Pere Gines

Summary

Country: Spain

Publications

  1. pmc MELD score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation
    Maria Carlota Londoño
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Institut de Investigacions Biomèdiques August Pi Sunyer, CIBER de Enfermedades Hepáticas y Digestivas and Centro de Investigaciones Biomédicas Esther Koplowitz, Barcelona, Spain
    Gut 56:1283-90. 2007
  2. doi request reprint The management of ascites and hyponatremia in cirrhosis
    Pere Gines
    Liver Unit, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Spain
    Semin Liver Dis 28:43-58. 2008
  3. doi request reprint Management of critically-ill cirrhotic patients
    Pere Gines
    Liver Unit, IMDiM, Hospital Clinic Barcelona, University of Barcelona and IDIBAPS and Ciberehd, Barcelona, Spain
    J Hepatol 56:S13-24. 2012
  4. doi request reprint Clinical trial: short-term effects of combination of satavaptan, a selective vasopressin V2 receptor antagonist, and diuretics on ascites in patients with cirrhosis without hyponatraemia--a randomized, double-blind, placebo-controlled study
    P Gines
    Liver Unit, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, CIBER de Enfermedades Hepáticas y Digestivas CIBEREHD, Barcelona, Catalunya, Spain
    Aliment Pharmacol Ther 31:834-45. 2010
  5. doi request reprint Complications of cirrhosis
    Pere Gines
    Liver Unit, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Spain
    Semin Liver Dis 28:1. 2008
  6. doi request reprint Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management
    Pere Gines
    Liver Unit, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas IDIBAPS, Barcelona, Catalunya, Spain
    Hepatology 48:1002-10. 2008
  7. doi request reprint Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial
    Pere Gines
    Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
    Hepatology 48:204-13. 2008
  8. ncbi request reprint Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells
    Pau Sancho-Bru
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Hospital Clinic, Villarroel 170, Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 291:G877-84. 2006
  9. ncbi request reprint Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis
    Pere Gines
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, University of Barcelona, Instituto Reina Sofia de Investigacion Nefrologica, Barcelona, Catalunya, Spain
    Gastroenterology 123:1839-47. 2002
  10. ncbi request reprint Renal failure in patients with cirrhosis and sepsis unrelated to spontaneous bacterial peritonitis: value of MELD score
    Carlos Terra
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Gastroenterology 129:1944-53. 2005

Detail Information

Publications82

  1. pmc MELD score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation
    Maria Carlota Londoño
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Institut de Investigacions Biomèdiques August Pi Sunyer, CIBER de Enfermedades Hepáticas y Digestivas and Centro de Investigaciones Biomédicas Esther Koplowitz, Barcelona, Spain
    Gut 56:1283-90. 2007
    ....
  2. doi request reprint The management of ascites and hyponatremia in cirrhosis
    Pere Gines
    Liver Unit, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Spain
    Semin Liver Dis 28:43-58. 2008
    ..This article focuses on the pathophysiology, clinical consequences, current management, and new treatment modalities for ascites and dilutional hyponatremia in cirrhosis...
  3. doi request reprint Management of critically-ill cirrhotic patients
    Pere Gines
    Liver Unit, IMDiM, Hospital Clinic Barcelona, University of Barcelona and IDIBAPS and Ciberehd, Barcelona, Spain
    J Hepatol 56:S13-24. 2012
    ..This review will focus on the diagnostic approach and treatment strategies currently recommended in the critical care management of patients with cirrhosis...
  4. doi request reprint Clinical trial: short-term effects of combination of satavaptan, a selective vasopressin V2 receptor antagonist, and diuretics on ascites in patients with cirrhosis without hyponatraemia--a randomized, double-blind, placebo-controlled study
    P Gines
    Liver Unit, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, CIBER de Enfermedades Hepáticas y Digestivas CIBEREHD, Barcelona, Catalunya, Spain
    Aliment Pharmacol Ther 31:834-45. 2010
    ..There is little information on the effects of vaptans in patients with cirrhosis...
  5. doi request reprint Complications of cirrhosis
    Pere Gines
    Liver Unit, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Spain
    Semin Liver Dis 28:1. 2008
  6. doi request reprint Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management
    Pere Gines
    Liver Unit, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas IDIBAPS, Barcelona, Catalunya, Spain
    Hepatology 48:1002-10. 2008
    ..Treatment with vaptans represents a novel approach to improving serum sodium concentration in cirrhosis...
  7. doi request reprint Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial
    Pere Gines
    Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
    Hepatology 48:204-13. 2008
    ..01 for all compared to placebo). Thirst was significantly more common in patients treated with satavaptan compared to those treated with placebo, whereas the frequency of other adverse events was similar among groups...
  8. ncbi request reprint Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells
    Pau Sancho-Bru
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Hospital Clinic, Villarroel 170, Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 291:G877-84. 2006
    ..We conclude that NE stimulates NF-kappaB and induces cell contraction and proinflammatory effects in human HSC. Catecholamines may participate in the pathogenesis of portal hypertension and liver fibrosis by targeting HSC...
  9. ncbi request reprint Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis
    Pere Gines
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, University of Barcelona, Instituto Reina Sofia de Investigacion Nefrologica, Barcelona, Catalunya, Spain
    Gastroenterology 123:1839-47. 2002
    ..However, its effect on survival and healthcare costs is still uncertain...
  10. ncbi request reprint Renal failure in patients with cirrhosis and sepsis unrelated to spontaneous bacterial peritonitis: value of MELD score
    Carlos Terra
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Gastroenterology 129:1944-53. 2005
    ..Background &..
  11. ncbi request reprint Increased plasma levels of neuropeptide Y in hepatorenal syndrome
    Juan Uriz
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Barcelona, Spain
    J Hepatol 36:349-55. 2002
    ..To investigate the relationship between neuropeptide Y (NPY), a potent renal vasoconstrictor peptide released upon marked stimulations of sympathetic nervous system (SNS), and renal and circulatory function in cirrhosis...
  12. ncbi request reprint Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: results of a prospective, nonrandomized study
    Rolando Ortega
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Catalunya, Spain
    Hepatology 36:941-8. 2002
    ..In conclusion, terlipressin therapy reverses HRS in a high proportion of patients. Recurrence rate after treatment withdrawal is uncommon. Albumin appears to improve markedly the beneficial effects of terlipressin...
  13. pmc Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C
    Jordi Colmenero
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Catalonia, Spain
    Am J Physiol Gastrointest Liver Physiol 297:G726-34. 2009
    ..Controlled studies are warranted to assess the effect of AT1 receptor blockers in chronic liver injury...
  14. doi request reprint Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study
    Monica Guevara
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 57:759-65. 2012
    ..Whether albumin has similar beneficial effects in patients with infections other than SBP is unknown...
  15. ncbi request reprint Hyponatremia impairs early posttransplantation outcome in patients with cirrhosis undergoing liver transplantation
    Maria Carlota Londoño
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Gastroenterology 130:1135-43. 2006
    ..We aimed to assess the effects of hyponatremia at the time of transplantation on posttransplantation outcome in patients with cirrhosis...
  16. ncbi request reprint Increased carbon monoxide production in patients with cirrhosis with and without spontaneous bacterial peritonitis
    Dara de Las Heras
    Liver Unit, Department of Pulmonary Medicine, and Hormonal Laboratory, Hospital Clinic, University of Barcelona, Catalunya, Spain
    Hepatology 38:452-9. 2003
    ..Increased CO production may participate in the disturbance of circulatory function that occurs during severe bacterial infections in cirrhosis...
  17. doi request reprint Hyponatremia in patients treated with terlipressin for severe gastrointestinal bleeding due to portal hypertension
    Elsa Solá
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    Hepatology 52:1783-90. 2010
    ....
  18. doi request reprint Prognostic importance of the cause of renal failure in patients with cirrhosis
    Marta Martín-Llahí
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Gastroenterology 140:488-496.e4. 2011
    ..The prognostic value of the different causes of renal failure in cirrhosis is not well established. This study investigated the predictive value of the cause of renal failure in cirrhosis...
  19. ncbi request reprint Advances in the pathogenesis and treatment of type-1 and type-2 hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 46:935-46. 2007
  20. ncbi request reprint Management of cirrhosis and ascites
    Pere Gines
    Liver Unit, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain
    N Engl J Med 350:1646-54. 2004
  21. ncbi request reprint MELD score and clinical type predict prognosis in hepatorenal syndrome: relevance to liver transplantation
    Carlo Alessandria
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Hepatology 41:1282-9. 2005
    ..These data can be useful in the management of patients with HRS, particularly for patients who are candidates for liver transplantation...
  22. doi request reprint Renal failure and hyponatremia in patients with cirrhosis and skin and soft tissue infection. A retrospective study
    Gustavo Pereira
    University of Barcelona, Barcelona, Spain
    J Hepatol 56:1040-6. 2012
    ..This study aimed at assessing the characteristics, occurrence of renal failure, and outcome of cirrhotic patients with skin and soft tissue infection...
  23. doi request reprint Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells
    Pau Sancho-Bru
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Barcelona, Catalonia, Spain
    Liver Int 30:31-41. 2010
    ..Activated hepatic stellate cells (HSC) and other fibrogenic cell types are frequently found around hepatocellular carcinoma. It is unknown whether hepatocarcinoma cells regulate the biological functions of HSC...
  24. ncbi request reprint Hyponatremia in cirrhosis: clinical features and management
    Marta Martín-Llahí
    Liver Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Gastroenterol Clin Biol 30:1144-51. 2006
    ..In addition, the possible beneficial effects of these drugs in the prevention of hepatic encephalopathy would be worth studying...
  25. doi request reprint Factors related to quality of life in patients with cirrhosis and ascites: relevance of serum sodium concentration and leg edema
    Elsa Solá
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 57:1199-206. 2012
    ..We aimed at assessing the relationship between serum sodium concentration and other clinical and analytical parameters on HRQL in cirrhosis with ascites...
  26. doi request reprint Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver
    Montserrat Moreno
    Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica Esther Koplowitz, Barcelona, Catalonia, Spain
    Am J Physiol Gastrointest Liver Physiol 296:G147-56. 2009
    ..These results indicate that atorvastatin attenuates the pathogenic events induced by ANG II in the liver both in vivo and in vitro. Therefore, statins could have beneficial effects in conditions characterized by hepatic inflammation...
  27. doi request reprint Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration
    Monica Guevara
    Liver Unit Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    Liver Int 30:1137-42. 2010
    ..In conclusion, in patients with refractory ascites, the occurrence of HE is related to the impairment of liver and renal function and presence of hyponatraemia...
  28. ncbi request reprint Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: Relationship with ascites and hepatorenal syndrome
    Christina Esteva-Font
    Molecular Biology Laboratory, Fundacio Puigvert, Barcelona, Spain
    Hepatology 44:1555-63. 2006
    ..Finally, aquaporin-1 does not appear to play a role in the progressive dysregulation of extracellular fluid volume in cirrhosis...
  29. ncbi request reprint Effects of celecoxib and naproxen on renal function in nonazotemic patients with cirrhosis and ascites
    Joan Claria
    DNA Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Hepatology 41:579-87. 2005
    ..Further studies are needed to evaluate the long-term safety of this drug in cirrhosis...
  30. doi request reprint LEFT ventricular function assessed by echocardiography in cirrhosis: relationship to systemic hemodynamics and renal dysfunction
    André Nazar
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 58:51-7. 2013
    ..The current study aimed at assessing the potential role of cardiac abnormalities in the pathogenesis of circulatory and renal dysfunction in cirrhosis...
  31. doi request reprint Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis
    Claudia Fagundes
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 57:267-73. 2012
    ..We aimed at assessing the usefulness of neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of tubular damage, in the differential diagnosis of impairment of kidney function in cirrhosis...
  32. doi request reprint Acute kidney injury is an early predictor of mortality for patients with alcoholic hepatitis
    Jose Altamirano
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Clin Gastroenterol Hepatol 10:65-71.e3. 2012
    ..We studied effects of acute kidney injury (AKI) on survival of patients with AH...
  33. doi request reprint Management of patients with cirrhosis awaiting liver transplantation
    Andres Cardenas
    GI Unit, Institut Clinic de Malalties Digestives i Metaboliques, Hospital Clinic, and University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, CIBER de Enfermedades Hepáticas y Digestivas CIBEREHD, Barcelona, Spain
    Gut 60:412-21. 2011
    ..Therefore the appropriate prevention, recognition and treatment of the above-mentioned complications of cirrhosis will have a positive impact on the outcome before and after liver transplantation...
  34. doi request reprint Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis
    Marlene Dominguez
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Catalonia, Spain
    Gastroenterology 136:1639-50. 2009
    ..We performed a prospective study to associate hepatic expression of the CXC subfamily of chemokines with histology findings and prognosis of patients with AH...
  35. doi request reprint Predictors of response to therapy with terlipressin and albumin in patients with cirrhosis and type 1 hepatorenal syndrome
    André Nazar
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    Hepatology 51:219-26. 2010
    ..001). Corresponding values in patients with an increase in mean arterial pressure >or=5 mm Hg or <5 mm Hg at day 3 were 73% and 36%, respectively (P = 0.037)...
  36. doi request reprint Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short-term risk of severe sepsis, hepatorenal syndrome, and death
    Juan Acevedo
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain Institut d Investigacions Biomèdiques August Pi Sunyer IDIBAPS, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHED, Barcelona, Spain
    Hepatology 58:1757-65. 2013
    ..Hepatology 2013;58:1757-1765). ..
  37. doi request reprint Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study
    Marta Martín-Llahí
    Liver Unit, Hospital Clinic, University of Barcelona School of Medicine, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Spain
    Gastroenterology 134:1352-9. 2008
    ..Hepatorenal syndrome is common in patients with advanced cirrhosis and constitutes a major problem in liver transplantation. There is no effective medical treatment for hepatorenal syndrome...
  38. ncbi request reprint Genomic and functional characterization of stellate cells isolated from human cirrhotic livers
    Pau Sancho-Bru
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalonia, Spain
    J Hepatol 43:272-82. 2005
    ..Knowledge on human HSCs is based on studies using HSCs isolated from normal livers. We investigated the phenotypic, genomic and functional characteristics of HSCs from human cirrhotic livers...
  39. ncbi request reprint New treatments of hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institut of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Spain
    Semin Liver Dis 26:254-64. 2006
    ....
  40. doi request reprint Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis
    Monica Guevara
    Liver Unit, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona, Spain
    Am J Gastroenterol 104:1382-9. 2009
    ..The aim of this study was to investigate whether hyponatremia is a risk factor of overt hepatic encephalopathy (HE) in cirrhosis...
  41. doi request reprint Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis
    Pau Sancho-Bru
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Hepatology 55:1931-41. 2012
    ..73, 95% confidence interval 0.60-0.87). Keratin7 expression provided additional discrimination potential to the age, bilirubin, international normalization ratio, creatinine (ABIC) score...
  42. doi request reprint Cerebral magnetic resonance imaging reveals marked abnormalities of brain tissue density in patients with cirrhosis without overt hepatic encephalopathy
    Monica Guevara
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 55:564-73. 2011
    ..We applied advanced magnetic resonance imaging and Voxed based Morphometry analysis to assess brain tissue density in patients with cirrhosis...
  43. ncbi request reprint Hepatic stellate cell activation in liver transplant patients with hepatitis C recurrence and in non-transplanted patients with chronic hepatitis C
    Laura Cisneros
    Liver Unit, Centro de Investigación Biomédica en Red de Enfermedades hepaticos y digestivas, Barcelona, Spain
    Liver Transpl 13:1017-27. 2007
    ..In LT patients, the amount of activated HSC and TGFbeta(1) expression correlated with fibrosis stage and progression, without any apparent influence of the type of calcineurin inhibitor administered...
  44. ncbi request reprint External validation of a prognostic model for predicting survival of cirrhotic patients with refractory ascites
    Jordi Guardiola
    Gastroenterology Unit, Hospital de l Alt Penedès, Vilafranca del Penedès, Barcelona, Spain
    Am J Gastroenterol 97:2374-8. 2002
    ..Recently, we developed a model to predict survival of patients with RA. The aim of this study was to establish its generalizability for predicting the survival of patients with RA...
  45. ncbi request reprint Effects of dilutional hyponatremia on brain organic osmolytes and water content in patients with cirrhosis
    Tea Restuccia
    Liver Unit, Hospital Clinic, Barcelona, Spain
    Hepatology 39:1613-22. 2004
    ..These findings may be relevant to the pathogenesis of encephalopathy in hyponatremic patients...
  46. ncbi request reprint Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II
    Ramon Bataller
    Department of Medicine, Hospital Clinic, Institut d Investigacions Biomédiques August Pi y Sunyer, University of Brescia School of Medicine, Barcelona, Catalonia, Spain
    Gastroenterology 125:117-25. 2003
    ..The aim of this study was to investigate whether quiescent and activated human hepatic stellate cells contain the components of the renin-angiotensin system and synthesize angiotensin II...
  47. ncbi request reprint Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury
    Pau Sancho-Bru
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Barcelona, Catalonia, Spain
    Gastroenterology 133:2019-28. 2007
    ..Recent studies have suggested that the kallikrein-kinin system regulates tissue fibrogenesis. We hypothesize that bradykinin (BK), the main effector peptide of this system, regulates hepatic fibrogenesis...
  48. ncbi request reprint Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity
    Jordi Colmenero
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Barcelona, Catalonia, Spain
    Gastroenterology 132:687-97. 2007
    ..Alcoholic hepatitis (AH) is a form of acute-on-chronic liver failure for which current therapy is not fully effective. We investigated the hepatic expression of candidate genes in patients with AH to identify new targets for therapy...
  49. ncbi request reprint Hepatic hemodynamics and transient elastography in alcoholic foamy degeneration: report of 2 cases
    Pablo Ruiz
    Liver Unit, Hospital Clinic, Institut d Investigaciones Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Ann Hepatol 11:399-403. 2012
    ..In both cases there was rapid resolution of biochemical and clinical abnormalities after complete abstinence, which is the mainstay of treatment for AFD...
  50. doi request reprint Hepatorenal syndrome: a severe, but treatable, cause of kidney failure in cirrhosis
    Claudia Fagundes
    Liver Unit, Hospital Clinic and University of Barcelona School of Medicine, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Ciber de Enfermedades Hepáticas y Digestivas CIBERHED, Insituto Reina Sofia de Investigación Nefrológica IRSIN, Barcelona, Catalunya, Spain
    Am J Kidney Dis 59:874-85. 2012
    ..The drug of choice is the vasopressin analogue terlipressin. Renal replacement therapy should not be used as first-line therapy...
  51. doi request reprint Tolvaptan, an oral vasopressin antagonist, in the treatment of hyponatremia in cirrhosis
    Andres Cardenas
    GI Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 56:571-8. 2012
    ..Specific data on the safety and efficacy of tolvaptan in patients with cirrhosis and hyponatremia has not been exclusively evaluated...
  52. doi request reprint [Hyponatremia in liver cirrhosis: pathogenesis and treatment]
    Monica Guevara
    Servei d Hepatologia, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Endocrinol Nutr 57:15-21. 2010
    ..Since hypervolemic hyponatremia is by far the most frequent form of this disorder, the present chapter will concentrate specifically on hypervolemic hyponatremia in cirrhosis...
  53. doi request reprint A new scoring system for prognostic stratification of patients with alcoholic hepatitis
    Marlene Dominguez
    Liver Unit, Institut Clínic Malalties Digestives i Metabòliques, Hospital Clinic, and Centro de Investigación Biomédica Esther Koplowitz, Barcelona, Catalonia, Spain
    Am J Gastroenterol 103:2747-56. 2008
    ..We aimed at developing a scoring system capable of providing prognostic stratification of patients with AH...
  54. ncbi request reprint Management of refractory ascites
    Andres Cardenas
    Liver Unit, Institute of Digestive Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Clin Gastroenterol Hepatol 3:1187-91. 2005
  55. doi request reprint A modified acute kidney injury classification for diagnosis and risk stratification of impairment of kidney function in cirrhosis
    Claudia Fagundes
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 59:474-81. 2013
    ..The Acute Kidney Injury Network (AKIN) criteria are widely used in nephrology, but information on cirrhosis is limited. We aimed at evaluating the AKIN criteria and their relationship with the cause of kidney impairment and survival...
  56. doi request reprint Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis
    Silvia Affò
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Centre Esther Koplowitz, CIBER de Enfermedades Hepáticas y Digestivas CIBEREHD, Barcelona, Spain
    Gut 62:452-60. 2013
    ..The identification of targets for therapy is hampered by the lack of animal models of advanced AH. The authors performed a translational study through a transcriptome analysis in patients with AH to identify new molecular targets...
  57. ncbi request reprint Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation
    Odette Viñas
    Laboratory of Immunology, Hospital Clinic, University of Barcelona School of Medicine, Institut d Investigacios Biomèdiques August Pi Sunyer IDIBAPS, Villaroel 170, 08036 Barcelona, Catalonia, Spain
    Hepatology 38:919-29. 2003
    ..In conclusion, human activated HSCs express molecules for antigen presentation, internalize macromolecules, and modulate T-lymphocyte proliferation. These results suggest that HSCs may play a role in the immune function of the liver...
  58. doi request reprint Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: a prospective study
    Javier Fernandez
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 55:1551-61. 2012
    ..45), and recent use of β-lactams (HR, 2.39) were independently associated with the development of multiresistant infections. Results in the second series were similar to those observed in the first series...
  59. doi request reprint The amount of alcohol consumption negatively impacts short-term mortality in Mexican patients with alcoholic hepatitis
    Jose Altamirano
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Spain
    Am J Gastroenterol 106:1472-80. 2011
    ..The aims of the present study were to identify the prognostic factors of short-term mortality in Mexican patients with AH and to validate the existing prognostic models...
  60. doi request reprint Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans
    Montserrat Moreno
    Liver Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hepatology 51:974-85. 2010
    ..Conclusion: Ghrelin exerts antifibrotic effects in the liver and may represent a novel antifibrotic therapy...
  61. doi request reprint Clinically relevant differences in the model for end-stage liver disease and model for end-stage liver disease-sodium scores determined at three university-based laboratories of the same area
    Xavier Xiol
    Liver Transplant Unit, Institut d Investigacio Biomedica de Bellvitge, Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    Liver Transpl 15:300-5. 2009
    ..Alternatively, the possibility of setting up a central laboratory in each organ procurement area should be considered...
  62. ncbi request reprint Hepatorenal syndrome in cirrhosis: pathogenesis and treatment
    Vicente Arroyo
    Liver Unit, Institute of Digestive Disease, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Gastroenterology 122:1658-76. 2002
  63. ncbi request reprint Therapy insight: Management of hepatorenal syndrome
    Andres Cardenas
    Institut de Malalties Digestives, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 3:338-48. 2006
    ..For prevention of HRS, albumin infusion is recommended in patients with spontaneous bacterial peritonitis, and pentoxifylline treatment is recommended in patients with acute alcoholic hepatitis...
  64. doi request reprint Cigarette smoking exacerbates nonalcoholic fatty liver disease in obese rats
    Lorenzo Azzalini
    Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d Investigacions Biomediques August Pi i Sunyer, and Liver Unit, Hospital Clinic, Barcelona, Catalonia, Spain
    Hepatology 51:1567-76. 2010
    ..Finally, smoking regulated ERK and AKT phosphorylation. The deleterious effects of CS were not observed after a short exposure (5 days)...
  65. doi request reprint Results of pretransplant treatment of hepatorenal syndrome with terlipressin
    Elsa Solá
    Liver Unit, Hospital Clinic and University of Barcelona, Barcelona, Spain
    Curr Opin Organ Transplant 18:265-70. 2013
    ..Pretransplant care of HRS is of utmost importance in order to secure a good posttransplant outcome. We review the advances during the last year in the diagnosis and management of HRS in candidates who are awaiting liver transplantation...
  66. ncbi request reprint Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival
    Javier Fernandez
    Liver Unit, Department of Surgery and Centro de Investigaciones Biomédicas Esther Koplowitz, IMDiM, IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 44:1288-95. 2006
    ..Hydrocortisone administration in these patients is associated with a high frequency of shock resolution and high survival rate...
  67. ncbi request reprint Hepatorenal syndrome
    Andres Cardenas
    Liver Unit, Institut de Malalties Digestives Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Villaroel 170, Barcelona 08036, Spain
    Clin Liver Dis 10:371-85, ix-x. 2006
    ..This article focuses on the pathogenesis, clinical features, diagnostic approach, and current treatment of HRS in cirrhosis...
  68. ncbi request reprint Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis
    Javier Fernandez
    Liver Unit, Hospital Clinic Barcelona, Barcelona, Spain
    Gastroenterology 133:818-24. 2007
    ..Norfloxacin is highly effective in preventing spontaneous bacterial peritonitis recurrence in cirrhosis, but its role in the primary prevention of this complication is uncertain...
  69. doi request reprint Renal and circulatory dysfunction in cirrhosis: current management and future perspectives
    Elsa Solá
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 53:1135-45. 2010
    ..This article reviews our current knowledge, as well as future perspectives, on the management of circulatory and renal dysfunction in chronic liver failure...
  70. ncbi request reprint [Dilutional hyponatremia, hepatorenal syndrome and liver transplantation]
    Andres Cardenas
    Institut de Malalties Digestives i Metaboliques, Universidad de Barcelona, Hospital Clinic, Barcelona, Espana
    Gastroenterol Hepatol 31:29-36. 2008
    ..The present review discusses new concepts of the physiopathology, evaluation and treatment of cirrhotic patients with dilutional hyponatremia and HRS and the relationship of these entities with LT...
  71. ncbi request reprint Effects of treatment of hepatorenal syndrome before transplantation on posttransplantation outcome. A case-control study
    Tea Restuccia
    Liver Unit, Institute for Digestive Diseases, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona 08036, Catalunya, Spain
    J Hepatol 40:140-6. 2004
    ..Pretransplant renal function is the major determinant of survival after liver transplantation (LTx). Patients with hepatorenal syndrome (HRS) have a poor outcome after LTx compared with patients transplanted without HRS...
  72. ncbi request reprint Liver fibrogenesis: a new role for the renin-angiotensin system
    Ramon Bataller
    Institut de Malalties Digestives i Metaboliques, Hospital Clinic, IDIBAPS, Barcelona, Catalonia, Spain
    Antioxid Redox Signal 7:1346-55. 2005
    ..Although no prospective studies have evaluated the antifibrotic effect of RAS inhibitors in patients with chronic liver diseases, controlled clinical trials are under way...
  73. ncbi request reprint Hepatorenal syndrome
    Monica Guevara
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain
    Dig Dis 23:47-55. 2005
    ....
  74. doi request reprint Pathogenesis and treatment of hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, CIBERehd, Hospital Clinic, University of Barcelona, Spain
    Semin Liver Dis 28:81-95. 2008
    ..However, effective treatments of HRS (vasoconstrictors associated with intravenous albumin, transjugular intrahepatic portacaval shunt, albumin dialysis) that can improve survival have recently been introduced...
  75. pmc Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells
    Cristiana Bertolani
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I 50134 Florence, Italy, and the Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Am J Pathol 169:2042-53. 2006
    ....
  76. ncbi request reprint [New therapeutic strategies in liver fibrosis: pathogenic basis]
    Ramon Bataller
    Servicio de Hepatologia, Institut de Malalties Digestives, Hospital Clinico, IDIBAPS, Barcelona, Spain
    Med Clin (Barc) 118:339-46. 2002
  77. doi request reprint Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats
    Montserrat Moreno
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Catalonia, Spain
    Hepatology 51:942-52. 2010
    ..Conclusion: Short-term treatment with HSC-targeted losartan markedly reduces advanced liver fibrosis. This approach may provide a novel means to treat chronic liver diseases...
  78. ncbi request reprint What's new in the treatment of ascites and spontaneous bacterial peritonitis
    Andres Cardenas
    Liver Unit, University of Barcelona Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Curr Gastroenterol Rep 10:7-14. 2008
    ..The following review is divided into two parts; the first discusses ascites and renal function abnormalities, including hyponatremia and HRS, and the second discusses SBP management...
  79. ncbi request reprint Portal hypertension
    Andres Cardenas
    GI Unit, Institut de Malaties Digestives, Hospital Clinic and University of Barcelona, Spain
    Curr Opin Gastroenterol 25:195-201. 2009
    ..Advances in the diagnosis and management of portal hypertension over the last year are reviewed...
  80. ncbi request reprint Effects of contrast media on renal function in patients with cirrhosis: a prospective study
    Monica Guevara
    Liver Unit, Hospital Clinic, Barcelona, Spain
    Hepatology 40:646-51. 2004
    ..Cirrhosis does not appear to be a risk factor for the development of contrast media-induced nephrotoxicity...
  81. doi request reprint Acute-on-chronic liver failure: the kidneys
    Andres Cardenas
    GI Unit, Institut de Malaties Digestives, Hospital Clinic and University of Barcelona, Spain
    Curr Opin Crit Care 17:184-9. 2011
    ..Kidney function is almost universally altered in patients with ACLF due to underlying circulatory abnormalities. We review current advances during the past year in the diagnosis and management of renal failure in ACLF...
  82. ncbi request reprint Hepatorenal syndrome
    Pere Gines
    Liver Unit, Hospital Cli nic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain
    Lancet 362:1819-27. 2003
    ..Although these findings need to be confirmed, these two strategies represent innovative approaches to lower the frequency of HRS in clinical practice...