T Herraiz

Summary

Country: Spain

Publications

  1. doi request reprint beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)
    T Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Madrid, Spain
    Food Chem Toxicol 48:839-45. 2010
  2. ncbi request reprint Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay
    Tomas Herraiz
    Spanish Council for Scientific Research CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierve 3, 28006, Madrid, Spain
    Free Radic Res 38:323-31. 2004
  3. ncbi request reprint Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva, 3, 28006, Madrid, Spain
    Biochem Biophys Res Commun 326:378-86. 2005
  4. ncbi request reprint Relative exposure to beta-carbolines norharman and harman from foods and tobacco smoke
    T Herraiz
    Spanish Council for Scientific Research, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, E 28006 Madrid, Spain
    Food Addit Contam 21:1041-50. 2004
  5. ncbi request reprint Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee
    Tomas Herraiz
    Spanish Council for Scientific Research CSIC Instituto de Fermentaciones Industriales, Juan de la Cierva, 3, 28006 Madrid, Spain
    Life Sci 78:795-802. 2006
  6. ncbi request reprint Analysis of monoamine oxidase enzymatic activity by reversed-phase high performance liquid chromatography and inhibition by beta-carboline alkaloids occurring in foods and plants
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006 Madrid, Spain
    J Chromatogr A 1120:237-43. 2006
  7. ncbi request reprint Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006, Madrid, Spain
    Toxicol Appl Pharmacol 216:387-98. 2006
  8. ncbi request reprint Identification and occurrence of beta-carboline alkaloids in raisins and inhibition of monoamine oxidase (MAO)
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006 Madrid, Spain
    J Agric Food Chem 55:8534-40. 2007
  9. doi request reprint Oxidative metabolism of the bioactive and naturally occurring beta-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes
    Tomas Herraiz
    Spanish Council for Scientific Research, Instituto de Fermentaciones Industriales, CSIC, Juan de Cierva, 3, 28006 Madrid, Spain
    Chem Res Toxicol 21:2172-80. 2008
  10. doi request reprint Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO)
    Tomas Herraiz
    Instituto de Fermentaciones Industriales, Spanish Council for Scientific Research, Madrid, Spain
    Free Radic Res 43:975-84. 2009

Detail Information

Publications23

  1. doi request reprint beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)
    T Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Madrid, Spain
    Food Chem Toxicol 48:839-45. 2010
    ..harmala containing beta-carbolines should contribute to the psychopharmacological and toxicological effects of this plant and could be the basis for its purported antidepressant actions...
  2. ncbi request reprint Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay
    Tomas Herraiz
    Spanish Council for Scientific Research CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierve 3, 28006, Madrid, Spain
    Free Radic Res 38:323-31. 2004
    ..This activity could be of biological significance given the physiological concentrations and body distribution of some indoles...
  3. ncbi request reprint Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva, 3, 28006, Madrid, Spain
    Biochem Biophys Res Commun 326:378-86. 2005
    ..The presence of MAO inhibitors in smoke like beta-carbolines and others may help us to understand some of the purported neuropharmacological effects associated with smoking...
  4. ncbi request reprint Relative exposure to beta-carbolines norharman and harman from foods and tobacco smoke
    T Herraiz
    Spanish Council for Scientific Research, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, E 28006 Madrid, Spain
    Food Addit Contam 21:1041-50. 2004
    ..Many other foodstuffs might also contribute with minor amounts of norharman and harman. Foods and tobacco smoke might be potential contributors to the reported endogenous presence of beta-carbolines in humans...
  5. ncbi request reprint Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee
    Tomas Herraiz
    Spanish Council for Scientific Research CSIC Instituto de Fermentaciones Industriales, Juan de la Cierva, 3, 28006 Madrid, Spain
    Life Sci 78:795-802. 2006
    ....
  6. ncbi request reprint Analysis of monoamine oxidase enzymatic activity by reversed-phase high performance liquid chromatography and inhibition by beta-carboline alkaloids occurring in foods and plants
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006 Madrid, Spain
    J Chromatogr A 1120:237-43. 2006
    ..These results suggest that beta-carbolines from foods, plants, and mammals may exert inhibitory actions on MAO enzymes...
  7. ncbi request reprint Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006, Madrid, Spain
    Toxicol Appl Pharmacol 216:387-98. 2006
    ..Altogether, these results suggest that CYP2D6 can play an important role in the metabolic outcome of both MPTP and beta-carbolines...
  8. ncbi request reprint Identification and occurrence of beta-carboline alkaloids in raisins and inhibition of monoamine oxidase (MAO)
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006 Madrid, Spain
    J Agric Food Chem 55:8534-40. 2007
    ..The results also show that some raisins can be a source of dietary exposure to bioactive beta-carbolines...
  9. doi request reprint Oxidative metabolism of the bioactive and naturally occurring beta-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes
    Tomas Herraiz
    Spanish Council for Scientific Research, Instituto de Fermentaciones Industriales, CSIC, Juan de Cierva, 3, 28006 Madrid, Spain
    Chem Res Toxicol 21:2172-80. 2008
    ..Results in this work show that beta-carbolines are good ligands and substrates for P450 1A2/1A1, contributing to the explanation of some of their toxicological effects...
  10. doi request reprint Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO)
    Tomas Herraiz
    Instituto de Fermentaciones Industriales, Spanish Council for Scientific Research, Madrid, Spain
    Free Radic Res 43:975-84. 2009
    ....
  11. ncbi request reprint Identification and occurrence of tryptamine- and tryptophan-derived tetrahydro-beta-carbolines in commercial sausages
    Tomas Herraiz
    Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva, 3, 28006, Madrid, Spain
    J Agric Food Chem 52:2652-8. 2004
    ..Also, 1 and 3 were more concentrated in the outer part of the sausage, likely to be in contact with smoke. It is concluded that some dry-fermented and/or smoked sausages may be significant dietary sources of tetrahydro-beta-carbolines...
  12. ncbi request reprint Tetrahydro-beta-carboline alkaloids occur in fruits and fruit juices. Activity as antioxidants and radical scavengers
    Tomas Herraiz
    Spanish Council for Scientific Research, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
    J Agric Food Chem 51:7156-61. 2003
    ..This suggests that tetrahydro-beta-carboline alkaloids might act as antioxidants when absorbed and accumulated in the body, contributing to the antioxidant effect of fruit products containing these compounds...
  13. ncbi request reprint L-tryptophan reacts with naturally occurring and food-occurring phenolic aldehydes to give phenolic tetrahydro-beta-carboline alkaloids: activity as antioxidants and free radical scavengers
    Tomas Herraiz
    Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    J Agric Food Chem 51:2168-73. 2003
    ....
  14. ncbi request reprint Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay
    Tomas Herraiz
    Free Radic Res 36:923-8. 2002
    ..These results suggest that food and naturally-occurring tetrahydro-beta-carboline alkaloids if accumulated in tissues, as reported elsewhere, might exhibit antioxidant activity...
  15. ncbi request reprint Identification and occurrence of the bioactive beta-carbolines norharman and harman in coffee brews
    T Herraiz
    Spanish Council for Scientific Research, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, E 28006 Madrid, Spain
    Food Addit Contam 19:748-54. 2002
    ..These results support our previous conclusion that foods containing beta-carbolines are an important exogenous source of these alkaloids in humans...
  16. ncbi request reprint Identification and occurrence of the novel alkaloid pentahydroxypentyl-tetrahydro-beta-carboline-3-carboxylic acid as a tryptophan glycoconjugate in fruit juices and jams
    Tomas Herraiz
    Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva, 3, 28006, Madrid, Spain
    J Agric Food Chem 50:4690-5. 2002
    ..Fruit-derived products and other foods containing this compound might be an exogenous dietary source of this glucose-derived tetrahydro-beta-carboline...
  17. ncbi request reprint Tetrahydro-beta-carboline-3-carboxylic acid compounds in fish and meat: possible precursors of co-mutagenic beta-carbolines norharman and harman in cooked foods
    T Herraiz
    Instituto de Fermentaciones Industriales, CSIC, Madrid, Spain
    Food Addit Contam 17:859-66. 2000
    ..The tetrahydro-beta-carbolines THCA and MTCA were chemical precursors of the co-mutagens norharman and harman during cooking. These and previous results confirm that foods are an important source of beta-carbolines in humans...
  18. ncbi request reprint Analysis of tetrahydro-beta-carboline-3-carboxylic acids in foods by solid-phase extraction and reversed-phase high-performance liquid chromatography combined with fluorescence detection
    T Herraiz
    Instituto de Fermentaciones Industriales, CSIC, Madrid, Spain
    J Chromatogr A 871:23-30. 2000
    ..Several foods and beverages contained THCA and MTCA in varying proportions. Their occurrence in foods implies that diet is a source of these compounds in humans...
  19. ncbi request reprint Presence of tetrahydro-beta-carboline-3-carboxylic acids in foods by gas chromatography-mass spectrometry as their N-methoxycarbonyl methyl ester derivatives
    T Herraiz
    Instituto de Fermentaciones Industriales, CSIC, Madrid, Spain
    J Chromatogr A 765:265-77. 1997
    ..These results prove the presence of TH beta C-3-COOHs in commercial foodstuffs suggesting their uptake during the daily consumption of foods...
  20. ncbi request reprint 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid and 1,2, 3,4-tetrahydro-beta-carboline-3-carboxylic acid in fruits
    T Herraiz
    Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    J Agric Food Chem 47:4883-7. 1999
    ..Fruit ripening and softening during storage were accompanied with a significant increase of MTCA, in both pears and bananas. Those and previous results confirm that foods are an important source of tetrahydro-beta-carbolines in humans...
  21. ncbi request reprint Analysis of the bioactive alkaloids tetrahydro-beta-carboline and beta-carboline in food
    T Herraiz
    Instituto de Fermentaciones Industriales CSIC, Madrid, Spain
    J Chromatogr A 881:483-99. 2000
    ..The occurrence of biologically relevant THbetaCs and betaCs in foods highlights the interest of accomplishing their analysis. Foods containing those compounds represent a source of possible THbetaCs and betaCs in humans...
  22. ncbi request reprint Tetrahydro-beta-carbolines, potential neuroactive alkaloids, in chocolate and cocoa
    T Herraiz
    Instituto de Fermentaciones Industriales, Spanish National Research Council, Juan de la Cierva 3, 28006, Madrid, Spain
    J Agric Food Chem 48:4900-4. 2000
    ..The possible biological implications of this novel group of alkaloids in chocolate are discussed...
  23. ncbi request reprint Evaluation of solid-phase extraction procedures in peptide analysis
    T Herraiz
    Instituto de Fermentaciones Industriales, CSIC, Madrid, Spain
    J Chromatogr A 708:209-21. 1995
    ..It can be concluded that SPE using these procedures is a useful tool for the isolation and fractionation of peptides from biological and food samples...