Juan J Gomez-Reino

Summary

Country: Spain

Publications

  1. doi request reprint Biologic monotherapy as initial treatment in patients with early rheumatoid arthritis
    Juan Gomez-Reino
    Division of Rheumatology, Department of Medicine, Hospital Clinico Universitario, A Choupana s n, 15706 Santiago, Spain
    Rheumatology (Oxford) 51:v31-7. 2012
  2. doi request reprint Change in the discontinuation pattern of tumour necrosis factor antagonists in rheumatoid arthritis over 10 years: data from the Spanish registry BIOBADASER 2.0
    Juan J Gomez-Reino
    Rheumatology Department, Hospital Clinico Universitario, Santiago de Compostela, Spain
    Ann Rheum Dis 71:382-5. 2012
  3. pmc Efficacy and safety of the human anti-IL-1β monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, Phase II, dose-finding study
    Rieke Alten
    Department of Internal Medicine II, Schlosspark Klinik Teaching Hospital of the Charité, University Medicine Berlin, Heubnerweg, Berlin 14059, Germany
    BMC Musculoskelet Disord 12:153. 2011
  4. pmc DAS-28-based EULAR response and HAQ improvement in rheumatoid arthritis patients switching between TNF antagonists
    Federico Navarro-Sarabia
    Rheumatology Service, Hospital Universitario Virgen Macarena, Sevilla, Spain
    BMC Musculoskelet Disord 10:91. 2009
  5. pmc Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study
    Marian Suarez-Gestal
    Laboratorio de Investigacion 10 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela 15706, Spain
    Arthritis Res Ther 11:R69. 2009
  6. pmc Survival of TNF antagonists in spondylarthritis is better than in rheumatoid arthritis. Data from the Spanish registry BIOBADASER
    Loreto Carmona
    Research Unit, Spanish Society of Rheumatology, Madrid, Spain Marques de Duero 5, 28001 Madrid, Spain
    Arthritis Res Ther 8:R72. 2006
  7. ncbi request reprint Risk of tuberculosis in patients treated with tumor necrosis factor antagonists due to incomplete prevention of reactivation of latent infection
    Juan J Gomez-Reino
    Hospital Clinico Universitario, University of Santiago de Compostela School of Medicine, Santiago, Spain
    Arthritis Rheum 57:756-61. 2007
  8. pmc Switching TNF antagonists in patients with chronic arthritis: an observational study of 488 patients over a four-year period
    Juan J Gomez-Reino
    Rheumatology Service and Department of Medicine, Hospital Clinico Universitario, Medical School, Universidad de Santiago de Compostela, Spain
    Arthritis Res Ther 8:R29. 2006
  9. pmc Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study
    Marian Suarez-Gestal
    Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria Hospital Clinico Universitario de Santiago, Travesia Choupana sn, Santiago de Compostela, 15706, Spain
    Arthritis Res Ther 12:R72. 2010
  10. pmc Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians
    Julio Rodriguez-Lopez
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 8:R55. 2006

Collaborators

Detail Information

Publications48

  1. doi request reprint Biologic monotherapy as initial treatment in patients with early rheumatoid arthritis
    Juan Gomez-Reino
    Division of Rheumatology, Department of Medicine, Hospital Clinico Universitario, A Choupana s n, 15706 Santiago, Spain
    Rheumatology (Oxford) 51:v31-7. 2012
    ..Although results cannot be compared across clinical trials, tocilizumab was the only biologic agent to demonstrate superiority to MTX as monotherapy in patients with RA with limited/no exposure to MTX...
  2. doi request reprint Change in the discontinuation pattern of tumour necrosis factor antagonists in rheumatoid arthritis over 10 years: data from the Spanish registry BIOBADASER 2.0
    Juan J Gomez-Reino
    Rheumatology Department, Hospital Clinico Universitario, Santiago de Compostela, Spain
    Ann Rheum Dis 71:382-5. 2012
    ..To investigate in rheumatoid arthritis (RA) the rate and reason of discontinuation of tumour necrosis factor (TNF) antagonists over the past decade...
  3. pmc Efficacy and safety of the human anti-IL-1β monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, Phase II, dose-finding study
    Rieke Alten
    Department of Internal Medicine II, Schlosspark Klinik Teaching Hospital of the Charité, University Medicine Berlin, Heubnerweg, Berlin 14059, Germany
    BMC Musculoskelet Disord 12:153. 2011
    ....
  4. pmc DAS-28-based EULAR response and HAQ improvement in rheumatoid arthritis patients switching between TNF antagonists
    Federico Navarro-Sarabia
    Rheumatology Service, Hospital Universitario Virgen Macarena, Sevilla, Spain
    BMC Musculoskelet Disord 10:91. 2009
    ..The aim of this study was to evaluate treatment response in a clinical setting based on HAQ improvement and EULAR response criteria in RA patients who were switched to a second or a third TNF antagonist due to failure with the first one...
  5. pmc Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study
    Marian Suarez-Gestal
    Laboratorio de Investigacion 10 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela 15706, Spain
    Arthritis Res Ther 11:R69. 2009
    ..We aimed to replicate association of newly identified systemic lupus erythematosus (SLE) loci...
  6. pmc Survival of TNF antagonists in spondylarthritis is better than in rheumatoid arthritis. Data from the Spanish registry BIOBADASER
    Loreto Carmona
    Research Unit, Spanish Society of Rheumatology, Madrid, Spain Marques de Duero 5, 28001 Madrid, Spain
    Arthritis Res Ther 8:R72. 2006
    ..Because chronic therapy is necessary, continual review of this issue is necessary...
  7. ncbi request reprint Risk of tuberculosis in patients treated with tumor necrosis factor antagonists due to incomplete prevention of reactivation of latent infection
    Juan J Gomez-Reino
    Hospital Clinico Universitario, University of Santiago de Compostela School of Medicine, Santiago, Spain
    Arthritis Rheum 57:756-61. 2007
    ....
  8. pmc Switching TNF antagonists in patients with chronic arthritis: an observational study of 488 patients over a four-year period
    Juan J Gomez-Reino
    Rheumatology Service and Department of Medicine, Hospital Clinico Universitario, Medical School, Universidad de Santiago de Compostela, Spain
    Arthritis Res Ther 8:R29. 2006
    ..This issue will deserve continuous reassessment with the arrival of new medications...
  9. pmc Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study
    Marian Suarez-Gestal
    Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria Hospital Clinico Universitario de Santiago, Travesia Choupana sn, Santiago de Compostela, 15706, Spain
    Arthritis Res Ther 12:R72. 2010
    ..This study is very important because, according to published simulations, associations as strong as the reported ones will mean that these SNPs could be used as predictors of response at the individual level...
  10. pmc Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians
    Julio Rodriguez-Lopez
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 8:R55. 2006
    ..It remains possible that lifestyle, environmental or genetic differences allow for an important effect of asporin variants in other ethnic groups as has been reported in the Japanese, but this should be supported by additional studies...
  11. pmc Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study
    Elisa Alonso-Perez
    Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    PLoS ONE 7:e45356. 2012
    ..The first published analyses seem to indicate that this is the case for some of them, but results are still inconclusive and we aimed to further explore this question...
  12. ncbi request reprint NUCB2/nesfatin-1: a new adipokine expressed in human and murine chondrocytes with pro-inflammatory properties, an in vitro study
    Morena Scotece
    SERGAS, Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Santiago de Compostela, 15706, Spain
    J Orthop Res 32:653-60. 2014
    ..Finally, nesfatin-1 provoked a clear induction of pro-inflammatory agents, such as COX-2, IL-8, IL-6, and MIP-1α in human primary chondrocytes from OA patients...
  13. ncbi request reprint Lack of association of ankylosing spondylitis with the most common NOD2 susceptibility alleles to Crohn's disease
    Isabel Ferreiros-Vidal
    Research Laboratory 2 and the Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    J Rheumatol 30:102-4. 2003
    ..To investigate whether the 3 most common mutations in the NOD2 gene that confer susceptibility to Crohn's disease (CD) are also associated with ankylosing spondylitis (AS)...
  14. ncbi request reprint Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: a multicenter active-surveillance report
    Juan J Gomez-Reino
    Hospital Clinico Universitario and Universidad de Santiago de Compostela, Santiago, Spain
    Arthritis Rheum 48:2122-7. 2003
    ..We undertook this study to determine and describe the long-term safety of 2 of these agents, infliximab and etanercept, in rheumatic diseases based on a national active-surveillance system following the commercialization of the drugs...
  15. doi request reprint Association of anti-citrullinated vimentin and anti-citrullinated α-enolase antibodies with subsets of rheumatoid arthritis
    Ariana Montes
    Instituto de Investigacion Sanitaria and Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Rheum 64:3102-10. 2012
    ....
  16. doi request reprint Demyelinating disease in patients treated with TNF antagonists in rheumatology: data from BIOBADASER, a pharmacovigilance database, and a systematic review
    María Cruz Fernández-Espartero
    Rheumatology Department, Hospital Universitario de Móstoles, Mostoles, Spain
    Semin Arthritis Rheum 41:524-33. 2011
    ..To estimate the rate of demyelinating diseases in patients with rheumatic diseases treated with tumor necrosis factor (TNF) antagonists and to describe the cases reported to 3 different pharmacovigilance sources...
  17. pmc Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility
    Rebeca Dieguez-Gonzalez
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 11:R42. 2009
    ..We hypothesized that there is a similar association with RA, including polymorphisms in TNFAIP3 and the intergenic region...
  18. doi request reprint Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis
    Rebeca Dieguez-Gonzalez
    Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Rheum 58:1264-74. 2008
    ..The present study was undertaken to investigate the role of genetic variation in IRF5 in susceptibility to RA...
  19. pmc Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study
    Julio Rodriguez-Lopez
    Research Laboratory 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 8:R1. 2006
    ....
  20. doi request reprint Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors
    Marian Suarez-Gestal
    Hospital Clinico Universitario de Santiago, Travesia de Choupana s n, Santiago de Compostela, Spain
    Arthritis Rheum 60:2558-64. 2009
    ..The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility...
  21. doi request reprint Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis
    Julio Rodriguez-Lopez
    Hospital Clinico Universitario Santiago, Santiago de Compostela, Spain
    Arthritis Rheum 58:435-41. 2008
    ....
  22. doi request reprint Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes
    Rodolfo Gomez
    SERGAS, Santiago University Clinical Hospital Research Laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, Institute of Medical Research IDIS, Santiago de Compostela, 15706, Spain
    J Orthop Res 31:1046-52. 2013
    ..In this work we have described for the first time that NO is able to exert a control on LCN2 expression, suggesting the existence of a feedback loop regulating its expression...
  23. doi request reprint Particular association of clinical and genetic features with autoimmunity to citrullinated α-enolase in rheumatoid arthritis
    Ariana Montes
    Instituto de Investigacion Sanitaria Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Rheum 63:654-61. 2011
    ..To confirm that the presence of anti-citrullinated α-enolase peptide 1 (anti-CEP-1) antibodies identifies a subgroup of patients with rheumatoid arthritis (RA)...
  24. ncbi request reprint Association of PDCD1 with susceptibility to systemic lupus erythematosus: evidence of population-specific effects
    Isabel Ferreiros-Vidal
    Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela, Spain
    Arthritis Rheum 50:2590-7. 2004
    ..This study sought to determine the role of PDCD1 in susceptibility to SLE in the Spanish population...
  25. doi request reprint Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis
    Beatriz Orosa
    Laboratorio de Investigación 8 y Servicio de Reumatología, Instituto de Investigación Sanitaria IDIS, Hospital Clínico Universitario de Santiago de Compostela CHUS, SERGAS, Santiago de Compostela, Spain
    Ann Rheum Dis 73:298-305. 2014
    ..To investigate the effect of lysophosphatidic acid (LPA) receptor inhibition in a mouse model of autoantibody-mediated arthritis...
  26. doi request reprint Comparative effectiveness of switching to alternative tumour necrosis factor (TNF) antagonists versus switching to rituximab in patients with rheumatoid arthritis who failed previous TNF antagonists: the MIRAR Study
    Juan J Gomez-Reino
    Department of Rheumatology Unit, Hospital Clinico Universitario, Santiago de Compostela, Santiago, Spain
    Ann Rheum Dis 71:1861-4. 2012
    ..To compare the effectiveness of switching to rituximab (RTX) with switching to alternative tumour necrosis factor (TNF) antagonists in patients with rheumatoid arthritis (RA) failing on TNF antagonists...
  27. pmc Association of systemic lupus erythematosus clinical features with European population genetic substructure
    Elisa Alonso-Perez
    Laboratorio de Investigacion, Instituto de Investigacion Sanitaria, Universitario de Santiago Hospital Clinico Santiago de Compostela, Santiago de Compostela, Spain
    PLoS ONE 6:e29033. 2011
    ..These results should be taken into account in future research and suggest new hypotheses and possible underlying mechanisms to be investigated. A first hypothesis linking photosensitivity with variation in skin pigmentation is suggested...
  28. pmc Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model
    Samuel Garcia
    Research Laboratory and Rheumatology Unit, Complexo Hospitalario Universitario de Santiago de Compostela CHUS, SERGAS, Biomedical Research Institute IDIS, Travesia da Choupana s n, Santiago de Compostela, 15706 A Coruna, Spain
    Arthritis Res Ther 12:R224. 2010
    ..However, the role of specific MMPs in arthritis pathogenesis is largely unknown. The aim of the present study was to investigate the role of Mmp-8 (collagenase-2) in an arthritis model...
  29. pmc Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage
    Samuel Garcia
    Research Laboratory and Rheumatology Unit, Hospital Clinico Universitario, Choupana s n, Santiago de Compostela, 15706 Spain
    Arthritis Res Ther 12:R33. 2010
    ..The aim of this study was to investigate the association of PI3Kinase/Akt and the mitochondrial apoptotic pathway in the resistance of rheumatoid arthritis (RA) fibroblast like synovial cells (FLS) to Fas-mediated apoptosis...
  30. ncbi request reprint Worsening of obstructive sleep apnoeas in a patient with rheumatoid arthritis treated with anti-tumor necrosis factor
    Carlos Zamarron
    Sleep Unit, Division of Respiratory Medicine, Department of Medicine of the Hospital Clinico Universitario and Santiago Medical School, Santiago, Spain
    Respir Med 98:123-5. 2004
    ..Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab...
  31. doi request reprint Lysophosphatidic acid receptor 1 suppression sensitizes rheumatoid fibroblast-like synoviocytes to tumor necrosis factor-induced apoptosis
    Beatriz Orosa
    Complexo Hospitalario Universitario de Santiago de Compostela, SERGAS, Santiago de Compostela, Spain
    Arthritis Rheum 64:2460-70. 2012
    ..To investigate the role of lysophosphatidic acid (LPA) receptors in the proliferation and apoptosis of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA)...
  32. doi request reprint Efficacy and safety of TNF antagonists in sarcoidosis: data from the Spanish registry of biologics BIOBADASER and a systematic review
    Jose Ramon Maneiro
    Rheumatology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain
    Semin Arthritis Rheum 42:89-103. 2012
    ..To evaluate the safety, efficacy, and effectiveness of TNF antagonists in patients with sarcoidosis...
  33. doi request reprint At the crossroad between immunity and metabolism: focus on leptin
    Javier Conde
    Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammation Disease, Building C, Level 2, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Calle Choupana s n, Santiago de Compostela, 15706, Spain
    Expert Rev Clin Immunol 6:801-8. 2010
    ..Thus, leptin can easily be considered a frank mediator of the inflammatory/immune response...
  34. doi request reprint Rheumatoid factor as predictor of response to abatacept, rituximab and tocilizumab in rheumatoid arthritis: Systematic review and meta-analysis
    R J Maneiro
    Rheumatology Unit, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain
    Semin Arthritis Rheum 43:9-17. 2013
    ..To identify if rheumatoid factor (RF) is predictor of response to rituximab (RTX), abatacept (ABT), and tocilizumab (TCZ) in rheumatoid arthritis (RA)...
  35. ncbi request reprint Safety profile of protein kinase inhibitors in rheumatoid arthritis: systematic review and meta-analysis
    Eva Salgado
    Rheumatology Unit, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain
    Ann Rheum Dis 73:871-82. 2014
    ..To summarise the adverse events (AE) reported in patients with rheumatoid arthritis (RA) treated with protein kinase inhibitors (PKi), and identify family and molecule-related AEs...
  36. pmc Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice
    Samuel Garcia
    Research Laboratory, Hospital Clinico Universitario, Choupana s n, 15706 Santiago de Compostela, Spain
    Arthritis Res Ther 8:R14. 2006
    ..Our results provide evidence of the contribution of PARP-1 to the progression of arthritis and identify this protein as a potential therapeutic target for the treatment of rheumatoid arthritis...
  37. pmc Ultrasonographic assessment of enthesitis in HLA-B27 positive patients with rheumatoid arthritis, a matched case-only study
    Antonio Mera-Varela
    Research Laboratory 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    PLoS ONE 8:e58616. 2013
    ..We aimed to replicate this study with a sensitive and quantitative assessment of enthesitis by using standardized ultrasonography (US)...
  38. ncbi request reprint Infections in patients with rheumatic diseases treated with TNF antagonists
    Beatriz Pérez-Zafrilla
    Rheumatology Service and Department of Medicine, Hospital Clinico Universitario, Medical School, Universidad de Santiago de Compostela, Santiago, Spain
    Curr Pharm Biotechnol 13:1418-25. 2012
    ..Preventive strategies and patient selection have an important impact on the risk of these infections...
  39. doi request reprint Demyelinating disease in patients treated with TNF antagonists in rheumatology: data from BIOBADASER, a pharmacovigilance database, and a systematic review
    María Cruz Fernández-Espartero
    Rheumatology Department, Hospital Universitario de Móstoles, Mostoles, Spain
    Semin Arthritis Rheum 40:330-7. 2011
    ..To estimate the rate of demyelinating diseases in patients with rheumatic diseases treated with tumor necrosis factor (TNF) antagonists and to describe the cases reported to 3 different pharmacovigilance sources...
  40. ncbi request reprint Maintenance therapy of lupus nephritis with mycophenolate or azathioprine: systematic review and meta-analysis
    Jose R Maneiro
    Rheumatology Department, Complejo Hospitalario Universitario de Santiago de Compostela, c Travesía da Choupana s n, 15701 Santiago de Compostela, Spain
    Rheumatology (Oxford) 53:834-8. 2014
    ..The objective of this study was to summarize the comparative efficacy and safety of MMF and AZA as maintenance therapy for LN...
  41. doi request reprint Discovery of serum proteomic biomarkers for prediction of response to infliximab (a monoclonal anti-TNF antibody) treatment in rheumatoid arthritis: an exploratory analysis
    Ignacio Ortea
    Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    J Proteomics 77:372-82. 2012
    ....
  42. pmc Reference genes for normalization of gene expression studies in human osteoarthritic articular cartilage
    Manuel Pombo-Suarez
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    BMC Mol Biol 9:17. 2008
    ..We have examined ten well-known reference genes to determine the most adequate for this application...
  43. doi request reprint Lack of association with rheumatoid arthritis of selected polymorphisms in 4 candidate genes: CFH, CD209, eotaxin-3, and MHC2TA
    Rebeca Dieguez-Gonzalez
    Laboratorio de Investigacion 10, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    J Rheumatol 36:1590-5. 2009
    ..These SNP have been reported as important for RA (eotaxin-3 and MHC2TA) or for other immune-mediated diseases (CFH and CD209)...
  44. ncbi request reprint Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line
    Anna Iacono
    Santiago University Clinical Hospital, Santiago de Compostela, Spain
    Arthritis Rheum 62:1675-82. 2010
    ..We undertook this study to evaluate the effect of oleocanthal and its derivatives on the modulation of NO production in chondrocytes...
  45. ncbi request reprint An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
    Lorraine Southam
    Botnar Research Centre, University of Oxford, UK
    Hum Mol Genet 16:2226-32. 2007
    ..A small but persistent imbalance of GDF5 expression throughout life therefore appears to render an individual more susceptible to OA...
  46. pmc A broad analysis of IL1 polymorphism and rheumatoid arthritis
    Alyssa K Johnsen
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 58:1947-57. 2008
    ..The aim of this study was to perform a broad and well-powered search for association between allelic polymorphism in IL1A and IL1B and the susceptibility to or severity of RA...
  47. ncbi request reprint SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis
    Javier Costas
    Research Laboratory 2, Rheumatology Unit, and National Genotyping Center, Hospital Clinco Universitario de Santiago, 15706 Santiago de Compostela, Spain
    J Rheumatol 33:1048-51. 2006
    ..To explore the role of single nuclear polymorphisms (SNP) in 2 candidate genes, SUMO4 and MAP3K7IP2, in susceptibility to rheumatoid arthritis (RA)...
  48. ncbi request reprint Polymorphism of the interleukin-1 receptor antagonist gene: a factor in susceptibility to rheumatoid arthritis in a Spanish population
    Patricia E Carreira
    Servicio de Reumatoloía, Hospital 12 de Octubre, Madrid, Spain
    Arthritis Rheum 52:3015-9. 2005
    ..To assess whether an interleukin-1 receptor antagonist gene (IL1RN) polymorphism is associated with disease susceptibility and/or severity in a Spanish population of patients with rheumatoid arthritis (RA)...