Research Topics
Species | J M HernandezSummaryCountry: Spain Publications
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Publications
Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4EoJ M Hernandez
Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
Haematologica 85:481-5. 2000..These subtle chromosomal abnormalities may be difficult to detect in poor-quality metaphase preparations and if missed could lead to incorrect assignment to risk groups and influence the therapy decision-making process...- Clinical, hematological and cytogenetic characteristics of atypical chronic myeloid leukemiaJ M Hernandez
Department of Hematology, Hospital Universitario and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Spain
Ann Oncol 11:441-4. 2000..Some cases have an absolute monocytosis but can be distinguished from chronic myelomonocytic leukemia (CMML) by the presence of a higher percentage (> 15%) of circulating immature granulocytes... 
Novel genomic imbalances in B-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogeneticsJ M Hernandez
Servicio de Hematologia, Hospital Universitario and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Salamanca, Spain
Am J Pathol 158:1843-50. 2001..05). In summary, chromosomal imbalances in regions 3q, 4q, 5q, 7q, 9q, 12q, and 20q have been detected by CGH in SMZL. Patients with SMZL displaying genetic losses by CGH had a short survival...- Additional cytogenetic changes do not influence the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with an ATRA plus anthracyclin based protocol. A report of the Spanish group PETHEMAJ M Hernandez
Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
Haematologica 86:807-13. 2001..clinical and biological presenting features; 2. disease outcome... 
Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donorsM Garayoa
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Universidad de Salamanca CSIC, Salamanca, Spain
Leukemia 23:1515-27. 2009..All MM-MSCs were cytogenetically normal for the tested genomic alterations. Therefore we cannot support a common progenitor for myeloma PCs and MSCs...- Two cases of myeloid disorders and a t(8;12) (q12;p13)J M Hernandez
Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
Haematologica 85:31-4. 2000..Some of these abnormalities showed a rearrangement of the ETV6 gene. We studied the 12p region in one case with a t(8;12)(q12;p13) by fluorescence in situ hybridization (FISH)... - Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profilingN C Gutierrez
Servicio de Hematologia, Hospital Universitario, Centro de Investigación del Cáncer IBMCC USAL CSIC, Salamanca, Spain
Leukemia 24:629-37. 2010.... - Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridizationN C Gutierrez
Servicio de Hematologia, Hospital Universitario de Salamanca, Spain
Leukemia 15:840-5. 2001..In addition, PCL patients showed losses of 2q and 6p that were not present in MM. The CGH data show differences in chromosomal imbalances between MM and PCL... - Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myelomaA Armellini
Haematology Department, University Hospital of Salamanca, Salamanca, Spain
Br J Haematol 141:212-5. 2008..RCBTB2 expression was weaker in hyperdiploid versus non-hyperdiploid cases while RAN was more expressed in symptomatic MM and cell lines... - Identification of a novel recurrent gain on 20q13 in chronic lymphocytic leukemia by array CGH and gene expression profilingA E Rodriguez
IBMCC, Centro de Investigacion del Cancer, Universidad de Salamanca CSIC, and Department of Hematology, Hospital Clinico Universitario de Salamanca, Salamanca, Spain
Ann Oncol 23:2138-46. 2012..The aim of this study was to analyze the genomic imbalances in CLL cytogenetic subsets from both genomic and gene expression perspectives to identify new recurrent alterations... - Genetic heterogeneity of BCR/ABL+ adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristicsD Primo
, University of Salamanca, Salamanca, Spain
Leukemia 19:713-20. 2005..However, relapse-free survival (RFS) was significantly shorter in cases with supernumerary Ph, trisomy 8, and del(9p21), the latter being the most powerful independent prognostic factor for RFS... - Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patientsR Garcia-Sanz
Servicio de Hematologia, Hospital Universitario de, Salamanca, Spain
Int J Cancer 112:884-9. 2004..Moreover, our results underline the high prognostic value of proliferative activity of PC, a parameter that should be considered in routine laboratory investigations of MM... - Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: t(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated withN C Gutierrez
Servicios de Hematología Hospital Universitario de Salamanca and Centro de Investigación del Cáncer CIC, Universidad de Salamanca CSIC, Spain
Leukemia 21:143-50. 2007..In summary, RB deletion as a sole abnormality does not lead to a shortening in the survival of MM patients, whereas t(4;14) confers the worst prognosis in MM patients treated with high-dose chemotherapy... - Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization studyJ L Garcia
Servicio de Hematología and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Spain
Leukemia 17:2016-24. 2003..Concerning outcome, the presence of abnormalities on 1q (ascertained either by cytogenetics or by CGH), and imbalances on 7q (P=0.01) were associated with a short survival... - Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemiaN C Gutierrez
Servicio de Hematologia, Hospital Universitario de Salamanca and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Spain
Leukemia 19:402-9. 2005..In the latter cluster, CD34 upregulation and serine proteases downregulation is consistent with a maturation arrest and lack of granulocytic differentiation... - Post-treatment bone marrow residual disease > 5% by flow cytometry is highly predictive of short progression-free and overall survival in patients with Waldenström's macroglobulinemiaR Garcia-Sanz
Hospital Universitario de Salamanca, University of Salamanca, Spain
Clin Lymphoma Myeloma Leuk 11:168-71. 2011..001). Intensive and rituximab-containing therapies correlated with deeper tumor cell reductions. Finally, the B-cell decrease correlated with the better overall and progression-free survival... - The presence of DRB1*01 allele in multiple myeloma patients is associated with an indolent diseaseM Alcoceba
Departamento de Hematologia, Hospital Universitario de Salamanca, Salamanca, Spain
Tissue Antigens 71:548-51. 2008..This would translate into a more appropriate disease control associated with more indolent disease and prolonged survival... - Gene expression profiling of B lymphocytes and plasma cells from Waldenström's macroglobulinemia: comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individualsN C Gutierrez
Servicio de Hematologia, Hospital Universitario de Salamanca and Centro de Investigación del Cáncer CIC, Universidad de Salamanca CSIC, Salamanca, Spain
Leukemia 21:541-9. 2007..In addition, three of the target genes activated by PAX5 - CD79, BLNK and SYK - were upregulated in WM-PC. In summary, these results indicate that both PC and BL from WM are genetically different from the MM and CLL cell counterpart... - Incidence and characterization of secondary myelodysplastic syndromes following autologous transplantationM f Del Cañizo
Servicio de Hematologia, Hospital Universitario de Salamanca, P masculine de San Vicente, 58 182, 37007 Salamanca, Spain
Haematologica 85:403-9. 2000..The aim of the present study was to analyze Spanish experience regarding the incidence and characteristics of sMDS and sAML following autologous transplantation... - Pegylated liposomal doxorubicin, melphalan and prednisone therapy for elderly patients with multiple myelomaR Garcia-Sanz
University Hospital of Salamanca, Grupo Español de Mieloma, Red Española de Mieloma, Salamanca, Spain
Hematol Oncol 24:205-11. 2006..In conclusion, pegylated liposomal doxorubicin can be safely added to the other chemotherapeutic drugs in the treatment of elderly MM patients, which can be very useful for patients in whom novel agents are not tolerated or inefficient...