Carmen Guaza

Summary

Country: Spain

Publications

  1. ncbi request reprint Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia
    José Borrell
    Psychobiology Group, Neural Plasticity Department, Cajal Institute, 28002, Madrid, Spain
    Neuropsychopharmacology 26:204-15. 2002
  2. doi request reprint Anandamide enhances IL-10 production in activated microglia by targeting CB(2) receptors: roles of ERK1/2, JNK, and NF-kappaB
    Fernando Correa
    Functional and Systems Neurobiology Department, Neuroimmunology Group, Instituto Cajal, CSIC, Madrid, Spain
    Glia 58:135-47. 2010
  3. ncbi request reprint Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis
    Silvia Ortega-Gutierrez
    Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, CSIC, Madrid, Spain
    FASEB J 19:1338-40. 2005
  4. doi request reprint CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation
    Miriam Hernangómez
    Department of Functional and Systems Neurobiology, Neuroimmunology Group, Instituto Cajal, CSIC, Madrid, Spain
    Glia 60:1437-50. 2012
  5. doi request reprint The endocannabinoid system is modulated in response to spinal cord injury in rats
    Daniel Garcia-Ovejero
    Laboratorio de Neuroinflamacion, Unidad de Neurología Experimental Research Unit associated to the Instituto Cajal, CSIC, Madrid, Hospital Nacional de Paraplejicos, Toledo, Spain
    Neurobiol Dis 33:57-71. 2009
  6. doi request reprint Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system
    Ricardo Llorente
    Departamento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Dev Neurobiol 68:1334-47. 2008
  7. ncbi request reprint The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection
    Leyre Mestre
    Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, CSIC, Avda Dr Arce 37, 28002 Madrid, Spain
    Biochem Pharmacol 72:869-80. 2006
  8. ncbi request reprint Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2)
    Fernando Correa
    Neuroimmunology Group, Functional and Systems Neurobiology Department, Instituto Cajal, CSIC Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Biochem J 409:761-70. 2008
  9. doi request reprint Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide
    Frida Loría
    Neuroimmunology Group, Department of Functional and Systems Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Eur J Neurosci 28:633-41. 2008
  10. doi request reprint A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells
    Fernando Correa
    Neuroimmunology Group, Functional and Systems Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Biochem Pharmacol 77:86-100. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia
    José Borrell
    Psychobiology Group, Neural Plasticity Department, Cajal Institute, 28002, Madrid, Spain
    Neuropsychopharmacology 26:204-15. 2002
    ..These results illustrate the critical influence of prenatal immune events upon adult CNS functioning in association with the putative role of the immune system in the etiopathogenesis of schizophrenia...
  2. doi request reprint Anandamide enhances IL-10 production in activated microglia by targeting CB(2) receptors: roles of ERK1/2, JNK, and NF-kappaB
    Fernando Correa
    Functional and Systems Neurobiology Department, Neuroimmunology Group, Instituto Cajal, CSIC, Madrid, Spain
    Glia 58:135-47. 2010
    ..Accordingly, pharmacological modulation of AEA uptake and degradation might be a useful tool for treating neuroinflammatory diseases...
  3. ncbi request reprint Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis
    Silvia Ortega-Gutierrez
    Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, CSIC, Madrid, Spain
    FASEB J 19:1338-40. 2005
    ..Overall, these results suggest that agents able to activate the endocannabinoid system could constitute a new series of drugs for the treatment of MS...
  4. doi request reprint CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation
    Miriam Hernangómez
    Department of Functional and Systems Neurobiology, Neuroimmunology Group, Instituto Cajal, CSIC, Madrid, Spain
    Glia 60:1437-50. 2012
    ..Our findings provide a new mechanism of action of AEA to limit immune response in the inflamed brain...
  5. doi request reprint The endocannabinoid system is modulated in response to spinal cord injury in rats
    Daniel Garcia-Ovejero
    Laboratorio de Neuroinflamacion, Unidad de Neurología Experimental Research Unit associated to the Instituto Cajal, CSIC, Madrid, Hospital Nacional de Paraplejicos, Toledo, Spain
    Neurobiol Dis 33:57-71. 2009
    ..CB(2) receptor was strongly upregulated after lesion, and mostly expressed by immune infiltrates and astrocytes. The endocannabinoid system may represent an interesting target for new therapeutical approaches to spinal cord injury...
  6. doi request reprint Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system
    Ricardo Llorente
    Departamento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Dev Neurobiol 68:1334-47. 2008
    ..We provide direct evidence for gender-dependent cellular and biochemical effects of MD on developmental hippocampus, including changes in the endocannabinoid system...
  7. ncbi request reprint The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection
    Leyre Mestre
    Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, CSIC, Avda Dr Arce 37, 28002 Madrid, Spain
    Biochem Pharmacol 72:869-80. 2006
    ..Overexpression of COX-2 and the subsequent increase of PGE2 could be affecting flow blood and/or immune reactivity...
  8. ncbi request reprint Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2)
    Fernando Correa
    Neuroimmunology Group, Functional and Systems Neurobiology Department, Instituto Cajal, CSIC Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Biochem J 409:761-70. 2008
    ..Overall, our findings provide new mechanistic insights into the activities of AEA in immune-related disorders, which may be relevant for the clinical management of such diseases...
  9. doi request reprint Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide
    Frida Loría
    Neuroimmunology Group, Department of Functional and Systems Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Eur J Neurosci 28:633-41. 2008
    ..This study overall highlights the potential therapeutic effects of endocannabinoids in MS...
  10. doi request reprint A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells
    Fernando Correa
    Neuroimmunology Group, Functional and Systems Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Biochem Pharmacol 77:86-100. 2009
    ....
  11. doi request reprint The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells
    Fernando Correa
    Neuroimmunology Group, Functional and Systems Neurobiology Department, Cajal Institute, CSCI, 28002 Madrid, Spain
    Brain Behav Immun 25:736-49. 2011
    ..Accordingly, pharmacological modulation of endocannabinoids might be a useful tool for treating neuroinflammatory diseases...
  12. pmc Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors
    Leyre Mestre
    Neuroimmunology Group, Functional and Systems Neurobiology Department, Cajal Institute, CSIC, 28002 Madrid, Spain
    J Neuroinflammation 8:102. 2011
    ..In the present study we investigated the effects of anandamide (AEA) in the regulation of VCAM-1 expression induced by Theiler's virus (TMEV) infection of brain endothelial cells using in vitro and in vivo approaches...
  13. ncbi request reprint The role of cannabinoid system on immune modulation: therapeutic implications on CNS inflammation
    Fernando Correa
    Neural Plasticity Unit, Neuroimmunology Group, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mini Rev Med Chem 5:671-5. 2005
    ....
  14. ncbi request reprint Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    Eduardo Molina-Holgado
    Department of Neural Plasticity, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 22:9742-53. 2002
    ..These data identify oligodendrocytes as potential targets of cannabinoid action in the CNS...
  15. ncbi request reprint Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis
    Leyre Mestre
    Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, CSIC, 28002 Madrid, Spain
    J Neurochem 92:1327-39. 2005
    ..Taken together, these results point to the manipulation of the endocannabinoid system as a possible strategy to develop future MS therapeutic drugs...
  16. ncbi request reprint Therapeutic action of cannabinoids in a murine model of multiple sclerosis
    Angel Arevalo-Martin
    Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 23:2511-6. 2003
    ....
  17. doi request reprint The endocannabinoid anandamide from immunomodulation to neuroprotection. Implications for multiple sclerosis
    Fernando G Correa
    Functional and Systems Neurobiology Department, Cajal Institute, CSIC, Avda Doctor Arce, Madrid, Spain
    Vitam Horm 81:207-30. 2009
    ..This chapter focuses on our current understanding of the function of anandamide (AEA), its biological and therapeutic implications, as well as a description of its effects on neuroimmune modulation...
  18. ncbi request reprint Neurobehavioral and immunological consequences of prenatal immune activation in rats. Influence of antipsychotics
    Eva Romero
    Cajal Institute, Spanish Council for Scientific Research CSIC, Avda Doctor Arce, Madrid, Spain
    Neuropsychopharmacology 32:1791-804. 2007
    ....
  19. ncbi request reprint Cannabinoid system and neuroinflammation: implications for multiple sclerosis
    Fernando Correa
    Neuroimmunology Group, Functional and Systems Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuroimmunomodulation 14:182-7. 2007
    ..The effects of cannabinoids on cytokine brain work and on the regulation of neuroinflammatory processes may affect chronic inflammatory demyelinating diseases such as multiple sclerosis...
  20. ncbi request reprint Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures
    Silvia Ortega-Gutierrez
    Neural Plasticity Department, Neuroimmunology Group, Cajal Institute, CSIC, Madrid, Spain
    Glia 52:163-8. 2005
    ..These results confirm the ability of UCM707 to reinforce the beneficial effects induced by anandamide and make it an attractive candidate for the management of those pathologies with neuroinflammation as one of their hallmarks...
  21. ncbi request reprint Therapeutic potential of CB2 targeting in multiple sclerosis
    Fabian Docagne
    Grupo de Neuroinmunología, Instituto Ramón y Cajal, CSIC Avda Dr Arce, 37, 28002 Madrid, Spain
    Expert Opin Ther Targets 12:185-95. 2008
    ..Thus, new hopes in MS therapy have arisen from the evidence for a cannabinoid receptor, termed CB2, which is devoid of psychoactive effects in animal models...
  22. ncbi request reprint The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety
    Eva Maria Marco
    Departamento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, c Jose Antonio Novais 2, Ciudad Universitaria, Madrid, Spain
    Behav Brain Res 163:212-8. 2005
    ..We provide the first evidence for the involvement of the kappa-opioid receptor in the stimulatory effect of nicotine on adrenocortical activity...
  23. doi request reprint Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice
    Diego Gómez-Nicola
    Neural Plasticity Group, Functional and Systems Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Exp Neurol 222:235-42. 2010
    ..How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated...
  24. pmc Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling
    Fernando Correa
    Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, CSIC Avda Dr Arce 37, 28002, Madrid, Spain
    Br J Pharmacol 145:441-8. 2005
    ..In contrast, the addition of exogenous mIL-10 reduced the secretion of IL-12p40 in response to LPS...
  25. doi request reprint Viral models of multiple sclerosis: neurodegeneration and demyelination in mice infected with Theiler's virus
    Miriam Mecha
    Neuroimmunology Group, Functional and System Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Prog Neurobiol 101:46-64. 2013
    ..Despite their limitations, viral models remain an important tool to study the etiology of MS, and to understand the clinical and pathological variability associated with this disease...
  26. ncbi request reprint Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments
    Felix Hernandez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Madrid, Spain
    J Neurochem 83:1529-33. 2002
    ..Additionally, these experiments suggest that destabilization of microtubules and alteration of intracellular metabolic pathways contribute to AD pathogenesis independent of toxicity triggered by the aberrant tau deposits...
  27. ncbi request reprint Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells
    Jose M Vela
    Neural Plasticity Unit, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, Madrid, Spain
    Mol Cell Neurosci 20:489-502. 2002
    ..These results support a role for IL-1beta in promoting mitotic arrest and differentiation of oligodendrocyte progenitors as well as maturation and survival of differentiating oligodendrocytes...
  28. doi request reprint Altered immune function in unaffected first-degree biological relatives of schizophrenia patients
    Isabel Martínez-Gras
    Department of Psychiatry, Faculty of Medicine, Complutense University, Madrid, Spain
    Psychiatry Res 200:1022-5. 2012
    ..This finding may provide a new data for considering cytokines as schizophrenic disease biomarkers...
  29. ncbi request reprint Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood
    Miguel Biscaia
    Departamento de Psicobiología de la UNED, Madrid, Spain
    Psychopharmacology (Berl) 170:301-8. 2003
    ..Despite the increasing use of cannabis among adolescents, there is scarce information about the long-term effects of cannabinoid receptor agonists in appropriate animal models...
  30. doi request reprint Understanding microglia-neuron cross talk: relevance of the microglia-neuron cocultures
    Fernando G Correa
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Methods Mol Biol 1041:215-29. 2013
    ..this coculture allows to combine neurons and microglial cells coming from wild-type and KO mice, making this coculture a useful method to study in vitro the interaction of different sets of ligand-receptor...
  31. ncbi request reprint Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes
    Eduardo Molina-Holgado
    Department of Neural Plasticity, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Neurochem 81:1242-52. 2002
    ..Overall, these data suggest a novel mechanism of action of IL-4 and IL-10, which abrogates NOS-2 expression in viral-infected glial cells...
  32. pmc Prospects for cannabinoid therapies in basal ganglia disorders
    Javier Fernandez-Ruiz
    Departamento de Bioquimica y Biologia Molecular III, Instituto Universitario de Investigación en Neuroquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 163:1365-78. 2011
    ....