M Guzman

Summary

Country: Spain

Publications

  1. ncbi request reprint Control of the cell survival/death decision by cannabinoids
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    J Mol Med (Berl) 78:613-25. 2001
  2. ncbi request reprint Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
    C Sanchez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Res 61:5784-9. 2001
  3. ncbi request reprint The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan
    C Sanchez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Pharmacol 59:955-9. 2001
  4. ncbi request reprint Ceramide: a new second messenger of cannabinoid action
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain
    Trends Pharmacol Sci 22:19-22. 2001
  5. doi request reprint JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells
    M M Caffarel
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 27:5033-44. 2008
  6. pmc Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
    D Vara
    Department of Biochemistry and Molecular Biology, School of Medicine, Alcala University, Madrid, Spain
    Cell Death Differ 18:1099-111. 2011
  7. doi request reprint The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
    C Andradas
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 30:245-52. 2011
  8. ncbi request reprint Effects of extracellular ATP on hepatic fatty acid metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, Madrid, Spain
    Am J Physiol 270:G701-7. 1996
  9. doi request reprint The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas
    E Pérez-Gómez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 32:2534-42. 2013
  10. pmc Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action
    M Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Cell Death Differ 18:959-73. 2011

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Control of the cell survival/death decision by cannabinoids
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    J Mol Med (Berl) 78:613-25. 2001
    ..Ongoing investigation is in search for cannabinoid-based therapeutic strategies devoid of nondesired psychotropic effects...
  2. ncbi request reprint Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
    C Sanchez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Res 61:5784-9. 2001
    ..These results support a therapeutic approach for the treatment of malignant gliomas devoid of psychotropic side effects...
  3. ncbi request reprint The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan
    C Sanchez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Pharmacol 59:955-9. 2001
    ..This is the first report showing that a G-protein-coupled receptor induces sphingomyelin hydrolysis through FAN and that the CB(1) cannabinoid receptor may signal independently of G(i/o) proteins...
  4. ncbi request reprint Ceramide: a new second messenger of cannabinoid action
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain
    Trends Pharmacol Sci 22:19-22. 2001
    ..Ceramide in turn mediates cannabinoid-induced apoptosis, as shown by in vitro and in vivo studies. These findings provide a new perspective on how cannabinoids act, and raise exciting physiological and therapeutic questions...
  5. doi request reprint JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells
    M M Caffarel
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 27:5033-44. 2008
    ..In summary, this is the first report showing not only that cannabinoids regulate JunD but, more generally, that JunD activation reduces the proliferation of cancer cells, which points to a new target to inhibit breast cancer progression...
  6. pmc Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
    D Vara
    Department of Biochemistry and Molecular Biology, School of Medicine, Alcala University, Madrid, Spain
    Cell Death Differ 18:1099-111. 2011
    ..Moreover, cannabinoids were also able to inhibit tumor growth and ascites in an orthotopic model of HCC xenograft. Our findings may contribute to the design of new therapeutic strategies for the management of HCC...
  7. doi request reprint The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
    C Andradas
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 30:245-52. 2011
    ..These findings reveal the importance of GPR55 in human cancer, and suggest that it could constitute a new biomarker and therapeutic target in oncology...
  8. ncbi request reprint Effects of extracellular ATP on hepatic fatty acid metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, Madrid, Spain
    Am J Physiol 270:G701-7. 1996
    ....
  9. doi request reprint The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas
    E Pérez-Gómez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 32:2534-42. 2013
    ..Altogether, these findings reveal the pivotal importance of GPR55 in skin tumor development, and suggest that this receptor may be used as a new biomarker and therapeutic target in squamous cell carcinomas...
  10. pmc Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action
    M Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Cell Death Differ 18:959-73. 2011
    ....
  11. ncbi request reprint Effects of cannabinoids on energy metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Life Sci 65:657-64. 1999
    ..Anandamide has also been shown to exert metabolic effects in hepatocytes, cells that do not express cannabinoid receptors. The biological role of cannabinoids as modulators of metabolism is as yet unclear...
  12. ncbi request reprint Is there an astrocyte-neuron ketone body shuttle?
    M Guzman
    Dept Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Trends Endocrinol Metab 12:169-73. 2001
    ..These findings support the notion that astrocytes might supply neurons with ketone bodies in situ, and raise the possibility that astrocyte ketogenesis is a cytoprotective pathway...
  13. pmc A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid 28040, Spain
    Br J Cancer 95:197-203. 2006
    ....
  14. ncbi request reprint Treatment with anabolic steroids increases the activity of the mitochondrial outer carnitine palmitoyltransferase in rat liver and fast-twitch muscle
    M Guzman
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, Complutense University, Madrid, Spain
    Biochem Pharmacol 41:833-5. 1991
    ..In addition, our results are at odds with the notion that (most of) the metabolic effects of anabolic steroids on muscle are only evident when physical training is parallely performed...
  15. ncbi request reprint Effect of nanoparticles on digitoxin uptake and pharmacologic activity in rat glomerular mesangial cell cultures
    M Guzman
    Department of Pharmacy and Pharmaceutical Technology, University of Alcala de Henares, Madrid, Spain
    Drug Deliv 7:215-22. 2000
    ..Therefore, PCL-NP improved drug uptake by the cells without altering the pharmacologic activity and toxicity of the drug. Thus, they can be a useful approach to target drugs to the kidneys or the heart...
  16. ncbi request reprint The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes
    C Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FEBS Lett 489:149-53. 2001
    ..Data indicate that AMPK may protect cells from apoptosis induced by stress stimuli...