F Graus

Summary

Country: Spain

Publications

  1. ncbi request reprint [Limbic encephalitis: a probably under-recognized syndrome]
    F Graus
    Servicio de Neurologia, Hospital Clinic, Barcelona
    Neurologia 20:24-30. 2005
  2. pmc Patterns of care and outcome for patients with glioblastoma diagnosed during 2008-2010 in Spain
    Francesc Graus
    Service of Neurology, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Neuro Oncol 15:797-805. 2013
  3. pmc Paraneoplastic neurological syndromes
    Francesc Graus
    Service of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Curr Opin Neurol 25:795-801. 2012
  4. pmc Human epidermal growth factor receptor 2 overexpression in breast cancer of patients with anti-Yo--associated paraneoplastic cerebellar degeneration
    Iñigo Rojas-Marcos
    Service of Neurology and Pathology, Hospital Juan Ramon Jimenez, Huelva, Spain
    Neuro Oncol 14:506-10. 2012
  5. pmc Validation of the new Graded Prognostic Assessment scale for brain metastases: a multicenter prospective study
    Salvador Villa
    Department of Radiation Oncology and Clinical Epidemiology, Geneva University Hospital, Geneva, Switzerland
    Radiat Oncol 6:23. 2011
  6. pmc Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations
    F Graus
    Servei de Neurologia, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Neurology 71:930-6. 2008
  7. ncbi request reprint Neuro-oncology: setting new standards of management
    Francesc Graus
    Servei de Neurologia, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Lancet Neurol 5:8-9. 2006
  8. pmc Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes
    F Graus
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Villarroel 170, Barcelona 08036, Spain
    J Neuroimmunol 165:166-71. 2005
  9. ncbi request reprint Paraneoplastic neurological syndromes: diagnosis and treatment
    Francesc Graus
    aService of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Curr Opin Neurol 20:732-7. 2007
  10. doi request reprint Antiglycine-receptor encephalomyelitis with rigidity
    Natàlia Mas
    Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 82:1399-401. 2011

Detail Information

Publications93

  1. ncbi request reprint [Limbic encephalitis: a probably under-recognized syndrome]
    F Graus
    Servicio de Neurologia, Hospital Clinic, Barcelona
    Neurologia 20:24-30. 2005
    ..On the contrary, immunosuppressant treatment is not usually effective in limbic encephalitis associated to anti-Hu antibodies...
  2. pmc Patterns of care and outcome for patients with glioblastoma diagnosed during 2008-2010 in Spain
    Francesc Graus
    Service of Neurology, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Neuro Oncol 15:797-805. 2013
    ..To assess management patterns and outcome in patients with glioblastoma multiforme (GBM) treated during 2008-2010 in Spain...
  3. pmc Paraneoplastic neurological syndromes
    Francesc Graus
    Service of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Curr Opin Neurol 25:795-801. 2012
    ..This review describes relevant advances in paraneoplastic neurological syndromes (PNS) with emphasis on particular syndromes and the impact of antibodies against surface antigens in their management...
  4. pmc Human epidermal growth factor receptor 2 overexpression in breast cancer of patients with anti-Yo--associated paraneoplastic cerebellar degeneration
    Iñigo Rojas-Marcos
    Service of Neurology and Pathology, Hospital Juan Ramon Jimenez, Huelva, Spain
    Neuro Oncol 14:506-10. 2012
    ..Although the expression of cdr2 onconeural antigen is not high in HER2-positive breast cancers, HER2 overexpression seems to be an important requirement to develop an anti-Yo-associated PCD...
  5. pmc Validation of the new Graded Prognostic Assessment scale for brain metastases: a multicenter prospective study
    Salvador Villa
    Department of Radiation Oncology and Clinical Epidemiology, Geneva University Hospital, Geneva, Switzerland
    Radiat Oncol 6:23. 2011
    ..We evaluated the new Graded Prognostic Assessment (GPA) scale in a prospective validation study to compare it with two published prognostic indexes...
  6. pmc Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations
    F Graus
    Servei de Neurologia, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Neurology 71:930-6. 2008
    ..To report the frequency and type of antibodies against neuronal surface antigens (NSA-ab) in limbic encephalitis (LE)...
  7. ncbi request reprint Neuro-oncology: setting new standards of management
    Francesc Graus
    Servei de Neurologia, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Lancet Neurol 5:8-9. 2006
  8. pmc Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes
    F Graus
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Villarroel 170, Barcelona 08036, Spain
    J Neuroimmunol 165:166-71. 2005
    ..0006). We conclude that the recognition of AGNA is helpful since this antibody is found in PNS associated with SCLC, particularly LEMS, in which other onconeural antibodies are absent...
  9. ncbi request reprint Paraneoplastic neurological syndromes: diagnosis and treatment
    Francesc Graus
    aService of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Curr Opin Neurol 20:732-7. 2007
    ..The most relevant advances in the field of paraneoplastic neurological syndromes are described, with special emphasis on particular clinical-immunological associations and practical issues for the diagnosis and treatment of these disorders...
  10. doi request reprint Antiglycine-receptor encephalomyelitis with rigidity
    Natàlia Mas
    Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 82:1399-401. 2011
    ..Glycine receptor antibodies (GlyR-ab) were reported in a patient with progressive encephalomyelitis with rigidity and myoclonus (PERM)...
  11. doi request reprint Antibodies and neuronal autoimmune disorders of the CNS
    Francesc Graus
    Servei de Neurologia, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, Villarroel 170, 08036, Barcelona, Spain
    J Neurol 257:509-17. 2010
    ....
  12. ncbi request reprint SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome
    L Sabater
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona 08036, Spain
    Neurology 70:924-8. 2008
    ..This study was undertaken to identify the antigen recognized by AGNA and to confirm the association with paraneoplastic LEMS in a larger series...
  13. ncbi request reprint Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients
    F Graus
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, Villaroel 170, Barcelona 08036, Spain
    Brain 124:1138-48. 2001
    ..Finally, the predictors of mortality and PEM evolution found in the study may be important in the design of future therapeutic protocols, and emphasize the importance of early diagnosis and treatment of the underlying tumour...
  14. ncbi request reprint MRI and CSF oligoclonal bands after autologous hematopoietic stem cell transplantation in MS
    A Saiz
    Services of Neurology, , , University of Barcelona, Spain
    Neurology 56:1084-9. 2001
    ....
  15. ncbi request reprint [Clinical outcome 6 years after autologous hematopoietic stem cell transplantation in multiple sclerosis]
    A Saiz
    Servicio de Neurologia, Hematología Hospital Clínic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona
    Neurologia 23:405-7. 2008
    ..We describe the clinical outcome of 14 patients included in a protocol of AHSCT after a median follow-up period of 6 years...
  16. ncbi request reprint Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival
    F Graus
    Service of Neurology, Hospital Clinic i Provincial, Barcelona, Spain
    J Clin Oncol 15:2866-72. 1997
    ..Based on these observations, we conducted a multicenter prospective study of SCLC patients without PEM/SN to determine the incidence and prognostic implications of HuAb...
  17. ncbi request reprint Value of Hu antibody determinations in the follow-up of paraneoplastic neurologic syndromes
    A Lladó
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona Spain
    Neurology 63:1947-9. 2004
    ..No correlation was observed between Hu-Ab titers and neurologic outcome, tumor evolution, or type of treatment. Serial Hu-Ab determinations are not useful for monitoring the clinical outcome of patients with PNS...
  18. doi request reprint Does gender matter in glioblastoma?
    E Verger
    Institute of Haematology and Oncology, Department of Radiation Oncology, Hospital Clinic, University of Barcelona, Spain
    Clin Transl Oncol 13:737-41. 2011
    ..Independent predictors were older age and low KPS. These poor risk variables were more frequent in women and their survival was therefore lower than men in our series...
  19. doi request reprint Anti-Hu-associated brainstem encephalitis
    A Saiz
    Servei de Neurologia, Hospital Clinic, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 80:404-7. 2009
    ..A series of patients with anti-Hu-associated brainstem encephalitis is reviewed to better define the clinical presentation and to improve its recognition...
  20. ncbi request reprint Effect of glatiramer acetate (Copaxone) on the immunophenotypic and cytokine profile and BDNF production in multiple sclerosis: a longitudinal study
    Y Blanco
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Neurosci Lett 406:270-5. 2006
    ....
  21. ncbi request reprint [Clinical spectrum associated with aquaporin-4 antibodies (NMO-IgG)]
    Y Blanco
    Servei de Neurologia, Hospital Clinic, Universitat de Barcelona e Institut d Investigació August Pi i Sunyer IDIBAPS, Barcelona, Espana
    Neurologia 25:5-12. 2010
    ....
  22. pmc Protein kinase Cgamma autoimmunity in paraneoplastic cerebellar degeneration and non-small-cell lung cancer
    L Sabater
    Service of Neurology, Hospital Clinic, and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 77:1359-62. 2006
    ..The clinical and immunological profiles of patients with paraneoplastic cerebellar degeneration (PCD) and non-small-cell lung cancer (NSCLC) are not well known...
  23. ncbi request reprint No association of the Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) to multiple sclerosis
    Y Blanco
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Neurosci Lett 396:217-9. 2006
    ..Moreover, we did not observe, in a subgroup of 12 MS patients, that the methionine substitution at position 66 in the prodomain had negative impact in the capacity to produce BDNF by peripheral blood mononuclear cells (PBMC)...
  24. ncbi request reprint P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer
    F Graus
    Services of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Neurology 59:764-6. 2002
    ..Seven of 15 CSF samples had VGCC antibodies, with evidence of intrathecal synthesis in four. VGCC antibodies should be looked for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar dysfunction...
  25. ncbi request reprint The impact of the introduction of the 14-3-3 protein assay in the surveillance of sporadic Creutzfeldt-Jakob disease in Catalonia
    A Saiz
    Service of Neurology, Hospital Clinic, Barcelona, Spain
    J Neurol 248:592-4. 2001
    ..Our findings suggest an improvement of case ascertainment in part due to the introduction of the 14-3-3 assay in the surveillance system...
  26. doi request reprint Analysis of antibodies to neuronal surface antigens in adult opsoclonus-myoclonus
    L Sabater
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, and Institut d Investigació Biomèdica August Pi i Sunye, Barcelona, Spain
    J Neuroimmunol 196:188-91. 2008
    ..OMS sera did not label live CGN by immunocytochemistry. Unlike pediatric OMS, NSA-ab were not detected in adult cases suggesting that the immunity to NSA in OMS is heterogeneous...
  27. ncbi request reprint [Paraneoplastic retinopathy and anti-recoverin antibodies]
    L Bataller
    Servicio de Neurologia, Hospital Universitario La Fe, Valencia, Spain
    Neurologia 17:156. 2002
  28. pmc Recommended diagnostic criteria for paraneoplastic neurological syndromes
    F Graus
    Service of Neurology, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    J Neurol Neurosurg Psychiatry 75:1135-40. 2004
    ....
  29. ncbi request reprint Evolution of brain-derived neurotrophic factor levels after autologous hematopietic stem cell transplantation in multiple sclerosis
    Y Blanco
    Services of Neurology, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Neurosci Lett 380:122-6. 2005
    ..Our study suggests that AHSCT can reduce BDNF levels to values associated with lower activity. This decrease does not seem to correlate with the brain atrophy measures observed in the MRI...
  30. ncbi request reprint 14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis
    A Martinez-Yelamos
    Service of Neurology, Ciutat Sanitaria Universitaria de Bellvitge, L Hospitalet, Spain
    Neurology 57:722-4. 2001
    ..8; 95% CI 2.86 to 76.8). The detection of the 14-3-3 protein in the CSF at the first neurologic event suggestive of MS may be a useful predictor of short-term evolution...
  31. ncbi request reprint Prevalence of restless legs syndrome and REM sleep behavior disorder in multiple sclerosis
    M J Gómez-Choco
    Service of Neurology, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Mult Scler 13:805-8. 2007
    ..Our study shows that RLS in MS is not more frequent than in the general population, and that RBD, although uncommon, may occur in the setting of this neurological disease...
  32. ncbi request reprint Clinical and MRI outcome after autologous hematopoietic stem cell transplantation in MS
    A Saiz
    Services of Neurology, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    Neurology 62:282-4. 2004
    ..The mean change in T2 lesion volume from baseline to the third year was -20.2% and that of the corpus callosum area was -12.7%; 50% of this reduction was seen during the first year...
  33. ncbi request reprint Homer 3 autoimmunity in subacute idiopathic cerebellar ataxia
    L Zuliani
    Service of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Neurology 68:239-40. 2007
  34. ncbi request reprint Dramatic improvement of POEMS syndrome following autologous haematopoietic cell transplantation
    M Rovira
    Department of Haematology, BMT Unit, Postgraduate School of Haematology Farreras Valenti, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Br J Haematol 115:373-5. 2001
    ..We believe that this is the first reported case of POEMS syndrome treated with AHCT, a procedure that could be considered in similarly affected patients...
  35. doi request reprint Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months
    S Llufriu
    Neurology Service, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer, 08036 Barcelona, Spain
    Neurology 73:949-53. 2009
    ..Plasma exchange (PE) is used to treat severe episodes of CNS demyelination unresponsive to corticosteroids. Predictors of long-term response are not well known...
  36. pmc GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders
    A Boronat
    Servei de Neurologia, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Neurology 76:795-800. 2011
    ..We analyzed the frequency of GABA(B)R-ab in 147 patients with LE or neurologic syndromes associated with GAD-ab...
  37. ncbi request reprint [HLA-DRB1 typing in Caucasians patients with neuromyelitis optica]
    Y Blanco
    Servicio de Neurologia, Hospital Clínicm, Barcelona, Espana
    Rev Neurol 53:146-52. 2011
    ..Our study was aimed to analyze HLA-DRB1 distribution in Caucasians NMO patients...
  38. ncbi request reprint [MM1 variant of sporadic Creutzfeldt-Jakob disease with long duration akinetic mutism state]
    R Sanchez-Valle
    Unit de ECJ, Servei de Neurologia, Hospital Clinic, Institut d Investgació, Biomedica August Pi i Sunyer, Universitat de Barcelona
    Neurologia 21:444-6. 2006
    ....
  39. ncbi request reprint Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis
    F Graus
    Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain
    Neurosci Lett 112:14-8. 1990
    ..Although the Hu is also expressed by neural cells other than neurons, the strongest staining of mature neurons could indicate that Hu plays a role in the process of neuronal differentiation...
  40. doi request reprint Analysis of relapses in anti-NMDAR encephalitis
    I Gabilondo
    Center for Neuroimmunology, Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Neurology 77:996-9. 2011
    ..The clinical characteristics of patients with relapsing anti-NMDA receptor (NMDAR) encephalitis are not well-defined. In this study, we report the clinical profile and outcome of relapses in a series of anti-NMDAR encephalitis...
  41. ncbi request reprint Absence of REM sleep, altered NREM sleep and supranuclear horizontal gaze palsy caused by a lesion of the pontine tegmentum
    F Valldeoriola
    Sleep Disorders Unit, Universitat de Barcelona, Hospital Clinic i Provincial, Spain
    Sleep 16:184-8. 1993
    ..Interruption of connections between the tegmentum of the pons and the reticular nuclei of the thalamus could be the cause of the absence of sleep spindles...
  42. ncbi request reprint Revised diagnostic criteria for neuromyelitis optica (NMO). Application in a series of suspected patients
    Albert Saiz
    Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, University of Barcelona, Villarroel 170, Barcelona, 08036 Spain
    J Neurol 254:1233-7. 2007
    ..25%; 87.5% vs. 62.5; 83.3% vs. 75%), but slightly lower sensitivity (87.5% vs. 93.7%). Our study confirms NMO-IgG as a highly specific marker of NMO, and the usefulness of the revised diagnostic criteria in predicting a diagnosis of NMO...
  43. ncbi request reprint Antineuronal antibodies in a group of children with obsessive-compulsive disorder and Tourette syndrome
    Astrid Morer
    Department of Child and Adolescent Psychiatry and Psychology, Institut Clínic de Neurociències, Hospital Clinic Universitari, Carrer Villarroel 170, Barcelona 08036, Spain
    J Psychiatr Res 42:64-8. 2008
    ..Though the study supports the hypothesis of an autoimmune process underlying OCD or TS in some patients, further research is needed...
  44. ncbi request reprint CD34+ selected autologous peripheral blood stem cell transplantation for multiple sclerosis: report of toxicity and treatment results at one year of follow-up in 15 patients
    Enric Carreras
    BMT Unit, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Haematologica 88:306-14. 2003
    ..We report the results of a phase II trial to evaluate feasibility and toxicity of CD34+ selected ASCT (CD34+/ASCT) and treatment results at one year of follow-up...
  45. ncbi request reprint Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis
    Alex Iranzo
    Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer, C Villaroel 170, 08036 Barcelona, Spain
    Ann Neurol 59:178-81. 2006
    ..In addition, these observations suggest that impairment of the limbic system may play a role in the pathogenesis of RBD...
  46. ncbi request reprint Pure sensory neuropathy in primary Sjögren's syndrome. Longterm prospective followup and review of the literature
    Josep Font
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Rheumatol 30:1552-7. 2003
    ..To study the clinical course, response to therapy, and longterm outcome of pure sensory neuropathy (PSN) in a series of patients with primary Sjögren's syndrome (SS) followed prospectively in our referral centers...
  47. doi request reprint Midbrain lesions and paroxysmal dysarthria in multiple sclerosis
    Y Blanco
    Service of Neurology, Hospital Clinic, Universitat de Barcelona and IDIBAPS, Villaroel 170, Barcelona, Spain
    Mult Scler 14:694-7. 2008
    ..All three patients had an acute lower midbrain lesion. The location was central in two patients and left paramedian in the other, and probably involving cerebellothalamocortical pathways. Treatment with carbamazepine was effective...
  48. ncbi request reprint Detection of 14-3-3 protein in the CSF of a patient with Hashimoto's encephalopathy
    L E Hernández Echebarría
    Service of Neurology, Hospital de Leon, Barcelona, Spain
    Neurology 54:1539-40. 2000
  49. doi request reprint White matter abnormalities in primary Sjögren syndrome
    M Akasbi
    Sjögren Syndrome Research Group AGAUR, Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Department of Autoimmune Diseases, Hospital do Meixoeiro, Vigo, Spain
    QJM 105:433-43. 2012
    ..Objective: To describe the main characteristics of patients with primary Sjögren syndrome (SS) and white matter abnormalities (WMA) seen by a specialist SS unit...
  50. pmc Pure sensory neuropathy in patients with primary Sjögren's syndrome: clinical, immunological, and electromyographic findings
    J Font
    Department of Internal Medicine, Hospital Clinic, Barcelona, Spain
    Ann Rheum Dis 49:775-8. 1990
    ..These findings indicate that in patients with a sensory neuropathy the diagnosis of Sjögren's syndrome has to be considered, even if the patient denies the presence of sicca symptoms, and that appropriate tests must be carried out...
  51. ncbi request reprint Central nervous system involvement in mantle cell lymphoma
    A Ferrer
    Department of Hematology, Hospital Clinic, Postgraduate School of Hematology Farreras Valenti, Institut d Investigacio Biomedica August Pi i Sunyer, Barcelona, Spain
    Ann Oncol 19:135-41. 2008
    ..Extranodal involvement, including central nervous system (CNS), is a frequent event in patients with mantle cell lymphoma (MCL). However, the incidence, risk factors, and impact on outcome remain controversial...
  52. doi request reprint Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study
    Lidia Sabater
    Service of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer, Spain
    J Neuroimmunol 215:31-5. 2009
    ..Our data show that NMO-IgG induces a complement-dependent cytotoxicity of astrocytes in vitro, and suggest that a mechanism of cellular death by necrosis might be implicated in the pathophysiology of NMO...
  53. pmc REM sleep behavior disorder and narcoleptic features in anti-Ma2-associated encephalitis
    Yaroslau Compta
    Neurology Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Sleep 30:767-9. 2007
    ....
  54. doi request reprint Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association
    Albert Saiz
    Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Brain 131:2553-63. 2008
    ..Lastly, in patients who develop neurological syndromes that suggest a PNS, the finding of GAD-ab does not rule out this possibility and appropriate studies should be done to confirm an underlying cancer...
  55. ncbi request reprint [Transplantation of haematopoietic stem cells in multiple sclerosis]
    A Saiz
    Servicio de Neurologia, Institut d Investigacio Biomedica August Pi i Sunyer, Hospital Clinic de Barcelona, Barcelona, Espana
    Rev Neurol 35:1136-41. 2002
    ..In any case, this treatment cannot be considered to cure the MS since the probability of patients having no signs of active disease 3 years after transplantation is 12% in SP MS and 0% in PP MS...
  56. ncbi request reprint [New treatments in brain tumors]
    F Graus
    Servicio de Neurologia, Hospital Clinic, Barcelona
    Neurologia 14:21-5. 1999
    ....
  57. ncbi request reprint [NMO-IgG antibodies in neuromyelitis optica: a report of 2 cases]
    L Zuliani
    Servicio de Neurologia, Hospital Clinico, Barcelona, Spain
    Neurologia 21:314-7. 2006
    ..The antigen responsible for this immune response seems to be aquaporin-4 water channel...
  58. ncbi request reprint Clinical and genetic features of human prion diseases in Catalonia: 1993-2002
    R Sanchez-Valle
    Services of Neurology, Institut d Investigació Biomédica August Pi i Sunyer IDABAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Eur J Neurol 11:649-55. 2004
    ..No case of variant CJD was registered. The study confirms in our population the consistent pattern reported worldwide on human prion diseases. Atypical features were seen more frequently in sporadic 129 V/V CJD and fCJD cases...
  59. ncbi request reprint Episodic hyperhidrosis as the only clinical manifestation of neuromyotonia
    M J Gómez-Choco
    Service of Neurology, Hospital Clinic, Barcelona, Spain
    Neurology 65:1331-2. 2005
  60. ncbi request reprint Pre-irradiation semi-intensive chemotherapy with carboplatin and cyclophosphamide in malignant glioma: a phase II study
    N Viñolas
    Institut Clinic de Malalties Hemato Oncológique, Hospital Clinic, University of Barcelona, Spain
    Anticancer Drugs 13:163-7. 2002
    ..No toxic death was related to treatment. This regimen showed limited activity in malignant glioma with large residual disease after surgery or biopsy...
  61. ncbi request reprint Salvage treatment with etoposide (VP-16), ifosfamide and cytarabine (Ara-C) for patients with recurrent primary central nervous system lymphoma
    Eduardo Arellano-Rodrigo
    Service of Hematology, Institut de Recerca Biomèdica August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Eur J Haematol 70:219-24. 2003
    ..However, the prognosis of patients who fail or relapse after initial response is poor. Very little data is available on salvage treatment at recurrence...
  62. pmc ZIC antibodies in paraneoplastic cerebellar degeneration and small cell lung cancer
    Lidia Sabater
    Service of Neurology Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neuroimmunol 201:163-5. 2008
    ..Our study suggests that 1) the incidence of isolated ZIC antibodies is low in PCD patients and SCLC and 2) ZIC antibodies are probably directed to epitopes shared by the three ZIC proteins...
  63. ncbi request reprint Autologous haematopoietic-stem-cell transplantation for multiple sclerosis
    Yolanda Blanco
    Service of Neurology, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, Spain
    Lancet Neurol 4:54-63. 2005
    ..The course of MS seems to be stabilised after autologous HSCT, especially in ambulatory patients with evidence of active disease. Autologous HSCT deserves further study in randomised controlled trials...
  64. ncbi request reprint Tau protein in cerebrospinal fluid: a possible marker of poor outcome in patients with early relapsing-remitting multiple sclerosis
    Antonio Martínez-Yélamos
    Department of Neurology, Hospital de Viladecans, Av Gava 380 08840 Viladecans, Barcelona, Spain
    Neurosci Lett 363:14-7. 2004
    ..CSF-TAU was the only independent variable to predict the time to next relapse. CSF-TAU, as a marker of axonal loss, may help us to predict short-term outcome in patients with early RRMS...
  65. ncbi request reprint BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis
    Lidia Sabater
    Service of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neuroimmunol 170:186-90. 2005
    ..Our study suggests BRSK2 may be an autoantigen involved in the pathogenesis of SCLC-associated limbic encephalitis...
  66. ncbi request reprint Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis
    Fabian Bernal
    Service of Neurology, Hospital Clinic Barcelona, Universitat de Barcelona, and Institut d Investigació Biomèdica August Pi i Sunyer, Villarroel 170, 08036 Barcelona, Spain
    Acta Neuropathol 103:509-15. 2002
    ..Our data point out to an induction of a cytotoxic, non-apoptotic, neuronal death in anti-Hu-associated PEM. The increased ICAM-1 immunoreactivity may favor the infiltration of lymphocytes in the pathological areas...
  67. ncbi request reprint [Comparative analysis of patients with narcolepsy-cataplexy, narcolepsy without cataplexy and idiopathic hypersomnia]
    Jose E Martinez-Rodriguez
    Servicio de Neurologia, Hospital Clinic, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Espana
    Med Clin (Barc) 128:361-4. 2007
    ....
  68. ncbi request reprint Isolated frontal disequilibrium as presenting form of anti-Hu paraneoplastic encephalomyelitis
    Yaroslau Compta
    Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Barcelona, Catalonia, Spain
    Mov Disord 22:736-8. 2007
    ..Only mild residual hyperintensities persist on follow-up MRI. A paraneoplastic syndrome should be considered in the differential diagnosis of subacute, fast progressive gait disorders...
  69. doi request reprint Neurologic complications of hematopoietic cell transplantation
    Albert Saiz
    Service of Neurology and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Semin Neurol 30:287-95. 2010
    ....
  70. ncbi request reprint Changes of matrix metalloproteinase-9 and its tissue inhibitor (TIMP-1) after autologous hematopoietic stem cell transplantation in multiple sclerosis
    Yolanda Blanco
    Services of Neurology, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, University of Barcelona, Villarroel 170, Barcelona 08036, Spain
    J Neuroimmunol 153:190-4. 2004
    ..MMP-9 mRNA levels correlated with the CD4+ T cell count (p<0.0001). The significant and persistent change in MMP-9 activity after AHSCT may be caused in part by the effect of AHSCT in the CD4+ T cell count...
  71. doi request reprint [Central nervous system involvement in primary Sjögren syndrome]
    Marta Ramírez
    Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Barcelona, Spain
    Med Clin (Barc) 133:349-59. 2009
    ..Differential diagnosis includes the coexistence of other systemic autoimmune diseases (lupus, antiphospholipid syndrome, vasculitis), cerebrovascular disease and multiple sclerosis...
  72. ncbi request reprint No association of inducible nitric oxide synthase gene ( NOS2A) to multiple sclerosis
    Yolanda Blanco
    Servei de Neurologia, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    J Neurol 250:598-600. 2003
    ..No association was found between MS susceptibility, course or outcome of the disease, and NOS2A polymorphisms...
  73. doi request reprint Cannabis use in Spanish patients with multiple sclerosis: fulfilment of patients' expectations?
    Jose E Martinez-Rodriguez
    Neurology Service, Hospital del Mar, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    J Neurol Sci 273:103-7. 2008
    ..The aim of the study was to evaluate the prevalence of cannabis use, related factors, and degree of satisfaction in Spanish patients with multiple sclerosis (MS) prior to the establishment of medically supervised use...
  74. ncbi request reprint Carbonic anhydrase-related protein VIII: autoantigen in paraneoplastic cerebellar degeneration
    Luis Bataller
    Service of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Ann Neurol 56:575-9. 2004
    ..The patient had intrathecal synthesis of CARP VIII antibodies. One of seven melanomas tested expressed CARP VIII. These data suggest CARP VIII may be an autoantigen involved in the pathogenesis of melanoma-associated PCD...
  75. ncbi request reprint Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial
    Eugenia Verger
    Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Int J Radiat Oncol Biol Phys 61:185-91. 2005
    ..To evaluate the safety profile and efficacy of whole brain radiotherapy (WBRT) concomitantly with temozolomide (TMZ) in patients with brain metastases (BM)...
  76. ncbi request reprint Evaluation of hypothalamic-specific autoimmunity in patients with narcolepsy
    Jose E Martinez-Rodriguez
    Neurology Service, Hospital Clínic de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Sleep 30:27-8. 2007
    ..The screening of the hypothalmic library detected some reactive clones but not a common reactivity. Our study did not find any evidence of hypothalamic-specific autoimmunity in narcolepsy...
  77. ncbi request reprint Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas
    Marta Brell
    Institut d Investigacio Biomedica de Bellvitge, Hospital Universitari de Bellvitge, Barcelona, Spain
    Clin Cancer Res 11:5167-74. 2005
    ..The aim of this study was to evaluate the prognostic significance of MGMT in patients with anaplastic glioma...
  78. pmc Central hypoventilation as the presenting symptom in Hu associated paraneoplastic encephalomyelitis
    Manuel J Gómez-Choco
    Hospital Clinic, Service of Neurology, Villarroel 170, Barcelona 08036, Spain
    J Neurol Neurosurg Psychiatry 78:1143-5. 2007
    ..All patients had normal brain imaging studies and the cause of central hypoventilation was an unsolved problem until Hu antibodies were determined...
  79. pmc Paraneoplastic limbic encephalitis associated with potassium channel antibodies: value of anti-glial nuclear antibodies in identifying the tumour
    Luigi Zuliani
    J Neurol Neurosurg Psychiatry 78:204-5. 2007
  80. ncbi request reprint Voltage-gated potassium channel antibodies in limbic encephalitis
    Patricia Pozo-Rosich
    Neurosciences Group, Weatherall Insitute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Neurol 54:530-3. 2003
    ..VGKC antibodies do not unambiguously discriminate between idiopathic or paraneoplastic LE but probably indicate a good response to immunotherapy...
  81. ncbi request reprint P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 164:161-5. 2005
    ..In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis...
  82. doi request reprint Limbic encephalitis: an expanding concept
    Francesc Graus
    Neurology 70:500-1. 2008
  83. ncbi request reprint Clinical analysis of anti-Ma2-associated encephalitis
    Josep Dalmau
    Department of Neurology, 3 W Gates, Division of Neuro Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Brain 127:1831-44. 2004
    ..In young male patients, the primary tumour is usually in the testis, in other patients the leading neoplasm is lung cancer...
  84. ncbi request reprint The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction
    Luis Bataller
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, USA
    Ann Neurol 53:123-7. 2003
    ..These findings suggest epitope spreading between the Tr antigen and the MAZ-DCC complex and offer a possible model of immune-mediated cerebellar disease...
  85. ncbi request reprint Prognostic implication of clinical, radiologic, and pathologic features in patients with anaplastic gliomas
    Avelina Tortosa
    Neuropathology Institute of Catalonia, Bellvitge Hospital CSUB, L Hospitalet, Spain
    Cancer 97:1063-71. 2003
    ..Previous studies merged patients with anaplastic glioma and the much more common glioblastoma multiforme. Therefore, the conclusions on prognostic factors reflected in part the consequences of an analysis in a heterogeneous population...
  86. ncbi request reprint Autoantigen diversity in the opsoclonus-myoclonus syndrome
    Luis Bataller
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Ann Neurol 53:347-53. 2003
    ....
  87. ncbi request reprint Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: an analysis of the CHOD/BVAM regimen followed by two different radiotherapy treatments
    E M Bessell
    Department of Clinical Oncology, Nottingham City Hospital, Nottingham, United Kingdom
    J Clin Oncol 20:231-6. 2002
    ....
  88. ncbi request reprint Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer
    Iñigo Rojas-Marcos
    Service of Neurology, Ciutat Sanitaria i Universitaria de Bellvitge, Hospitalet, Spain
    Medicine (Baltimore) 82:216-23. 2003
    ..In patients with possible PNS, a coincidental association between the tumor and the neurologic disorder cannot be excluded...
  89. ncbi request reprint Qualitative evidence of anti-Yo-specific intrathecal antibody synthesis in patients with paraneoplastic cerebellar degeneration
    Oliver Stich
    Neurologische Klinik und Poliklinik der Albert Ludwigs Universitaet Freiburg, D 79106 Freiburg, Germany
    J Neuroimmunol 141:165-9. 2003
    ..These results could be of interest in detection of intrathecal-specific IgG synthesis in nervous system infectious diseases provided that the target antigen is known...
  90. ncbi request reprint Discrepancies in the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease
    Raquel Sanchez-Valle
    Arch Neurol 61:604. 2004
  91. ncbi request reprint Primary non-Hodgkin's lymphoma of the CNS treated with CHOD/BVAM or BVAM chemotherapy before radiotherapy: long-term survival and prognostic factors
    Eric M Bessell
    Department of Clinical Oncology, Nottingham City Hospital, Nottingham City, United Kingdom
    Int J Radiat Oncol Biol Phys 59:501-8. 2004
    ....
  92. pmc Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study
    Iñigo Rojas-Marcos
    Department of Neurology, Hospital Juan Ramon Jimenez, Ronda Norte s n, 21005 Huelva, Spain
    Neuro Oncol 9:75-7. 2007
    ..We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer...
  93. pmc CNS Hodgkin lymphoma
    Elizabeth R Gerstner
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Blood 112:1658-61. 2008
    ....