Isabel Guerrero

Summary

Country: Spain

Publications

  1. ncbi request reprint Development. Longing for ligand: hedgehog, patched, and cell death
    Isabel Guerrero
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Madrid E 28049, Spain
    Science 301:774-6. 2003
  2. ncbi request reprint A conserved mechanism of Hedgehog gradient formation by lipid modifications
    Isabel Guerrero
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid Cantoblanco, E 28049 Madrid, Spain
    Trends Cell Biol 17:1-5. 2007
  3. pmc Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
    Ainhoa Callejo
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 108:12591-8. 2011
  4. ncbi request reprint Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
    Ainhoa Callejo
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 133:471-83. 2006
  5. doi request reprint Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif
    Aphrodite Bilioni
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, c Nicolas Cabrera 1, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Dev Biol 376:198-212. 2013
  6. pmc Patched, the receptor of Hedgehog, is a lipoprotein receptor
    Ainhoa Callejo
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 105:912-7. 2008
  7. ncbi request reprint The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
    Nicole Gorfinkiel
    Centro de Biologia Molecular, Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Dev Cell 8:241-53. 2005
  8. ncbi request reprint The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog
    David Sanchez-Hernandez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 139:3849-58. 2012
  9. ncbi request reprint Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
    Carlos Torroja
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 131:2395-408. 2004
  10. pmc Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing development
    Elvira Benítez
    Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 136:1211-21. 2009

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Development. Longing for ligand: hedgehog, patched, and cell death
    Isabel Guerrero
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Madrid E 28049, Spain
    Science 301:774-6. 2003
  2. ncbi request reprint A conserved mechanism of Hedgehog gradient formation by lipid modifications
    Isabel Guerrero
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid Cantoblanco, E 28049 Madrid, Spain
    Trends Cell Biol 17:1-5. 2007
    ..We propose that the cholesterol moiety functions to restrict the dilution and deregulated spread of the morphogen in the extracellular space...
  3. pmc Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
    Ainhoa Callejo
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 108:12591-8. 2011
    ..We also show that Dlp is needed in Hh-producing cells to allow for Hh release and that Ihog, which has been previously described as an Hh coreceptor, anchors Hh to the basolateral part of the disk epithelium...
  4. ncbi request reprint Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
    Ainhoa Callejo
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 133:471-83. 2006
    ..All these data show that the interaction of lipid-modified Hh with HSPG is important both for precise Hh spreading through the epithelium surface and for correct Hh reception...
  5. doi request reprint Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif
    Aphrodite Bilioni
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, c Nicolas Cabrera 1, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Dev Biol 376:198-212. 2013
    ..Furthermore, this protein complex is part of thin filopodia-like structures or cytonemes, suggesting that the interaction between Dally, Ihog, Boi and Shf/DmWif is required for cytoneme-mediated Hh distribution during gradient formation...
  6. pmc Patched, the receptor of Hedgehog, is a lipoprotein receptor
    Ainhoa Callejo
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 105:912-7. 2008
    ..However, by using different Ptc mutants, we show that Lp internalization does not play a major role in Hh signal transduction but does in Hh gradient formation...
  7. ncbi request reprint The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
    Nicole Gorfinkiel
    Centro de Biologia Molecular, Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Dev Cell 8:241-53. 2005
    ..We also show that human WIF inhibits Wg signaling in Drosophila without affecting the Hh pathway, indicating that different WIF family members might have divergent functions in each pathway...
  8. ncbi request reprint The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog
    David Sanchez-Hernandez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 139:3849-58. 2012
    ..These results are important both from the evolutionary perspective and for understanding the mechanisms of morphogen distribution in a morphogenetic field...
  9. ncbi request reprint Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
    Carlos Torroja
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 131:2395-408. 2004
    ....
  10. pmc Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing development
    Elvira Benítez
    Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 136:1211-21. 2009
    ..We conclude that by preventing Bowl accumulation in the wing, primordial Lines permits the correct balance of nuclear co-repressors that control the activity of the Wingless, Notch and Hedgehog pathways...
  11. doi request reprint Secreted frizzled-related proteins are required for Wnt/β-catenin signalling activation in the vertebrate optic cup
    Pilar Esteve
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, 28049 Madrid, Spain
    Development 138:4179-84. 2011
    ..Collectively, these data demonstrate that, in vivo, the levels of Wnt signalling activation strongly depend on the tissue distribution of Sfrps, which should be viewed as multifunctional regulators of Wnt signalling...
  12. doi request reprint Hedgehog on the move: a precise spatial control of Hedgehog dispersion shapes the gradient
    Ana Citlali Gradilla
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, c Nicolas Cabrera 1, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Curr Opin Genet Dev 23:363-73. 2013
    ..Dispersion of Hh is also determined by its hydrophobic nature, and the mechanisms that include membrane-tethered transport of Hh are increasingly proposed. ..
  13. ncbi request reprint The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteins
    Nicole Gorfinkiel
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Mech Dev 121:449-62. 2004
    ..We also show that Ring/Sce interacts directly with PcG proteins, as it occurs in mammals...
  14. doi request reprint SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis
    Pilar Esteve
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Nat Neurosci 14:562-9. 2011
    ..Together, these data indicate that Sfrps inhibit the ADAM10 metalloprotease, which might have important implications in pathological events, including cancer and Alzheimer's disease...
  15. ncbi request reprint Mechanisms of Hedgehog gradient formation and interpretation
    Carlos Torroja
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    J Neurobiol 64:334-56. 2005
    ..Here, we review the mechanisms affecting the dynamics of Hh gradient formation, mostly in the context of Drosophila wing development, although parallel findings in vertebrate systems are also discussed...
  16. doi request reprint Cytoneme-mediated cell-to-cell signaling during development
    Ana Citlali Gradilla
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, CSIC UAM, c Nicolas Cabrera 1, Cantoblanco, 28049, Madrid, Spain
    Cell Tissue Res 352:59-66. 2013
    ..The processes that initiate and regulate the formation, orientation and dynamics of cytonemes are poorly understood but are potentially extremely important areas for our knowledge of intercellular communication...
  17. ncbi request reprint Functional characterization of human mesenchymal stem cells that maintain osteochondral fates
    Marina Romero-Prado
    Departamento de Biologia Molecular, Centro de Biologia Molecular, Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Cell Biochem 98:1457-70. 2006
    ..These specific cellular conditions match those observed during endochondral bone formation...
  18. ncbi request reprint Development of the Drosophila genital disc requires interactions between its segmental primordia
    Nicole Gorfinkiel
    Centro de Biologia Molecular Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 130:295-305. 2003
    ..Collectively, these findings suggest that interaction between segmental primordia is required for the normal development of the genital disc...