Pablo Gastaminza

Summary

Country: Spain

Publications

  1. pmc Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection
    Pablo Gastaminza
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 9203, USA
    J Virol 85:5513-23. 2011
  2. pmc Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell culture
    Pablo Gastaminza
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 84:10999-1009. 2010
  3. pmc Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection
    Ken Takahashi
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:7431-6. 2010
  4. pmc Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus
    Ana Montero
    Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA
    Chem Biol 18:1453-62. 2011
  5. pmc A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro
    Guofeng Cheng
    Departments of Molecular and Experimental Medicine, Chemistry, and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:3088-93. 2008
  6. pmc Persistent hepatitis C virus infection in vitro: coevolution of virus and host
    Jin Zhong
    Department of Molecular and Experimental Medicine, SBR 10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Virol 80:11082-93. 2006
  7. pmc The autophagy machinery is required to initiate hepatitis C virus replication
    Marlene Dreux
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:14046-51. 2009
  8. pmc Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection
    Pablo Gastaminza
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:291-6. 2010
  9. ncbi request reprint Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
    Mansun Law
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 14:25-7. 2008
  10. pmc Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion
    Pablo Gastaminza
    The Scripps Research Institute, Maildrop SBR 10, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 82:2120-9. 2008

Collaborators

Detail Information

Publications14

  1. pmc Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection
    Pablo Gastaminza
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 9203, USA
    J Virol 85:5513-23. 2011
    ....
  2. pmc Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell culture
    Pablo Gastaminza
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 84:10999-1009. 2010
    ..Our study constitutes an initial approach toward understanding the structural characteristics of infectious HCV particles...
  3. pmc Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection
    Ken Takahashi
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:7431-6. 2010
    ....
  4. pmc Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus
    Ana Montero
    Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA
    Chem Biol 18:1453-62. 2011
    ..Our results indicate that supramolecular amphiphilic peptide structures constitute a class of highly selective HCV entry inhibitors...
  5. pmc A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro
    Guofeng Cheng
    Departments of Molecular and Experimental Medicine, Chemistry, and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:3088-93. 2008
    ..These results suggest a model in which C5A destabilizes viral membranes based on their lipid composition, offering a unique therapeutic approach to HCV and other viral infections...
  6. pmc Persistent hepatitis C virus infection in vitro: coevolution of virus and host
    Jin Zhong
    Department of Molecular and Experimental Medicine, SBR 10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Virol 80:11082-93. 2006
    ..Collectively, these results reveal the existence of coevolutionary events during persistent HCV infection that favor survival of both virus and host...
  7. pmc The autophagy machinery is required to initiate hepatitis C virus replication
    Marlene Dreux
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:14046-51. 2009
    ....
  8. pmc Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection
    Pablo Gastaminza
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:291-6. 2010
    ..Discovery of novel viral and cellular targets in this manner will broaden the therapeutic armamentarium against this virus, allowing for the development of drug mixtures that should reduce the likelihood of mutational escape...
  9. ncbi request reprint Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
    Mansun Law
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 14:25-7. 2008
    ..The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable...
  10. pmc Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion
    Pablo Gastaminza
    The Scripps Research Institute, Maildrop SBR 10, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 82:2120-9. 2008
    ..These results suggest that by coopting the VLDL assembly, maturation, degradation, and secretory machinery of the cell, HCV acquires its hepatocyte tropism and, by mimicry, its tendency to persist...
  11. pmc Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles
    Pablo Gastaminza
    The Scripps Research Institute, Maildrop SBR 1010550, North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 80:11074-81. 2006
    ..15 to 1.20 g/ml) from extracellular particles (approximately 1.03 to 1.16 g/ml). These results indicate that infectious HCV particles are assembled intracellularly and that their biochemical composition is altered during viral egress...
  12. pmc Robust hepatitis C virus infection in vitro
    Jin Zhong
    Departments of Molecular and Experimental Medicine and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:9294-9. 2005
    ..This system provides a powerful tool for the analysis of host-virus interactions that should facilitate the discovery of antiviral drugs and vaccines for this important human pathogen...
  13. pmc 3D structure of the influenza virus polymerase complex: localization of subunit domains
    Estela Area
    Centro Nacional de Biotecnologia, Cantoblanco, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 101:308-13. 2004
    ..This structural model is available for the polymerase of a negative-stranded RNA virus and provides a general delineation of the complex and its interaction with the template-associated nucleoprotein monomers in the RNP...
  14. pmc Mutations in the N-terminal region of influenza virus PB2 protein affect virus RNA replication but not transcription
    Pablo Gastaminza
    Centro Nacional de Biotecnologia, Campus de Cantoblanco, 28049 Madrid, Spain
    J Virol 77:5098-108. 2003
    ..These results indicate that the N-terminal region of PB2 plays a role in viral RNA replication...