Albert Hofman

Summary

Country: Spain

Publications

  1. ncbi Health promotion or pharmacological treatment for chronic diseases?
    M F Allam
    South Cordoba Health District, Spain
    J Prev Med Hyg 54:11-3. 2013
  2. ncbi Evaluation of the level of knowledge of Egyptian women of breast cancer and its risk factors. A cross sectional study
    M F Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    J Prev Med Hyg 53:195-8. 2012
  3. ncbi Parkinson's disease protects against smoking?
    Mohamed Farouk Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Behav Neurol 15:65-71. 2004
  4. ncbi Smoking and Parkinson's disease: systematic review of prospective studies
    Mohamed Farouk Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Mov Disord 19:614-21. 2004
  5. ncbi [Meta-analysis: the science of review in Neurology]
    M F Allam
    Catedra de Medicina Preventiva y Salud Publica, Universidad de Cordoba, Facultad de Medicina, Espana
    Rev Neurol 40:222-8. 2005
  6. ncbi Parkinson's disease risk factors: genetic, environmental, or both?
    Mohamed Farouk Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal, s n Cordoba E 14004, Spain
    Neurol Res 27:206-8. 2005
  7. ncbi Serum hepatitis: are surgeons and obstetricians putting themselves at risk?
    Mohamed Farouk Allam
    Preventive Medicine and Public Health Department, Faculty of Medicine, University of Cordoa, Spain
    Educ Health (Abingdon) 16:374-7. 2003
  8. ncbi [Young onset Parkinson's disease and smoking: meta-analysis]
    M F Allam
    Catedra de Medicina Preventiva y Salud Publica, Universidad de Cordoba, Facultad de Medicina, Cordoba, Espana
    Rev Neurol 37:1101-3. 2003
  9. ncbi Invasive pulmonary aspergillosis: retrospective case record review
    Mohamed Farouk Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Rev Iberoam Micol 21:35-8. 2004
  10. ncbi Parkinson's disease and tea: a quantitative review
    José Luis Barranco Quintana
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal, s n Cordoba 14004, Spain
    J Am Coll Nutr 28:1-6. 2009

Collaborators

Detail Information

Publications66

  1. ncbi Health promotion or pharmacological treatment for chronic diseases?
    M F Allam
    South Cordoba Health District, Spain
    J Prev Med Hyg 54:11-3. 2013
    ..Little care was given to non-pharmacological lines of treatment...
  2. ncbi Evaluation of the level of knowledge of Egyptian women of breast cancer and its risk factors. A cross sectional study
    M F Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    J Prev Med Hyg 53:195-8. 2012
    ..5%), hormonal therapy (75.7%) and previous breast cancer disease (70.8%). This study clearly illustrates the need for a health education program directed to Egyptian females to improve the knowledge of breast cancer...
  3. ncbi Parkinson's disease protects against smoking?
    Mohamed Farouk Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Behav Neurol 15:65-71. 2004
    ..movement disorders of PD protect against smoking. Another explanation is that failure to develop strong smoking habits in early adult life might be a prodromal symptom of the disease and could perhaps be its first clinical manifestation...
  4. ncbi Smoking and Parkinson's disease: systematic review of prospective studies
    Mohamed Farouk Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Mov Disord 19:614-21. 2004
    ..Further studies evaluating the association between smoking and PD in women are strongly needed...
  5. ncbi [Meta-analysis: the science of review in Neurology]
    M F Allam
    Catedra de Medicina Preventiva y Salud Publica, Universidad de Cordoba, Facultad de Medicina, Espana
    Rev Neurol 40:222-8. 2005
    ..Our objective was to explain, in simple terms, the technique of meta-analysis and this could permit its application and use in the clinical practice and neurological investigations...
  6. ncbi Parkinson's disease risk factors: genetic, environmental, or both?
    Mohamed Farouk Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal, s n Cordoba E 14004, Spain
    Neurol Res 27:206-8. 2005
    ..Future research for PD risk factors should consider that multiple interactions occur in PD, resulting in a complex trait, which includes genetic, acquired, and environmental components...
  7. ncbi Serum hepatitis: are surgeons and obstetricians putting themselves at risk?
    Mohamed Farouk Allam
    Preventive Medicine and Public Health Department, Faculty of Medicine, University of Cordoa, Spain
    Educ Health (Abingdon) 16:374-7. 2003
  8. ncbi [Young onset Parkinson's disease and smoking: meta-analysis]
    M F Allam
    Catedra de Medicina Preventiva y Salud Publica, Universidad de Cordoba, Facultad de Medicina, Cordoba, Espana
    Rev Neurol 37:1101-3. 2003
    ..Previous systemic reviews have reported a protective effect of smoking against Parkinson's disease (PD). However, the protective effect has not been examined before by any systemic review in patients with young onset PD...
  9. ncbi Invasive pulmonary aspergillosis: retrospective case record review
    Mohamed Farouk Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Rev Iberoam Micol 21:35-8. 2004
    ..Our findings match with previous studies, apart from the high frequency of lung transplantation in our series. We recommend further studies on large prospective cohorts...
  10. ncbi Parkinson's disease and tea: a quantitative review
    José Luis Barranco Quintana
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal, s n Cordoba 14004, Spain
    J Am Coll Nutr 28:1-6. 2009
    ..To evaluate the risk of PD associated with tea consumption. Material and..
  11. ncbi Role of members of university students' unions in tobacco prevention
    M F Allam
    Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Prev Med Hyg 48:136-40. 2007
    ....
  12. ncbi Parkinson's disease, smoking and family history: meta-analysis
    M F Allam
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Eur J Neurol 10:59-62. 2003
    ....
  13. doi Are patients and healthcare providers satisfied with health sector reform implemented in family health centres?
    M A Gadallah
    Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Qual Saf Health Care 19:e4. 2010
    ..In Egypt, the Health Sector Reform Program (HSRP) has been implemented since 1999 in primary healthcare (PHC) centres adopting the family health approach...
  14. doi Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
    Bente L Langdahl
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Bone 42:969-81. 2008
    ....
  15. ncbi Cerebral white matter lesions and the risk of dementia
    Niels D Prins
    Department of Epidemiology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Arch Neurol 61:1531-4. 2004
    ..To study the association between white matter lesions (WML) in specific locations and the risk of dementia...
  16. ncbi Genetic variation in Fcgamma receptor IIa protects against advanced peripheral atherosclerosis. The Rotterdam Study
    Irene M van der Meer
    Erasmus Medical Center, Department of Epidemiology and Biostatistics, 3000 DR Rotterdam, The Netherlands
    Thromb Haemost 92:1273-6. 2004
    ..52 (0.29-0.93) and 0.45 (0.23-0.86), for heterozygotes and H131 homozygotes, respectively; P trend=0.02). This is the first study showing that the H131 allele of FcgammaRIIa protects against advanced peripheral atherosclerosis...
  17. ncbi Plasma levels of antioxidants are not associated with Alzheimer's disease or cognitive decline
    Marianne J Engelhart
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Dement Geriatr Cogn Disord 19:134-9. 2005
    ..87 (95% CI 0.64-1.19) for vitamin A and 0.94 (95% CI 0.60-1.48) for vitamin E. Antioxidants were not related to CD in non-demented subjects. Our findings suggest no association between plasma levels of vitamin A and E and AD or CD...
  18. ncbi Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Lancet Neurol 5:655-60. 2006
    ..However, Abeta(1-42) concentrations may decrease early in the dementia process. We postulated that concentrations of Abeta(1-40) and Abeta(1-42) in plasma are associated with risk of dementia...
  19. doi Cataract surgery and the risk of aging macula disorder: the rotterdam study
    Lintje Ho
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 49:4795-800. 2008
    ..To investigate still-controversial associations between prior cataract surgery and aging macula disorder (AMD) in a general population...
  20. ncbi Polymorphisms and haplotypes in the C-reactive protein gene and risk of dementia
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurobiol Aging 28:1361-6. 2007
    ..Since serum levels of C-reactive protein are partly determined by genetic factors, we examined the association between genetic variation in the C-reactive protein gene with dementia and AD...
  21. ncbi Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study
    Lonneke M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Neurol 62:1265-9. 2005
    ..Most prognostic studies on Parkinson disease have been hospital based or have applied register-based case-finding methods. Potential under-representation of mild cases may have given biased results...
  22. ncbi Corticosteroids and the risk of atrial fibrillation
    Cornelis S van der Hooft
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Arch Intern Med 166:1016-20. 2006
    ..High-dose (pulse) corticosteroid therapy has been associated with the development of atrial fibrillation. This association, however, is mainly based on case reports...
  23. ncbi Serum uric acid levels and the risk of Parkinson disease
    Lonneke M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 58:797-800. 2005
    ..040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid...
  24. ncbi C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study
    Claire Siemes
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 24:5216-22. 2006
    ..The aim of this study was to examine whether C-reactive protein (CRP) levels and CRP gene variations were associated with an altered risk of colorectal, lung, breast, or prostate cancer...
  25. ncbi Blood pressure components and cardiovascular events in older adults: the Rotterdam study
    Francesco U S Mattace-Raso
    Section of Geriatric Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Geriatr Soc 52:1538-42. 2004
    ..To compare the strength of the relative risks of systolic (SBP) diastolic blood pressure (DBP) and pulse pressure (PP) as predictors of myocardial infarction and stroke in older adults...
  26. ncbi PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
    Bart Dermaut
    Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology VIB8, University of Antwerp, Antwerpen, Belgium
    Ann Neurol 53:409-12. 2003
    ..2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively...
  27. ncbi Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study
    Sarah E Vermeer
    Dept of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 34:1126-9. 2003
    ..In healthy elderly people, silent brain infarcts and white matter lesions are common, but little is known about their relevance. We examined the risk of stroke associated with these lesions in the general population...
  28. ncbi Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study
    Sarah E Vermeer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 34:392-6. 2003
    ..The incidence of silent brain infarcts is unknown. We investigated the incidence and cardiovascular risk factors for silent brain infarcts...
  29. ncbi Risk factors for progression of atherosclerosis measured at multiple sites in the arterial tree: the Rotterdam Study
    Irene M van der Meer
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Stroke 34:2374-9. 2003
    ..The present study was designed to identify risk factors for progression of atherosclerosis measured at multiple sites in the arterial tree...
  30. ncbi Atrial fibrillation and the prothrombotic state in the elderly: the Rotterdam Study
    Dwayne S G Conway
    Hemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, England
    Stroke 34:413-7. 2003
    ....
  31. ncbi Mutations in the hemochromatosis gene (HFE) and stroke
    Omer T Njajou
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Stroke 33:2363-6. 2002
    ..Carriers of HFE C282Y and H63D mutations have elevated serum iron levels and may have an increased risk for stroke. We studied the association between HFE gene mutations, carotid atherosclerosis, and stroke...
  32. ncbi Plasma amyloid beta, apolipoprotein E, lacunar infarcts, and white matter lesions
    Ewoud J van Dijk
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 55:570-5. 2004
    ..48 ml (95% CI = 0.04-0.91) and 0.24 ml (95% CI = -0.27-0.75). Higher Abeta levels are associated with more lacunar infarcts and white matter lesions in elderly subjects who carry an APOE epsilon4 allele...
  33. ncbi Alcohol consumption and risk of peripheral arterial disease: the Rotterdam study
    Rozemarijn Vliegenthart
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Am J Epidemiol 155:332-8. 2002
    ..65 (95% CI: 0.48, 0.87), 0.66 (95% CI: 0.42, 1.05), and 0.41 (95% CI: 0.21, 0.77), respectively. In conclusion, an inverse association between alcohol consumption and peripheral arterial disease was found in nonsmoking men and women...
  34. ncbi Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study
    Sarah E Vermeer
    Department of Epidemiology, Erasmus Medical Centre Rotterdam, The Netherlands
    Stroke 33:21-5. 2002
    ..It is unclear whether risk factors for silent infarcts differ from those for symptomatic stroke. We investigated the prevalence of, and cardiovascular risk factors for, silent brain infarcts...
  35. ncbi Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study)
    Gysèle S Bleumink
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 94:384-6. 2004
    ....
  36. ncbi Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study
    Hermien W Goderie-Plomp
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:3261-9. 2004
    ..For men, no clear association was found, possibly due to insufficient power. No clear association between testosterone and incident vertebral fractures was observed in either men or women...
  37. ncbi Stroke is associated with coronary calcification as detected by electron-beam CT: the Rotterdam Coronary Calcification Study
    Rozemarijn Vliegenthart
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Stroke 33:462-5. 2002
    ..We examined whether coronary calcification as detected by electron-beam CT is related to the presence of stroke...
  38. ncbi Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction
    Gysèle S Bleumink
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Am Heart J 147:685-9. 2004
    ..We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects...
  39. doi Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Stroke 39:1421-6. 2008
    ..We investigated whether unrecognized MI is also a risk factor for dementia and cerebral small vessel disease (white matter lesions and brain infarction) in 2 population-based cohort studies...
  40. ncbi Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study
    Frank Jan de Jong
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:3014-8. 2007
    ..Possible effect modification by smoking and inflammatory markers was examined...
  41. ncbi Moderate alcohol consumption during pregnancy and the risk of low birth weight and preterm birth. The generation R study
    Vincent W V Jaddoe
    Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ann Epidemiol 17:834-40. 2007
    ..To examine the associations of alcohol consumption in different periods of pregnancy with the risks of low birth weight and preterm birth...
  42. ncbi Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
    Marjolijn Bornebroek
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuroepidemiology 28:193-6. 2007
    ..Several lines of evidence suggest a role of inflammatory processes in Parkinson disease, although it is still unclear whether inflammation is a cause or rather a consequence of neurodegeneration...
  43. pmc Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study
    Johanna M Geleijnse
    Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Eur J Epidemiol 22:763-70. 2007
    ..We examined sodium and potassium intake in relation to cardiovascular disease (CVD) and mortality in an unselected older population...
  44. pmc Determinants of chronic benzodiazepine use in the elderly: a longitudinal study
    Hendrika J Luijendijk
    Erasmus Medical Centre, Department of Epidemiology and Biostatistics, Rotterdam, The Netherlands
    Br J Clin Pharmacol 65:593-9. 2008
    ..When users were re-examined some years later, chronic somatic disease, pain and stress seemed to contribute to the continuation of benzodiazepine use...
  45. ncbi The female advantage in cardiovascular disease: do vascular beds contribute equally?
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Epidemiol 166:403-12. 2007
    ..Remarkably, it is absent in the aorta and the lower-extremity vessels. Factors causing this site-specific gender difference require further investigation...
  46. doi Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: the Rotterdam Study
    Ronald van der Knaap
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands
    Cancer 112:748-57. 2008
    ....
  47. doi Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures
    Gijsbertus Ziere
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    J Clin Psychopharmacol 28:411-7. 2008
    ..Exposure to antidepressants is associated with an increased risk of falls and fractures, but most previous studies incriminate tricyclic antidepressants (TCAs) rather than selective serotonin reuptake inhibitors (SSRIs)...
  48. ncbi Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study
    Sarah E Vermeer
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ann Neurol 51:285-9. 2002
    ..16-1.58). We concluded that total homocysteine levels are associated with silent brain infarcts and white matter lesions independent of each other and of other cardiovascular risk factors...
  49. doi Maternal smoking in prenatal and early postnatal life and the risk of respiratory tract infections in infancy. The Generation R study
    Liesbeth Duijts
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 23:547-55. 2008
    ..To assess the associations of maternal smoking during pregnancy and in the postnatal period with respiratory tract infections in young infants...
  50. pmc The -1997 G/T and Sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene in relation to changes in femoral neck bone mineral density and the risk of fracture in the elderly: the Rotterdam study
    Nahid Yazdanpanah
    Netherlands Institute for Health Science, Rotterdam, The Netherlands
    Calcif Tissue Int 81:18-25. 2007
    ..7, P = 0.001). We confirm that the COLIA1 Sp1 polymorphism influences BMD and the risk of fracture in postmenopausal Caucasian women. In contrast, we found no independent effect of the -1997 G/T promoter polymorphism on BMD or fracture...
  51. ncbi ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the Rotterdam study
    Mariette W C J Schoofs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam 300 DR, The Netherlands
    J Bone Miner Res 19:1490-6. 2004
    ..We did not observe an association between the ApoE polymorphism and osteoporosis in this study, which is thus far the largest study on ApoE and osteoporosis...
  52. ncbi Angiotensin-converting enzyme gene polymorphism and common carotid stiffness. The Rotterdam study
    Francesco U S Mattace-Raso
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Atherosclerosis 174:121-6. 2004
    ..No difference was seen for pulse wave velocity among genotypes. In conclusion, the results of this population-based study show that the ACE ID/DD genotypes are associated with higher common carotid stiffness...
  53. ncbi Methylenetetrahydrofolate reductase C677T genotype and PD
    Lonneke M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Ann Neurol 57:927-30. 2005
    ..Our findings support the hypothesis that homocysteine plays a role in the pathogenesis of Parkinson's disease...
  54. ncbi Growth, development and health from early fetal life until young adulthood: the Generation R Study
    Albert Hofman
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Sophia Children s Hospital, Rotterdam, The Netherlands
    Paediatr Perinat Epidemiol 18:61-72. 2004
    ..The study entered its pilot phase to test the logistics in December 2001. Full participant recruitment and complete data collection started in 2002...
  55. ncbi Cerebral changes on MRI and cognitive function: the CASCADE study
    Hedvig Söderlund
    The Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada, and Department of Psychology, Stockholm University, Stockholm, Sweden
    Neurobiol Aging 27:16-23. 2006
    ..The findings are consistent with findings from lesion and functional neuroimaging studies...
  56. ncbi Subjective complaints precede Parkinson disease: the rotterdam study
    Lonneke M L de Lau
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Neurol 63:362-5. 2006
    ..Neuronal degeneration and dopamine loss in the preclinical phase of Parkinson disease may produce subtle complaints before clinically recognizable symptoms emerge...
  57. ncbi Polymorphisms in the interleukin 6 and transforming growth factor beta1 gene and risk of dementia. The Rotterdam Study
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurosci Lett 402:113-7. 2006
    ..Associations did not differ across APOE genotypes. Our findings do not suggest involvement of genetic variance in IL-6 and TGFbeta1 in the development of dementia...
  58. ncbi Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study
    Michiel J Bos
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 37:1503-7. 2006
    ..We investigated the association between serum uric acid and coronary heart disease and stroke in a large prospective population-based study...
  59. ncbi The value of C-reactive protein in cardiovascular risk prediction: the Rotterdam Study
    Irene M van der Meer
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Arch Intern Med 163:1323-8. 2003
    ..Whether routine measurement of CRP has a role in the prediction of future coronary disease in everyday clinical practice has not yet been investigated...
  60. ncbi High serum C-reactive protein level is not an independent predictor for stroke: the Rotterdam Study
    Michiel J Bos
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Circulation 114:1591-8. 2006
    ..We studied the importance of CRP as a risk factor and as a risk predictor of future stroke...
  61. ncbi Glucocorticoid receptor variant and risk of dementia and white matter lesions
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neurobiol Aging 29:716-23. 2008
    ..A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities...
  62. ncbi Effects of maternal smoking in pregnancy on prenatal brain development. The Generation R Study
    Sabine J Roza
    The Generation R Study Group, Erasmus MC University Medical Centre Rotterdam, The Netherlands
    Eur J Neurosci 25:611-7. 2007
    ..Further research should focus on the causal pathway from prenatal cigarette exposure via brain development to behavioural and cognitive functions...
  63. ncbi Atherosclerosis and risk for dementia
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 61:403-10. 2007
    ..We investigated the association of atherosclerosis with dementia and subtypes of dementia during long follow-up, with various noninvasive measures of atherosclerosis...
  64. ncbi Retinal vessel diameters and the role of inflammation in cerebrovascular disease
    Frank Jan de Jong
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam
    Ann Neurol 61:491-5. 2007
    ..Weaker associations were found with arteriolar diameters. Our findings support the hypothesis that larger retinal venular diameters reflect systemic inflammation and suggest that inflammation is involved in cerebrovascular disease...
  65. ncbi The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men
    Lisette Stolk
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:3206-12. 2007
    ..An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. Its gene contains a functional valine to methionine substitution at codon 158...
  66. ncbi HMG-CoA reductase inhibitors and the risk of vertebral fracture
    Mariette W C J Schoofs
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam 3000 DR, The Netherlands
    J Bone Miner Res 19:1525-30. 2004
    ..Randomized trials on statins and fractures, carried out in populations at risk for fractures, are needed...