Research Topics
Genomes and Genes | Felipe GarciaSummaryCountry: Spain Publications
| Collaborators
|
Detail Information
Publications
Flow-cytometric assessment of lymphocyte cytokine production in tuberculosisM Garcia
Internal Medicine Department, Clinica Puerta de Hierro, Universidad Autonoma, Madrid, Spain
Tuberculosis (Edinb) 82:37-41. 2002..These data indicate that the immunosuppression observed in PBL during active tuberculosis infection may be related to IL10 production, and to the compartmentalization of the antigen-Th1 response to sites of active MTB infection...- Depressive symptoms after initiation of interferon therapy in human immunodeficiency virus-infected patients with chronic hepatitis CMontserrat Laguno
Infectious Diseases Unit, Hospital Clinic Universitari de Barcelona, Barcelona, Spain
Antivir Ther 9:905-9. 2004..In this study, we evaluated the incidence and management of depressive symptoms during IFN-alpha therapy in HIV-infected patients with CHC... - A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized studyFelipe Garcia
Infectious Diseases Unit, Clinic Institute of Infectious Diseases and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
AIDS 17:43-51. 2003.... 
Influence of a vaccination schedule on viral load rebound and immune responses in successfully treated HIV-infected patientsPedro Castro
Medical Intensive Care Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 25:1249-59. 2009..However, it induced an increase in T cell activation and a drop in CD4(+) T cells, although these changes did not influence the VL rebound dynamics after HAART interruption...- Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell activationAnna Suy
Gynecology Department, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
J Infect Dis 196:1191-201. 2007.... - Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIVNuria Climent
Hospital Clinic, Barcelona, Spain
Immunol Cell Biol 87:634-9. 2009..As IFN-gamma, TNF-alpha and IL-6 promote the Th1 versus Th2 phenotype and improve T helper proliferation responses and antigen-specific CTL responses ADA may be considered a promising candidate for therapeutic vaccine adjuvant... 
Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progressionMarta Rodríguez-García
Service of Immunology, Hospital Clinic de Barcelona, Barcelona, Spain
PLoS ONE 5:e9436. 2010..Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of alpha-defensins1-3 production by DC on disease progression...- Clinicoimmunological progression and response to treatment of long-term nonprogressor HIV-hepatitis C virus-coinfected patientsPedro Castro
Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
AIDS Res Hum Retroviruses 23:863-7. 2007..HCV-treated LTNP could have a worse HIV progression than HIV-HCV-treated NP or untreated coinfected LTNP. HCV infection does not have a deleterious effect on the progression of LTNP... - Phenotypic and functional characteristics of HIV-specific CD8 T cells and gag sequence variability after autologous dendritic cells based therapeutic vaccineAnna Lopez
Retrovirology and Viral Immunopathology Laboratory, Hospital Clinic, University of Barcelona, Barcelona, Spain
Vaccine 27:6166-78. 2009..Taken together, heterogeneity in the maturation status of HIV-specific CD8 T cells may be partially involved in the drop of peptide-specific IFN-gamma production during immunizations... - Dynamics of T cells subsets and lymphoproliferative responses during structured treatment interruption cycles and after definitive interruption of HAART in early chronic HIV type-1-infected patientsAgnes Libois
Infectious Diseases Unit, School of Medicine, University of Barcelona, Spain
AIDS Res Hum Retroviruses 22:657-66. 2006..Conversely, higher and longer viral replication after cessation of HAART overwhelms the immune system. These data may help to guide future immune-based therapies... - Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activationJosé M Martinez-Navio
Department of Biochemistry and Molecular Biology, Faculty of Biology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Immunology 128:393-404. 2009.... - Assessment of migration of HIV-1-loaded dendritic cells labeled with 111In-oxine used as a therapeutic vaccine in HIV-1-infected patientsAlba Ruiz
Infectious Diseases Unit, Hospital Clinic, Villarroel 170, Barcelona, Spain
Immunotherapy 1:347-54. 2009..92, p = 0.03). If more than 20,000 ILDCs had migrated, they could have been detected. In future trials, a higher number of DCs or alternative methods should be used to assess the migration of DCs to lymph nodes... - Pharmacokinetics and pharmacodynamics of low dose mycophenolate mofetil in HIV-infected patients treated with abacavir, efavirenz and nelfinavirOlga Millán
Servei Immunologia, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
Clin Pharmacokinet 44:525-38. 2005..Due to the low doses involved, pharmacokinetic-pharmacodynamic monitoring is recommended... - Factors associated with collagen deposition in lymphoid tissue in long-term treated HIV-infected patientsAlba Diaz
Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS 24:2029-39. 2010..The factors associated with fibrosis in lymphoid tissue in long-term treated HIV-infected patients and their correlation with immune reconstitution were assessed... - Short Communication: Natural killer cells and expression of KIR receptors in chronic HIV type 1-infected patients after different strategies of structured therapy interruptionGabriel Mestre
Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 24:1485-95. 2008..This finding suggests that STI could decrease the number of NK subsets, which is related to the worst clinical development in these patients... - Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV type 1-infected patients using a nonnucleoside reverse transcriptase inhibitor-based or a boosted protease inhibitor-based antiretroviral regimen: three-year results (The Advanz TJose M Miro
Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 26:747-57. 2010..At 1 and 3 years, the immune reconstitution induced by an efavirenz-based regimen in very immunosuppressed patients was at least as potent as that induced by a ritonavir-boosted protease inhibitor-based antiretroviral regimen... - Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individualsNuria Climent
Service of Immunology, Hospital Clinic de Barcelona, Barcelona, Spain
PLoS ONE 6:e19644. 2011..These results evidence the adjuvant role of the vector itself (MVA) and support the clinical development of prophylactic and therapeutic anti-HIV vaccines based on MVA-B... - Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitorJose L Blanco
Infectious Diseases Service, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Barcelona, Spain
AIDS 19:829-31. 2005..Only one of the 66 patients developed changes in their pattern of mutations able to generate or increase resistance to new drugs... - Incidence and risk factors for mitochondrial toxicity in treated HIV/HCV-coinfected patientsMontse Laguno
Infectious Diseases Unit, Hospital Clinic Barcelona, Barcelona, Spain
Antivir Ther 10:423-9. 2005.... - Similar HIV-1 evolution and immunological responses at 10 years despite several therapeutic strategies and host HLA TypesMireia Arnedo-Valero
Microbiology, Hospital Clinic, Faculty of Medicine, University of Barcelona, Barcelona, Spain
J Med Virol 73:495-501. 2004..These results suggest that, in this case, an effective immunological response to STI depended more on the virus than on the characteristics of the host... - Restoration of T cell responses to toxoplasma gondii after successful combined antiretroviral therapy in patients with AIDS with previous toxoplasmic encephalitisMarylène Lejeune
Immunology Service, Hospital Clinic Institut d Investigacions Biomèdiques Augustí Pi i Suñer, University of Barcelona, Barcelona, Spain
Clin Infect Dis 52:662-70. 2011..It is unknown whether a Toxoplasma gondii-specific T cell response is restored after successful combined antiretroviral therapy (cART) in patients with AIDS and current or previous toxoplasmic encephalitis (TE)... - Redistribution of FOXP3-positive regulatory T cells from lymphoid tissues to peripheral blood in HIV-infected patientsAna Mozos
Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
J Acquir Immune Defic Syndr 46:529-37. 2007..Design: Paired samples from lymphoid tissue and peripheral blood were simultaneously obtained from 27 HIV-infected patients (before and after highly active antiretroviral therapy [HAART]) and 6 controls... - Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: down-regulation of TREM-1 as putative underlying mechanismCarlos del Fresno
Research Unit, La Paz Hospital, Madrid, Spain
PLoS ONE 3:e2667. 2008..We conclude that down-regulation of TREM-1 expression in cystic fibrosis patients is at least partly responsible for the endotoxin tolerance state in which their monocytes are locked... - HIV-1 upregulates intercellular adhesion molecule-1 gene expression in lymphoid tissue of patients with chronic HIV-1 infectionMarta Garrido
Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
J Acquir Immune Defic Syndr 46:268-74. 2007..Our main objective was to study ICAM-1 expression in LT from HIV-1-infected persons and to correlate this expression with LT viral load and the immunoarchitecture alteration before and after highly active antiretroviral therapy (HAART)... - Impact of alpha-defensins1-3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effectsMarta Rodríguez-García
Service of Immunology, Hospital Clinic Universitari de Barcelona, School of Medicine, University of Barcelona, Barcelona, Spain
Clin Immunol 131:374-84. 2009..Results suggest that alpha-defensins1-3 might modulate the maturation and differentiation of MDDCs in vivo and therefore could be of special interest in the field of vaccine development... - Influence of Episodes of Intermittent Viremia ("Blips") on Immune Responses and Viral Load Rebound in Successfully Treated HIV-Infected PatientsPedro Castro
1 Medical Intensive Care Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 29:68-76. 2013..After treatment interruption, they showed greater specific immune responses against HIV, which did not prevent a higher virological rebound. EIV between 20 and 200 copies/ml did not have this deleterious effect... - Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected IndividualsVíctor Casanova
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
PLoS ONE 7:e51287. 2012..Taken together, these findings suggest that ADA would promote enhanced and correctly polarized T-cell responses in strategies targeting asymptomatic HIV-infected individuals... - Therapeutic vaccines against HIV infectionFelipe Garcia
Hospital Clinic HIVACAT, IDIBAPS, University of Barcelona, Barcelona, Spain
Hum Vaccin Immunother 8:569-81. 2012.... - Post-exposure prophylaxis for HIV infection: a clinical trial comparing lopinavir/ritonavir versus atazanavir each with zidovudine/lamivudineVicens Diaz-Brito
Hospital Clinic, University of Barcelona, Barcelona, Spain
Antivir Ther 17:337-46. 2012..A clinical trial comparing the rate of discontinuation and tolerability of two post-exposure prophylaxis (PEP) regimens was performed... - Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infectionFelipe Garcia
Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
J Infect Dis 191:1680-5. 2005..This response was associated with changes in HIV-1-specific CD4(+) lymphoproliferative and CD8(+) T cell responses. These changes were not observed in a group of nonimmunized control patients... - A new multidisciplinary home care telemedicine system to monitor stable chronic human immunodeficiency virus-infected patients: a randomized studyAgathe Leon
Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
PLoS ONE 6:e14515. 2011..This clinical scenario requires a new approach to simplify follow-up appointments and facilitate access to healthcare professionals... - Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adultsEsteban Martinez
Infectious Diseases Unit, Hospital Clinic, University of Barcelona, Calle Villarroel 170, 08036 Barcelona, Spain
Lancet 364:65-7. 2004..666, 95% CI 1.246-91.294, p=0.031). These results suggest that the risk of pancreatitis is heightened when didanosine and tenofovir are given together... - Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopeniaCarlos Cervera
Services of Infectious Diseases, Hospital Clinic of Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain
Eur J Haematol 87:87-91. 2011..Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia... - A cell-to-cell HIV transfer assay identifies humoral responses with broad neutralization activitySonsoles Sánchez-Palomino
Infectious Diseases Unit HIVACAT, Hospital Clinic, Barcelona, Spain
Vaccine 29:5250-9. 2011.... - Prevalence of dihydropteroate synthase genotypes before and after the introduction of combined antiretroviral therapy and their influence on the outcome of Pneumocystis pneumonia in HIV-1-infected patientsMiriam J Alvarez-Martinez
Hospital Clínic IDIBAPS Institut d Investigació August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
Diagn Microbiol Infect Dis 68:60-5. 2010..However, their presence did not worsen prognosis of PcP. The response to TMP-SMX with therapeutic doses was successful in most cases... - Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent mannerM Carmen González-León
Research Unit, La Paz Hospital, Madrid, Spain
J Endotoxin Res 12:296-306. 2006..We conclude that NO stimulates SOCS-1 overexpression in a pathway at least partially regulated by TNF-alpha... - Effect of mycophenolate mofetil on immune response and plasma and lymphatic tissue viral load during and after interruption of highly active antiretroviral therapy for patients with chronic HIV infection: a randomized pilot studyFelipe Garcia
Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
J Acquir Immune Defic Syndr 36:823-30. 2004..005) after 6 months off HAART. We found that combining MMF and HAART delayed VL rebound and improved control of viral replication without HAART but only when inhibition of lymphocyte proliferation was achieved... - Human immature monocyte-derived dendritic cells produce and secrete alpha-defensins 1-3Marta Rodríguez García
Service of Immunology, Hospital Clinic Universitari de Barcelona, Villarroel 170, 08036, Barcelona, Spain
J Leukoc Biol 82:1143-6. 2007.... - [Use of non-occupational HIV post-exposure prophylaxis in Spain (2001-2005)]Nuria Vives
Centro de estudios epidemiológicos sobre ITS SIDA de Cataluña CEEISCAT CIBER Epidemiología y Salud Pública CIBERESP, Hospital Universitario Germans Trias i Pujol, Carretera de Canyet s n, Badalona, Barcelona, Spain
Enferm Infecc Microbiol Clin 26:546-51. 2008..The aim of this study is to describe the characteristics of the persons exposed, types of exposures, antiretroviral treatment prescribed, and outcome of HIV infection in cases of non-occupational exposure in Spain... - Generation and Characterization of a Defective HIV-1 Virus as an Immunogen for a Therapeutic VaccineCarmen Alvarez-Fernández
Institut dInvestigations Biomèdiques August Pi i Sunyer IDIBAPS AIDS Research Group, Hospital Clinic, Catalonian Center for HIV Vaccines HIVACAT and University of Barcelona, Barcelona, Spain
PLoS ONE 7:e48848. 2012..We designed and constructed a defective recombinant virus based on the HIV-1 genome generating infective but non-replicative virions able to elicit broad and strong cellular immune responses in HIV-1 seropositive individuals... - Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistenceLlucia Alos
Department of Pathology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
Mod Pathol 18:127-36. 2005..However, these parameters studied in lymphoid tissue are not re-established completely, even after 36 months of highly active antiretroviral therapy... - [Therapeutic and preventive vaccine against HIV problems and the necessity to develop one]Felipe Garcia
Unidad de Investigación en Inmunopatogenia del VIH, Servicio de Enfermedades Infecciosas, IDIBAPS, Hospital Clinic, Universidad de Barcelona
Rev Enferm 28:24-8. 2005..The upcoming work by the Spanish Group "RIS" on Therapeutic and Preventive Vaccines might place Spanish professionals in the front line in the international fight against AIDS... - Influence of repeated cycles of structured therapy interruption on the rate of recovery of CD4+ T cells after highly active antiretroviral therapy resumptionAgathe Leon
Infectious Diseases Department, Hospital Clinic of Barcelona, Villarroel 170, 08036 Barcelona, Spain
J Antimicrob Chemother 63:184-8. 2009..CD4+ T cell recovery dynamics were analysed during the 'on treatment' periods in structured therapy interruption (STI) as well as the long-term immune reconstitution with highly active antiretroviral therapy (HAART) after finishing STI... - Inflammatory responses in blood samples of human immunodeficiency virus-infected patients with pulmonary infectionsNatividad Benito
Service of Infectious Diseases, Institut Clínic de Infeccions i Inmunologia, Clinic Hospital IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
Clin Diagn Lab Immunol 11:608-14. 2004..An elevated IL-8 level (>61 pg/ml) at the time of admission was an independent factor associated with higher mortality (odds ratio, 12; 95% confidence interval, 1.2 to 235.5)... - A therapeutic dendritic cell-based vaccine for HIV-1 infectionFelipe Garcia
Infectious Diseases Department, Hospital Clinic HIV Development Program in Catalonia, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
J Infect Dis 203:473-8. 2011.... - Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02)Felipe Garcia
Hospital Clinic IDIBAPS, Barcelona, Spain
Vaccine 29:8309-16. 2011..To investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed... - Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection Workshop in dendritic cell-based vaccine clinical trials in HIV-1Felipe Garcia
Infectious Diseases Unit, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Spain
Vaccine 29:6454-63. 2011..This report summarizes the present situation of the field and the discussions and conclusions of this meeting... - Immune restoration in HIV-positive, antiretroviral-naive patients after 1 year of zidovudine/lamivudine plus nelfinavir or nevirapineMontserrat Plana
Institut Clinic d Infeccions i Immunologia, Immunology, Infectious Diseases and Microbiology Units, Institut de Investigació Biomèdica Agusti Pi i Suñer, Hospital Clinic, University of Barcelona, Barcelona, Spain
Antivir Ther 9:197-204. 2004..To evaluate the immunological response in HIV-1-infected, antiretroviral-naive patients receiving highly active antiretroviral therapy regimen of two nucleosides plus a protease inhibitor or a non-nucleoside reverse transcriptase inhibitor... - Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDSAlex Soriano
Service of Infectious Diseases and AIDS Unit, Hospital Clinic de Barcelona, Villarroel, 170, 08036, Barcelona, Spain
Immunogenetics 57:644-54. 2005..Further studies are required to confirm these findings... - Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytesVanesa Gómez-Piña
Research Unit, La Paz Hospital, Madrid, Spain
J Immunol 179:4065-73. 2007..We conclude that metalloproteinases are responsible for shedding of the TREM-1 ectodomain through proteolytic cleavage of its long juxtamembrane linker... - Metabolic and immunological effects of antiretroviral agents in healthy individuals receiving post-exposure prophylaxisFelipe Garcia
Infectious Diseases Unit, University of Barcelona, Barcelona, Spain
Antivir Ther 7:195-7. 2002..This antiretroviral regimen seems to have no effect on lymphocyte T cell subsets, however, it could have an immune-modulator role, inducing an increase in the proliferative responses to mitogens... - Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4Carlos del Fresno
Research Unit, Department of Surgical Research, La Paz Hospital, Madrid, Spain
J Immunol 174:3032-40. 2005..Altogether, our findings indicate that deactivation of human monocytes in the presence of tumor cells involves IRAK-M up-regulation, and this effect appears to be mediated by hyaluronan through the engagement of CD44 and TLR4... - Inflammatory responses associated with acute coronary syndrome up-regulate IRAK-M and induce endotoxin tolerance in circulating monocytesCarlos del Fresno
Research Unit, La Paz Hospital, Madrid, Spain
J Endotoxin Res 13:39-52. 2007..The magnitude of this response varies according to the clinical condition (UA, STEMI or NSTEMI), and is regulated by TNF-alpha...