Research Topics
| Carles GilSummaryCountry: Spain Publications
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Publications
C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neuronsCarles Gil
Departament de Bioquimica i de Biologia Molecular, Facultat de Medicina, Institut de Neurociencies, Universitat Autonoma de Barcelona, E 08193 Bellaterra Barcelona, Catalunya, Spain
Biochem J 373:613-20. 2003..The activation of PKC isoforms was determined by their translocation from the cytosolic compartment to the membranous compartment, showing a clear H(C)-TeTx-induced translocation of PKC-alpha and -beta, but not of PKC- epsilon...
Synaptic proteins and SNARE complexes are localized in lipid rafts from rat brain synaptosomesCarles Gil
Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Cerdanyola 08193, Catalunya, Spain
Biochem Biophys Res Commun 329:117-24. 2005..The results from the present work show that lipid microdomains are sites where SNARE proteins and complexes are actually present, as well as important elements in the control of regulated exocytosis...
The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathwaysImane Chaib-Oukadour
Departament de Bioquímica i de Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Bellaterra, Spain
J Neurochem 90:1227-36. 2004..These results point to an implication of both PI3K- and ERK-dependent pathways in the promotion of cerebellar granule cell survival by Hc-TeTx...
Synaptic proteins associate with a sub-set of lipid rafts when isolated from nerve endings at physiological temperatureCarles Gil
Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
Biochem Biophys Res Commun 348:1334-42. 2006..Finally, we detect the depolarization-induced enhancement of the cholesterol-dependent association of syntaxin 1 with Brij 98-rafts, under the same conditions in which prolonged neurotransmitter release is stimulated...
Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environmentArantza Rodríguez-Asiain
Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
Biochim Biophys Acta 1811:1124-35. 2011..Importantly, SMV also enhanced the activity of a constitutively active BRSK1 (T189E), underpinning that interaction with lipid rafts represents a new mechanism of BRSK1 activity modulation, additional to T-loop phosphorylation...
Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter releaseCarles Gil
Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
FEBS Lett 585:414-20. 2011..In conclusion, CK2 might control neurotransmitter release by acting on SNARE proteins attached to cholesterol-enriched microdomains...
Shedding of the p75NTR neurotrophin receptor is modulated by lipid raftsCarles Gil
Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Edifici M, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Catalunya, Spain
FEBS Lett 581:1851-8. 2007..In summary, our results point to a role of lipid rafts in the modulation of the shedding of the p75(NTR) receptor...
Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicityImane Chaib-Oukadour
Departament de Bioquimica i de Biologia Molecular, Institut de Neurociencies, Universitat Autonoma de Barcelona, Cerdanyola del Valles 08193, Spain
Mol Cell Neurosci 41:297-303. 2009..Taken together, our results strongly suggest that the recombinant H(C) fragment of tetanus toxin can act as a neuroprotector in a model of MPP(+)-triggered apoptosis...
Serotonin transport is modulated differently by tetanus toxin and growth factorsCarles Gil
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Neurochem Int 42:535-42. 2003..The differential effect on alpha- and beta-PKC isoenzymes found between NGF and TeTx action could explain this apparent discrepancy...
