Felix Gutierrez

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..There is a paucity of data on clinical epidemiology of osteonecrosis in HIV-infected patients. We aimed to describe patients' characteristics and natural history of this poorly known condition...

..Given the complex interaction between HIV and drugs in causing low bone mineral density, optimization of antiretroviral therapy and preemptive strategies aimed to prevent bone loss during therapy may be of paramount importance...

..The antifungal susceptibility profile was also determined. This report underscores the increasing importance of Paecilomyces species in human infections. Paecilomyces should be included among the etiological agents of pulmonary mycetoma...

..We aimed to determine whether monitoring the plasma concentration of efavirenz could predict neuropsychiatric adverse events associated with long-term therapy with efavirenz...

..To determine the population-based incidence of community-acquired pneumonia (CAP) in adults and to assess the relative importance of age and gender on the incidence of infections caused by different microbial pathogens...

..Coinfection with HHV-8 and occult lymphadenopatic KS should be considered in HIV-infected patients developing PH...

..Limited information exists on long-term prognosis of patients with sustained virologic response to antiretroviral therapy. We aimed to assess predictors of unfavorable clinical outcome in patients who maintain viral suppression with HAART...

..Patients with suboptimal response had a higher mortality over time, mainly due to diseases other than AIDS-defining events...

..Greater effort should be made to improve identification methods for microbial pathogens causing CAP...

..3% vs. 18.6%; OR=2.84; p=0.02). Community-acquired pneumonia of mixed etiology is uncommon. Patients with mixed pneumonia are more likely to have underlying medical conditions, and they may have a more severe course of disease...

..4% and a specificity of 89.7%. Testing concentrated urine samples with the ICT may be a useful technique for rapid diagnosis of pneumococcal pneumonia in adults with CAP...

..To determine whether an association existed between lopinavir (LPV) plasma concentrations and changes in lipid levels...

..To determine whether an association existed between lopinavir (LPV) plasma concentrations and changes in body fat composition...

..Switching to raltegravir in selected patients treated with ritonavir-boosted protease inhibitors may result in similar efficacy and lower plasma lipids...

..This review updates clinical and methodological recommendations for genotypic determination of HIV tropism to guide therapeutic decisions using CCR5 antagonists, considering the most recently reported data...

..Undetectable viral load and treatment with NNRTIs are protective factors, whereas hypertriglyceridemia is directly associated with low HDL-C levels...

..We describe the sociodemographic, epidemiological, and clinical characteristics of a cohort of naïve HIV-infected subjects (CoRIS cohort) according to their place of origin...

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..OS is increased among HIV-infected patients, but whether it implicates a higher risk for cardiovascular disease or the influence of antiretroviral therapy (ART) on OS remains unknown...

..To assess the presence of insulin resistance in human immunodeficiency virus (HIV)-infected patients receiving long-term antiretroviral therapy...

..Suboptimal baseline 25(OH)D levels increase the risk of developing secondary hyperparathyroidism among tenofovir users...

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..Genotypic assays may provide an easier alternative, but their sensitivity remains low. We hypothesize that combining clinical data with V3 sequences may improve the diagnostic accuracy of genotypic tools...

..There is broad cross-resistance between RAL and EVG, which should preclude their sequential use. Resistance to EVG seems to be more frequent and might be more influenced by integrase variability...

..001). Undetectable RAL C(t) was seen only in patients failing RAL without integrase resistance mutations (64.1% of them). RAL failures in the absence of integrase resistance mutations mainly reflect poor drug compliance...

..We evaluated endothelial dysfunction, an early event in the development of atherosclerosis, and pro-atherosclerotic plasma biomarkers in HIV-infected patients with lipodystrophy...

..We evaluated longitudinal changes in pro-atherosclerotic biomarkers in patients initiating abacavir or tenofovir...

..This observation has been reproduced in HIV-co-infected individuals. Controversy exists about the impact of IL28B alleles on HCV load...

..Ultrasonography and anthropometry are fairly accurate and reproducible methods for the evaluation of intraabdominal and peripheral fat. Its role for assessing facial fat seems to be more limited...

..Although the association of HIV with cardiovascular risk is controversial, coinfection with hepatitis C infection has been associated with a higher frequency of insulin resistance and acute myocardial infarction in some cohorts...

..There is a need to extend the programs in order to enhance access and adherence of IDUs to HAART and consider the treatment of drug addiction as an integral part of the treatment for HIV infection...

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..To assess the effects of initiating abacavir-containing therapy on plasma lipids and cardiovascular biomarkers...

..Results are similar to those obtained with Trofile. The concordance with ES Trofile is better with higher CD4 cell counts and nonexposure to antiretroviral therapy...

..8% in 1997 to 19.8% in 2006. This steady decrease in the prevalence of coinfection among Spanish patients was caused by a change in transmission routes of HIV infection...

..019) and current ART (p=0.021). Our results show that C-reactive protein is associated with traditional cardiovascular risk factors, and may then be a marker for cardiovascular risk linked to HIV infection and ART...

..We evaluated endothelial function and subclinical atherosclerosis in HIV-infected patients with and without HCV...

..We aimed to explore the diagnostic accuracy of MR-proANP and CT-proAVP to predict mortality in patients with CAP...

..This review summarizes clinical and methodological recommendations for the genotypic determination of HIV tropism to guide therapeutic decisions with CCR5 antagonists in HIV therapeutics...

..Although we did not find differences in virological and immunological responses to HAART, we did observe higher mortality in people with DHD. Increased efforts to early diagnose HIV infection are urgently needed...

..We evaluated the reliability of subtyping tools vs. phylogeny in a panel of HIV-1 pol sequences from the cohort of naïve patients of the HIV/AIDS Spanish Research Network (CoRIS)...

..Tuberculosis in immigrants is an emerging disease in industrialized countries...

..The temporal relationship between drug administration and clinical symptoms in this case suggests a probable interaction between the 2 drugs...

..We evaluated the efficacy and safety of an intensive versus a standard intervention in HIV-infected patients with moderate-high cardiovascular risk...

..To determine the characteristics of HIV-infection in foreign patients residing in Elche, Spain...

..The objective of this study was to estimate the prevalence and characteristics of the metabolic syndrome in patients with HIV infection from a Mediterranean cohort...

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..HIV-1 co-receptor usage may play a critical role in AIDS pathogenesis. Information on viral tropism in HIV-1 seroconverters is scarce, as is the relationship with transmission of drug-resistant viruses...

..Migration of women of childbearing age from Latin America to developed countries may spread the disease to non-endemic areas through vertical transmission...

..Pure X4 and X4R5 dual-tropic viruses may be recognized in approximately 15% of drug-naive HIV-1-positive patients. CCR5 antagonists are active against R5 viruses; therefore, HIV tropism should be known before their prescription...

..We aimed to study the usefulness of acute-phase proteins in the evolution and microbial diagnosis of community-acquired pneumonia (CAP)...

..To evaluate the usefulness of procalcitonin serum levels as a predictor of etiology and prognosis in adult patients with community-acquired pneumonia (CAP) when they are stratified according to severity...

..We found 14% prevalence, with one third of patients having nonpneumonic infections. A severity assessment score >1 and high C-reactive protein levels were predictors of pneumococcal co-infection...

..Both patients died. Although infrequent, infections by larval cestodes constitute a cause of disease in HIV-infected patients in developed countries, and might be linked with a more severe presentation...

..Immigration is an inexorable process. Immigrants may suffer infectious diseases commonly seen in our environment, or those more exotic or more prevalent in their own environment...

..To analyze Spanish scientific research output related to tuberculosis during the 10-year period from 1997 through 2006 and to consider it within the context of European Union (EU) productivity...

..To describe the characteristics of HIV infected adults according to their age at recruitment in CoRIS...

..However, no cases were found in Asian immigrants, highlighting the importance of primary prevention of this infection in pregnant women coming from that geographic region...

..Neither the interruption of antiretroviral therapy nor the use of metformin, glitazones or growth hormone analogs can be recommended due to their limited efficacy or associated complications...

..Assessment of functional clinical outcome variables, in addition to survival, is strongly recommended for this population...

..Universal HTLV antenatal screening is currently not mandatory in European countries. However, the large number of immigrants coming from HTLV-I endemic areas might force to change this recommendation in the near future...

..To describe the methodology and baseline results of the Spanish cohort of naïve HIV-infected patients included in the Research Network on HIV/AIDS (CoRIS)...

..No significant safety issues were identified; however, plasma amprenavir and ritonavir exposures were more variable in subjects with hepatic impairment, and those patients should be closely monitored for safety and virologic response...

..Physicians should be aware of the psychosocial consequences of BPC in HIV patients in order to improve patient well-being...

..Ankle-brachial index was associated with carotid intima-media thickness. Patients with low ankle-brachial index, but not those with high ankle-brachial index, had high carotid intima-media thickness...

..Thus, more than 80% patients with prior failure to nonnucleoside reverse transcriptase inhibitors could potentially benefit from etravirine rescue therapy...

..Among those with secondary IPA, most abscesses are secondary to a skeletal source. A bacterial etiology can be identified in most cases. The overall prognosis of patients with this condition is good...

..After starting ethambutol and rifampicin and discontinuing infliximab, a worsening appeared. M. marinum infection may have a potential local spread and systemic dissemination in patients treated with TNF-alpha inhibitors...

..CT may be a useful technique to diagnose and monitor facial lipoatrophy...

..To estimate the seroprevalence of infection by Trypanosoma cruzi and human T lymphotropic virus (HTLV) in pregnant Latin American women...

..ursingii bacteraemia. This report highlights the inadequacies of conventional phenotypic tests usually available in clinical microbiology laboratories for the identification of Acinetobacter species...

..To analyze the production and repercussions of the scientific activity of Spanish authors in the fields of microbiology, mycology, parasitology and virology...

..We analyzed survival, therapeutic response, and prognostic factors in patients with HIV-related Hodgkin lymphoma (HL) treated or not with highly active antiretroviral therapy (HAART)...

..pallidum infections are highly prevalent. However, information on seroprevalence of these infections among antenatal care attendees is very scarce and the majority of studies have been conducted in pregnant women from urban areas...

..Voriconazole and amphotericin B had the most potent activities in vitro against the isolates, with MIC geometric means of 0.11 and 0.30 microg/ml, respectively...

..To assess the accuracy of plasma levels of soluble Triggering Receptor Expressed on Myeloid cells (sTREM)-1 to diagnose infection in critical patients with systemic inflammatory response syndrome (SIRS)...