J M Hernandez

Summary

Country: Spain

Publications

  1. ncbi request reprint Additional cytogenetic changes do not influence the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with an ATRA plus anthracyclin based protocol. A report of the Spanish group PETHEMA
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Haematologica 86:807-13. 2001
  2. ncbi request reprint Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4Eo
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Haematologica 85:481-5. 2000
  3. ncbi request reprint Clinical, hematological and cytogenetic characteristics of atypical chronic myeloid leukemia
    J M Hernandez
    Department of Hematology, Hospital Universitario and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Spain
    Ann Oncol 11:441-4. 2000
  4. pmc Novel genomic imbalances in B-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogenetics
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Salamanca, Spain
    Am J Pathol 158:1843-50. 2001
  5. doi request reprint Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors
    M Garayoa
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Universidad de Salamanca CSIC, Salamanca, Spain
    Leukemia 23:1515-27. 2009
  6. ncbi request reprint Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization study
    J L Garcia
    Servicio de Hematología and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Spain
    Leukemia 17:2016-24. 2003
  7. doi request reprint Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling
    N C Gutierrez
    Servicio de Hematologia, Hospital Universitario, Centro de Investigación del Cáncer IBMCC USAL CSIC, Salamanca, Spain
    Leukemia 24:629-37. 2010
  8. ncbi request reprint Two cases of myeloid disorders and a t(8;12) (q12;p13)
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Haematologica 85:31-4. 2000
  9. ncbi request reprint Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients
    R Garcia-Sanz
    Servicio de Hematologia, Hospital Universitario de, Salamanca, Spain
    Int J Cancer 112:884-9. 2004
  10. ncbi request reprint Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridization
    N C Gutierrez
    Servicio de Hematologia, Hospital Universitario de Salamanca, Spain
    Leukemia 15:840-5. 2001

Collaborators

  • A Orfao
  • M T Ferro
  • P Marynen
  • L Vazquez
  • M Fernandez
  • A Martin
  • J Esteve
  • F Prosper
  • M Garayoa
  • R Lopez
  • A Sureda
  • R Nunez
  • J Blade
  • F Ramos
  • M Tormo
  • P Maiso
  • N C Gutierrez
  • J F San Miguel
  • R Garcia-Sanz
  • M Gonzalez
  • J L Garcia
  • J de las Rivas
  • M E Sarasquete
  • M Alcoceba
  • J Fernandez-Calvo
  • M Delgado
  • E Fermiñán
  • A E Rodriguez
  • A Risueño
  • P Martín-Jiménez
  • M C Chillon
  • A Armellini
  • A Balanzategui
  • J J Lahuerta
  • M V Mateos
  • D Primo
  • A Barez
  • M C Lopez-Berges
  • A Alegre
  • M B Gonzalez
  • G Martín-Nuñez
  • E Garcia
  • C Robledo
  • A García de Coca
  • R Fisac
  • J Conde
  • V Sandoval
  • I Recio
  • R J P Magalhães
  • B Paiva
  • A Caballero
  • B Vidriales
  • J F San-Miguel
  • J Alonso
  • L López-Anglada
  • D Del Carpio
  • A Aguilar
  • T Villaescusa
  • Em Ocio
  • N Puig
  • F V Ticona
  • M f Del Cañizo
  • C Chillón
  • I Misiewicz-Krzeminska
  • M Sierra
  • F J Fernández-Calvo
  • E Pérez-Persona
  • R Corral
  • M Megido
  • M Fuertes
  • L Marin
  • J M Ojanguren
  • L Palomera
  • D Carrera
  • L Rosinol
  • M V Castellanos
  • J M Ribera
  • M L Sanchez
  • L Escoda
  • M L Martin
  • M J Arcos
  • J L Bello
  • J C Hernández-Boluda
  • E M Ocio
  • S Gardella
  • J de la Rubia
  • J Garcia-Larana
  • B Gonzalez
  • M D Tabernero
  • R López-Pérez

Detail Information

Publications20

  1. ncbi request reprint Additional cytogenetic changes do not influence the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with an ATRA plus anthracyclin based protocol. A report of the Spanish group PETHEMA
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Haematologica 86:807-13. 2001
    ..clinical and biological presenting features; 2. disease outcome...
  2. ncbi request reprint Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4Eo
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Haematologica 85:481-5. 2000
    ..These subtle chromosomal abnormalities may be difficult to detect in poor-quality metaphase preparations and if missed could lead to incorrect assignment to risk groups and influence the therapy decision-making process...
  3. ncbi request reprint Clinical, hematological and cytogenetic characteristics of atypical chronic myeloid leukemia
    J M Hernandez
    Department of Hematology, Hospital Universitario and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Spain
    Ann Oncol 11:441-4. 2000
    ..Some cases have an absolute monocytosis but can be distinguished from chronic myelomonocytic leukemia (CMML) by the presence of a higher percentage (> 15%) of circulating immature granulocytes...
  4. pmc Novel genomic imbalances in B-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogenetics
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Salamanca, Spain
    Am J Pathol 158:1843-50. 2001
    ..05). In summary, chromosomal imbalances in regions 3q, 4q, 5q, 7q, 9q, 12q, and 20q have been detected by CGH in SMZL. Patients with SMZL displaying genetic losses by CGH had a short survival...
  5. doi request reprint Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors
    M Garayoa
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Universidad de Salamanca CSIC, Salamanca, Spain
    Leukemia 23:1515-27. 2009
    ..All MM-MSCs were cytogenetically normal for the tested genomic alterations. Therefore we cannot support a common progenitor for myeloma PCs and MSCs...
  6. ncbi request reprint Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization study
    J L Garcia
    Servicio de Hematología and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Spain
    Leukemia 17:2016-24. 2003
    ..Concerning outcome, the presence of abnormalities on 1q (ascertained either by cytogenetics or by CGH), and imbalances on 7q (P=0.01) were associated with a short survival...
  7. doi request reprint Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling
    N C Gutierrez
    Servicio de Hematologia, Hospital Universitario, Centro de Investigación del Cáncer IBMCC USAL CSIC, Salamanca, Spain
    Leukemia 24:629-37. 2010
    ....
  8. ncbi request reprint Two cases of myeloid disorders and a t(8;12) (q12;p13)
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Haematologica 85:31-4. 2000
    ..Some of these abnormalities showed a rearrangement of the ETV6 gene. We studied the 12p region in one case with a t(8;12)(q12;p13) by fluorescence in situ hybridization (FISH)...
  9. ncbi request reprint Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients
    R Garcia-Sanz
    Servicio de Hematologia, Hospital Universitario de, Salamanca, Spain
    Int J Cancer 112:884-9. 2004
    ..Moreover, our results underline the high prognostic value of proliferative activity of PC, a parameter that should be considered in routine laboratory investigations of MM...
  10. ncbi request reprint Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridization
    N C Gutierrez
    Servicio de Hematologia, Hospital Universitario de Salamanca, Spain
    Leukemia 15:840-5. 2001
    ..In addition, PCL patients showed losses of 2q and 6p that were not present in MM. The CGH data show differences in chromosomal imbalances between MM and PCL...
  11. doi request reprint Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma
    A Armellini
    Haematology Department, University Hospital of Salamanca, Salamanca, Spain
    Br J Haematol 141:212-5. 2008
    ..RCBTB2 expression was weaker in hyperdiploid versus non-hyperdiploid cases while RAN was more expressed in symptomatic MM and cell lines...
  12. ncbi request reprint Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia
    N C Gutierrez
    Servicio de Hematologia, Hospital Universitario de Salamanca and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Spain
    Leukemia 19:402-9. 2005
    ..In the latter cluster, CD34 upregulation and serine proteases downregulation is consistent with a maturation arrest and lack of granulocytic differentiation...
  13. doi request reprint Post-treatment bone marrow residual disease > 5% by flow cytometry is highly predictive of short progression-free and overall survival in patients with Waldenström's macroglobulinemia
    R Garcia-Sanz
    Hospital Universitario de Salamanca, University of Salamanca, Spain
    Clin Lymphoma Myeloma Leuk 11:168-71. 2011
    ..001). Intensive and rituximab-containing therapies correlated with deeper tumor cell reductions. Finally, the B-cell decrease correlated with the better overall and progression-free survival...
  14. doi request reprint Identification of a novel recurrent gain on 20q13 in chronic lymphocytic leukemia by array CGH and gene expression profiling
    A E Rodriguez
    IBMCC, Centro de Investigacion del Cancer, Universidad de Salamanca CSIC, and Department of Hematology, Hospital Clinico Universitario de Salamanca, Salamanca, Spain
    Ann Oncol 23:2138-46. 2012
    ..The aim of this study was to analyze the genomic imbalances in CLL cytogenetic subsets from both genomic and gene expression perspectives to identify new recurrent alterations...
  15. ncbi request reprint Genetic heterogeneity of BCR/ABL+ adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristics
    D Primo
    Servicio General de Citometría and Departamento de Medicina, University of Salamanca, Salamanca, Spain
    Leukemia 19:713-20. 2005
    ..However, relapse-free survival (RFS) was significantly shorter in cases with supernumerary Ph, trisomy 8, and del(9p21), the latter being the most powerful independent prognostic factor for RFS...
  16. ncbi request reprint Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: t(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated with
    N C Gutierrez
    Servicios de Hematología Hospital Universitario de Salamanca and Centro de Investigación del Cáncer CIC, Universidad de Salamanca CSIC, Spain
    Leukemia 21:143-50. 2007
    ..In summary, RB deletion as a sole abnormality does not lead to a shortening in the survival of MM patients, whereas t(4;14) confers the worst prognosis in MM patients treated with high-dose chemotherapy...
  17. doi request reprint The presence of DRB1*01 allele in multiple myeloma patients is associated with an indolent disease
    M Alcoceba
    Departamento de Hematologia, Hospital Universitario de Salamanca, Salamanca, Spain
    Tissue Antigens 71:548-51. 2008
    ..This would translate into a more appropriate disease control associated with more indolent disease and prolonged survival...
  18. ncbi request reprint Pegylated liposomal doxorubicin, melphalan and prednisone therapy for elderly patients with multiple myeloma
    R Garcia-Sanz
    University Hospital of Salamanca, Grupo Español de Mieloma, Red Española de Mieloma, Salamanca, Spain
    Hematol Oncol 24:205-11. 2006
    ..In conclusion, pegylated liposomal doxorubicin can be safely added to the other chemotherapeutic drugs in the treatment of elderly MM patients, which can be very useful for patients in whom novel agents are not tolerated or inefficient...
  19. ncbi request reprint Gene expression profiling of B lymphocytes and plasma cells from Waldenström's macroglobulinemia: comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individuals
    N C Gutierrez
    Servicio de Hematologia, Hospital Universitario de Salamanca and Centro de Investigación del Cáncer CIC, Universidad de Salamanca CSIC, Salamanca, Spain
    Leukemia 21:541-9. 2007
    ..In addition, three of the target genes activated by PAX5 - CD79, BLNK and SYK - were upregulated in WM-PC. In summary, these results indicate that both PC and BL from WM are genetically different from the MM and CLL cell counterpart...
  20. ncbi request reprint Incidence and characterization of secondary myelodysplastic syndromes following autologous transplantation
    M f Del Cañizo
    Servicio de Hematologia, Hospital Universitario de Salamanca, P masculine de San Vicente, 58 182, 37007 Salamanca, Spain
    Haematologica 85:403-9. 2000
    ..The aim of the present study was to analyze Spanish experience regarding the incidence and characteristics of sMDS and sAML following autologous transplantation...