in the Spanish population and meta-analysis
    Belén de la Hera
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    PLoS ONE 8:e62090. 2013
    ..We aimed at evaluating the role of HERV-K18 in chromosome 1 on autoimmune disease susceptibility...
  15. doi request reprint Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis
    Jose Ramon Lamas
    Rheumatology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, Madrid 28040, Spain
    Ann Rheum Dis 69:1880-5. 2010
    ..To elucidate disease-specific molecular changes occurring in osteoarthritis (OA) by analysing the differential gene expression profiles of bone marrow mesenchymal stem cells (BM-MSCs) from patients with OA compared with those without OA...
  16. pmc Anti-human herpesvirus 6A/B IgG correlates with relapses and progression in multiple sclerosis
    Isabel Ortega-Madueño
    Servicio de Análisis Clínicos Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    PLoS ONE 9:e104836. 2014
    ..To analyze the titers of the IgG and IgM antibodies against human herpesvirus 6A/B (HHV-6A/B) in multiple sclerosis (MS) patients treated with different disease modified therapies (DMTs) along two-years of follow-up...
  17. ncbi request reprint Abnormal transforming growth factor-beta expression in mesenchymal stem cells from patients with osteoarthritis
    Raquel Rollin
    Servicio de Cirugia Ortopedica y Traumatologia, Hospital Clinico San Carlos, Madrid, Spain
    J Rheumatol 35:904-6. 2008
    ..To determine the expression of the genes that code for the isoforms of transforming growth factor-beta (TGF-beta) and TGF-beta receptors (TBR) in mesenchymal stem cells (MSC) from patients with osteoarthritis (OA)...
  18. ncbi request reprint Interferon beta treatment: bioavailability and antiviral activity in multiple sclerosis patients
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    J Neurovirol 13:504-12. 2007
    ..5% to 12.2% in sera; furthermore, a good correlation with the bioavailability of interferon beta was found, because patients with a decrease in HHV-6 prevalence had higher levels of MxA (P = .046, at the third month)...
  19. doi request reprint Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis
    Jose Ramon Lamas
    UGC de Reumatología, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    Cytokine 61:720-3. 2013
    ..To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA)...
  20. pmc The DNA copy number of human endogenous retrovirus-W (MSRV-type) is increased in multiple sclerosis patients and is influenced by gender and disease severity
    Marta Garcia-Montojo
    Multiple Sclerosis Unit, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    PLoS ONE 8:e53623. 2013
    ..The present study addresses MSRV-type DNA load in relation with the gender differences and clinical status in MS and healthy controls...
  21. ncbi request reprint Active human herpesvirus 6 infection in patients with multiple sclerosis
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, c Martin Lagos s n, 28040 Madrid, Spain
    Arch Neurol 59:929-33. 2002
    ..Human herpesvirus 6 (HHV-6) has been linked with multiple sclerosis (MS)...
  22. doi request reprint Detection of human herpesvirus-6, Epstein-Barr virus and cytomegalovirus in formalin-fixed tissues from sudden infant death: a study with quantitative real-time PCR
    Roberto Alvarez-Lafuente
    Neurology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, Madrid 28040, Spain
    Forensic Sci Int 178:106-11. 2008
    ..The role of viruses in the context of sudden infant death in early childhood is still unclear, although there are many findings pointing to a viral infection possibly leading to death...
  23. doi request reprint Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab
    Luisa M Villar
    Department of Immunology, Ramon y Cajal University Hospital, Institute Ramon y Cajal for Biomedical Research, Madrid, Spain Spanish Network for the Research in Multiple Sclerosis, Spain
    Ann Neurol 77:447-57. 2015
    ....
  24. pmc Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis
    Belén de la Hera
    Immunology Dept, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    PLoS ONE 9:e90182. 2014
    ..Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts...
  25. doi request reprint HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-β therapy in multiple sclerosis
    Concepcion Nunez
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    J Med Genet 51:395-400. 2014
    ..We investigated the contribution conferred by HLA alleles on the development of NAbs in independent cohorts of Southern Europe...
  26. doi request reprint Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis
    Luisa M Villar
    Immunology and Neurology Service, Multiple Sclerosis Unit, Ramon y Cajal University Hospital, Madrid, Spain
    Ann Neurol 76:231-40. 2014
    ..To identify a biomarker distinguishing patients who, despite a primary progressive multiple sclerosis (PPMS) clinical course, may nonetheless benefit from immune therapy...
  27. doi request reprint The ubiquitin-proteasome pathway and viral infections in articular cartilage of patients with osteoarthritis
    Raquel Rollin
    Servicio de Reumatologia, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040, Madrid, Spain
    Rheumatol Int 29:969-72. 2009
    ....