Carles Gil

Summary

Country: Spain

Publications

  1. pmc C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons
    Carles Gil
    Departament de Bioquimica i de Biologia Molecular, Facultat de Medicina, Institut de Neurociencies, Universitat Autonoma de Barcelona, E 08193 Bellaterra Barcelona, Catalunya, Spain
    Biochem J 373:613-20. 2003
  2. ncbi request reprint Synaptic proteins and SNARE complexes are localized in lipid rafts from rat brain synaptosomes
    Carles Gil
    Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Cerdanyola 08193, Catalunya, Spain
    Biochem Biophys Res Commun 329:117-24. 2005
  3. ncbi request reprint The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways
    Imane Chaib-Oukadour
    Departament de Bioquímica i de Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurochem 90:1227-36. 2004
  4. ncbi request reprint Synaptic proteins associate with a sub-set of lipid rafts when isolated from nerve endings at physiological temperature
    Carles Gil
    Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Biochem Biophys Res Commun 348:1334-42. 2006
  5. doi request reprint Trk receptors need neutral sphingomyelinase activity to promote cell viability
    Ana Candalija
    Department of Biochemistry and Molecular Biology, Institute of Neurosciences, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Catalunya, Spain
    FEBS Lett 588:167-74. 2014
  6. doi request reprint Differential sensitivity to detergents of actin cytoskeleton from nerve endings
    Roger Cubi
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Catalunya, Spain Institut de Neurociències, Universitat Autonoma de Barcelona, Spain
    Biochim Biophys Acta 1828:2385-93. 2013
  7. doi request reprint Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment
    Arantza Rodríguez-Asiain
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1811:1124-35. 2011
  8. doi request reprint Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release
    Carles Gil
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    FEBS Lett 585:414-20. 2011
  9. ncbi request reprint Serotonin transport is modulated differently by tetanus toxin and growth factors
    Carles Gil
    Departament de Bioquimica i de Biologia Molecular, Institut de Neurociencies, Universitat Autonoma de Barcelona, E 08193 Cerdanyola del Vallès, Barcelona, Spain
    Neurochem Int 42:535-42. 2003
  10. doi request reprint Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity
    Imane Chaib-Oukadour
    Departament de Bioquimica i de Biologia Molecular, Institut de Neurociencies, Universitat Autonoma de Barcelona, Cerdanyola del Valles 08193, Spain
    Mol Cell Neurosci 41:297-303. 2009

Collaborators

Detail Information

Publications11

  1. pmc C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons
    Carles Gil
    Departament de Bioquimica i de Biologia Molecular, Facultat de Medicina, Institut de Neurociencies, Universitat Autonoma de Barcelona, E 08193 Bellaterra Barcelona, Catalunya, Spain
    Biochem J 373:613-20. 2003
    ..The activation of PKC isoforms was determined by their translocation from the cytosolic compartment to the membranous compartment, showing a clear H(C)-TeTx-induced translocation of PKC-alpha and -beta, but not of PKC- epsilon...
  2. ncbi request reprint Synaptic proteins and SNARE complexes are localized in lipid rafts from rat brain synaptosomes
    Carles Gil
    Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Cerdanyola 08193, Catalunya, Spain
    Biochem Biophys Res Commun 329:117-24. 2005
    ..The results from the present work show that lipid microdomains are sites where SNARE proteins and complexes are actually present, as well as important elements in the control of regulated exocytosis...
  3. ncbi request reprint The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways
    Imane Chaib-Oukadour
    Departament de Bioquímica i de Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurochem 90:1227-36. 2004
    ..These results point to an implication of both PI3K- and ERK-dependent pathways in the promotion of cerebellar granule cell survival by Hc-TeTx...
  4. ncbi request reprint Synaptic proteins associate with a sub-set of lipid rafts when isolated from nerve endings at physiological temperature
    Carles Gil
    Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Biochem Biophys Res Commun 348:1334-42. 2006
    ..Finally, we detect the depolarization-induced enhancement of the cholesterol-dependent association of syntaxin 1 with Brij 98-rafts, under the same conditions in which prolonged neurotransmitter release is stimulated...
  5. doi request reprint Trk receptors need neutral sphingomyelinase activity to promote cell viability
    Ana Candalija
    Department of Biochemistry and Molecular Biology, Institute of Neurosciences, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Catalunya, Spain
    FEBS Lett 588:167-74. 2014
    ..Finally, the assessment of nSMase activity promotion drives to the conclusion that neurotrophins can promote cell viability through Trk receptors in a manner depending on basal nSMase but not through SMase activity enhancement. ..
  6. doi request reprint Differential sensitivity to detergents of actin cytoskeleton from nerve endings
    Roger Cubi
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Catalunya, Spain Institut de Neurociències, Universitat Autonoma de Barcelona, Spain
    Biochim Biophys Acta 1828:2385-93. 2013
    ..In conclusion, the detergent of choice is important when events that depend on the actin cytoskeleton are going to be studied. ..
  7. doi request reprint Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment
    Arantza Rodríguez-Asiain
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1811:1124-35. 2011
    ..Importantly, SMV also enhanced the activity of a constitutively active BRSK1 (T189E), underpinning that interaction with lipid rafts represents a new mechanism of BRSK1 activity modulation, additional to T-loop phosphorylation...
  8. doi request reprint Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release
    Carles Gil
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    FEBS Lett 585:414-20. 2011
    ..In conclusion, CK2 might control neurotransmitter release by acting on SNARE proteins attached to cholesterol-enriched microdomains...
  9. ncbi request reprint Serotonin transport is modulated differently by tetanus toxin and growth factors
    Carles Gil
    Departament de Bioquimica i de Biologia Molecular, Institut de Neurociencies, Universitat Autonoma de Barcelona, E 08193 Cerdanyola del Vallès, Barcelona, Spain
    Neurochem Int 42:535-42. 2003
    ..The differential effect on alpha- and beta-PKC isoenzymes found between NGF and TeTx action could explain this apparent discrepancy...
  10. doi request reprint Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity
    Imane Chaib-Oukadour
    Departament de Bioquimica i de Biologia Molecular, Institut de Neurociencies, Universitat Autonoma de Barcelona, Cerdanyola del Valles 08193, Spain
    Mol Cell Neurosci 41:297-303. 2009
    ..Taken together, our results strongly suggest that the recombinant H(C) fragment of tetanus toxin can act as a neuroprotector in a model of MPP(+)-triggered apoptosis...
  11. ncbi request reprint Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts
    Carles Gil
    Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Edifici M, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Catalunya, Spain
    FEBS Lett 581:1851-8. 2007
    ..In summary, our results point to a role of lipid rafts in the modulation of the shedding of the p75(NTR) receptor...