Olga Abian

Summary

Affiliation: Hospital Universitario Miguel Servet
Country: Spain

Publications

  1. doi Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase
    Olga Abian
    Unidad de Investigación Traslacional, Miguel Servet Universitary Hospital, Zaragoza, Spain
    Mol Pharm 8:2390-7. 2011
  2. pmc Conformational stability of hepatitis C virus NS3 protease
    Olga Abian
    Institute of Biocomputation and Physics of Complex Systems, Universidad de Zaragoza, Zaragoza, Spain
    Biophys J 99:3811-20. 2010
  3. pmc Allosteric inhibitors of the NS3 protease from the hepatitis C virus
    Olga Abian
    Institute of Biocomputation and Physics of Complex Systems BIFI, Joint Unit IQFR CSIC BIFI, Universidad de Zaragoza, Zaragoza, Spain
    PLoS ONE 8:e69773. 2013
  4. doi Design and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteins
    Sara Ayuso-Tejedor
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    J Mol Biol 400:922-34. 2010
  5. doi Studying the allosteric energy cycle by isothermal titration calorimetry
    Marta Martinez-Julvez
    Institute of Biocomputation and Physics of Complex Systems BIFI, Universidad de Zaragoza, Zaragoza, Spain
    Methods Mol Biol 796:53-70. 2012
  6. pmc Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier
    Rafael Claveria-Gimeno
    Instituto Aragonés de Ciencias de la Salud IACS, Zaragoza, Spain IIS Aragón, Zaragoza, Spain Institute of Biocomputation and Physics of Complex Systems BIFI, Joint Unit IQFR CSIC BIFI, Universidad de Zaragoza, Zaragoza, Spain
    Int J Nanomedicine 10:2249-59. 2015
  7. doi Thermodynamics of zinc binding to hepatitis C virus NS3 protease: a folding by binding event
    Olga Abian
    Institute of Biocomputation and Physics of Complex Systems BIFI, Universidad de Zaragoza, Zaragoza 50009, Spain
    Proteins 77:624-36. 2009
  8. doi Shell Cross-Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti-HCV Therapy
    Isabel Jiménez-Pardo
    Departamento de Quimica Organica, Instituto de Ciencia de Materiales de Aragón ICMA Universidad de Zaragoza CSIC, 50009, Zaragoza, Spain
    Macromol Biosci 15:1381-91. 2015
  9. doi A unified framework based on the binding polynomial for characterizing biological systems by isothermal titration calorimetry
    Sonia Vega
    Institute of Biocomputation and Physics of Complex Systems BIFI, Joint Unit IQFR CSIC BIFI, Universidad de Zaragoza, Zaragoza, Spain
    Methods 76:99-115. 2015
  10. pmc Deconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms
    Sonia Vega
    Institute of Biocomputation and Physics of Complex Systems BIFI, Joint Unit IQFR CSIC BIFI, University of Zaragoza, Zaragoza, Spain
    Sci Rep 5:7988. 2015

Collaborators

Detail Information

Publications11

  1. doi Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase
    Olga Abian
    Unidad de Investigación Traslacional, Miguel Servet Universitary Hospital, Zaragoza, Spain
    Mol Pharm 8:2390-7. 2011
    ..These results support the potential role of NB-DNJ as a pharmacological chaperone, susceptible of being part of pharmaceutical formulation or combination therapy for GD in the future...
  2. pmc Conformational stability of hepatitis C virus NS3 protease
    Olga Abian
    Institute of Biocomputation and Physics of Complex Systems, Universidad de Zaragoza, Zaragoza, Spain
    Biophys J 99:3811-20. 2010
    ....
  3. pmc Allosteric inhibitors of the NS3 protease from the hepatitis C virus
    Olga Abian
    Institute of Biocomputation and Physics of Complex Systems BIFI, Joint Unit IQFR CSIC BIFI, Universidad de Zaragoza, Zaragoza, Spain
    PLoS ONE 8:e69773. 2013
    ....
  4. doi Design and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteins
    Sara Ayuso-Tejedor
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    J Mol Biol 400:922-34. 2010
    ..The structure of the apoflavodoxin thermal intermediate suggests that the regions of natively folded proteins that are easily responsive to thermal activation may contain cores of intermediate hydrophobicity...
  5. doi Studying the allosteric energy cycle by isothermal titration calorimetry
    Marta Martinez-Julvez
    Institute of Biocomputation and Physics of Complex Systems BIFI, Universidad de Zaragoza, Zaragoza, Spain
    Methods Mol Biol 796:53-70. 2012
    ....
  6. pmc Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier
    Rafael Claveria-Gimeno
    Instituto Aragonés de Ciencias de la Salud IACS, Zaragoza, Spain IIS Aragón, Zaragoza, Spain Institute of Biocomputation and Physics of Complex Systems BIFI, Joint Unit IQFR CSIC BIFI, Universidad de Zaragoza, Zaragoza, Spain
    Int J Nanomedicine 10:2249-59. 2015
    ..Thus, the antiviral activity of these compounds can be significantly improved, even completely rescued, using γ-cyclodextrin as carrier molecule. ..
  7. doi Thermodynamics of zinc binding to hepatitis C virus NS3 protease: a folding by binding event
    Olga Abian
    Institute of Biocomputation and Physics of Complex Systems BIFI, Universidad de Zaragoza, Zaragoza 50009, Spain
    Proteins 77:624-36. 2009
    ..The energetics of the conformational change is comparable to that of the folding of a protein of similar size. Therefore, zinc binding to NS3 protease can be considered as a "folding by binding" event...
  8. doi Shell Cross-Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti-HCV Therapy
    Isabel Jiménez-Pardo
    Departamento de Quimica Organica, Instituto de Ciencia de Materiales de Aragón ICMA Universidad de Zaragoza CSIC, 50009, Zaragoza, Spain
    Macromol Biosci 15:1381-91. 2015
    ..Furthermore, loaded with camptothecin, it is efficient in fighting against the hepatitis C virus while shows lower cytotoxicity than the free drug. ..
  9. doi A unified framework based on the binding polynomial for characterizing biological systems by isothermal titration calorimetry
    Sonia Vega
    Institute of Biocomputation and Physics of Complex Systems BIFI, Joint Unit IQFR CSIC BIFI, Universidad de Zaragoza, Zaragoza, Spain
    Methods 76:99-115. 2015
    ..The apparent complexity of this methodology, based on the binding polynomial, is overcome by its easy generalization to complex systems. ..
  10. pmc Deconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms
    Sonia Vega
    Institute of Biocomputation and Physics of Complex Systems BIFI, Joint Unit IQFR CSIC BIFI, University of Zaragoza, Zaragoza, Spain
    Sci Rep 5:7988. 2015
    ....
  11. doi Underexposed polar residues and protein stabilization
    Sara Ayuso-Tejedor
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza 50009, Spain
    Protein Eng Des Sel 24:171-7. 2011
    ..Simple equations combining these contributions predict stability changes in a large data set of 113 mutants (Y → F, Q → L or T → V) similarly well as more complex algorithms available on the Internet...