Research Topics
| Oreste GualilloSummaryCountry: Spain Publications
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Detail Information
Publications
Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of actionOreste Gualillo
Santiago University Clinical Hospital, Research Area, Laboratory 4, 15705 Santiago de Compostela, Spain
FEBS Lett 552:105-9. 2003..The development of ghrelin analogs, agonists and antagonists, appears as a suitable approach for possible therapeutic intervention in a variety of disease states linked to alterations in body weight homeostasis...
Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytesJavier Conde
Correspondence to Dr Oreste Gualillo, Santiago University Clinical Hospital, Research Laboratory 9 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases Building C, Level 2, Calle Choupana s n, 15706, Santiago de Compostela, Spain
Ann Rheum Dis 70:551-9. 2011..Recently, it has been demonstrated that adipose tissue might contribute to degenerative joint diseases via the secretion of potent bioactive molecules termed adipokines...
Beyond fat mass: exploring the role of adipokines in rheumatic diseasesMorena Scotece
Laboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, SERGAS, Institute of Medical Research IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain
ScientificWorldJournal 11:1932-47. 2011..The goal of this paper is to elucidate the recent findings concerning the involvement of adipokines in rheumatic diseases, such as rheumatoid arthritis (RA), osteoarthritis (OA), and systemic lupus erythematosus (SLE)...- Ghrelin, the same peptide for different functions: player or bystander?Francisca Lago
Santiago University Clinical Hospital, Research Area, Molecular and Cellular Cardiology Laboratory 1, 15705 Santiago de Compostela, Spain
Vitam Horm 71:405-32. 2005..In this review, we summarize several aspects of ghrelin biology and attempt to inform the reader with information regarding unexpected functions of this gastric peptide... - Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunityJavier Conde
NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Building C, Level 2, Santiago de Compostela, Spain
Biofactors 37:413-20. 2011..In this review article, we discuss the main biological activities of leptin, adiponectin, lipocalin-2, resistin, and visfatin, as well as their contributions to certain inflammatory conditions... - Leptin beyond body weight regulation--current concepts concerning its role in immune function and inflammationRocio Lago
Santiago University Clinical Hospital, Research Laboratory 4 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Calle Choupana s n, 15706 Santiago de Compostela, Spain
Cell Immunol 252:139-45. 2008..Here, we review the most recent advances on leptin biology with a particular attention to its adipokine facet, even though its role as metabolic hormone will be also addressed... - Adipokines as emerging mediators of immune response and inflammationFrancisca Lago
Molecular and Cellular Cardiology Research Laboratory, Santiago University Clinical Hospital, Santiago de Compostela, Spain
Nat Clin Pract Rheumatol 3:716-24. 2007.... - Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell lineAnna Iacono
Santiago University Clinical Hospital, Santiago de Compostela, Spain
Arthritis Rheum 62:1675-82. 2010..We undertook this study to evaluate the effect of oleocanthal and its derivatives on the modulation of NO production in chondrocytes... - Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytesJavier Conde
NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Santiago de Compostela, Spain
PLoS ONE 7:e52533. 2012..There are several factors involved in the pathogenesis of these diseases including pro-inflammatory cytokines, adipokines and adhesion molecules... - One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effectsOreste Gualillo
Santiago University Clinical Hospital, Research Laboratory 4 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago de Compostela, Spain
Mol Cell Endocrinol 256:1-8. 2006..In this review we will summarize the steps which led to the identification of pre-proghrelin gene products and will examine the significance and perspectives of the different peptides generated from the same ancestor gene... - The emerging role of adipokines as mediators of inflammation and immune responsesFrancisca Lago
Santiago University Clinical Hospital, Research Laboratory 1 Molecular and Cellular Cardiology, Santiago de Compostela, Spain
Cytokine Growth Factor Rev 18:313-25. 2007..Here, we review recent adipokine research, with particular attention to the roles of leptin, adiponectin, resistin, visfatin, apelin, vaspin and hepcidin in such conditions... - Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytesRodolfo Gomez
Santiago University Clinical Hospital, Santiago University School of Medicine, Santiago de Compostela, Spain
Arthritis Rheum 60:1704-9. 2009.... - Adipokines in the skeleton: influence on cartilage function and joint degenerative diseasesRodolfo Gomez
Research Laboratory 9, NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago University Clinical Hospital, Santiago de Compostela, Spain
J Mol Endocrinol 43:11-8. 2009..Herein, we review recent adipokine research, with particular emphasis to the role of leptin, adiponectin, resistin, and visfatin in chondrocyte function and skeleton, as well as in inflammatory and degenerative cartilage joint diseases... - What's new in our understanding of the role of adipokines in rheumatic diseases?Rodolfo Gomez
SERGAS, Santiago University Clinical Hospital, Research Laboratory, Institute of Medical Research, Travesía de la Choupana, Santiago de Compostela, Spain
Nat Rev Rheumatol 7:528-36. 2011.... - At the crossroad between immunity and metabolism: focus on leptinJavier Conde
Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammation Disease, Building C, Level 2, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Calle Choupana s n, Santiago de Compostela, 15706, Spain
Expert Rev Clin Immunol 6:801-8. 2010..Thus, leptin can easily be considered a frank mediator of the inflammatory/immune response... - The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectivesOreste Gualillo
Research Laboratory 4 Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain
Trends Cardiovasc Med 17:275-83. 2007..Here we review recent adipokine research, with particular attention to the roles of adiponectin, leptin, resistin, visfatin, apelin, omentin, and chemerin in such conditions... - Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytesMiguel Otero
NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases Laboratory, Santiago University Clinical Hospital, Research Laboratory 4, Santiago de Compostela, Spain
Life Sci 81:1452-60. 2007..This is the first report showing that NOS type II induction triggered by co-stimulation with leptin and interferon-gamma is mediated by a signaling pathway involving PI-3K, MEK1 and p38... - Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1Miguel Otero
NEIRID (NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases) Laboratory, Santiago University Clinical Hospital, Research Laboratory 4, Santiago de Compostela, Spain
Arthritis Res Ther 7:R581-91. 2005..This study indicates that leptin plays a proinflammatory role, in synergy with IL-1, by inducing NOS type II through a signalling pathway that involves JAK2, PI3K, MEK-1 and p38 kinase... - Leptin, from fat to inflammation: old questions and new insightsMiguel Otero
Santiago University Clinical Hospital, Research Laboratory 4 (Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago de Compostela, Spain
FEBS Lett 579:295-301. 2005..Here, we review the recent advances regarding leptin biology with a special focus on those actions relevant to the role of leptin in the pathophysiology of inflammatory processes and immune responses... - Ghrelin plasmatic levels in patients with fibromyalgiaMiguel Otero
Research Area, Research Laboratory 4, Santiago University Clinical Hospital, Trav. Choupana sn, 15706 Santiago de Compostela, Spain
Rheumatol Int 25:6-8. 2005..In conclusion, FM is not associated with deviation in ghrelin concentrations. Existing alterations in FM with respect to GH are unlikely due to circulating ghrelin... - Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytesMaría J Iglesias
Unidad de Investigación del Servicio de Cardiología, Laboratorio de Investigación 1, Planta Baja, Area de Investigación y Docencia, Hospital Clinico Universitario de Santiago de Compostela, Travesía Choupana s n, 15706, Santiago de Compostela, Spain
Cardiovasc Res 62:481-8. 2004..This work investigated whether cardiomyocytes synthesize and secrete ghrelin, and how its production in these cells responds to stress and exogenous apoptotic agents... - Unlike ghrelin, obestatin does not exert any relevant activity in chondrocytesRocio Lago
Ann Rheum Dis 66:1399-400. 2007 - Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific mannerRuben Nogueiras
Department of Physiology, University of Santiago de Compostela, School of Medicine, 15705, Santiago de Compostela, Spain
FEBS Lett 548:21-7. 2003..Thus, our data suggest that resistin is not exclusively localized in adipocytes, and indicate that its expression is regulated in a tissue- and sex-specific manner... - Regulation of resistin by gonadal, thyroid hormone, and nutritional statusRuben Nogueiras
Department of Physiology, Universitario de Santiago, Santiago de Compostela, Spain
Obes Res 11:408-14. 2003..The aim of this study was to assess the influence of gender, gonadal status, thyroid hormones, pregnancy, and food restriction on resistin mRNA levels in adipose tissue of rats... - Effect of food restriction on ghrelin in normal-cycling female rats and in pregnancyOreste Gualillo
Complexo Hospitalario Universitario de Santiago, Santiago, Spain
Obes Res 10:682-7. 2002..The aim of this study was to clarify the physiological implications of ghrelin in the regulation of energy balance, by assessing the effect of undernutrition throughout 21 days in normal-cycling and pregnant rats on ghrelin...