J C Gomez-Villamandos

Summary

Country: Spain

Publications

  1. pmc Pathogenic mechanisms implicated in the intravascular coagulation in the lungs of BVDV-infected calves challenged with BHV-1
    María A Risalde
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Campus of International Excellence ceiA3, Edificio Sanidad Animal, Campus de Rabanales, Córdoba 14014, Spain
    Vet Res 44:20. 2013
  2. doi request reprint Pathology of African swine fever: the role of monocyte-macrophage
    J C Gomez-Villamandos
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Campus of International Excellence ceiA3, Edificio Sanidad Animal, Campus de Rabanales, 14014 Cordoba, Spain
    Virus Res 173:140-9. 2013
  3. ncbi request reprint Classical Swine Fever: pathology of bone marrow
    J C Gomez-Villamandos
    Departamento Anatomía y Anatomía Patológica Comparadas, Edificio de Sanidad Animal, Campus Universitario de Rabanales, Cordoba, Spain
    Vet Pathol 40:157-63. 2003
  4. ncbi request reprint Neuropathologic study of experimental classical swine fever
    J C Gomez-Villamandos
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Edificio de Sanidad Animal, Campus de Rabanales, 14014, Cordoba Spain
    Vet Pathol 43:530-40. 2006
  5. ncbi request reprint African swine fever and classical swine fever: a review of the pathogenesis
    J C Gomez-Villamandos
    Dpto Anatomía, Patologica, Facultad de Veterinaria, Cordoba, Spain
    Dtsch Tierarztl Wochenschr 110:165-9. 2003
  6. ncbi request reprint Apoptosis of thymocytes in experimental African Swine Fever virus infection
    F J Salguero
    Departamento de Anatomia Patologica, Facultad de Veterinaria, Universidad de Cordoba, Campus Universitario de Rabanales, Edificio de Sanidad Animal, Cordoba, Spain
    Histol Histopathol 19:77-84. 2004
  7. ncbi request reprint African swine fever: Expression of interleukin-1 alpha and tumour necrosis factor-alpha by pulmonary intravascular macrophages
    L Carrasco
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Spain
    J Comp Pathol 126:194-201. 2002
  8. ncbi request reprint Changes in macrophages in spleen and lymph nodes during acute African swine fever: expression of cytokines
    F J Salguero
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Campus Universitario de Rabanales, 14014, Cordoba, Spain
    Vet Immunol Immunopathol 90:11-22. 2002
  9. doi request reprint Quantification and determination of spread mechanisms of bovine viral diarrhoea virus in blood and tissues from colostrum-deprived calves during an experimental acute infection induced by a non-cytopathic genotype 1 strain
    M Pedrera
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Excellence International Campus ceiA3, Edificio Sanidad Animal, Campus de Rabanales, Cordoba, Spain
    Transbound Emerg Dis 59:377-84. 2012
  10. ncbi request reprint Expression of proinflammatory cytokines by hepatic macrophages in acute classical swine fever
    A Nunez
    Departamento de Anatomía Patológica Comparada, Facultad de Veterinaria, Universidad de Córdoba Edifico de Sanidad Animal, Campus Universitario de Rabanales, 14014, Cordoba, Spain
    J Comp Pathol 133:23-32. 2005

Collaborators

  • A Nunez
  • V Molina
  • J M Sanchez-Vizcaino
  • C Sanchez
  • J Gutierrez
  • F Tecles
  • J Perez
  • R Panadero
  • P J Sánchez-Cordón
  • M Pedrera
  • F J Salguero
  • M A Risalde
  • L Carrasco
  • M J Bautista
  • M Fernández de Marco
  • J L Romero-Trevejo
  • M A Sierra
  • B Rodriguez-Sanchez
  • J Hervas
  • E Ruiz-Villamor
  • María A Risalde
  • J J Ceron
  • A I Raya
  • A Jover
  • A C Pérez de Diego
  • B Garfia
  • Pedro J Sánchez-Cordón
  • Bartolome Garfia
  • Fernando Romero-Palomo
  • F J Pleguezuelos
  • Miriam Pedrera
  • F Romero-Palomo
  • S Martinez-Subiela
  • I Greiser-Wilke
  • M M Fernández de Marco
  • S Romanini
  • J Jahn
  • P Sánchez-Cordón
  • F Diaz San Segundo
  • F de Chacón Lara
  • F Chacón de Lara
  • M Quezada
  • M D Laviada
  • J Martinez-Torrecuadrada
  • F Chacón-M de Lara
  • P J Wilkinson
  • J Martin de las Mulas

Detail Information

Publications40

  1. pmc Pathogenic mechanisms implicated in the intravascular coagulation in the lungs of BVDV-infected calves challenged with BHV-1
    María A Risalde
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Campus of International Excellence ceiA3, Edificio Sanidad Animal, Campus de Rabanales, Córdoba 14014, Spain
    Vet Res 44:20. 2013
    ..Moreover, animals pre-inoculated with BVDV displayed an alteration in the response of pro-inflammatory cytokines (TNFα and IL-1), which play a key role in activating the immune response, as well as in the local cell-mediated response...
  2. doi request reprint Pathology of African swine fever: the role of monocyte-macrophage
    J C Gomez-Villamandos
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Campus of International Excellence ceiA3, Edificio Sanidad Animal, Campus de Rabanales, 14014 Cordoba, Spain
    Virus Res 173:140-9. 2013
    ..Levels of IFN-β and -γ are increased from initial phase of acute ASF. Anti-inflammatory response, represented by increased level of IL-10, is observed also, although in the final phase of acute ASF only...
  3. ncbi request reprint Classical Swine Fever: pathology of bone marrow
    J C Gomez-Villamandos
    Departamento Anatomía y Anatomía Patológica Comparadas, Edificio de Sanidad Animal, Campus Universitario de Rabanales, Cordoba, Spain
    Vet Pathol 40:157-63. 2003
    ..Granulocyte changes would lead to the appearance of circulating immature forms, whereas lymphocyte apoptosis in bone marrow would contribute to lymphopenia...
  4. ncbi request reprint Neuropathologic study of experimental classical swine fever
    J C Gomez-Villamandos
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Edificio de Sanidad Animal, Campus de Rabanales, 14014, Cordoba Spain
    Vet Pathol 43:530-40. 2006
    ..However, the link between viral infection and the presence of cell infiltrate was far from clear...
  5. ncbi request reprint African swine fever and classical swine fever: a review of the pathogenesis
    J C Gomez-Villamandos
    Dpto Anatomía, Patologica, Facultad de Veterinaria, Cordoba, Spain
    Dtsch Tierarztl Wochenschr 110:165-9. 2003
    ..The causes of the thrombocytopenia and the mechanisms of the haemorrhages, which are characteristic in both infections, are described. Apoptotic cell death is regarded as the predominant cause of lymphopenia in both virus infections...
  6. ncbi request reprint Apoptosis of thymocytes in experimental African Swine Fever virus infection
    F J Salguero
    Departamento de Anatomia Patologica, Facultad de Veterinaria, Universidad de Cordoba, Campus Universitario de Rabanales, Edificio de Sanidad Animal, Cordoba, Spain
    Histol Histopathol 19:77-84. 2004
    ..With these results we suggest that ASFV infection of the thymus does not seem to play a critical role in the acute disease. Although severe apoptosis was observed, animals died because of the severe lesions found in the other organs...
  7. ncbi request reprint African swine fever: Expression of interleukin-1 alpha and tumour necrosis factor-alpha by pulmonary intravascular macrophages
    L Carrasco
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Spain
    J Comp Pathol 126:194-201. 2002
    ..Alveolar macrophages did not show a significant change in cytokine expression as a result of ASF infection, and viral replication was detected in only a low percentage of these cells...
  8. ncbi request reprint Changes in macrophages in spleen and lymph nodes during acute African swine fever: expression of cytokines
    F J Salguero
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Campus Universitario de Rabanales, 14014, Cordoba, Spain
    Vet Immunol Immunopathol 90:11-22. 2002
    ..Our results demonstrate that mononuclear phagocyte system cell activation results in the release of several cytokines that could induce apoptosis of lymphocytes and haemodynamic changes...
  9. doi request reprint Quantification and determination of spread mechanisms of bovine viral diarrhoea virus in blood and tissues from colostrum-deprived calves during an experimental acute infection induced by a non-cytopathic genotype 1 strain
    M Pedrera
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Excellence International Campus ceiA3, Edificio Sanidad Animal, Campus de Rabanales, Cordoba, Spain
    Transbound Emerg Dis 59:377-84. 2012
    ..This fact could influence in the appearance of bovine respiratory diseases because of the capacity of BVDV for enhancing susceptibility to secondary infections...
  10. ncbi request reprint Expression of proinflammatory cytokines by hepatic macrophages in acute classical swine fever
    A Nunez
    Departamento de Anatomía Patológica Comparada, Facultad de Veterinaria, Universidad de Córdoba Edifico de Sanidad Animal, Campus Universitario de Rabanales, 14014, Cordoba, Spain
    J Comp Pathol 133:23-32. 2005
    ....
  11. ncbi request reprint Early platelet aggregation as a cause of thrombocytopenia in classical swine fever
    M J Bautista
    Departamento de Anatomía y Anatomía Patalógica, Facultad de Veterinaria, Universidad de Cordoba, Spain
    Vet Pathol 39:84-91. 2002
    ....
  12. ncbi request reprint Evolution of T lymphocytes and cytokine expression in classical swine fever (CSF) virus infection
    P J Sánchez-Cordón
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Edificio de Sanidad Animal, Campus de Rabanales, 14014 Cordoba, Spain
    J Comp Pathol 132:249-60. 2005
    ....
  13. ncbi request reprint Development of microscopic lesions in splenic cords of pigs infected with African swine fever virus
    L Carrasco
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cŕdoba, Spain
    Vet Res 28:93-9. 1997
    ..It is likely that the ASF virus replication, and consequent cytopathic effects, observed in the fixed macrophages of splenic cords, may be responsible for the fibrin deposition...
  14. ncbi request reprint Lymphocyte apoptosis and thrombocytopenia in spleen during classical swine fever: role of macrophages and cytokines
    P J Sánchez-Cordón
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Córdoba Edificio de Sanidad Animal, Campus de Rabanales, 14014, Cordoba, Spain
    Vet Pathol 42:477-88. 2005
    ....
  15. ncbi request reprint A histopathologic, immunohistochemical, and ultrastructural study of the intestine in pigs inoculated with classical swine fever virus
    P J Sánchez-Cordón
    Departamento de Anatomia Patologica, Universidad de Cordoba, Campus Universitario de Rabanales, Edificio de Sanidad Animal, Spain
    Vet Pathol 40:254-62. 2003
    ..This suggests that monocytes-macrophages play an important role in the pathogenesis of intestinal lesions. An understanding of the function of these cells will require additional study...
  16. ncbi request reprint Proinflammatory cytokines induce lymphocyte apoptosis in acute African swine fever infection
    F J Salguero
    Departamento de Anatomia y Anatomia Patologica Comparadas, Edificio de Sanidad Animal, Campus Universitario de Rabanales, Universidad de Cordoba, 14014 Cordoba, Spain
    J Comp Pathol 132:289-302. 2005
    ....
  17. ncbi request reprint Subcellular changes in the tonsils of pigs infected with acute African swine fever virus
    J C Gomez-Villamandos
    Dpto Anatomía y Anatomía Patológica, Facultad de Veterinaria, Universidad de Cordoba, Spain
    Vet Res 28:179-89. 1997
    ....
  18. ncbi request reprint Pathogenesis of classical swine fever: renal haemorrhages and erythrodiapedesis
    J C Gomez-Villamandos
    Departamento de Anatomia Patologica, Universidad de Cordoba, Campus Universitario de Rabanales, Carretera de Madrid, 14014 Cordoba, Spain
    J Comp Pathol 123:47-54. 2000
    ..The results suggested that mast cell degranulation was linked to activation of the complement system...
  19. ncbi request reprint The role of pulmonary intravascular macrophages in the pathogenesis of African horse sickness
    L Carrasco
    Departmento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Avenida Medina Azahara s n, Cordoba, 14005, Spain
    J Comp Pathol 121:25-38. 1999
    ..This suggested that the PIMs, once activated, contributed to these vascular changes by releasing chemical inflammatory mediators...
  20. ncbi request reprint Immunohistochemical detection of the expression of pro-inflammatory cytokines by ovine pulmonary macrophages
    L Carrasco
    Departamento de Anatomia y Anatomia Patologica Comparadas, Edificio de Sanidad Animal, Facultad de Veterinaria, Universidad de Cordoba, Campus Universitario de Rabanales, 14014 Cordoba, Spain
    J Comp Pathol 131:285-93. 2004
    ..No differences between PIMS and AMs were found in respect of TNF-alpha expression. The evaluation of cytokine expression represents a valuable tool for studying the pathogenesis of disease in the ovine lung...
  21. doi request reprint Hepatic immune response in calves during acute subclinical infection with bovine viral diarrhoea virus type 1
    M A Risalde
    Department of Comparative Pathology, University of Cordoba, Cordoba, Spain
    Vet J 190:e110-6. 2011
    ..Serum haptoglobin and serum amyloid A increased transiently at 12dpi. Upregulation of some pro-inflammatory cytokines by hepatic macrophages is evident in subclinical acute BVDV type 1 infection in calves...
  22. ncbi request reprint Pathogenesis of African horse sickness: ultrastructural study of the capillaries in experimental infection
    J C Gomez-Villamandos
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Avenida de Medina Azahara 7, Cordoba, 14005, USA
    J Comp Pathol 121:101-16. 1999
    ....
  23. ncbi request reprint The role of B cells in the immune response to pestivirus (classical Swine Fever virus)
    P J Sánchez-Cordón
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Edificio de Sanidad Animal, Campus de Rabanales, 14014 Cordoba, Spain
    J Comp Pathol 135:32-41. 2006
    ..These changes may have influenced the late appearance of virus-specific antibodies in the study, as well as the progressive increase of immunoglobulins...
  24. ncbi request reprint Glomerulonephritis associated with simultaneous canine adenovirus-1 and Dirofilaria immitis infection in a dog
    P J Sánchez-Cordón
    Departamento Anatomía Patológica Comparada, Facultad de Veterinaria, Universidad de Cordoba, Spain
    J Vet Med B Infect Dis Vet Public Health 49:235-9. 2002
    ....
  25. ncbi request reprint Reovirus infection in psittacine birds (Psittacus erithacus): morphologic and immunohistochemical study
    P J Sánchez-Cordón
    Departamento de Anatomia Patologica, Facultad de Veterinaria, Universidad de Cordoba, Spain
    Avian Dis 46:485-92. 2002
    ....
  26. ncbi request reprint Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever
    J C Gomez-Villamandos
    Departamento Anatomia Patologica, Facultad de Veterinaria, Campus Universitario de Rabaneles, 14014 Cordoba, Spain
    J Comp Pathol 125:98-109. 2001
    ..Moreover, the secretory changes that occurred in macrophages in the initial phase of the infection suggested that macrophages release chemical mediators capable of modulating pathogenesis...
  27. doi request reprint Potential role of proinflammatory cytokines in the pathogenetic mechanisms of vascular lesions in goats naturally infected with bluetongue virus serotype 1
    P J Sánchez-Cordón
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Excellence International Campus ceiA3, Cordoba, Spain Center of Animal Health Surveillance VISAVET and Animal Health Department, Veterinary Faculty, Complutense University of Madrid, Madrid, Spain Department of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency AHVLA, New Haw, UK
    Transbound Emerg Dis 60:252-62. 2013
    ....
  28. doi request reprint Immunohistochemical detection of bluetongue virus in fixed tissue
    P J Sánchez-Cordón
    Department of Comparative Pathology, Veterinary Faculty, University of Cordoba, Edificio Sanidad Animal, Campus de Rabanales, 14014 Cordoba, Spain
    J Comp Pathol 143:20-8. 2010
    ..The immunohistochemical method described will be a useful tool for future research...
  29. ncbi request reprint Cytokine expression in paraffin wax-embedded tissues from conventional calves
    M Pedrera
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Edificio de Sanidad Animal, Campus de Rabanales, 14014, Cordoba, Spain
    J Comp Pathol 136:273-8. 2007
    ..The results will facilitate investigation of the role of these cytokine-producing cells in inflammatory disease processes in calves...
  30. ncbi request reprint An immunohistochemical study of the tonsils in pigs with acute African swine fever virus infection
    M Fernández de Marco
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, 14014 Cordoba, Spain
    Res Vet Sci 83:198-203. 2007
    ..With these results, we can conclude that the tonsil is suffering similar lesions than those observed in other lymphoid organs in acute African swine fever, even when the route of inoculation is the intramuscular and not oral-nasal...
  31. doi request reprint Characterization of apoptosis pathways (intrinsic and extrinsic) in lymphoid tissues of calves inoculated with non-cytopathic bovine viral diarrhoea virus genotype-1
    M Pedrera
    Department of Comparative Pathology, Veterinary Faculty, University of Cordoba, Edificio Sanidad Animal, Campus de Rabanales, 14014 Cordoba, Spain
    J Comp Pathol 146:30-9. 2012
    ....
  32. doi request reprint Response of proinflammatory and anti-inflammatory cytokines in calves with subclinical bovine viral diarrhea challenged with bovine herpesvirus-1
    M A Risalde
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Campus of International Excellence ceiA3, Campus de Rabanales, 14014, Cordoba, Spain
    Vet Immunol Immunopathol 144:135-43. 2011
    ..This alteration in the kinetic and magnitude of these cytokines, involved in cytotoxic mechanisms responsible for limiting the spread of secondary pathogens, facilitated the dissemination of BHV-1.1 in BVDV-infected calves...
  33. ncbi request reprint BSE infection in bovine PrP transgenic mice leads to hyperphosphorylation of tau-protein
    M J Bautista
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Campus de Rabanales, Carretera Madrid Cádiz s n, 14014 Cordoba, Spain
    Vet Microbiol 115:293-301. 2006
    ..Ultrastructural examination revealed a novel arrangement of intraneuronal tau deposits not hitherto reported...
  34. doi request reprint Effect of infection with BHV-1 on peripheral blood leukocytes and lymphocyte subpopulations in calves with subclinical BVD
    V Molina
    Department of Comparative Pathology, Faculty of Veterinary, University of Córdoba Agrifood Campus of International Excellence ceiA3, Campus de Rabanales, 14014 Cordoba, Spain
    Res Vet Sci 95:115-22. 2013
    ....
  35. ncbi request reprint Classical swine fever: morphological and morphometrical study of pulmonary intravascular macrophages
    L Carrasco
    , Edificio de Sanidad Animal, Facultad de Veterinaria, , 14014, Spain
    J Comp Pathol 125:1-7. 2001
    ..The results obtained suggest that macrophage activation and the subsequent release of pro-inflammatory mediators play an important role in the pathogenesis of CSF...
  36. ncbi request reprint Atoxoplasma spp. infection in captive canaries (Serinus canaria)
    P J Sánchez-Cordón
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Edificio de Sanidad Animal, Campus de Rabanales, 14014 Cordoba, Spain
    J Vet Med A Physiol Pathol Clin Med 54:23-6. 2007
    ..An usual finding was the presence of infected mononuclear cells adhered to the endothelium of the blood vessels in lung. The diagnosis was confirmed by ultrastructural examination of reprocessed paraffin-embedded tissues...
  37. ncbi request reprint Hepatitis associated with herpes viral infection in the tortoise (Testudo horsfieldii)
    J Hervas
    Departmento Anatomia Patològica Comparada, Facultad de Veterinaria, Universidad de Cordoba, Spain
    J Vet Med B Infect Dis Vet Public Health 49:111-4. 2002
    ..This article is the first description of a viral hepatitis in Testudo spp. with lesions compatible with herpesvirus infection, with no clinical signs or lesions in the respiratory system, oral cavity or other organs...
  38. doi request reprint Comparative study of clinical courses, gross lesions, acute phase response and coagulation disorders in sheep inoculated with bluetongue virus serotype 1 and 8
    P J Sánchez-Cordón
    Department of Comparative Pathology, Veterinary Faculty, University of Córdoba Agrifood Excellence International Campus ceiA3, Edificio Sanidad Animal, Campus de Rabanales, 14014 Cordoba, Spain
    Vet Microbiol 166:184-94. 2013
    ..To our knowledge, this is the first verification of a measurable APR in sheep with both experimental and naturally occurring bluetongue...
  39. ncbi request reprint Focal mesangial-sclerosing glomerulonephritis and acute-spontaneous infectious canine hepatitis: structural, immunohistochemical and subcellular studies
    J Hervas
    Dpto Anatomía Patológica, Facultad de Veterinaria, Cordoba, Spain
    Vet Immunol Immunopathol 57:25-32. 1997
    ....
  40. doi request reprint Morphological changes and virus distribution in the ileum of colostrum-deprived calves inoculated with non-cytopathic bovine viral diarrhoea virus genotype-1
    M Pedrera
    Department of Comparative Pathology, Veterinary Faculty, University of Cordoba, Edificio Sanidad Animal, Campus de Rabanales, Cordoba, Spain
    J Comp Pathol 141:52-62. 2009
    ..Characterization of the indirect pathogenic mechanisms involved in the lymphoid depletion associated with BVDV infection will require additional study...