Felipe Garcia

Summary

Country: Spain

Publications

  1. ncbi request reprint Flow-cytometric assessment of lymphocyte cytokine production in tuberculosis
    M Garcia
    Internal Medicine Department, Clinica Puerta de Hierro, Universidad Autonoma, Madrid, Spain
    Tuberculosis (Edinb) 82:37-41. 2002
  2. ncbi request reprint Depressive symptoms after initiation of interferon therapy in human immunodeficiency virus-infected patients with chronic hepatitis C
    Montserrat Laguno
    Infectious Diseases Unit, Hospital Clinic Universitari de Barcelona, Barcelona, Spain
    Antivir Ther 9:905-9. 2004
  3. ncbi request reprint Dynamics of T cells subsets and lymphoproliferative responses during structured treatment interruption cycles and after definitive interruption of HAART in early chronic HIV type-1-infected patients
    Agnes Libois
    Infectious Diseases Unit, School of Medicine, University of Barcelona, Spain
    AIDS Res Hum Retroviruses 22:657-66. 2006
  4. ncbi request reprint A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized study
    Felipe Garcia
    Infectious Diseases Unit, Clinic Institute of Infectious Diseases and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    AIDS 17:43-51. 2003
  5. doi request reprint Influence of a vaccination schedule on viral load rebound and immune responses in successfully treated HIV-infected patients
    Pedro Castro
    Medical Intensive Care Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 25:1249-59. 2009
  6. ncbi request reprint Plasma stromal cell-derived factor (SDF)-1 levels, SDF1-3'A genotype, and expression of CXCR4 on T lymphocytes: their impact on resistance to human immunodeficiency virus type 1 infection and its progression
    Alex Soriano
    Institut Clinic d Infeccions i Immunologia, Hospital Clinic Universitari, Barcelona, Spain
    J Infect Dis 186:922-31. 2002
  7. ncbi request reprint Pharmacokinetics and pharmacodynamics of low dose mycophenolate mofetil in HIV-infected patients treated with abacavir, efavirenz and nelfinavir
    Olga Millán
    Servei Immunologia, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Clin Pharmacokinet 44:525-38. 2005
  8. pmc Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals
    Víctor Casanova
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
    PLoS ONE 7:e51287. 2012
  9. doi request reprint Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV
    Nuria Climent
    Hospital Clinic, Barcelona, Spain
    Immunol Cell Biol 87:634-9. 2009
  10. pmc Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression
    Marta Rodríguez-García
    Service of Immunology, Hospital Clinic de Barcelona, Barcelona, Spain
    PLoS ONE 5:e9436. 2010

Detail Information

Publications60

  1. ncbi request reprint Flow-cytometric assessment of lymphocyte cytokine production in tuberculosis
    M Garcia
    Internal Medicine Department, Clinica Puerta de Hierro, Universidad Autonoma, Madrid, Spain
    Tuberculosis (Edinb) 82:37-41. 2002
    ..These data indicate that the immunosuppression observed in PBL during active tuberculosis infection may be related to IL10 production, and to the compartmentalization of the antigen-Th1 response to sites of active MTB infection...
  2. ncbi request reprint Depressive symptoms after initiation of interferon therapy in human immunodeficiency virus-infected patients with chronic hepatitis C
    Montserrat Laguno
    Infectious Diseases Unit, Hospital Clinic Universitari de Barcelona, Barcelona, Spain
    Antivir Ther 9:905-9. 2004
    ..In this study, we evaluated the incidence and management of depressive symptoms during IFN-alpha therapy in HIV-infected patients with CHC...
  3. ncbi request reprint Dynamics of T cells subsets and lymphoproliferative responses during structured treatment interruption cycles and after definitive interruption of HAART in early chronic HIV type-1-infected patients
    Agnes Libois
    Infectious Diseases Unit, School of Medicine, University of Barcelona, Spain
    AIDS Res Hum Retroviruses 22:657-66. 2006
    ..Conversely, higher and longer viral replication after cessation of HAART overwhelms the immune system. These data may help to guide future immune-based therapies...
  4. ncbi request reprint A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized study
    Felipe Garcia
    Infectious Diseases Unit, Clinic Institute of Infectious Diseases and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    AIDS 17:43-51. 2003
    ....
  5. doi request reprint Influence of a vaccination schedule on viral load rebound and immune responses in successfully treated HIV-infected patients
    Pedro Castro
    Medical Intensive Care Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 25:1249-59. 2009
    ..However, it induced an increase in T cell activation and a drop in CD4(+) T cells, although these changes did not influence the VL rebound dynamics after HAART interruption...
  6. ncbi request reprint Plasma stromal cell-derived factor (SDF)-1 levels, SDF1-3'A genotype, and expression of CXCR4 on T lymphocytes: their impact on resistance to human immunodeficiency virus type 1 infection and its progression
    Alex Soriano
    Institut Clinic d Infeccions i Immunologia, Hospital Clinic Universitari, Barcelona, Spain
    J Infect Dis 186:922-31. 2002
    ..EU subjects with sexual exposure to HIV-1, but not EU hemophiliacs, showed an underpresentation of SDF1-3'A allele frequency, which was coupled with high plasma SDF-1 levels and low CXCR4 expression...
  7. ncbi request reprint Pharmacokinetics and pharmacodynamics of low dose mycophenolate mofetil in HIV-infected patients treated with abacavir, efavirenz and nelfinavir
    Olga Millán
    Servei Immunologia, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Clin Pharmacokinet 44:525-38. 2005
    ..Due to the low doses involved, pharmacokinetic-pharmacodynamic monitoring is recommended...
  8. pmc Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals
    Víctor Casanova
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
    PLoS ONE 7:e51287. 2012
    ..Taken together, these findings suggest that ADA would promote enhanced and correctly polarized T-cell responses in strategies targeting asymptomatic HIV-infected individuals...
  9. doi request reprint Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV
    Nuria Climent
    Hospital Clinic, Barcelona, Spain
    Immunol Cell Biol 87:634-9. 2009
    ..As IFN-gamma, TNF-alpha and IL-6 promote the Th1 versus Th2 phenotype and improve T helper proliferation responses and antigen-specific CTL responses ADA may be considered a promising candidate for therapeutic vaccine adjuvant...
  10. pmc Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression
    Marta Rodríguez-García
    Service of Immunology, Hospital Clinic de Barcelona, Barcelona, Spain
    PLoS ONE 5:e9436. 2010
    ..Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of alpha-defensins1-3 production by DC on disease progression...
  11. ncbi request reprint Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell activation
    Anna Suy
    Gynecology Department, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Infect Dis 196:1191-201. 2007
    ....
  12. ncbi request reprint Predictors of tonsillar tissue HIV-1 viral burden at baseline and after 1 year of antiretroviral therapy
    Pilar Navarrete
    Infectious Diseases Unit, Clinic Institute of Infectious Diseases and Immunology, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Antivir Ther 8:635-7. 2003
    ..No correlation was observed after 1 year of antiretroviral therapy. A protease inhibitor-containing regimen was the best predictor of good tonsillar tissue virological response...
  13. ncbi request reprint Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor
    Jose L Blanco
    Infectious Diseases Service, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    AIDS 19:829-31. 2005
    ..Only one of the 66 patients developed changes in their pattern of mutations able to generate or increase resistance to new drugs...
  14. ncbi request reprint Clinicoimmunological progression and response to treatment of long-term nonprogressor HIV-hepatitis C virus-coinfected patients
    Pedro Castro
    Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    AIDS Res Hum Retroviruses 23:863-7. 2007
    ..HCV-treated LTNP could have a worse HIV progression than HIV-HCV-treated NP or untreated coinfected LTNP. HCV infection does not have a deleterious effect on the progression of LTNP...
  15. doi request reprint Phenotypic and functional characteristics of HIV-specific CD8 T cells and gag sequence variability after autologous dendritic cells based therapeutic vaccine
    Anna Lopez
    Retrovirology and Viral Immunopathology Laboratory, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Vaccine 27:6166-78. 2009
    ..Taken together, heterogeneity in the maturation status of HIV-specific CD8 T cells may be partially involved in the drop of peptide-specific IFN-gamma production during immunizations...
  16. doi request reprint Assessment of migration of HIV-1-loaded dendritic cells labeled with 111In-oxine used as a therapeutic vaccine in HIV-1-infected patients
    Alba Ruiz
    Infectious Diseases Unit, Hospital Clinic, Villarroel 170, Barcelona, Spain
    Immunotherapy 1:347-54. 2009
    ..92, p = 0.03). If more than 20,000 ILDCs had migrated, they could have been detected. In future trials, a higher number of DCs or alternative methods should be used to assess the migration of DCs to lymph nodes...
  17. pmc Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation
    José M Martinez-Navio
    Department of Biochemistry and Molecular Biology, Faculty of Biology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Immunology 128:393-404. 2009
    ....
  18. pmc Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals
    Nuria Climent
    Service of Immunology, Hospital Clinic de Barcelona, Barcelona, Spain
    PLoS ONE 6:e19644. 2011
    ..These results evidence the adjuvant role of the vector itself (MVA) and support the clinical development of prophylactic and therapeutic anti-HIV vaccines based on MVA-B...
  19. doi request reprint Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV type 1-infected patients using a nonnucleoside reverse transcriptase inhibitor-based or a boosted protease inhibitor-based antiretroviral regimen: three-year results (The Advanz T
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 26:747-57. 2010
    ..At 1 and 3 years, the immune reconstitution induced by an efavirenz-based regimen in very immunosuppressed patients was at least as potent as that induced by a ritonavir-boosted protease inhibitor-based antiretroviral regimen...
  20. doi request reprint Short Communication: Natural killer cells and expression of KIR receptors in chronic HIV type 1-infected patients after different strategies of structured therapy interruption
    Gabriel Mestre
    Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 24:1485-95. 2008
    ..This finding suggests that STI could decrease the number of NK subsets, which is related to the worst clinical development in these patients...
  21. doi request reprint Factors associated with collagen deposition in lymphoid tissue in long-term treated HIV-infected patients
    Alba Diaz
    Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS 24:2029-39. 2010
    ..The factors associated with fibrosis in lymphoid tissue in long-term treated HIV-infected patients and their correlation with immune reconstitution were assessed...
  22. doi request reprint Impact of alpha-defensins1-3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effects
    Marta Rodríguez-García
    Service of Immunology, Hospital Clinic Universitari de Barcelona, School of Medicine, University of Barcelona, Barcelona, Spain
    Clin Immunol 131:374-84. 2009
    ..Results suggest that alpha-defensins1-3 might modulate the maturation and differentiation of MDDCs in vivo and therefore could be of special interest in the field of vaccine development...
  23. pmc Influence of episodes of intermittent viremia ("blips") on immune responses and viral load rebound in successfully treated HIV-infected patients
    Pedro Castro
    Medical Intensive Care Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 29:68-76. 2013
    ..After treatment interruption, they showed greater specific immune responses against HIV, which did not prevent a higher virological rebound. EIV between 20 and 200 copies/ml did not have this deleterious effect...
  24. ncbi request reprint Similar HIV-1 evolution and immunological responses at 10 years despite several therapeutic strategies and host HLA Types
    Mireia Arnedo-Valero
    Microbiology, Hospital Clinic, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    J Med Virol 73:495-501. 2004
    ..These results suggest that, in this case, an effective immunological response to STI depended more on the virus than on the characteristics of the host...
  25. doi request reprint Restoration of T cell responses to toxoplasma gondii after successful combined antiretroviral therapy in patients with AIDS with previous toxoplasmic encephalitis
    Marylène Lejeune
    Immunology Service, Hospital Clinic Institut d Investigacions Biomèdiques Augustí Pi i Suñer, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 52:662-70. 2011
    ..It is unknown whether a Toxoplasma gondii-specific T cell response is restored after successful combined antiretroviral therapy (cART) in patients with AIDS and current or previous toxoplasmic encephalitis (TE)...
  26. ncbi request reprint Redistribution of FOXP3-positive regulatory T cells from lymphoid tissues to peripheral blood in HIV-infected patients
    Ana Mozos
    Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 46:529-37. 2007
    ..Design: Paired samples from lymphoid tissue and peripheral blood were simultaneously obtained from 27 HIV-infected patients (before and after highly active antiretroviral therapy [HAART]) and 6 controls...
  27. ncbi request reprint HIV-1 upregulates intercellular adhesion molecule-1 gene expression in lymphoid tissue of patients with chronic HIV-1 infection
    Marta Garrido
    Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 46:268-74. 2007
    ..Our main objective was to study ICAM-1 expression in LT from HIV-1-infected persons and to correlate this expression with LT viral load and the immunoarchitecture alteration before and after highly active antiretroviral therapy (HAART)...
  28. ncbi request reprint Incidence and risk factors for mitochondrial toxicity in treated HIV/HCV-coinfected patients
    Montse Laguno
    Infectious Diseases Unit, Hospital Clinic Barcelona, Barcelona, Spain
    Antivir Ther 10:423-9. 2005
    ....
  29. pmc Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: down-regulation of TREM-1 as putative underlying mechanism
    Carlos del Fresno
    Research Unit, La Paz Hospital, Madrid, Spain
    PLoS ONE 3:e2667. 2008
    ..We conclude that down-regulation of TREM-1 expression in cystic fibrosis patients is at least partly responsible for the endotoxin tolerance state in which their monocytes are locked...
  30. pmc Rate and predictors of non-AIDS events in a cohort of HIV-infected patients with a CD4 T cell count above 500 cells/mm³
    Constanza Lucero
    Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    AIDS Res Hum Retroviruses 29:1161-7. 2013
    ..Reduction of CIR of non-AIDS events after cART initiation depends on nadir CD4 T cell count. Most of the controllers patients had a CIR similar to noncontrollers. These data support the early initiation of cART in HIV-infected patients...
  31. pmc Use of RT-defective HIV virions: new tool to evaluate specific response in chronic asymptomatic HIV-infected individuals
    Alberto Crespo Guardo
    Retrovirology and Viral Immunopathology Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    PLoS ONE 8:e58927. 2013
    ..Generation of new reagents that can be used to screen or monitor HIV-1-specific responses constituted an interesting field in the development of HIV vaccines to improve their efficacy...
  32. pmc Evolution of broadly cross-reactive HIV-1-neutralizing activity: therapy-associated decline, positive association with detectable viremia, and partial restoration of B-cell subpopulations
    Carolina B Ferreira
    AIDS Research Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Virol 87:12227-36. 2013
    ..Our data suggest that HIV-1 broadly cross-neutralizing activity is variable over time and associated with detectable viremia and partial B-cell restoration. ..
  33. ncbi request reprint Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner
    M Carmen González-León
    Research Unit, La Paz Hospital, Madrid, Spain
    J Endotoxin Res 12:296-306. 2006
    ..We conclude that NO stimulates SOCS-1 overexpression in a pathway at least partially regulated by TNF-alpha...
  34. ncbi request reprint Central nervous system opportunistic infections in developed countries in the highly active antiretroviral therapy era
    Christian Manzardo
    Infectious Diseases Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Neurovirol 11:72-82. 2005
    ....
  35. pmc Generation and characterization of a defective HIV-1 Virus as an immunogen for a therapeutic vaccine
    Carmen Alvarez-Fernández
    Institut dInvestigations Biomèdiques August Pi i Sunyer IDIBAPS AIDS Research Group, Hospital Clinic, Catalonian Center for HIV Vaccines HIVACAT and University of Barcelona, Barcelona, Spain
    PLoS ONE 7:e48848. 2012
    ..We designed and constructed a defective recombinant virus based on the HIV-1 genome generating infective but non-replicative virions able to elicit broad and strong cellular immune responses in HIV-1 seropositive individuals...
  36. doi request reprint Therapeutic vaccines against HIV infection
    Felipe Garcia
    Hospital Clinic HIVACAT, IDIBAPS, University of Barcelona, Barcelona, Spain
    Hum Vaccin Immunother 8:569-81. 2012
    ....
  37. doi request reprint Post-exposure prophylaxis for HIV infection: a clinical trial comparing lopinavir/ritonavir versus atazanavir each with zidovudine/lamivudine
    Vicens Diaz-Brito
    Hospital Clinic, University of Barcelona, Barcelona, Spain
    Antivir Ther 17:337-46. 2012
    ..A clinical trial comparing the rate of discontinuation and tolerability of two post-exposure prophylaxis (PEP) regimens was performed...
  38. ncbi request reprint Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infection
    Felipe Garcia
    Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    J Infect Dis 191:1680-5. 2005
    ..This response was associated with changes in HIV-1-specific CD4(+) lymphoproliferative and CD8(+) T cell responses. These changes were not observed in a group of nonimmunized control patients...
  39. pmc A new multidisciplinary home care telemedicine system to monitor stable chronic human immunodeficiency virus-infected patients: a randomized study
    Agathe Leon
    Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    PLoS ONE 6:e14515. 2011
    ..This clinical scenario requires a new approach to simplify follow-up appointments and facilitate access to healthcare professionals...
  40. ncbi request reprint Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adults
    Esteban Martinez
    Infectious Diseases Unit, Hospital Clinic, University of Barcelona, Calle Villarroel 170, 08036 Barcelona, Spain
    Lancet 364:65-7. 2004
    ..666, 95% CI 1.246-91.294, p=0.031). These results suggest that the risk of pancreatitis is heightened when didanosine and tenofovir are given together...
  41. doi request reprint A cell-to-cell HIV transfer assay identifies humoral responses with broad neutralization activity
    Sonsoles Sánchez-Palomino
    Infectious Diseases Unit HIVACAT, Hospital Clinic, Barcelona, Spain
    Vaccine 29:5250-9. 2011
    ....
  42. doi request reprint Prevalence of dihydropteroate synthase genotypes before and after the introduction of combined antiretroviral therapy and their influence on the outcome of Pneumocystis pneumonia in HIV-1-infected patients
    Miriam J Alvarez-Martinez
    Hospital Clínic IDIBAPS Institut d Investigació August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Diagn Microbiol Infect Dis 68:60-5. 2010
    ..However, their presence did not worsen prognosis of PcP. The response to TMP-SMX with therapeutic doses was successful in most cases...
  43. doi request reprint Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia
    Carlos Cervera
    Services of Infectious Diseases, Hospital Clinic of Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain
    Eur J Haematol 87:87-91. 2011
    ..Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia...
  44. ncbi request reprint Effect of mycophenolate mofetil on immune response and plasma and lymphatic tissue viral load during and after interruption of highly active antiretroviral therapy for patients with chronic HIV infection: a randomized pilot study
    Felipe Garcia
    Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    J Acquir Immune Defic Syndr 36:823-30. 2004
    ..005) after 6 months off HAART. We found that combining MMF and HAART delayed VL rebound and improved control of viral replication without HAART but only when inhibition of lymphocyte proliferation was achieved...
  45. ncbi request reprint [Use of non-occupational HIV post-exposure prophylaxis in Spain (2001-2005)]
    Nuria Vives
    Centro de estudios epidemiológicos sobre ITS SIDA de Cataluña CEEISCAT CIBER Epidemiología y Salud Pública CIBERESP, Hospital Universitario Germans Trias i Pujol, Carretera de Canyet s n, Badalona, Barcelona, Spain
    Enferm Infecc Microbiol Clin 26:546-51. 2008
    ..The aim of this study is to describe the characteristics of the persons exposed, types of exposures, antiretroviral treatment prescribed, and outcome of HIV infection in cases of non-occupational exposure in Spain...
  46. ncbi request reprint Human immature monocyte-derived dendritic cells produce and secrete alpha-defensins 1-3
    Marta Rodríguez-García
    Service of Immunology, Hospital Clinic Universitari de Barcelona, Villarroel 170, 08036, Barcelona, Spain
    J Leukoc Biol 82:1143-6. 2007
    ....
  47. pmc Inflammatory responses in blood samples of human immunodeficiency virus-infected patients with pulmonary infections
    Natividad Benito
    Service of Infectious Diseases, Institut Clínic de Infeccions i Inmunologia, Clinic Hospital IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
    Clin Diagn Lab Immunol 11:608-14. 2004
    ..An elevated IL-8 level (>61 pg/ml) at the time of admission was an independent factor associated with higher mortality (odds ratio, 12; 95% confidence interval, 1.2 to 235.5)...
  48. pmc A therapeutic dendritic cell-based vaccine for HIV-1 infection
    Felipe Garcia
    Infectious Diseases Department, Hospital Clinic HIV Development Program in Catalonia, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    J Infect Dis 203:473-8. 2011
    ....
  49. ncbi request reprint Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistence
    Llucia Alos
    Department of Pathology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Mod Pathol 18:127-36. 2005
    ..However, these parameters studied in lymphoid tissue are not re-established completely, even after 36 months of highly active antiretroviral therapy...
  50. doi request reprint Influence of repeated cycles of structured therapy interruption on the rate of recovery of CD4+ T cells after highly active antiretroviral therapy resumption
    Agathe Leon
    Infectious Diseases Department, Hospital Clinic of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Antimicrob Chemother 63:184-8. 2009
    ..CD4+ T cell recovery dynamics were analysed during the 'on treatment' periods in structured therapy interruption (STI) as well as the long-term immune reconstitution with highly active antiretroviral therapy (HAART) after finishing STI...
  51. ncbi request reprint [Therapeutic and preventive vaccine against HIV problems and the necessity to develop one]
    Felipe Garcia
    Unidad de Investigación en Inmunopatogenia del VIH, Servicio de Enfermedades Infecciosas, IDIBAPS, Hospital Clinic, Universidad de Barcelona
    Rev Enferm 28:24-8. 2005
    ..The upcoming work by the Spanish Group "RIS" on Therapeutic and Preventive Vaccines might place Spanish professionals in the front line in the international fight against AIDS...
  52. doi request reprint Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02)
    Felipe Garcia
    Hospital Clinic IDIBAPS, Barcelona, Spain
    Vaccine 29:8309-16. 2011
    ..To investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed...
  53. doi request reprint Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection Workshop in dendritic cell-based vaccine clinical trials in HIV-1
    Felipe Garcia
    Infectious Diseases Unit, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Spain
    Vaccine 29:6454-63. 2011
    ..This report summarizes the present situation of the field and the discussions and conclusions of this meeting...
  54. ncbi request reprint Immune restoration in HIV-positive, antiretroviral-naive patients after 1 year of zidovudine/lamivudine plus nelfinavir or nevirapine
    Montserrat Plana
    Institut Clinic d Infeccions i Immunologia, Immunology, Infectious Diseases and Microbiology Units, Institut de Investigació Biomèdica Agusti Pi i Suñer, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Antivir Ther 9:197-204. 2004
    ..To evaluate the immunological response in HIV-1-infected, antiretroviral-naive patients receiving highly active antiretroviral therapy regimen of two nucleosides plus a protease inhibitor or a non-nucleoside reverse transcriptase inhibitor...
  55. ncbi request reprint Group A streptococcal infections in injection drug users in Barcelona, Spain: epidemiologic, clinical, and microbiologic analysis of 3 clusters of cases from 2000 to 2003
    Josep M Sierra
    Hospital Clinic Universitari, Barcelona, Spain
    Medicine (Baltimore) 85:139-46. 2006
    ..Clonality (emm 25.2) but not mutations in the csrRS genes was associated with more severe GAS soft-tissue infections...
  56. ncbi request reprint Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes
    Vanesa Gómez-Piña
    Research Unit, La Paz Hospital, Madrid, Spain
    J Immunol 179:4065-73. 2007
    ..We conclude that metalloproteinases are responsible for shedding of the TREM-1 ectodomain through proteolytic cleavage of its long juxtamembrane linker...
  57. ncbi request reprint Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS
    Alex Soriano
    Service of Infectious Diseases and AIDS Unit, Hospital Clinic de Barcelona, Villarroel, 170, 08036, Barcelona, Spain
    Immunogenetics 57:644-54. 2005
    ..Further studies are required to confirm these findings...
  58. ncbi request reprint Metabolic and immunological effects of antiretroviral agents in healthy individuals receiving post-exposure prophylaxis
    Felipe Garcia
    Infectious Diseases Unit, University of Barcelona, Barcelona, Spain
    Antivir Ther 7:195-7. 2002
    ..This antiretroviral regimen seems to have no effect on lymphocyte T cell subsets, however, it could have an immune-modulator role, inducing an increase in the proliferative responses to mitogens...
  59. ncbi request reprint Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4
    Carlos del Fresno
    Research Unit, Department of Surgical Research, La Paz Hospital, Madrid, Spain
    J Immunol 174:3032-40. 2005
    ..Altogether, our findings indicate that deactivation of human monocytes in the presence of tumor cells involves IRAK-M up-regulation, and this effect appears to be mediated by hyaluronan through the engagement of CD44 and TLR4...
  60. ncbi request reprint Inflammatory responses associated with acute coronary syndrome up-regulate IRAK-M and induce endotoxin tolerance in circulating monocytes
    Carlos del Fresno
    Research Unit, La Paz Hospital, Madrid, Spain
    J Endotoxin Res 13:39-52. 2007
    ..The magnitude of this response varies according to the clinical condition (UA, STEMI or NSTEMI), and is regulated by TNF-alpha...