Guillermo M Albaiceta

Summary

Affiliation: Hospital Universitario Central de Asturias
Country: Spain

Publications

  1. ncbi request reprint [Pressure-volume curves in acute pulmonary injury]
    Guillermo Muñiz-Albaiceta
    Unidad de Cuidados Intensivos, Hospital Universitario Central de Asturias, Departamento de Biologia Funcional, Universidad de Oviedo, Oviedo, Asturias, Espana
    Med Intensiva 33:243-50. 2009
  2. pmc Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10
    Emilio García-Prieto
    Department of Biología Funcional, Universidad de Oviedo, Instituto Universitario de Oncologia IUOPA, Oviedo, Spain
    PLoS ONE 5:e13242. 2010
  3. pmc MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia
    Adrián González-López
    Departamento de Biologia Funcional, Instituto Universitario de Oncologia del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
    PLoS ONE 7:e39940. 2012
  4. doi request reprint Mechanical ventilation causes monocyte deactivation in intact and endotoxin-treated mice
    Guillermo M Albaiceta
    Intensive Care Unit, Department of Haematology, Hospital Universitario Central de Asturias, University of Oviedo, Oviedo, Spain
    J Trauma 64:470-6. 2008
  5. doi request reprint Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury
    Guillermo M Albaiceta
    Department of Biología Funcional, Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Oviedo, Spain
    Am J Respir Cell Mol Biol 43:555-63. 2010
  6. doi request reprint Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury
    Guillermo M Albaiceta
    Department of Biologia Functional, Universidad de Oviedo, and Intensive Care Unit, Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Spain
    Am J Physiol Lung Cell Mol Physiol 294:L535-43. 2008
  7. ncbi request reprint Therapeutic implications of immunoparalysis in critically ill patients
    Guillermo M Albaiceta
    Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
    Inflamm Allergy Drug Targets 6:191-6. 2007
  8. pmc Comparative study of four sigmoid models of pressure-volume curve in acute lung injury
    Guillermo M Albaiceta
    Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
    Biomed Eng Online 6:7. 2007
  9. ncbi request reprint Inspiratory vs. expiratory pressure-volume curves to set end-expiratory pressure in acute lung injury
    Guillermo M Albaiceta
    Department of Intensive Medicine, Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Spain
    Intensive Care Med 31:1370-8. 2005
  10. ncbi request reprint Tomographic study of the inflection points of the pressure-volume curve in acute lung injury
    Guillermo M Albaiceta
    Department of Intensive Medicine, Hospital Universitario Central de Asturias, Oveido, Spain
    Am J Respir Crit Care Med 170:1066-72. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint [Pressure-volume curves in acute pulmonary injury]
    Guillermo Muñiz-Albaiceta
    Unidad de Cuidados Intensivos, Hospital Universitario Central de Asturias, Departamento de Biologia Funcional, Universidad de Oviedo, Oviedo, Asturias, Espana
    Med Intensiva 33:243-50. 2009
    ..It remains to be determined if new data derived from these curves are useful to optimize ventilatory settings or to predict the response of a patient to a change in the ventilatory settings...
  2. pmc Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10
    Emilio García-Prieto
    Department of Biología Funcional, Universidad de Oviedo, Instituto Universitario de Oncologia IUOPA, Oviedo, Spain
    PLoS ONE 5:e13242. 2010
    ..Matrix metalloproteinases (MMPs) may have pro and antifibrotic roles within the lungs, due to its ability to modulate collagen turnover and immune mediators. MMP-8 is a collagenase that also cleaves a number of cytokines and chemokines...
  3. pmc MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia
    Adrián González-López
    Departamento de Biologia Funcional, Instituto Universitario de Oncologia del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
    PLoS ONE 7:e39940. 2012
    ..These results show that MMP-8 can modulate the levels of S100A8 and S100A9 and its absence promotes the lung inflammatory response during endotoxemia...
  4. doi request reprint Mechanical ventilation causes monocyte deactivation in intact and endotoxin-treated mice
    Guillermo M Albaiceta
    Intensive Care Unit, Department of Haematology, Hospital Universitario Central de Asturias, University of Oviedo, Oviedo, Spain
    J Trauma 64:470-6. 2008
    ..We hypothesized that mechanical ventilation could also be a cause...
  5. doi request reprint Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury
    Guillermo M Albaiceta
    Department of Biología Funcional, Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Oviedo, Spain
    Am J Respir Cell Mol Biol 43:555-63. 2010
    ..We conclude that MMP-8 promotes acute inflammation after ventilation with high pressures, and its short-term inhibition could be a therapeutic goal to limit VILI...
  6. doi request reprint Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury
    Guillermo M Albaiceta
    Department of Biologia Functional, Universidad de Oviedo, and Intensive Care Unit, Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Spain
    Am J Physiol Lung Cell Mol Physiol 294:L535-43. 2008
    ..These results show that MMP-9 protects against ventilator-induced lung injury by decreasing alveolar neutrophilic infiltration, probably by modulation of the cytokine response in the air spaces...
  7. ncbi request reprint Therapeutic implications of immunoparalysis in critically ill patients
    Guillermo M Albaiceta
    Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
    Inflamm Allergy Drug Targets 6:191-6. 2007
    ....
  8. pmc Comparative study of four sigmoid models of pressure-volume curve in acute lung injury
    Guillermo M Albaiceta
    Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
    Biomed Eng Online 6:7. 2007
    ..Mathematical models of the static pressure-volume curve of the respiratory system have been proposed to overcome the inter- and intra-observer variability derived from eye-fitting. However, different models have not been compared...
  9. ncbi request reprint Inspiratory vs. expiratory pressure-volume curves to set end-expiratory pressure in acute lung injury
    Guillermo M Albaiceta
    Department of Intensive Medicine, Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Spain
    Intensive Care Med 31:1370-8. 2005
    ....
  10. ncbi request reprint Tomographic study of the inflection points of the pressure-volume curve in acute lung injury
    Guillermo M Albaiceta
    Department of Intensive Medicine, Hospital Universitario Central de Asturias, Oveido, Spain
    Am J Respir Crit Care Med 170:1066-72. 2004
    ..There were no significant changes in hyperinflated lung tissue. These results support the use of the deflation limb of the pressure-volume curve for positive end-expiratory pressure setting in patients with acute lung injury...
  11. pmc Beyond volutrauma in ARDS: the critical role of lung tissue deformation
    Guillermo M Albaiceta
    Intensive Care Unit, Hospital Universitario Central de Asturias, Departamento de Biologia Funcional, Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Celestino Villamil s n, 33006 Oviedo, Spain
    Crit Care 15:304. 2011
    ..Focusing on tissue deformation could lead to new bedside monitoring and ventilatory strategies...
  12. doi request reprint Inflammation and matrix remodeling during repair of ventilator-induced lung injury
    Adrián González-López
    Department of Biología Funcional, Universidad de Oviedo, Spain
    Am J Physiol Lung Cell Mol Physiol 301:L500-9. 2011
    ..An adequate inflammatory response and extracellular matrix remodeling are essential for recovery. MMP-2 could play a key role in epithelial repair after VILI and acute respiratory distress syndrome...
  13. doi request reprint Impairment of autophagy decreases ventilator-induced lung injury by blockade of the NF-κB pathway
    Inés López-Alonso
    Department of Functional Biology, University of Oviedo, Oviedo, Spain
    Am J Physiol Lung Cell Mol Physiol 304:L844-52. 2013
    ..In conclusion, impairment of autophagy results in an ameliorated inflammatory response to mechanical ventilation and decreases lung injury. The accumulation of ubiquitinated IκB may be responsible for this effect...
  14. doi request reprint Effects of melatonin in an experimental model of ventilator-induced lung injury
    Paula R Pedreira
    Intensive Care Unit, Hospital Universitario Central de Asturias, Celestino Villamil s n, Oviedo, Spain
    Am J Physiol Lung Cell Mol Physiol 295:L820-7. 2008
    ..These results suggest that melatonin decreases VILI by increasing the anti-inflammatory response despite an unexpected increase in oxidative stress...
  15. ncbi request reprint Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia
    Alina Aguirre
    Departamento de Biologia Funcional, Area de Fisiologia, IUOPA, Universidad de Oviedo, Oviedo, Spain
    J Mol Med (Berl) 92:665-76. 2014
    ..Similar results were found in human bronchial cells exposed to LPS. Our results demonstrate the central role of autophagy in the regulation of the lung response to endotoxemia and sepsis and its potential modulation by nutrition...
  16. doi request reprint Lung strain and biological response in mechanically ventilated patients
    Adrián González-López
    Departamento de Biologia Funcional, Instituto Universitario de Oncologia del Principado de Asturias IUOPA, Universidad de Oviedo, Oviedo, Spain
    Intensive Care Med 38:240-7. 2012
    ..Since strain has been proposed as a marker of such deformation, we studied the relationships between strain and matrix remodeling and inflammation markers in mechanically ventilated patients with and without acute lung injury (ALI)...
  17. doi request reprint Diagnosing brain death by CT perfusion and multislice CT angiography
    Dolores Escudero
    Department of Intensive Care Medicine, Hospital Universitario Central de Asturias, C Celestino Villamil S N, 33006 Oviedo, Spain
    Neurocrit Care 11:261-71. 2009
    ..This study was designed to assess the accuracy of cerebral multislice computed tomographic angiography (CTA) and CT perfusion (CTP) in diagnosing BD...
  18. doi request reprint Static pressure-volume curves of the respiratory system: were they just a passing fad?
    Guillermo M Albaiceta
    Intensive Care Unit, Asturias Central University Hospital, Oviedo, Spain
    Curr Opin Crit Care 14:80-6. 2008
    ....
  19. ncbi request reprint Differences in the deflation limb of the pressure-volume curves in acute respiratory distress syndrome from pulmonary and extrapulmonary origin
    Guillermo M Albaiceta
    Intensive Care Unit, Hospital Central de Asturias, Celestino Villamil s n, 33006, Oviedo, Spain
    Intensive Care Med 29:1943-9. 2003
    ..To assess the differences in the deflation pressure-volume (PV) curves between acute respiratory distress syndrome from pulmonary (ARDSp) and extrapulmonary (ARDSe) origin...
  20. ncbi request reprint Application of continuous positive airway pressure to trace static pressure-volume curves of the respiratory system
    Guillermo M Albaiceta
    Servicio de Medicina Intensiva, Hospital Central de Asturias, Universidad de Oviedo, Spain
    Crit Care Med 31:2514-9. 2003
    ..To evaluate a new technique for pressure-volume curve tracing...
  21. ncbi request reprint Predicting the probability of survival in intensive care unit patients from a small number of variables and training examples
    Oscar Luaces
    Artificial Intelligence Center, Universidad de Oviedo at Gijón, Gijon, Asturias, Spain
    Artif Intell Med 45:63-76. 2009
    ..In this paper, we propose a new method to build scoring functions able to make reliable predictions, though functions whose induction only requires records from a small set of patients described by a few variables...