Research Topics
Genomes and Genes | Isabel GuerreroSummaryCountry: Spain Publications
| Collaborators
|
Detail Information
Publications
Development. Longing for ligand: hedgehog, patched, and cell deathIsabel Guerrero
, CSIC-UAM, , Madrid E-28049, Spain
Science 301:774-6. 2003- A conserved mechanism of Hedgehog gradient formation by lipid modificationsIsabel Guerrero
Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid Cantoblanco, E 28049 Madrid, Spain
Trends Cell Biol 17:1-5. 2007..We propose that the cholesterol moiety functions to restrict the dilution and deregulated spread of the morphogen in the extracellular space... - Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epitheliumAinhoa Callejo
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Proc Natl Acad Sci U S A 108:12591-8. 2011..We also show that Dlp is needed in Hh-producing cells to allow for Hh release and that Ihog, which has been previously described as an Hh coreceptor, anchors Hh to the basolateral part of the disk epithelium... - Patched, the receptor of Hedgehog, is a lipoprotein receptorAinhoa Callejo
Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Proc Natl Acad Sci U S A 105:912-7. 2008..However, by using different Ptc mutants, we show that Lp internalization does not play a major role in Hh signal transduction but does in Hh gradient formation... - The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified HedgehogNicole Gorfinkiel
Centro de Biologia Molecular, Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Dev Cell 8:241-53. 2005..We also show that human WIF inhibits Wg signaling in Drosophila without affecting the Hh pathway, indicating that different WIF family members might have divergent functions in each pathway... - Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transductionCarlos Torroja
Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Development 131:2395-408. 2004.... - Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing developmentElvira Benítez
Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Development 136:1211-21. 2009..We conclude that by preventing Bowl accumulation in the wing, primordial Lines permits the correct balance of nuclear co-repressors that control the activity of the Wingless, Notch and Hedgehog pathways... - The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteinsNicole Gorfinkiel
Centro de Biologia Molecular Severo Ochoa, CSIC UAM Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Mech Dev 121:449-62. 2004..We also show that Ring/Sce interacts directly with PcG proteins, as it occurs in mammals... - Mechanisms of Hedgehog gradient formation and interpretationCarlos Torroja
, CSIC, , Cantoblanco, E-28049 Madrid, Spain
J Neurobiol 64:334-56. 2005..Here, we review the mechanisms affecting the dynamics of Hh gradient formation, mostly in the context of Drosophila wing development, although parallel findings in vertebrate systems are also discussed... - Secreted frizzled-related proteins are required for Wnt/?-catenin signalling activation in the vertebrate optic cupPilar Esteve
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, 28049 Madrid, Spain
Development 138:4179-84. 2011..Collectively, these data demonstrate that, in vivo, the levels of Wnt signalling activation strongly depend on the tissue distribution of Sfrps, which should be viewed as multifunctional regulators of Wnt signalling... - SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesisPilar Esteve
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
Nat Neurosci 14:562-9. 2011..Together, these data indicate that Sfrps inhibit the ADAM10 metalloprotease, which might have important implications in pathological events, including cancer and Alzheimer's disease... - Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrixAinhoa Callejo
Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Cantoblanco, Spain
Development 133:471-83. 2006..All these data show that the interaction of lipid-modified Hh with HSPG is important both for precise Hh spreading through the epithelium surface and for correct Hh reception... - Functional characterization of human mesenchymal stem cells that maintain osteochondral fatesMarina Romero-Prado
, , Severo Ochoa, Facultad de Ciencias, , Cantoblanco, 28049 Madrid, Spain
J Cell Biochem 98:1457-70. 2006..These specific cellular conditions match those observed during endochondral bone formation... - Development of the Drosophila genital disc requires interactions between its segmental primordiaNicole Gorfinkiel
Centro de Biologia Molecular Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Development 130:295-305. 2003..Collectively, these findings suggest that interaction between segmental primordia is required for the normal development of the genital disc...