Luis A Garcia Rodriguez

Summary

Country: Spain

Publications

  1. doi Use of proton pump inhibitors and the risk of coronary events in new users of low-dose acetylsalicylic acid in UK primary care
    Luis A Garcia Rodriguez
    Luis A García Rodríguez, Spanish Centre for Pharmacoepidemiologic Research CEIFE, Almirante 28 2, E 28004, Madrid, Spain, Tel 34 91 531 3404, Fax 34 91 531 2871, E mail
    Thromb Haemost 111:131-9. 2014
  2. doi Mortality after hemorrhagic stroke: data from general practice (The Health Improvement Network)
    Antonio Gonzalez-Perez
    Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain
    Neurology 81:559-65. 2013
  3. doi Antithrombotic drugs and risk of hemorrhagic stroke in the general population
    Luis A García-Rodriguez
    Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain
    Neurology 81:566-74. 2013
  4. doi Cardiovascular and upper gastrointestinal bleeding consequences of low-dose acetylsalicylic acid discontinuation
    Lucía Cea Soriano
    Luis A García Rodríguez, Spanish Centre for Pharmacoepidemiologic Research CEIFE, Almirante 28 2, E 28004, Madrid, Spain, Tel 34 91 531 3404, Fax 34 91 531 2871, E mail
    Thromb Haemost 110:1298-304. 2013
  5. doi Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Recent Results Cancer Res 191:67-93. 2013
  6. pmc Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism
    Consuelo Huerta
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Thromb J 6:10. 2008
  7. pmc Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications
    Sonia Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    BMC Med 4:22. 2006
  8. pmc Risk of serious skin disorders among users of oral antifungals: a population-based study
    Jordi Castellsague
    Novartis Global Epidemiology, Barcelona, Spain
    BMC Dermatol 2:14. 2002
  9. pmc Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations
    F J de Abajo
    División de Farmacoepidemiología y Farmacovigilancia, Agencia Española del Medicamento, Madrid, Spain
    BMC Clin Pharmacol 1:1. 2001
  10. pmc Risk of mortality in a cohort of patients newly diagnosed with chronic atrial fibrillation
    Ana Ruigómez
    Centro Español de Investigación Farmacoepidemiológica, Spain
    BMC Cardiovasc Disord 2:5. 2002

Collaborators

Detail Information

Publications69

  1. doi Use of proton pump inhibitors and the risk of coronary events in new users of low-dose acetylsalicylic acid in UK primary care
    Luis A Garcia Rodriguez
    Luis A García Rodríguez, Spanish Centre for Pharmacoepidemiologic Research CEIFE, Almirante 28 2, E 28004, Madrid, Spain, Tel 34 91 531 3404, Fax 34 91 531 2871, E mail
    Thromb Haemost 111:131-9. 2014
    ..96 [0.62-1.48]). In conclusion, among first-time users of ASA for the secondary prevention of cardiovascular events, PPI use was not shown to be associated with an increased risk of non-fatal MI or coronary death. ..
  2. doi Mortality after hemorrhagic stroke: data from general practice (The Health Improvement Network)
    Antonio Gonzalez-Perez
    Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain
    Neurology 81:559-65. 2013
    ..To investigate short-term case fatality and long-term mortality after intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) using data from The Health Improvement Network database...
  3. doi Antithrombotic drugs and risk of hemorrhagic stroke in the general population
    Luis A García-Rodriguez
    Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain
    Neurology 81:566-74. 2013
    ..To investigate the relationship between hemorrhagic stroke and use of antiplatelets and warfarin using data from The Health Improvement Network...
  4. doi Cardiovascular and upper gastrointestinal bleeding consequences of low-dose acetylsalicylic acid discontinuation
    Lucía Cea Soriano
    Luis A García Rodríguez, Spanish Centre for Pharmacoepidemiologic Research CEIFE, Almirante 28 2, E 28004, Madrid, Spain, Tel 34 91 531 3404, Fax 34 91 531 2871, E mail
    Thromb Haemost 110:1298-304. 2013
    ..In conclusion, preventing patients with cardiovascular disease from discontinuing ASA could result in substantial clinical and economic gains. ..
  5. doi Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Recent Results Cancer Res 191:67-93. 2013
    ..The possible use of coxibs to prevent CRC will depend mainly on research progresses in biomarkers able to identify the patients uniquely susceptible to developing thrombotic events by inhibition of COX-2...
  6. pmc Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism
    Consuelo Huerta
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Thromb J 6:10. 2008
    ..The aim of this study was to determine whether a diagnosis of VTE increases the long-term risk of myocardial infarction (MI)...
  7. pmc Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications
    Sonia Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    BMC Med 4:22. 2006
    ....
  8. pmc Risk of serious skin disorders among users of oral antifungals: a population-based study
    Jordi Castellsague
    Novartis Global Epidemiology, Barcelona, Spain
    BMC Dermatol 2:14. 2002
    ..Serious skin disorders have been associated with the use of oral antifungals in a number of case reports and series of cases. However the incidence of these disorders remains unknown...
  9. pmc Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations
    F J de Abajo
    División de Farmacoepidemiología y Farmacovigilancia, Agencia Española del Medicamento, Madrid, Spain
    BMC Clin Pharmacol 1:1. 2001
    ..The coating of aspirin has been proposed as an approach to reduce such a risk. To test this hypothesis, we carried out a population based case-control study...
  10. pmc Risk of mortality in a cohort of patients newly diagnosed with chronic atrial fibrillation
    Ana Ruigómez
    Centro Español de Investigación Farmacoepidemiológica, Spain
    BMC Cardiovasc Disord 2:5. 2002
    ..To evaluate the role of co-morbidity and other factors on the risk of dying among AF patients...
  11. pmc Predictors and prognosis of paroxysmal atrial fibrillation in general practice in the UK
    Ana Ruigómez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    BMC Cardiovasc Disord 5:20. 2005
    ....
  12. ncbi The ever growing story of cyclo-oxygenase inhibition
    Luis Alberto Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica, 28004 Madrid, Spain
    Lancet 368:1745-7. 2006
  13. doi Acid-suppressive drugs and community-acquired pneumonia
    Luis Alberto Garcia Rodriguez
    Spanish Centre for Pharmacoepidemiological Research CEIFE, Madrid, Spain
    Epidemiology 20:800-6. 2009
    ..Acid suppression may increase the risk of community-acquired pneumonia. We investigated this association in the United Kingdom primary care system taking account of the potential for confounding by indication...
  14. ncbi Use of acid-suppressing drugs and the risk of bacterial gastroenteritis
    Luis Alberto García Rodríguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Clin Gastroenterol Hepatol 5:1418-23. 2007
    ..Gastric acid is a defense mechanism against gastrointestinal infections caused by ingested bacteria. Studies have suggested that the use of acid-suppressing drugs may increase the risk of gastroenteritis (GE)...
  15. ncbi Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Gastroenterology 132:498-506. 2007
    ..Whether use of selective inhibitors of cyclooxygenase-2 (COXIBs) will translate into a clinically relevant reduced toxicity has not been widely investigated in the general population...
  16. doi Use of multiple international healthcare databases for the detection of rare drug-associated outcomes: a pharmacoepidemiological programme comparing rosuvastatin with other marketed statins
    Luis A Garcia Rodriguez
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Pharmacoepidemiol Drug Saf 19:1218-24. 2010
    ..These studies used a coordinated methodology to facilitate future meta-analysis...
  17. doi Heart failure, myocardial infarction, lung cancer and death in COPD patients: a UK primary care study
    Luis A Garcia Rodriguez
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Respir Med 104:1691-9. 2010
    ..The aim of this study was to establish the incidence of lung cancer, myocardial infarction and heart failure in patients with COPD in UK primary care...
  18. doi The safety of rosuvastatin in comparison with other statins in over 100,000 statin users in UK primary care
    Luis Alberto García-Rodríguez
    Spanish Centre for Pharmacoepidemiological Research CEIFE, Madrid, Spain
    Pharmacoepidemiol Drug Saf 17:943-52. 2008
    ..To compare mortality and the incidence of hospitalization for myopathy, rhabdomyolysis, acute renal failure and acute liver injury in patients receiving rosuvastatin and those taking other statins...
  19. ncbi Chronic obstructive pulmonary disease in UK primary care: incidence and risk factors
    Luis A Garcia Rodriguez
    Spanish Centre for Pharmacoepidemiological Research CEIFE, Madrid, 28004, Spain
    COPD 6:369-79. 2009
    ..While the risk factors are similar in smokers and never smokers, some were unique to never smokers. Moreover, subjects who stopped smoking had a substantially lower COPD risk than those who continued smoking...
  20. doi Relationship between gastroesophageal reflux disease and COPD in UK primary care
    Luis A Garcia Rodriguez
    Spanish Centre for Pharmacoepidemiological Research, CEIFE, Madrid, Spain
    Chest 134:1223-30. 2008
    ..The aim of this study was to investigate the relationship between diagnoses of COPD and gastroesophageal reflux disease (GERD) in primary care...
  21. doi Role of dose potency in the prediction of risk of myocardial infarction associated with nonsteroidal anti-inflammatory drugs in the general population
    Luis Alberto García Rodríguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    J Am Coll Cardiol 52:1628-36. 2008
    ..We verified whether the degree of inhibition of whole blood cyclooxygenase (COX)-2 by average circulating drug levels can be a surrogate biochemical predictor of the risk of MI by NSAIDs...
  22. doi Rheumatoid arthritis in UK primary care: incidence and prior morbidity
    L A García Rodríguez
    Spanish Centre for Pharmacoepidemiological Research CEIFE, Madrid, Spain
    Scand J Rheumatol 38:173-7. 2009
    ..To estimate the incidence of rheumatoid arthritis (RA) in primary care and to investigate associations with consultation behaviour, risk factors, and comorbidities, using the UK General Practice Research Database (GPRD)...
  23. pmc NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies
    Luis Alberto García Rodríguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    PLoS ONE 6:e16780. 2011
    ..There appeared to be a disproportionate increase in non-fatal versus fatal events, however, numbers of fatal events in individual studies were too small, and event rates too low, to be meaningful...
  24. ncbi Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease
    Luis Alberto García Rodríguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Gastroenterology 130:1588-94. 2006
    ..We explored the relationship between infectious gastroenteritis and the occurrence of IBD using data from the General Practice Research Database...
  25. doi Increased risk of stroke after discontinuation of acetylsalicylic acid: a UK primary care study
    Luis A Garcia Rodriguez
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid 28004, Spain
    Neurology 76:740-6. 2011
    ..This study evaluated the risk of ischemic stroke (IS) and TIA after low-dose ASA discontinuation in patients with cardiovascular disease or cerebrovascular disease...
  26. ncbi Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs
    Luis Alberto García Rodríguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Am J Epidemiol 159:23-31. 2004
    ..2) for duodenal ulcers. The risk of symptomatic ulcer for aspirin and nonaspirin NSAIDs was elevated throughout treatment. These findings suggest that NSAIDs might not only complicate but also originate clinically relevant peptic ulcers...
  27. ncbi Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Circulation 109:3000-6. 2004
    ..Some reports suggest that concurrent aspirin and ibuprofen might be associated with lower cardioprotection than aspirin alone because of a pharmacodynamic interaction...
  28. pmc Association between aspirin and upper gastrointestinal complications: systematic review of epidemiologic studies
    L A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Br J Clin Pharmacol 52:563-71. 2001
    ..This study summarizes the relative risk (RR) for serious upper gastrointestinal complications (UGIC) associated with aspirin exposure in general and with specific aspirin doses and formulations in particular...
  29. ncbi The effect of NSAIDs on the risk of coronary heart disease: fusion of clinical pharmacology and pharmacoepidemiologic data
    L A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Clin Exp Rheumatol 19:S41-4. 2001
    ..In light of these findings, the potential minor cardiovascular effects of specific COX-2 inhibitors need to be evaluated in large populations...
  30. doi The safety of rosuvastatin in comparison with other statins in over 25,000 statin users in the Saskatchewan Health Databases
    Luis Alberto García-Rodríguez
    Spanish Centre for Pharmacoepidemiological Research CEIFE, Madrid, Spain
    Pharmacoepidemiol Drug Saf 17:953-61. 2008
    ..To compare mortality and the incidence of hospitalization for myopathy, rhabdomyolysis, acute renal failure and acute liver injury in patients receiving rosuvastatin and those taking other statins...
  31. pmc Discontinuation of low dose aspirin and risk of myocardial infarction: case-control study in UK primary care
    Luis A Garcia Rodriguez
    Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain
    BMJ 343:d4094. 2011
    ..To evaluate the risk of myocardial infarction and death from coronary heart disease after discontinuation of low dose aspirin in primary care patients with a history of cardiovascular events...
  32. doi Risk of upper gastrointestinal bleeding with low-dose acetylsalicylic acid alone and in combination with clopidogrel and other medications
    Luis A Garcia Rodriguez
    Spanish Centre for Pharmacoepidemiological Research, Madrid 28004, Spain
    Circulation 123:1108-15. 2011
    ..This study evaluated the risk of upper gastrointestinal bleeding (UGIB) associated with use of low-dose acetylsalicylic acid (ASA) alone and in combination with other gastrotoxic medications...
  33. pmc Long-term use of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    BMC Med 3:17. 2005
    ..Our aim has been to evaluate the association between the chronic use of tNSAIDs and the risk of myocardial infarction (MI) in patients...
  34. ncbi Upper gastrointestinal complications among users of paracetamol
    Antonio Gonzalez-Perez
    Spanish Centre for Pharmacoepidemiological Research, Madrid, Spain
    Basic Clin Pharmacol Toxicol 98:297-303. 2006
    ..More data are needed to confirm or refute the suggestion that high-dose paracetamol is associated with an increased risk of upper gastrointestinal complications of the same magnitude as the one observed with traditional NSAIDs...
  35. ncbi Nonsteroidal antiinflammatory drugs as a trigger of clinical heart failure
    Luis Alberto García Rodríguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Epidemiology 14:240-6. 2003
    ....
  36. ncbi Risk of irritable bowel syndrome after an episode of bacterial gastroenteritis in general practice: influence of comorbidities
    Ana Ruigómez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Clin Gastroenterol Hepatol 5:465-9. 2007
    ....
  37. doi Predictors and time trends in clopidogrel and proton pump inhibitor coprescription with low-dose acetylsalicylic acid
    Lucía Cea Soriano
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Pharmacoepidemiol Drug Saf 21:463-9. 2012
    ....
  38. ncbi Risk factors and short-term mortality of venous thromboembolism diagnosed in the primary care setting in the United Kingdom
    Consuelo Huerta
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Arch Intern Med 167:935-43. 2007
    ..Our aim was to study the clinical spectrum of VTE, assess its incidence in the general population, and evaluate potential risk factors...
  39. ncbi Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Almirante 28 2, 28004 Madrid, Spain
    Cancer Epidemiol Biomarkers Prev 13:649-53. 2004
    ..However, these studies show conflicting results...
  40. doi Gastroesophageal reflux disease in primary care: using changes in proton pump inhibitor therapy as an indicator of partial response
    Ana Ruigómez
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Scand J Gastroenterol 47:751-61. 2012
    ..We aimed to characterize partial response to PPIs among adult patients in UK primary care...
  41. doi Treatment patterns in paediatric patients with a new diagnosis of gastroesophageal reflux disease
    Ana Ruigómez
    Spanish Centre for Pharmacoepidemiologic Research, CEIFE, Madrid, Spain
    Eur J Gastroenterol Hepatol 23:232-7. 2011
    ..Few data exist on the treatment of gastroesophageal reflux disease (GERD) in paediatrics. The objective of this study was to examine treatment patterns of GERD in paediatrics in the primary care...
  42. doi Effect of baseline gastrointestinal risk and use of proton pump inhibitors on frequency of discontinuation of aspirin for secondary cardiovascular prevention in United kingdom primary care
    Elisa Martín Merino
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Am J Cardiol 112:1075-82. 2013
    ..Further studies need to confirm factors with the potential to increase adherence to long-term aspirin. ..
  43. ncbi Hormone therapy and cerebrovascular events: a population-based nested case-control study
    Alejandro Arana
    Novartis, Clinical Safety and Epidemiology, Madrid, Spain
    Menopause 13:730-6. 2006
    ..The authors aimed to evaluate the association between the use of HT and the incidence of first cerebrovascular event...
  44. ncbi Gallbladder disease in the general population: association with cardiovascular morbidity and therapy
    Antonio Gonzalez-Perez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Pharmacoepidemiol Drug Saf 16:524-31. 2007
    ..Additionally the use of thiazide diuretics may also be a risk factor for this condition. We aimed to evaluate different cardiovascular conditions and related drugs that could be associated with GB disease...
  45. doi Follow-up of a cohort of children and adolescents with gastro-esophageal reflux disease who were free of reflux esophagitis at initial diagnosis
    Ana Ruigómez
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Scand J Gastroenterol 45:814-21. 2010
    ..Here we aimed to describe the natural history of GERD in a pediatric population with no reflux esophagitis at initial diagnosis, assessing diagnoses of new esophageal complications and extra-esophageal conditions...
  46. ncbi Cancer incidence in a general population of asthma patients
    Antonio Gonzalez-Perez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Pharmacoepidemiol Drug Saf 15:131-8. 2006
    ..Several studies have assessed the association between asthma and cancer but none of them revealed a clear pattern of association. We aimed to examine the association between asthma, chronic obstructive pulmonary disease (COPD), and cancer...
  47. doi Epidemiology of meningioma in the United Kingdom
    Lucía Cea-Soriano
    Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain
    Neuroepidemiology 39:27-34. 2012
    ..Data on the epidemiology and aetiology of meningioma are limited...
  48. doi Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding
    Elvira L Massó González
    Spanish Centre for Pharmacoepidemiological Research, Madrid, Spain
    Arthritis Rheum 62:1592-601. 2010
    ....
  49. doi Androgen deprivation therapy and the risk of coronary heart disease and heart failure in patients with prostate cancer: a nested case-control study in UK primary care
    Elisa Martín-Merino
    Spanish Centre for Pharmacoepidemiological Research CEIFE, Madrid, Spain
    Drug Saf 34:1061-77. 2011
    ..However, several randomized controlled trials and observational studies have suggested that ADT may increase the risk of cardiovascular events...
  50. pmc Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug-drug interaction?
    Luis Alberto García Rodríguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    PLoS Med 4:e157. 2007
    ..Furthermore, estrogen confers atheroprotection via COX-2-dependent PGI2 in mice, raising the possibility that COX inhibitors may undermine the cardioprotection, suggested by observational studies, of endogenous or exogenous estrogens...
  51. pmc Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis
    Antonio Gonzalez-Perez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    BMC Cancer 3:28. 2003
    ..Studies assessing the effects of NSAIDs on other cancers have shown conflicting results. Therefore, we conducted a meta-analysis to evaluate the relationship between NSAID use and cancer other than colorectal...
  52. pmc Contemporary epidemiology of gout in the UK general population
    Lucía Cea Soriano
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Almirante 28 2, 28004, Madrid, Spain
    Arthritis Res Ther 13:R39. 2011
    ..The objective of this study was to investigate the contemporary incidence of gout, examine potential risk factors, and evaluate specific gout treatment patterns in the general population...
  53. ncbi Respiratory medications and the risk of cardiac arrhythmias
    Consuelo Huerta
    Centro Español de Investigación Farmacoepidemiológica, Almirante 28, 2o, 28004 Madrid, Spain
    Epidemiology 16:360-6. 2005
    ..Most of these drugs have been associated indirectly with cardiac rhythm disorders, but epidemiologic evidence is limited...
  54. doi Risk factors for falls with use of acid-suppressive drugs
    Lucía Cea-Soriano
    Spanish Centre for Pharmacoepidemiologic Research, CEIFE, Madrid, Spain
    Epidemiology 24:600-7. 2013
    ..As these acid-suppressive drugs may have uncommon adverse effects on the central nervous system (CNS), such as dizziness, we investigated whether their use is associated with falls as a possible mechanism for increasing fracture risk...
  55. ncbi Labor induction with dinoprostone or oxytocine and postpartum disseminated intravascular coagulation: a hospital-based case-control study
    Francisco J de Abajo
    Division of Pharmacoepidemiology and Pharmacovigilance, Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain
    Am J Obstet Gynecol 191:1637-43. 2004
    ..This study was undertaken to test the hypothesis of an association between pharmacologic agents used for labor induction, in particular dinoprostone, and postpartum disseminated intravascular coagulation (DIC)...
  56. ncbi Breast cancer incidence and use of antihypertensive medication in women
    Antonio Gonzalez-Perez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Pharmacoepidemiol Drug Saf 13:581-5. 2004
    ..Breast cancer is the most common cancer in women worldwide. We attempted to investigate the association between the risk of breast cancer and use of captopril and other antihypertensive medication...
  57. ncbi Risk of acute liver injury in patients with diabetes
    Consuelo Huerta
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Pharmacotherapy 22:1091-6. 2002
    ....
  58. ncbi Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population
    Consuelo Huerta
    Centro Español de Investigación Farmacoepidemiológica, Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain
    Am J Kidney Dis 45:531-9. 2005
    ..Despite these studies, little is known about the effect of dose and duration of therapy, risk of individual NSAIDs, comorbidity, or concomitant use of other nephrotoxic drugs...
  59. doi Risk of cardiovascular and cerebrovascular events after atrial fibrillation diagnosis
    Ana Ruigómez
    Spanish Centre for Pharmacoepidemiological Research CEIFE, Madrid, Spain
    Int J Cardiol 136:186-92. 2009
    ..This study aimed to evaluate the risk of ischemic cerebrovascular events (ICVE), coronary events (CE) or heart failure (HF) following a diagnosis of AF...
  60. doi Prevalence, incidence, morbidity and treatment patterns in a cohort of patients diagnosed with anxiety in UK primary care
    Elisa Martín-Merino
    Centro Español de Investigación Farmacoepidemiológica, Almirante 28 no 2, Madrid, Spain
    Fam Pract 27:9-16. 2010
    ..Anxiety disorders are common and can cause substantial quality of life impairment...
  61. ncbi Risk of irritable bowel syndrome among asthma patients
    Consuelo Huerta
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Pharmacoepidemiol Drug Saf 11:31-5. 2002
    ..An association between Irritable Bowel Syndrome (IBS) and bronchial hyper-responsiveness has been suggested. Only a few studies have specifically studied the association between IBS and asthma...
  62. ncbi Risk of cerebrovascular accident after a first diagnosis of atrial fibrillation
    Ana Ruigómez
    Spanish Centre for Pharmacoepidemiological Research CEIFE, Madrid, Spain
    Clin Cardiol 30:624-8. 2007
    ..Atrial fibrillation is the most common cardiac arrhythmia and a major risk factor for cerebrovascular accident, including ischemic stroke and transient ischemic attack...
  63. ncbi Comparison of gastro-oesophageal reflux disease and heartburn diagnoses in UK primary care
    Ana Ruigómez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Curr Med Res Opin 22:1661-8. 2006
    ..It is unclear how gastro-oesophageal reflux disease (GORD) is diagnosed in primary care. The aim of this study is to compare patients given a diagnosis of GORD with those diagnosed with heartburn...
  64. pmc Chest pain without established ischaemic heart disease in primary care patients: associated comorbidities and mortality
    Ana Ruigómez
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Br J Gen Pract 59:e78-86. 2009
    ..The remainder have what is generally referred to as non-cardiac chest pain, which has been associated with gastrointestinal, neuromusculoskeletal, pulmonary, and psychiatric causes...
  65. ncbi Breast cancer risk among users of antidepressant medications
    Antonio Gonzalez-Perez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Epidemiology 16:101-5. 2005
    ..Breast cancer is the most common cancer in women. Laboratory studies suggest that antidepressants may promote breast cancer tumor growth. Several epidemiologic studies have evaluated this association with conflicting results...
  66. doi Challenges of using primary care electronic medical records in the UK to study medications in pregnancy
    Lucía Cea-Soriano
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain
    Pharmacoepidemiol Drug Saf 22:977-85. 2013
    ..This paper aimed to assess the prescription of medications during pregnancy by primary care physicians in the UK...
  67. pmc Acute and clinically relevant drug-induced liver injury: a population based case-control study
    Francisco J de Abajo
    Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid, Spain
    Br J Clin Pharmacol 58:71-80. 2004
    ..To provide quantitative information about the absolute and relative risks of acute and clinically relevant drug-induced liver injury...
  68. doi Do oral antimuscarinic drugs carry an increased risk of acute urinary retention?
    Elisa Martín-Merino
    Spanish Center for Pharmacoepidemiological Research, Madrid, Spain
    J Urol 182:1442-8. 2009
    ..We determined whether men treated with oral antimuscarinics are at increased risk for acute urinary retention...
  69. doi Use of non-steroidal antiinflammatory drugs and type-specific risk of acute coronary syndrome
    Hector Bueno
    Department of Cardiology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Am J Cardiol 105:1102-6. 2010
    ..This risk was stronger when NSAIDs were used at high doses or in patients with previous ischemic heart disease...