Roberto Alvarez-Lafuente

Summary

Affiliation: Hospital Universitario
Country: Spain

Publications

  1. ncbi request reprint MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Neurol 17:129-35. 2010
  2. doi request reprint CD46 expression and HHV-6 infection in patients with multiple sclerosis
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Acta Neurol Scand 120:246-50. 2009
  3. doi request reprint CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Ciudad Universitaria, Madrid, Spain
    Mult Scler 17:513-20. 2011
  4. pmc MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up
    Maria Inmaculada Dominguez-Mozo
    Servicio de Neurologia, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    BMC Neurol 12:107. 2012
  5. ncbi request reprint Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA
    Alfonso Martinez
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:685-9. 2007
  6. ncbi request reprint Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Brain Pathol 16:20-7. 2006
  7. ncbi request reprint Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, 28040, Spain
    J Clin Virol 37:S24-6. 2006
  8. ncbi request reprint Beta-interferon treatment reduces human herpesvirus-6 viral load in multiple sclerosis relapses but not in remission
    Roberto Alvarez-Lafuente
    Unidad de Investigacion, Hospital Clinico San Carlos, Madrid, Espana
    Eur Neurol 52:87-91. 2004
  9. doi request reprint Herpesvirus active replication in multiple sclerosis: a genetic control?
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    J Neurol Sci 311:98-102. 2011
  10. ncbi request reprint Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, 28040 Madrid, Spain
    Arch Neurol 61:1523-7. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Neurol 17:129-35. 2010
    ....
  2. doi request reprint CD46 expression and HHV-6 infection in patients with multiple sclerosis
    R Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Acta Neurol Scand 120:246-50. 2009
    ..The aim of this study was to investigate the possible association between the levels of the CD46 expression, and the presence and viral load of HHV-6 in patients with multiple sclerosis (MS)...
  3. doi request reprint CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Ciudad Universitaria, Madrid, Spain
    Mult Scler 17:513-20. 2011
    ..In a prior study of our group we found an up-regulation of CD46 expression in a cohort of Spanish multiple sclerosis (MS) patients...
  4. pmc MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up
    Maria Inmaculada Dominguez-Mozo
    Servicio de Neurologia, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    BMC Neurol 12:107. 2012
    ..2. To study MHC2TA expression in MS patients with and without minor allele C. 3. To analyze the relation between MHC2TA mRNA levels and HHV-6 active infection in MS patients...
  5. ncbi request reprint Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA
    Alfonso Martinez
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:685-9. 2007
    ..Besides, this report indicates that when patients are grouped based upon a well-defined molecular event, complex diseases may reveal themselves as being constituted by distinct entities in which some genes may have a strong influence...
  6. ncbi request reprint Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    Brain Pathol 16:20-7. 2006
    ..This study was undertaken in order to investigate the possible relation of HHV-6 and EBV in relapsing-remitting MS (RRMS)...
  7. ncbi request reprint Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, 28040, Spain
    J Clin Virol 37:S24-6. 2006
    ..Although the etiology of multiple sclerosis (MS) remains uncertain, clinical, epidemiological, and laboratory findings suggest that environmental factors may be involved in the disease...
  8. ncbi request reprint Beta-interferon treatment reduces human herpesvirus-6 viral load in multiple sclerosis relapses but not in remission
    Roberto Alvarez-Lafuente
    Unidad de Investigacion, Hospital Clinico San Carlos, Madrid, Espana
    Eur Neurol 52:87-91. 2004
    ....
  9. doi request reprint Herpesvirus active replication in multiple sclerosis: a genetic control?
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    J Neurol Sci 311:98-102. 2011
    ..The results show that MS patients without HHV-6 active replication are better responders to interferon beta treatment than those with HHV-6 active replication...
  10. ncbi request reprint Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, 28040 Madrid, Spain
    Arch Neurol 61:1523-7. 2004
    ..Recent studies have focused on the relationship between human herpesvirus 6 (HHV-6) and multiple sclerosis (MS)...
  11. ncbi request reprint JC virus in cerebrospinal fluid samples of multiple sclerosis patients at the first demyelinating event
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid 28040, Spain
    Mult Scler 13:590-5. 2007
    ....
  12. pmc Role of the human endogenous retrovirus HERV-K18 in autoimmune disease susceptibility: study in the Spanish population and meta-analysis
    Belén de la Hera
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    PLoS ONE 8:e62090. 2013
    ..We aimed at evaluating the role of HERV-K18 in chromosome 1 on autoimmune disease susceptibility...
  13. doi request reprint Anti-JCV antibodies detection and JCV DNA levels in PBMC, serum and urine in a cohort of Spanish Multiple Sclerosis patients treated with natalizumab
    Maria Inmaculada Dominguez-Mozo
    Unidad de Esclerosis Multiple, Hospital Clínico San Carlos Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, 28040, Madrid, Spain
    J Neuroimmune Pharmacol 8:1277-86. 2013
    ..Further research would be necessary to understand the different JCV excretion profiles in urine. ..
  14. pmc HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV
    Marta Garcia-Montojo
    Multiple Sclerosis Unit, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Profesor Martín Lagos s n, 28240, Madrid, Spain
    Retrovirology 11:2. 2014
    ..A possible link between the HERV-W copy on chromosome Xq22.3, that contains an almost complete open reading frame, and the gender differential prevalence in MS has been suggested...
  15. doi request reprint Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis
    Jose Ramon Lamas
    Rheumatology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, Madrid 28040, Spain
    Ann Rheum Dis 69:1880-5. 2010
    ..To elucidate disease-specific molecular changes occurring in osteoarthritis (OA) by analysing the differential gene expression profiles of bone marrow mesenchymal stem cells (BM-MSCs) from patients with OA compared with those without OA...
  16. ncbi request reprint Anti-Human Herpesvirus 6A/B IgG Correlates with Relapses and Progression in Multiple Sclerosis
    Isabel Ortega-Madueño
    Servicio de Análisis Clínicos Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    PLoS ONE 9:e104836. 2014
    ..To analyze the titers of the IgG and IgM antibodies against human herpesvirus 6A/B (HHV-6A/B) in multiple sclerosis (MS) patients treated with different disease modified therapies (DMTs) along two-years of follow-up...
  17. ncbi request reprint Abnormal transforming growth factor-beta expression in mesenchymal stem cells from patients with osteoarthritis
    Raquel Rollin
    Servicio de Cirugia Ortopedica y Traumatologia, Hospital Clinico San Carlos, Madrid, Spain
    J Rheumatol 35:904-6. 2008
    ..To determine the expression of the genes that code for the isoforms of transforming growth factor-beta (TGF-beta) and TGF-beta receptors (TBR) in mesenchymal stem cells (MSC) from patients with osteoarthritis (OA)...
  18. doi request reprint Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis
    Jose Ramon Lamas
    UGC de Reumatología, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    Cytokine 61:720-3. 2013
    ..To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA)...
  19. ncbi request reprint Interferon beta treatment: bioavailability and antiviral activity in multiple sclerosis patients
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    J Neurovirol 13:504-12. 2007
    ..5% to 12.2% in sera; furthermore, a good correlation with the bioavailability of interferon beta was found, because patients with a decrease in HHV-6 prevalence had higher levels of MxA (P = .046, at the third month)...
  20. pmc The DNA copy number of human endogenous retrovirus-W (MSRV-type) is increased in multiple sclerosis patients and is influenced by gender and disease severity
    Marta Garcia-Montojo
    Multiple Sclerosis Unit, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    PLoS ONE 8:e53623. 2013
    ..The present study addresses MSRV-type DNA load in relation with the gender differences and clinical status in MS and healthy controls...
  21. ncbi request reprint Active human herpesvirus 6 infection in patients with multiple sclerosis
    Roberto Alvarez-Lafuente
    Servicio de Neurologia, Hospital Clinico San Carlos, c Martin Lagos s n, 28040 Madrid, Spain
    Arch Neurol 59:929-33. 2002
    ..Human herpesvirus 6 (HHV-6) has been linked with multiple sclerosis (MS)...
  22. doi request reprint Detection of human herpesvirus-6, Epstein-Barr virus and cytomegalovirus in formalin-fixed tissues from sudden infant death: a study with quantitative real-time PCR
    Roberto Alvarez-Lafuente
    Neurology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, Madrid 28040, Spain
    Forensic Sci Int 178:106-11. 2008
    ..The role of viruses in the context of sudden infant death in early childhood is still unclear, although there are many findings pointing to a viral infection possibly leading to death...
  23. pmc Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis
    Belén de la Hera
    Immunology Dept, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    PLoS ONE 9:e90182. 2014
    ..Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts...
  24. ncbi request reprint HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-β therapy in multiple sclerosis
    Concepcion Nunez
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    J Med Genet 51:395-400. 2014
    ..We investigated the contribution conferred by HLA alleles on the development of NAbs in independent cohorts of Southern Europe...
  25. doi request reprint The ubiquitin-proteasome pathway and viral infections in articular cartilage of patients with osteoarthritis
    Raquel Rollin
    Servicio de Reumatologia, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040, Madrid, Spain
    Rheumatol Int 29:969-72. 2009
    ....