Gabriel Herrero-Beaumont

Summary

Country: Spain

Publications

  1. ncbi Cartilage and bone biological markers in the synovial fluid of osteoarthritic patients after hyaluronan injections in the knee
    G Herrero-Beaumont
    Inflammation Research Unit, Fundacion Jimenez Diaz, Avda Reyes Catolicos 2, 28040 Madrid, Spain
    Clin Chim Acta 308:107-15. 2001
  2. ncbi Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1beta, but not by TNFalpha
    M Angeles Alvarez-Soria
    Joint and Bone Research Unit, Fundacion Jimenez Diaz, Universidad Autonoma, Avenida Reyes Catolicos 2, 28040 Madrid, Spain
    Rheumatol Int 27:911-7. 2007
  3. ncbi Characterization of a new experimental model of osteoporosis in rabbits
    Santos Castañeda
    Department of Rheumatology, Hospital de la Princesa, Universidad Autonoma, Madrid, Spain
    J Bone Miner Metab 26:53-9. 2008
  4. doi Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics
    Gabriel Herrero-Beaumont
    Bone and Joint Research Unit, Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Semin Arthritis Rheum 39:71-80. 2009
  5. pmc Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities
    Yves Henrotin
    Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, 4000, Belgium
    BMC Res Notes 6:115. 2013
  6. doi Abatacept mechanism of action: concordance with its clinical profile
    Gabriel Herrero-Beaumont
    Laboratorio de Patología Osteoarticular, Servicio de Reumatologia, Instituto de Investigacion Sanitaria, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain
    Reumatol Clin 8:78-83. 2012
  7. pmc Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility
    Rebeca Dieguez-Gonzalez
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 11:R42. 2009
  8. ncbi Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator
    Gabriel Herrero-Beaumont
    Rheumatology Department, Fundacion Jimenez Diaz Capio, Madrid, Spain
    Arthritis Rheum 56:555-67. 2007
  9. ncbi The reverse glucosamine sulfate pathway: application in knee osteoarthritis
    Gabriel Herrero-Beaumont
    Rheumatology Department, Joint and Bone Research Laboratory, Fundacion Jimenez Diaz Capio, Autonomous University of Madrid, Avenida Reyes Catolicos 2, 28040 Madrid, Spain
    Expert Opin Pharmacother 8:215-25. 2007
  10. doi Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis
    Gabriel Herrero-Beaumont
    Bone and Joint Research Unit, Service of Rheumatology, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Ann Rheum Dis 70:1523-5. 2011

Collaborators

Detail Information

Publications32

  1. ncbi Cartilage and bone biological markers in the synovial fluid of osteoarthritic patients after hyaluronan injections in the knee
    G Herrero-Beaumont
    Inflammation Research Unit, Fundacion Jimenez Diaz, Avda Reyes Catolicos 2, 28040 Madrid, Spain
    Clin Chim Acta 308:107-15. 2001
    ..To evaluate synovial fluid levels of cartilage and bone biological markers after repetitive intra-articular injections of sodium hyaluronate (HA) in knee osteoarthritis (OA) patients...
  2. ncbi Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1beta, but not by TNFalpha
    M Angeles Alvarez-Soria
    Joint and Bone Research Unit, Fundacion Jimenez Diaz, Universidad Autonoma, Avenida Reyes Catolicos 2, 28040 Madrid, Spain
    Rheumatol Int 27:911-7. 2007
    ..NSAIDs were unable to modify the expression of these mediators induced by IL-1beta. Therefore, the increase in PGE2 synthesis, induced by IL-1beta, does not seem to mediate the increase in EP receptor expression, in rabbit chondrocytes...
  3. ncbi Characterization of a new experimental model of osteoporosis in rabbits
    Santos Castañeda
    Department of Rheumatology, Hospital de la Princesa, Universidad Autonoma, Madrid, Spain
    J Bone Miner Metab 26:53-9. 2008
    ..Osteoporosis can be induced experimentally in rabbits through isolated MPH or by a combination of OVX and medium dose corticosteroid for 4 weeks. OVX alone was not sufficient to induce osteoporosis...
  4. doi Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics
    Gabriel Herrero-Beaumont
    Bone and Joint Research Unit, Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Semin Arthritis Rheum 39:71-80. 2009
    ....
  5. pmc Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities
    Yves Henrotin
    Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, 4000, Belgium
    BMC Res Notes 6:115. 2013
    ..This paper summarizes the available evidence for beneficial effects of GlcN on joint health and proposes new insight into the design of future clinical trials aimed at identifying beneficial physiological effect of GlcN on joint tissues...
  6. doi Abatacept mechanism of action: concordance with its clinical profile
    Gabriel Herrero-Beaumont
    Laboratorio de Patología Osteoarticular, Servicio de Reumatologia, Instituto de Investigacion Sanitaria, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain
    Reumatol Clin 8:78-83. 2012
    ..Abatacept in combination with methotrexate prevents the progression of joint damage and improves physical function in rheumatoid arthritis patients...
  7. pmc Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility
    Rebeca Dieguez-Gonzalez
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 11:R42. 2009
    ..We hypothesized that there is a similar association with RA, including polymorphisms in TNFAIP3 and the intergenic region...
  8. ncbi Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator
    Gabriel Herrero-Beaumont
    Rheumatology Department, Fundacion Jimenez Diaz Capio, Madrid, Spain
    Arthritis Rheum 56:555-67. 2007
    ..To assess the effects of the prescription formulation of glucosamine sulfate (1,500 mg administered once daily) on the symptoms of knee osteoarthritis (OA) during a 6-month treatment course...
  9. ncbi The reverse glucosamine sulfate pathway: application in knee osteoarthritis
    Gabriel Herrero-Beaumont
    Rheumatology Department, Joint and Bone Research Laboratory, Fundacion Jimenez Diaz Capio, Autonomous University of Madrid, Avenida Reyes Catolicos 2, 28040 Madrid, Spain
    Expert Opin Pharmacother 8:215-25. 2007
    ..However, the activity of glucosamine sulfate has recently been related to its capacity to downregulate the catabolic effects of pro-inflammatory molecules, such as IL-1, which are present in osteoarthritic cartilage...
  10. doi Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis
    Gabriel Herrero-Beaumont
    Bone and Joint Research Unit, Service of Rheumatology, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Ann Rheum Dis 70:1523-5. 2011
    ..Four clinical settings could arise from this relationship, and furthermore two phenotypes may be identified whether early osteoarthritis coexists with high or low BMD...
  11. doi Chronic arthritis aggravates vascular lesions in rabbits with atherosclerosis: a novel model of atherosclerosis associated with chronic inflammation
    Raquel Largo
    Fundacion Jimenez Diaz, and Universidad Autónoma, Madrid, Spain
    Arthritis Rheum 58:2723-34. 2008
    ..To determine whether systemic inflammation induced by chronic antigen-induced arthritis (AIA) accelerates vascular lesions in rabbits with atherosclerosis...
  12. pmc Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
    Miriam Bellido
    Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Avda, Reyes Catolicos, 2, 28040 Madrid, Spain
    Arthritis Res Ther 12:R152. 2010
    ..Osteoporosis (OP) increases cartilage damage in a combined rabbit model of OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at subchondral bone aggravates cartilage damage in this experimental model...
  13. doi Effects of estrogen deficiency and low bone mineral density on healthy knee cartilage in rabbits
    Santos Castañeda
    Bone and Joint Research Unit, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    J Orthop Res 28:812-8. 2010
    ..01). Although low bone mineral density contributes to the minor osteoarthritic alterations observed in our model, estrogen deficiency itself seems to act directly to induce the main pathogenic effects in healthy cartilage of the rabbit...
  14. doi Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis
    Juan Moreno-Rubio
    Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Arthritis Rheum 62:478-88. 2010
    ....
  15. doi Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1beta-stimulated human osteoarthritic synoviocytes and chondrocytes
    Jorge A Roman-Blas
    Joint and Bone Research Unit, Rheumatology Service, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Eur J Pharmacol 623:125-31. 2009
    ..Therefore, NAC might have a symptomatic effect on the synovium rather than a structural effect on the cartilage in osteoarthritis...
  16. pmc RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis
    María J Martínez-Calatrava
    Bone and Joint Research Unit, Service of Rheumatology, IIS Fundación Jiménez D237 az, Universidad Autonoma, Av, Reyes Catolicos 2, 28040, Madrid, Spain
    Arthritis Res Ther 14:R149. 2012
    ..This study aimed to determine whether RANKL produced by chondrocytes induces osteoclastogenesis and juxta-articular bone loss associated with chronic arthritis...
  17. pmc Osteoarthritis associated with estrogen deficiency
    Jorge A Roman-Blas
    Bone and Joint Research Unit, Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid 28040, Spain
    Arthritis Res Ther 11:241. 2009
    ..Thus, a better understanding of how estrogen acts on joints and other tissues in OA will aid the development of specific and safe estrogen ligands as novel therapeutic agents targeting the OA joint as a whole organ...
  18. pmc Lipid transport and metabolism in healthy and osteoarthritic cartilage
    Amanda Villalvilla
    Osteoarticular Pathology Laboratory, IIS Fundación Jiménez Díaz, Madrid 28040, Spain
    Int J Mol Sci 14:20793-808. 2013
    ..This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage. ..
  19. doi Update on the use of abatacept for the treatment of rheumatoid arthritis
    Esther F Vicente Rabaneda
    Rheumatology Department, Hospital Universitario de la Princesa, IIS Princesa, Universidad Autonoma de Madrid, C Diego de Leon 62, 28006 Madrid, Spain
    Expert Rev Clin Immunol 9:599-621. 2013
    ..This article reviews published data on clinical and radiographic efficacy as well as the safety of this drug, incorporating recent relevant information reported at scientific meetings. ..
  20. pmc The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo
    Jessica Andrés-Bergós
    Joint and Bone Research Unit, IIS Fundación Jiménez Díaz, Universidad Autonoma de Madrid, Madrid, Spain
    J Biol Chem 287:33615-28. 2012
    ..Thiamet-G administration to C57/bl mice induced a significant expansion in the growth plate height and in the hypertrophic zone height. Therefore, our results show that O-GlcNAc glycosylation has chondromodulating activity...
  21. doi Subchondral bone as a key target for osteoarthritis treatment
    Santos Castañeda
    Department of Rheumatology, Hospital de la Princesa, IIS Princesa, Universidad Autonoma, Madrid, Spain
    Biochem Pharmacol 83:315-23. 2012
    ....
  22. doi 6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity
    Amanda Villalvilla
    Osteoarticular Pathology Lab, IIS Fundación Jiménez Díaz, Avda Reyes Catolicos, Madrid, Spain
    Mol Nutr Food Res 58:256-66. 2014
    ..Given the widespread use and demonstrated properties of GDs, we set out to study their anti-inflammatory and anticatabolic properties in chondrocytes...
  23. doi An OA phenotype may obtain major benefit from bone-acting agents
    Jorge A Roman-Blas
    Bone and Joint Research Unit, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Semin Arthritis Rheum 43:421-8. 2014
    ..Despite this, the treatment of knee OA patients with antiresorptive drugs has given discordant results, suggesting the existence of a particular patient subset with good response to halting high subchondral remodeling...
  24. ncbi Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis
    Raquel Largo
    Joint and Bone Research Laboratory, Fundacion Jimenez Diaz, Reyes Catolicos 2, Universidad Autonoma, Madrid, Spain
    Am J Physiol Heart Circ Physiol 297:H268-76. 2009
    ..GS also prevented the development of inflammation-associated aortic lesions. These results suggest an atheroprotective effect of GS...
  25. doi PTH [1-34] enhances bone response around titanium implants in a rabbit model of osteoporosis
    M Isabel Almagro
    Department of Dentistry, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Clin Oral Implants Res 24:1027-34. 2013
    ..Therefore, we studied the effects of intermittent PTH [1-34] on bone response around titanium implants in experimental osteoporosis induced by ovariectomy and glucocorticoid administration...
  26. doi Efficacy and safety of a selective estrogen receptor β agonist, ERB-041, in patients with rheumatoid arthritis: a 12-week, randomized, placebo-controlled, phase II study
    Jorge A Roman-Blas
    Universidad Autonoma, Madrid, Spain
    Arthritis Care Res (Hoboken) 62:1588-93. 2010
    ..This study aimed to compare the efficacy and safety of one of these agonists, ERB-041, in subjects with rheumatoid arthritis (RA)...
  27. doi Dynamic ultrasound assessment of medial meniscal subluxation in knee osteoarthritis
    Carlos Acebes
    Department of Rheumatology, Fundacion Jimenez Diaz, 28040 Madrid, Spain
    Rheumatology (Oxford) 52:1443-7. 2013
    ..The aim of this study was to assess MMS in patients with knee OA and in asymptomatic controls by US in different weight-bearing positions...
  28. ncbi Ultrasonographic assessment of Baker's cysts after intra-articular corticosteroid injection in knee osteoarthritis
    J Carlos Acebes
    Department of Rheumatology, Fundacion Jimenez Diaz, Madrid, Spain
    J Clin Ultrasound 34:113-7. 2006
    ..To assess sonographic changes in Baker's cysts (BCs) of patients with knee osteoarthritis after a single intra-articular corticosteroid injection...
  29. ncbi Transdermal fentanyl for the treatment of pain caused by rheumatoid arthritis
    Gabriel Herrero-Beaumont
    Fundacion Jimenez Diaz, Avenida de los Reyes Catolicos 2, 28040 Madrid, Spain
    Rheumatol Int 24:325-32. 2004
    ..001), and in quality of life (Short Form 36 physical P < 0.001, mental P < 0.05). Treatment was assessed favorably: > or = 78% would recommend it. Transdermal fentanyl should be considered in treatment programs for patients with RA...
  30. ncbi Benefits of transdermal fentanyl in patients with rheumatoid arthritis or with osteoarthritis of the knee or hip: an open-label study to assess pain control
    Karel Pavelka
    Institute of Rheumatology, Prague, Czech Republic
    Curr Med Res Opin 20:1967-77. 2004
    ....
  31. ncbi Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis
    Eric Abadie
    Department of Registration and Clinical Studies, French Agency For the Safety of Health Products AFSSAPS, France
    Osteoarthritis Cartilage 12:263-8. 2004
    ..Recently, new technology has been developed to detect a structural change of the OA joint earlier than conventional X-rays...
  32. doi Does oral glucosamine prevent subchondral bone loss in an animal model of osteoarthritis? Comment on the article by Wang et al
    Santos Castañeda
    Arthritis Rheum 58:635. 2008