G M Albaiceta
Affiliation: Hospital Central de Asturias
López Alonso I, Blázquez Prieto J, Amado Rodríguez L, Gonzalez Lopez A, Astudillo A, Sanchez M, et al
. Preventing loss of mechanosensation by the nuclear membranes of alveolar cells reduces lung injury in mice during mechanical ventilation. Sci Transl Med. 2018;10: pubmed publisher
BlÃ¡zquez Prieto J, LÃ³pez Alonso I, Amado RodrÃguez L, Batalla SolÃs E, GonzÃ¡lez LÃ³pez A, Albaiceta G. Exposure to mechanical ventilation promotes tolerance to ventilator-induced lung injury by Ccl3 downregulation. Am J Physiol Lung Cell Mol Physiol. 2015;309:L847-56 pubmed publisher
..We conclude that previous exposure to noninjurious ventilation induces a state of tolerance to VILI. Downregulation of the chemokine gene Ccl3 could be the mechanism responsible for this effect. ..
Aguirre A, BlÃ¡zquez Prieto J, Amado Rodríguez L, LÃ³pez Alonso I, Batalla SolÃs E, GonzÃ¡lez LÃ³pez A, et al
. Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia. J Mol Med (Berl). 2017;95:487-497 pubmed publisher
..Absence of Mmp14 decreases activated MMP-2 and increases S100A9 levels in lung tissue. â€¢ MMP-14 ameliorates inflammation by promoting S100A9 cleavage by activated MMP-2. ..
Amado Rodríguez L, del Busto C, García Prieto E, Albaiceta G. Mechanical ventilation in acute respiratory distress syndrome: The open lung revisited. Med Intensiva. 2017;41:550-558 pubmed publisher
..Lastly, a series of knowledge-based recommendations are proposed that can be helpful for the ventilator assisted management of ARDS at the patient bedside. ..