Consuelo Guerri

Summary

Country: Spain

Publications

  1. doi request reprint Neuroimmune activation and myelin changes in adolescent rats exposed to high-dose alcohol and associated cognitive dysfunction: a review with reference to human adolescent drinking
    Maria Pascual
    Corresponding author Department of Cellular Pathology, Centro de Investigacion Principe Felipe, C Eduardo Primo Yúfera 3, 46012 Valencia, Spain
    Alcohol Alcohol 49:187-92. 2014
  2. doi request reprint Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence
    Consuelo Guerri
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    Alcohol 44:15-26. 2010
  3. pmc Foetal Alcohol Spectrum Disorders and alterations in brain and behaviour
    Consuelo Guerri
    Department of Cell Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    Alcohol Alcohol 44:108-14. 2009
  4. doi request reprint Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
    Silvia Alfonso-Loeches
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, 46012 Valencia, Spain
    J Neurosci 30:8285-95. 2010
  5. ncbi request reprint Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes
    Soraya L Valles
    Instituto de Investigaciones Citológicas FVIB, Valencia, Spain
    Brain Pathol 14:365-71. 2004
  6. doi request reprint Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells
    Sara Fernandez-Lizarbe
    Department of Cellular Pathology, Príncipe Felipe Research Centre, Eduardo Primo Yúfera, Valencia, Spain
    J Neurochem 126:261-73. 2013
  7. ncbi request reprint RhoE participates in the stimulation of the inflammatory response induced by ethanol in astrocytes
    Rosa M Guasch
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    Exp Cell Res 313:3779-88. 2007
  8. doi request reprint Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells
    Ana M Blanco
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurochem 106:625-39. 2008
  9. doi request reprint Toll-like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse
    Silvia Alfonso-Loeches
    Department of Cellular Pathology, Príncipe Felipe Research Centre, Avda Autopista del Saler 16, Valencia, Spain
    Glia 60:948-64. 2012
  10. doi request reprint Critical role of TLR4 response in the activation of microglia induced by ethanol
    Sara Fernandez-Lizarbe
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia 46012, Spain
    J Immunol 183:4733-44. 2009

Collaborators

Detail Information

Publications31

  1. doi request reprint Neuroimmune activation and myelin changes in adolescent rats exposed to high-dose alcohol and associated cognitive dysfunction: a review with reference to human adolescent drinking
    Maria Pascual
    Corresponding author Department of Cellular Pathology, Centro de Investigacion Principe Felipe, C Eduardo Primo Yúfera 3, 46012 Valencia, Spain
    Alcohol Alcohol 49:187-92. 2014
    ..The aim of the study was to assess whether intermittent ethanol administration to adolescent rats activates innate immune response and TLRs signalling causing myelin disruption and long-term cognitive and behavioural deficits...
  2. doi request reprint Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence
    Consuelo Guerri
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    Alcohol 44:15-26. 2010
    ....
  3. pmc Foetal Alcohol Spectrum Disorders and alterations in brain and behaviour
    Consuelo Guerri
    Department of Cell Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    Alcohol Alcohol 44:108-14. 2009
    ..Finally, the potential molecular mechanisms that underlie the neuroteratological effects of alcohol are discussed, with particular emphasis on the role of glial cells in long-term neurodevelopmental liabilities...
  4. doi request reprint Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
    Silvia Alfonso-Loeches
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, 46012 Valencia, Spain
    J Neurosci 30:8285-95. 2010
    ..Our findings support the critical role of the TLR4 response in the neuroinflammation, brain injury, and possibly in the neurodegeneration induced by chronic ethanol intake...
  5. ncbi request reprint Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes
    Soraya L Valles
    Instituto de Investigaciones Citológicas FVIB, Valencia, Spain
    Brain Pathol 14:365-71. 2004
    ....
  6. doi request reprint Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells
    Sara Fernandez-Lizarbe
    Department of Cellular Pathology, Príncipe Felipe Research Centre, Eduardo Primo Yúfera, Valencia, Spain
    J Neurochem 126:261-73. 2013
    ..In summary, we provide evidence for a mechanism by which ethanol triggers TLR4/TLR2 association contributing to the neuroinflammation and neurodegeneration associated with alcohol abuse. ..
  7. ncbi request reprint RhoE participates in the stimulation of the inflammatory response induced by ethanol in astrocytes
    Rosa M Guasch
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    Exp Cell Res 313:3779-88. 2007
    ..These findings provide new insights into the molecular mechanism involved in the inflammatory responses in astrocytes...
  8. doi request reprint Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells
    Ana M Blanco
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurochem 106:625-39. 2008
    ..These results suggest that TLRs receptors are important targets of ethanol-induced inflammatory damage in the brain...
  9. doi request reprint Toll-like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse
    Silvia Alfonso-Loeches
    Department of Cellular Pathology, Príncipe Felipe Research Centre, Avda Autopista del Saler 16, Valencia, Spain
    Glia 60:948-64. 2012
    ..In summary, the present results suggest that ethanol-induced neuroinflammation might be involved in myelin disruptions and white matter loss observed in human alcoholics...
  10. doi request reprint Critical role of TLR4 response in the activation of microglia induced by ethanol
    Sara Fernandez-Lizarbe
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia 46012, Spain
    J Immunol 183:4733-44. 2009
    ....
  11. ncbi request reprint Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats
    Maria Pascual
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, 16 46013 Valencia, Spain
    Eur J Neurosci 25:541-50. 2007
    ..Accordingly, administering indomethacin protects against ethanol-induced brain damage and prevents detrimental ethanol effects on cognitive and motor processes...
  12. doi request reprint Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage
    Maria Pascual
    Department of Cell Pathology, Príncipe Felipe Research Center, Avda Autopista del Saler 16, 46012 Valencia, Spain
    Brain Behav Immun 25:S80-91. 2011
    ....
  13. ncbi request reprint The peptide NAP promotes neuronal growth and differentiation through extracellular signal-regulated protein kinase and Akt pathways, and protects neurons co-cultured with astrocytes damaged by ethanol
    Maria Pascual
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurochem 103:557-68. 2007
    ..These results indicate that the protective actions of NAP are mediated by triggering signalling pathways which are important in neuronal growth and differentiation contributing to the restoration of PEE-associated neuronal plasticity...
  14. doi request reprint Neuronal polarization is impaired in mice lacking RhoE expression
    Blanca Peris
    Department of Cellular Pathology, Prince Felipe Research Centre, Valencia, Spain
    J Neurochem 121:903-14. 2012
    ..These findings support our previous report revealing the important role of RhoE in the normal development of the nervous system and may provide novel therapeutic targets in neurodegenerative disorders...
  15. doi request reprint Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat
    Maria Pascual
    Department of Cellular Pathology, Valencia, Spain
    J Neurochem 108:920-31. 2009
    ....
  16. ncbi request reprint Ethanol exposure during embryogenesis decreases the radial glial progenitorpool and affects the generation of neurons and astrocytes
    Gemma Rubert
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurosci Res 84:483-96. 2006
    ....
  17. doi request reprint Neural differentiation from human embryonic stem cells as a tool to study early brain development and the neuroteratogenic effects of ethanol
    Raquel Talens-Visconti
    Cell Pathology Laboratory, Centro de Investigacion Principe Felipe, Valencia, Spain
    Stem Cells Dev 20:327-39. 2011
    ..The results provide new insights into the effects of ethanol on human embryogenesis and neuroprogenitors and offer an opportunity to delineate potential therapeutic strategies to restore early ethanol-induced brain damage...
  18. doi request reprint RhoE stimulates neurite-like outgrowth in PC12 cells through inhibition of the RhoA/ROCK-I signalling
    Raquel Talens-Visconti
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurochem 112:1074-87. 2010
    ..These findings provide new insights into the molecular mechanism implicated in neuronal development and may provide novel therapeutic targets in neurodegenerative disorders...
  19. doi request reprint Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning
    Maria Pascual
    Department of Cell Pathology, Príncipe Felipe Research Center, Avda Autopista del Saler, 16, 46012 Valencia, Spain
    Neuropharmacology 62:2309-19. 2012
    ..They also suggest that epigenetic mechanisms might open up avenues to new treatments for binge drinking-induced drug addiction during adolescence...
  20. doi request reprint Role of TLR4 in ethanol effects on innate and adaptive immune responses in peritoneal macrophages
    Maria Pascual
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    Immunol Cell Biol 89:716-27. 2011
    ..Taken together, our findings support the role of TLR4 in the effects of ethanol on the immune system, and suggest that alterations in the function of this receptor might modulate the immune response induced by alcohol abuse...
  21. pmc RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice
    Enric Mocholí
    Department of Chemistry, Biochemistry and Molecular Biology, School of Health Sciences, Universidad CEU Cardenal Herrera, Moncada, Valencia, Spain
    PLoS ONE 6:e19236. 2011
    ....
  22. ncbi request reprint Ceramide pathways modulate ethanol-induced cell death in astrocytes
    Maria Pascual
    Instituto de Investigaciones Citológicas Centro Investigación Hospital La Fe, Valencia, Spain
    J Neurochem 87:1535-45. 2003
    ..These findings provide an insight into the mechanisms involved in ethanol-induced astroglial cell death during brain development...
  23. doi request reprint Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain
    Silvia Alfonso-Loeches
    Cell Pathology Laboratory, Prince Felipe Research Centre, Valencia, Spain
    Crit Rev Clin Lab Sci 48:19-47. 2011
    ....
  24. ncbi request reprint Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes
    Ana M Blanco
    Unidad de Patología Celular, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Immunol 175:6893-9. 2005
    ..In summary, these findings indicate that both TLR4 and IL-1RI activation occur upon ethanol treatment, and suggest that signaling through these receptors mediates ethanol-induced inflammatory events in astrocytes and brain...
  25. doi request reprint Gender differences in alcohol-induced neurotoxicity and brain damage
    Silvia Alfonso-Loeches
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, C Eduardo Primo Yúfera 3, Valencia 46012, Spain
    Toxicology 311:27-34. 2013
    ....
  26. ncbi request reprint Lipid rafts regulate ethanol-induced activation of TLR4 signaling in murine macrophages
    Sara Fernandez-Lizarbe
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Avda Autopista del Saler 16, 46013 Valencia, Spain
    Mol Immunol 45:2007-16. 2008
    ....
  27. ncbi request reprint RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line
    Enric Poch
    Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera CEU, Valencia, Spain
    Exp Cell Res 313:719-31. 2007
    ....
  28. ncbi request reprint Ethanol intake enhances inflammatory mediators in brain: role of glial cells and TLR4/IL-1RI receptors
    Ana María Blanco
    Centro de Investigacion Principe Felipe, Cell Pathology Laboratory, Avda Autopista del Saler 16, 46013 Valencia, Spain
    Front Biosci 12:2616-30. 2007
    ..In summary, current results suggest that TLR4/ IL-1RI are important targets of ethanol-induced inflammatory brain damage...
  29. ncbi request reprint The RhoA/ROCK-I/MLC pathway is involved in the ethanol-induced apoptosis by anoikis in astrocytes
    Rebeca Miñambres
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, c EP Autopista del Saler 16 3, 46013 Valencia, Spain
    J Cell Sci 119:271-82. 2006
    ..All of these findings strongly support that ethanol-exposed astrocytes undergo apoptosis by anoikis and also that the RhoA/ROCK-I/MLC pathway participates in this process...
  30. ncbi request reprint Chronic ethanol consumption enhances interleukin-1-mediated signal transduction in rat liver and in cultured hepatocytes
    Soraya L Valles
    Instituto de Investigaciones Citologicas, Valencia, Spain
    Alcohol Clin Exp Res 27:1979-86. 2003
    ....
  31. doi request reprint Ethanol intake and ethanol-induced locomotion and locomotor sensitization in Cyp2e1 knockout mice
    Merce Correa
    Department of Psicobiology, University Jaume I, Castello, Principe Felipe Institute, Valencia, Spain
    Pharmacogenet Genomics 19:217-25. 2009
    ..Recent studies, however, suggest that cytochrome, in particular the isoform P450 2E1, can also contribute to the central metabolism of ethanol...