Oreste Gualillo

Summary

Country: Spain

Publications

  1. ncbi Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action
    Oreste Gualillo
    Santiago University Clinical Hospital, Research Area, Laboratory 4, 15705 Santiago de Compostela, Spain
    FEBS Lett 552:105-9. 2003
  2. doi Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes
    Javier Conde
    Correspondence to Dr Oreste Gualillo, Santiago University Clinical Hospital, Research Laboratory 9 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases Building C, Level 2, Calle Choupana s n, 15706, Santiago de Compostela, Spain
    Ann Rheum Dis 70:551-9. 2011
  3. pmc Beyond fat mass: exploring the role of adipokines in rheumatic diseases
    Morena Scotece
    Laboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, SERGAS, Institute of Medical Research IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain
    ScientificWorldJournal 11:1932-47. 2011
  4. ncbi Adiponectin and leptin: new targets in inflammation
    Morena Scotece
    NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Santiago de Compostela, Spain
    Basic Clin Pharmacol Toxicol 114:97-102. 2014
  5. ncbi NUCB2/nesfatin-1: a new adipokine expressed in human and murine chondrocytes with pro-inflammatory properties, an in vitro study
    Morena Scotece
    SERGAS, Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Santiago de Compostela, 15706, Spain
    J Orthop Res 32:653-60. 2014
  6. doi Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity
    Javier Conde
    NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Building C, Level 2, Santiago de Compostela, Spain
    Biofactors 37:413-20. 2011
  7. ncbi Ghrelin, the same peptide for different functions: player or bystander?
    Francisca Lago
    Santiago University Clinical Hospital, Research Area, Molecular and Cellular Cardiology Laboratory 1, 15705 Santiago de Compostela, Spain
    Vitam Horm 71:405-32. 2005
  8. pmc Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes
    Javier Conde
    NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Santiago de Compostela, Spain
    PLoS ONE 7:e52533. 2012
  9. ncbi Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery?
    Morena Scotece
    Santiago University Clinical Hospital, SERGAS, Division of Rheumatology, Research Laboratory 9, Santiago de Compostela, 15706, Spain
    Expert Opin Drug Discov 9:945-57. 2014
  10. ncbi Leptin beyond body weight regulation--current concepts concerning its role in immune function and inflammation
    Rocio Lago
    Santiago University Clinical Hospital, Research Laboratory 4 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Calle Choupana s n, 15706 Santiago de Compostela, Spain
    Cell Immunol 252:139-45. 2008

Collaborators

Detail Information

Publications33

  1. ncbi Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action
    Oreste Gualillo
    Santiago University Clinical Hospital, Research Area, Laboratory 4, 15705 Santiago de Compostela, Spain
    FEBS Lett 552:105-9. 2003
    ..The development of ghrelin analogs, agonists and antagonists, appears as a suitable approach for possible therapeutic intervention in a variety of disease states linked to alterations in body weight homeostasis...
  2. doi Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes
    Javier Conde
    Correspondence to Dr Oreste Gualillo, Santiago University Clinical Hospital, Research Laboratory 9 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases Building C, Level 2, Calle Choupana s n, 15706, Santiago de Compostela, Spain
    Ann Rheum Dis 70:551-9. 2011
    ..Recently, it has been demonstrated that adipose tissue might contribute to degenerative joint diseases via the secretion of potent bioactive molecules termed adipokines...
  3. pmc Beyond fat mass: exploring the role of adipokines in rheumatic diseases
    Morena Scotece
    Laboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, SERGAS, Institute of Medical Research IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain
    ScientificWorldJournal 11:1932-47. 2011
    ..The goal of this paper is to elucidate the recent findings concerning the involvement of adipokines in rheumatic diseases, such as rheumatoid arthritis (RA), osteoarthritis (OA), and systemic lupus erythematosus (SLE)...
  4. ncbi Adiponectin and leptin: new targets in inflammation
    Morena Scotece
    NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Santiago de Compostela, Spain
    Basic Clin Pharmacol Toxicol 114:97-102. 2014
    ..In this MiniReview, we discuss the role of adipokines in osteoarthritis and rheumatoid arthritis providing an updated overview of their pathophysiological role and potential use as therapeutic targets. ..
  5. ncbi NUCB2/nesfatin-1: a new adipokine expressed in human and murine chondrocytes with pro-inflammatory properties, an in vitro study
    Morena Scotece
    SERGAS, Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Santiago de Compostela, 15706, Spain
    J Orthop Res 32:653-60. 2014
    ..Finally, nesfatin-1 provoked a clear induction of pro-inflammatory agents, such as COX-2, IL-8, IL-6, and MIP-1α in human primary chondrocytes from OA patients...
  6. doi Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity
    Javier Conde
    NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Building C, Level 2, Santiago de Compostela, Spain
    Biofactors 37:413-20. 2011
    ..In this review article, we discuss the main biological activities of leptin, adiponectin, lipocalin-2, resistin, and visfatin, as well as their contributions to certain inflammatory conditions...
  7. ncbi Ghrelin, the same peptide for different functions: player or bystander?
    Francisca Lago
    Santiago University Clinical Hospital, Research Area, Molecular and Cellular Cardiology Laboratory 1, 15705 Santiago de Compostela, Spain
    Vitam Horm 71:405-32. 2005
    ..In this review, we summarize several aspects of ghrelin biology and attempt to inform the reader with information regarding unexpected functions of this gastric peptide...
  8. pmc Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes
    Javier Conde
    NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Santiago de Compostela, Spain
    PLoS ONE 7:e52533. 2012
    ..There are several factors involved in the pathogenesis of these diseases including pro-inflammatory cytokines, adipokines and adhesion molecules...
  9. ncbi Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery?
    Morena Scotece
    Santiago University Clinical Hospital, SERGAS, Division of Rheumatology, Research Laboratory 9, Santiago de Compostela, 15706, Spain
    Expert Opin Drug Discov 9:945-57. 2014
    ..Specifically, future research should look into the intimate mechanisms regulating peripheral and central activity of adipokines as it has potential for novel drug discovery. ..
  10. ncbi Leptin beyond body weight regulation--current concepts concerning its role in immune function and inflammation
    Rocio Lago
    Santiago University Clinical Hospital, Research Laboratory 4 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Calle Choupana s n, 15706 Santiago de Compostela, Spain
    Cell Immunol 252:139-45. 2008
    ..Here, we review the most recent advances on leptin biology with a particular attention to its adipokine facet, even though its role as metabolic hormone will be also addressed...
  11. ncbi Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line
    Anna Iacono
    Santiago University Clinical Hospital, Santiago de Compostela, Spain
    Arthritis Rheum 62:1675-82. 2010
    ..We undertook this study to evaluate the effect of oleocanthal and its derivatives on the modulation of NO production in chondrocytes...
  12. ncbi An update on leptin as immunomodulator
    Javier Conde
    SERGAS Servizo Galego de Saude and IDIS Instituto de Investigación Sanitaria de Santiago, the NEIRID Lab Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain
    Expert Rev Clin Immunol 10:1165-70. 2014
    ..In this review, we have explored the recent evidence about the relationship between leptin and immune system, summarizing the most important findings related to the involvement of leptin in both innate and adaptive immune response. ..
  13. pmc Adipokines, metabolic syndrome and rheumatic diseases
    Vanessa Abella
    SERGAS, Research Laboratory 9, NEIRID Lab Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, Institute of Medical Research IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain Department of Molecular and Cellular Biology, University of Coruña UDC, 15071 A Coruna, Spain
    J Immunol Res 2014:343746. 2014
    ..In the present paper, we review recent evidence of the role played by adipokines in the modulation of MetS in the general population, and in patients with rheumatic diseases. ..
  14. ncbi Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes
    Miguel Otero
    NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases Laboratory, Santiago University Clinical Hospital, Research Laboratory 4, Santiago de Compostela, Spain
    Life Sci 81:1452-60. 2007
    ..This is the first report showing that NOS type II induction triggered by co-stimulation with leptin and interferon-gamma is mediated by a signaling pathway involving PI-3K, MEK1 and p38...
  15. ncbi Adipokines as emerging mediators of immune response and inflammation
    Francisca Lago
    Molecular and Cellular Cardiology Research Laboratory, Santiago University Clinical Hospital, Santiago de Compostela, Spain
    Nat Clin Pract Rheumatol 3:716-24. 2007
    ....
  16. doi What's new in our understanding of the role of adipokines in rheumatic diseases?
    Rodolfo Gomez
    SERGAS, Santiago University Clinical Hospital, Research Laboratory, Institute of Medical Research, Travesía de la Choupana, Santiago de Compostela, Spain
    Nat Rev Rheumatol 7:528-36. 2011
    ....
  17. doi Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes
    Rodolfo Gomez
    Santiago University Clinical Hospital, Santiago University School of Medicine, Santiago de Compostela, Spain
    Arthritis Rheum 60:1704-9. 2009
    ....
  18. doi Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases
    Rodolfo Gomez
    Research Laboratory 9, NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago University Clinical Hospital, Santiago de Compostela, Spain
    J Mol Endocrinol 43:11-8. 2009
    ..Herein, we review recent adipokine research, with particular emphasis to the role of leptin, adiponectin, resistin, and visfatin in chondrocyte function and skeleton, as well as in inflammatory and degenerative cartilage joint diseases...
  19. ncbi The emerging role of adipokines as mediators of inflammation and immune responses
    Francisca Lago
    Santiago University Clinical Hospital, Research Laboratory 1 Molecular and Cellular Cardiology, Santiago de Compostela, Spain
    Cytokine Growth Factor Rev 18:313-25. 2007
    ..Here, we review recent adipokine research, with particular attention to the roles of leptin, adiponectin, resistin, visfatin, apelin, vaspin and hepcidin in such conditions...
  20. ncbi One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects
    Oreste Gualillo
    Santiago University Clinical Hospital, Research Laboratory 4 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago de Compostela, Spain
    Mol Cell Endocrinol 256:1-8. 2006
    ..In this review we will summarize the steps which led to the identification of pre-proghrelin gene products and will examine the significance and perspectives of the different peptides generated from the same ancestor gene...
  21. ncbi Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes
    Rodolfo Gomez
    SERGAS IDIS, Servizo Galego de Saude and Instituto de Investigación Sanitaria de Santiago, The NEIRID NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases Laboratory, Santiago University Clinical Hospital, Research Laboratory 9, Santiago de Compostela, Spain
    J Orthop Res 32:1137-46. 2014
    ..2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:1137-1146, 2014. ..
  22. doi Adipokines as drug targets in joint and bone disease
    Morena Scotece
    SERGAS, Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Santiago de Compostela 15706, Spain
    Drug Discov Today 19:241-58. 2014
    ..We discuss clinical implications and then survey attempts to exploit this role for therapeutic gain, which holds potential as a novel approach for drug development in bone and joint disease. ..
  23. ncbi The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives
    Oreste Gualillo
    Research Laboratory 4 Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain
    Trends Cardiovasc Med 17:275-83. 2007
    ..Here we review recent adipokine research, with particular attention to the roles of adiponectin, leptin, resistin, visfatin, apelin, omentin, and chemerin in such conditions...
  24. ncbi At the crossroad between immunity and metabolism: focus on leptin
    Javier Conde
    Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammation Disease, Building C, Level 2, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Calle Choupana s n, Santiago de Compostela, 15706, Spain
    Expert Rev Clin Immunol 6:801-8. 2010
    ..Thus, leptin can easily be considered a frank mediator of the inflammatory/immune response...
  25. pmc Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1
    Miguel Otero
    NEIRID NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases Laboratory, Santiago University Clinical Hospital, Research Laboratory 4, Santiago de Compostela, Spain
    Arthritis Res Ther 7:R581-91. 2005
    ..This study indicates that leptin plays a proinflammatory role, in synergy with IL-1, by inducing NOS type II through a signalling pathway that involves JAK2, PI3K, MEK-1 and p38 kinase...
  26. ncbi Leptin, from fat to inflammation: old questions and new insights
    Miguel Otero
    Santiago University Clinical Hospital, Research Laboratory 4 Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago de Compostela, Spain
    FEBS Lett 579:295-301. 2005
    ..Here, we review the recent advances regarding leptin biology with a special focus on those actions relevant to the role of leptin in the pathophysiology of inflammatory processes and immune responses...
  27. doi Ghrelin requires p53 to stimulate lipid storage in fat and liver
    Begoña Porteiro
    Department of Physiology, Centre of Research in Molecular Medicine and Chronic Diseases of the University of Santiago de Compostela CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Avda Barcelona s n, 15782, Santiago de Compostela A Coruña, Spain, and CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Endocrinology 154:3671-9. 2013
    ..Thus, our results show that p53 is necessary for the actions of ghrelin on WAT and liver, leading to changes in expression levels of lipogenic and adipogenic genes, and modifying body weight. ..
  28. ncbi Ghrelin plasmatic levels in patients with fibromyalgia
    Miguel Otero
    Research Area, Research Laboratory 4, Santiago University Clinical Hospital, Trav Choupana sn, 15706 Santiago de Compostela, Spain
    Rheumatol Int 25:6-8. 2005
    ..In conclusion, FM is not associated with deviation in ghrelin concentrations. Existing alterations in FM with respect to GH are unlikely due to circulating ghrelin...
  29. ncbi Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes
    María J Iglesias
    Unidad de Investigación del Servicio de Cardiología, Laboratorio de Investigación 1, Planta Baja, Area de Investigación y Docencia, Hospital Clinico Universitario de Santiago de Compostela, Travesía Choupana s n, 15706, Santiago de Compostela, Spain
    Cardiovasc Res 62:481-8. 2004
    ..This work investigated whether cardiomyocytes synthesize and secrete ghrelin, and how its production in these cells responds to stress and exogenous apoptotic agents...
  30. ncbi Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, School of Medicine, 15705, Santiago de Compostela, Spain
    FEBS Lett 548:21-7. 2003
    ..Thus, our data suggest that resistin is not exclusively localized in adipocytes, and indicate that its expression is regulated in a tissue- and sex-specific manner...
  31. ncbi Regulation of resistin by gonadal, thyroid hormone, and nutritional status
    Ruben Nogueiras
    Department of Physiology, Universitario de Santiago, Santiago de Compostela, Spain
    Obes Res 11:408-14. 2003
    ..The aim of this study was to assess the influence of gender, gonadal status, thyroid hormones, pregnancy, and food restriction on resistin mRNA levels in adipose tissue of rats...
  32. pmc Unlike ghrelin, obestatin does not exert any relevant activity in chondrocytes
    Rocio Lago
    Ann Rheum Dis 66:1399-400. 2007
  33. ncbi Effect of food restriction on ghrelin in normal-cycling female rats and in pregnancy
    Oreste Gualillo
    Complexo Hospitalario Universitario de Santiago, Santiago, Spain
    Obes Res 10:682-7. 2002
    ..The aim of this study was to clarify the physiological implications of ghrelin in the regulation of energy balance, by assessing the effect of undernutrition throughout 21 days in normal-cycling and pregnant rats on ghrelin...