Luis M Garcia-Segura

Summary

Country: Spain

Publications

  1. ncbi request reprint Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection
    Luis M Garcia-Segura
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Neuroendocrinology 84:275-9. 2006
  2. pmc Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats
    Ignacio Gonzalez-Burgos
    Centro de Investigacion Biomedica de Occidente, Guadalajara, Jalisco 44340, Mexico
    Neural Plast 2012:309494. 2012
  3. pmc Estradiol meets notch signaling in developing neurons
    Maria Angeles Arevalo
    Instituto Cajal, Consejo Superior de Investigaciones Científicas Madrid, Spain
    Front Endocrinol (Lausanne) 2:21. 2011
  4. doi request reprint A new mathematical function to evaluate neuronal morphology using the Sholl analysis
    Luis Miguel Garcia-Segura
    Instituto Cajal, CSIC, 28002 Madrid, Spain Electronic address
    J Neurosci Methods 226:103-9. 2014
  5. ncbi request reprint Aromatase: a neuroprotective enzyme
    Luis M Garcia-Segura
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Prog Neurobiol 71:31-41. 2003
  6. pmc Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide
    María Santos-Galindo
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Biol Sex Differ 2:7. 2011
  7. pmc Steroids and neuroprotection: New advances
    Luis M Garcia-Segura
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Front Neuroendocrinol 30:v-ix. 2009
  8. ncbi request reprint Steroids and glial cell function
    Luis M Garcia-Segura
    Instituto Cajal, C S I C, Madrid, Spain
    Glia 54:485-98. 2006
  9. doi request reprint The role of glia in the hypothalamus: implications for gonadal steroid feedback and reproductive neuroendocrine output
    Luis Miguel Garcia-Segura
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Reproduction 135:419-29. 2008
  10. ncbi request reprint Estradiol, insulin-like growth factor-I and brain aging
    Luis M Garcia-Segura
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Psychoneuroendocrinology 32:S57-61. 2007

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection
    Luis M Garcia-Segura
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Neuroendocrinology 84:275-9. 2006
    ..Conversely, IGF-I regulates ERalpha transcriptional activity in neuroblastoma cells and the PI3K/Akt/GSK3 signaling pathway is involved in this effect...
  2. pmc Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats
    Ignacio Gonzalez-Burgos
    Centro de Investigacion Biomedica de Occidente, Guadalajara, Jalisco 44340, Mexico
    Neural Plast 2012:309494. 2012
    ..These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines...
  3. pmc Estradiol meets notch signaling in developing neurons
    Maria Angeles Arevalo
    Instituto Cajal, Consejo Superior de Investigaciones Científicas Madrid, Spain
    Front Endocrinol (Lausanne) 2:21. 2011
    ..This interaction is relevant for the control of neuronal differentiation, since the downregulation of Notch signaling by estradiol results in the upregulation of neurogenin 3, which in turn promotes dendritogenesis...
  4. doi request reprint A new mathematical function to evaluate neuronal morphology using the Sholl analysis
    Luis Miguel Garcia-Segura
    Instituto Cajal, CSIC, 28002 Madrid, Spain Electronic address
    J Neurosci Methods 226:103-9. 2014
    ..A different method is the quantification of the number of bifurcations of the neurites (BN)...
  5. ncbi request reprint Aromatase: a neuroprotective enzyme
    Luis M Garcia-Segura
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Prog Neurobiol 71:31-41. 2003
    ..Aromatase may thus represent an important pharmacological target for therapies conducted to prevent aging-associated neurodegenerative disorders...
  6. pmc Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide
    María Santos-Galindo
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Biol Sex Differ 2:7. 2011
    ..abstract:..
  7. pmc Steroids and neuroprotection: New advances
    Luis M Garcia-Segura
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Front Neuroendocrinol 30:v-ix. 2009
    ..This special issue of Frontiers in Neuroendocrinology contains a collection of reviews of the most recent ideas and findings on these various aspects of sex steroid-dependent neuroprotection..
  8. ncbi request reprint Steroids and glial cell function
    Luis M Garcia-Segura
    Instituto Cajal, C S I C, Madrid, Spain
    Glia 54:485-98. 2006
    ....
  9. doi request reprint The role of glia in the hypothalamus: implications for gonadal steroid feedback and reproductive neuroendocrine output
    Luis Miguel Garcia-Segura
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Reproduction 135:419-29. 2008
    ..The glial cells, therefore, are central to the coordination of endocrine and local inputs that bring about neural plasticity and adapt reproductive capacity to homeostatic signals...
  10. ncbi request reprint Estradiol, insulin-like growth factor-I and brain aging
    Luis M Garcia-Segura
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Psychoneuroendocrinology 32:S57-61. 2007
    ..Therefore, it is important to determine whether aging affects the signaling of estradiol and IGF-I in the brain...
  11. ncbi request reprint Cajal and glial cells
    Luis M Garcia-Segura
    Instituto Cajal CSIC, Avenida del Doctor Arce 37, 28002 Madrid, Spain
    Prog Brain Res 136:255-60. 2002
  12. ncbi request reprint Interactions of estradiol and insulin-like growth factor-I signalling in the nervous system: new advances
    Luis M Garcia-Segura
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Prog Brain Res 181:251-72. 2010
    ..Current investigations are evidencing the role exerted by key signalling molecules, such as glycogen synthase kinase 3 and beta-catenin, in the cross-talk of estrogen receptors and IGF-I receptors in neural cells...
  13. ncbi request reprint Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones
    George Barreto
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Endocrinology 150:5010-5. 2009
    ..These findings indicate that estradiol, raloxifene, and tamoxifen are potential candidates for the control of astrogliosis in young and older individuals and after a prolonged depletion of ovarian hormones...
  14. ncbi request reprint Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury
    Amanda Sierra
    Instituto Cajal, C S I C, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Eur J Neurosci 18:1458-67. 2003
    ..This raises the possibility that the up-regulation of StAR expression and the subsequent modifications in steroidogenesis may be part of the mechanisms used by the brain to cope with neurodegeneration...
  15. ncbi request reprint Pubertal maturation modifies the regulation of insulin-like growth factor-I receptor signaling by estradiol in the rat prefrontal cortex
    Amaya Sanz
    Department of Functional and Systems Neurobiology, Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Dev Neurobiol 68:1018-28. 2008
    ....
  16. ncbi request reprint Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone
    George Barreto
    Instituto Cajal, C S I C, Madrid, Spain
    Eur J Neurosci 25:3039-46. 2007
    ..The regulation of gliosis may be part of the neuroprotective mechanism of testosterone...
  17. doi request reprint Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-α and -β
    Daniela Grassi
    Instituto Cajal, Consejo Suerior de Investigaciones Científicas, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Endocrinology 154:2092-100. 2013
    ..These findings suggest that estradiol and T regulate AVP expression in SH-SY5Y cells through ERs, exerting a stimulatory action via ERα and an inhibitory action via ERβ...
  18. doi request reprint Role of astroglia in the neuroplastic and neuroprotective actions of estradiol
    Inigo Azcoitia
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense de Madrid, Madrid, Spain
    Eur J Neurosci 32:1995-2002. 2010
    ....
  19. doi request reprint G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons
    Isabel Ruiz-Palmero
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Mol Cell Endocrinol 372:105-15. 2013
    ..These findings suggest that GPER participates in the control of hippocampal neuritogenesis by a mechanism involving the activation of PI3K signaling...
  20. doi request reprint Actions of estrogens on glial cells: Implications for neuroprotection
    Maria Angeles Arevalo
    Instituto Cajal, CSIC, Madrid, Spain
    Biochim Biophys Acta 1800:1106-12. 2010
    ..Therefore, glial cells are important players in the neuroprotective and reparative mechanisms of estrogenic compounds...
  21. doi request reprint Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress
    Isabel Calmarza-Font
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Behav Brain Res 227:287-90. 2012
    ..Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress...
  22. ncbi request reprint Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones
    Daniel Garcia-Ovejero
    Instituto Cajal, CSIC, Madrid, Spain
    Brain Res Brain Res Rev 48:273-86. 2005
    ..In addition, glial cells are targets for steroids and mediate some of the effects of these molecules on neurons, including the regulation of survival and regeneration...
  23. doi request reprint Estrogen receptor ligands counteract cognitive deficits caused by androgen deprivation in male rats
    Natalia Lagunas
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Horm Behav 59:581-4. 2011
    ....
  24. doi request reprint Selective estrogen receptor modulators as brain therapeutic agents
    Maria Angeles Arevalo
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    J Mol Endocrinol 46:R1-9. 2011
    ..New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain...
  25. doi request reprint Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs
    Silvia Tapia-González
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    J Endocrinol 198:219-30. 2008
    ..The findings support the potential therapeutic role of oestrogenic compounds as protective anti-inflammatory agents for the central nervous system...
  26. ncbi request reprint Neuroprotective effects of soy phytoestrogens in the rat brain
    Inigo Azcoitia
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Gynecol Endocrinol 22:63-9. 2006
    ..Genistein showed neuroprotective effects only at high dose (10 mg/kg), suggesting that other components in the soy extract are involved in the neuroprotective effect...
  27. doi request reprint Aromatase expression in the normal and epileptic human hippocampus
    Josue G Yague
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Brain Res 1315:41-52. 2010
    ..The widespread expression of aromatase in a large population of neurons in the normal and damaged hippocampus suggests that local estrogen formation may play an important role in human hippocampal function...
  28. ncbi request reprint An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat
    Margarita Perez-Martin
    Instituto Cajal, C S I C, E 28002 Madrid, Spain
    Eur J Neurosci 18:923-30. 2003
    ....
  29. doi request reprint Behavioral effects of estradiol therapy in ovariectomized rats depend on the age when the treatment is initiated
    Yolanda Diz-Chaves
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Exp Gerontol 47:93-9. 2012
    ..Thus, our findings indicate that age affects the outcome of estradiol therapy in the brain...
  30. ncbi request reprint Aromatase, the enzyme responsible for estrogen biosynthesis, is expressed by human and rat glioblastomas
    Josue G Yague
    Instituto Cajal, C S I C, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Neurosci Lett 368:279-84. 2004
    ..By analogy to the implication of aromatase into the growth of other forms of estrogen-sensitive tumors, such as some breast cancers, it is conceivable that the expression of aromatase may play a role in the growth of glioblastomas...
  31. ncbi request reprint Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain
    Pablo Mendez
    Instituto Cajal, C S I C, Av Dr Arce 37, 28002, Madrid, Spain
    Brain Res Mol Brain Res 112:170-6. 2003
    ....
  32. ncbi request reprint Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity
    Sergio Veiga
    Instituto Cajal, C S I C, Madrid, Spain
    J Neurosci Res 80:129-37. 2005
    ..These findings suggest that the PBR is involved in control of neuronal survival and gliosis after brain injury and identify this molecule as a potential target for neuroprotective interventions...
  33. ncbi request reprint Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective
    Iratxe Ciriza
    Instituto Cajal, C S I C, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    J Neurobiol 66:916-28. 2006
    ....
  34. doi request reprint Progesterone regulates the phosphorylation of protein phosphatases in the brain
    Miguel A R Amorim
    Instituto Cajal, CSIC, Madrid, Spain
    J Neurosci Res 88:2826-32. 2010
    ....
  35. ncbi request reprint Extragonadal synthesis of estradiol is protective against kainic acid excitotoxic damage to the hippocampus
    Sergio Veiga
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Spain
    Neuroreport 16:1599-603. 2005
    ..These findings indicate that extragonadal estradiol exerts a neuroprotective effect in both sexes, which prevents neuronal loss as a consequence of mild neurodegenerative signals...
  36. ncbi request reprint Selective estrogen receptor modulators protect hippocampal neurons from kainic acid excitotoxicity: differences with the effect of estradiol
    Iratxe Ciriza
    Instituto Cajal, C S I C, E 28002 Madrid, Spain
    J Neurobiol 61:209-21. 2004
    ....
  37. pmc Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice
    Yolanda Diz-Chaves
    Instituto Cajal, CSIC, E 28002, Madrid, Spain
    J Neuroinflammation 9:71. 2012
    ..In this study we have explored whether prenatal stress results in alterations in the immune response in the hippocampus of female mice during adult life...
  38. doi request reprint Gonadal hormones and the control of reactive gliosis
    Maria Angeles Arevalo
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Horm Behav 63:216-21. 2013
    ..However, the precise functional consequences of the regulation of reactive gliosis by gonadal hormones under acute and chronic neurodegenerative conditions are still not fully clarified...
  39. doi request reprint Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice
    Yolanda Diz-Chaves
    Instituto Cajal, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Brain Behav Immun 28:196-206. 2013
    ..These findings indicate that prenatal stress induces a basal proinflammatory status in the hippocampal formation during adulthood that results in an enhanced activation of microglia and astrocytes in response to a proinflammatory insult...
  40. ncbi request reprint Sex hormones and brain aging
    Sergio Veiga
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain
    Exp Gerontol 39:1623-31. 2004
    ..Therefore, steroidogenic acute regulatory protein, peripheral-type benzodiazepine receptor and aromatase are attractive pharmacological targets to promote neuroprotection in the aged brain...
  41. ncbi request reprint Sex differences, developmental changes, response to injury and cAMP regulation of the mRNA levels of steroidogenic acute regulatory protein, cytochrome p450scc, and aromatase in the olivocerebellar system
    Esteban Lavaque
    Instituto Cajal, C S I C, E 28002 Madrid, Spain
    J Neurobiol 66:308-18. 2006
    ....
  42. ncbi request reprint Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: cellular and molecular mechanisms
    Pablo Mendez
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, E 28002 Madrid, Spain
    Front Neuroendocrinol 27:391-403. 2006
    ..In turn, IGF-I may regulate ER transcriptional activity in neuronal cells. In conclusion, ERs appear to be part of the signaling mechanism of IGF-I, and IGF-I receptor part of the mechanism of estradiol signaling in the nervous system...
  43. doi request reprint Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
    Maria Angeles Arevalo
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, Madrid, Spain
    J Steroid Biochem Mol Biol 131:52-6. 2012
    ..This article is part of a Special Issue entitled 'Neurosteroids'...
  44. ncbi request reprint Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase
    Sergio Veiga
    Instituto Cajal, C S I C, E 28002 Madrid, Spain
    J Neurobiol 56:398-406. 2003
    ..These findings suggest that estradiol formation by aromatase mediates neuroprotective effects of pregnenolone and DHEA against excitotoxic-induced neuronal death in the hippocampus...
  45. doi request reprint Sub-chronic exposure to the insecticide dimethoate induces a proinflammatory status and enhances the neuroinflammatory response to bacterial lypopolysaccharide in the hippocampus and striatum of male mice
    Mariana Astiz
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain Electronic address
    Toxicol Appl Pharmacol 272:263-71. 2013
    ....
  46. ncbi request reprint Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum
    Christian Guerra-Araiza
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Dev Neurobiol 67:510-20. 2007
    ..The regulation of Tau expression and phosphorylation by progesterone may contribute to the hormonal regulation of cerebellar function by the modification of neuronal cytoskeleton...
  47. ncbi request reprint Neuroactive steroids prevent peripheral myelin alterations induced by diabetes
    Sergio Veiga
    Instituto Cajal, C S I C, Avenida Dr Arce 37, 28002 Madrid, Spain
    Neurosci Lett 402:150-3. 2006
    ..These results suggest that neuroactive steroids such as progesterone and dihydroprogesterone may represent therapeutic alternatives to counteract peripheral myelin alterations induced by diabetes...
  48. ncbi request reprint Interactions of estrogen and insulin-like growth factor-I in the brain: molecular mechanisms and functional implications
    Gloria Patricia Cardona-Gomez
    Instituto Cajal, C S I C, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    J Steroid Biochem Mol Biol 83:211-7. 2002
    ..These findings suggest that estrogen effects in the brain may be mediated in part by the activation of the signaling pathways of the IGF-I receptor...
  49. pmc Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats
    Eva Baquedano
    Department of Pediatrics, Universidad Autónoma de Madrid Hospital Infantil Universitario Niño Jesús, Madrid, Spain
    PLoS ONE 6:e27549. 2011
    ..These changes could condition the response of this axis to future physiological and pathophysiological situations...
  50. pmc An in vitro experimental model of neuroinflammation: the induction of interleukin-6 in murine astrocytes infected with Theiler's murine encephalomyelitis virus, and its inhibition by oestrogenic receptor modulators
    Nazario Rubio
    Instituto Cajal C S I C, Madrid, Spain
    Immunology 133:360-9. 2011
    ..Finally, this in vitro neuroinflammation model was fully inhibited, as demonstrated by ELISA and qPCR, by five selective oestrogen receptor modulators...
  51. doi request reprint Estrogen receptor alpha is involved in the estrogenic regulation of arginine vasopressin immunoreactivity in the supraoptic and paraventricular nuclei of ovariectomized rats
    Daniela Grassi
    Instituto Cajal, CSIC E 28002 Madrid, Spain
    Neurosci Lett 474:135-9. 2010
    ..This finding suggests that estradiol may regulate arginine vasopressin levels on the supraoptic and paraventricular nuclei by acting on afferent neurons expressing estrogen receptor alpha...
  52. pmc Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide
    Maria J Bellini
    Instituto Cajal, CSIC, Madrid, Spain
    J Neuroinflammation 8:21. 2011
    ..In this study we have assessed the efficacy of exogenous IGF-I and IGF-I gene therapy in reducing the inflammatory response of astrocytes from cerebral cortex...
  53. ncbi request reprint Minireview: Role of glia in neuroendocrine function
    Luis M Garcia-Segura
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Endocrinology 145:1082-6. 2004
    ..Therefore, glial cells are a key element to understanding hormonal actions in the nervous system and the regulation of neuroendocrine events...
  54. ncbi request reprint Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators
    Estefanía Acaz-Fonseca
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Mol Cell Endocrinol 389:48-57. 2014
    ..Therefore, SERMs represent therapeutic alternatives to estradiol for the activation of astroglia-mediated neuroprotective mechanisms. ..
  55. ncbi request reprint Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress
    Natalia Lagunas
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, Madrid, Spain
    Horm Behav 58:786-91. 2010
    ..Therefore, a prolonged deprivation of ovarian hormones may represent a risk factor for the development of depressive and anxiety symptoms after the exposure to stressful experiences...
  56. ncbi request reprint Sex differences and effects of estrogenic compounds on the expression of inflammatory molecules by astrocytes exposed to the insecticide dimethoate
    Mariana Astiz
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002, Madrid, Spain
    Neurotox Res 25:271-85. 2014
    ..The selective action of estradiol on male astrocytes and the sexually dimorphic action of DMT suggest that the pesticide may have different neurological outcomes in males and females...
  57. doi request reprint Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells
    Josue G Yague
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain
    Endocrine 35:252-61. 2009
    ..3 aromatase transcripts. The cell specific regulation of CYP19A1 by vitamin D, dexamethasone, and mifepristone opens the possibility for cellular selective modulation of estrogen biosynthesis within the brain...
  58. pmc Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease
    Anna M Barron
    Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 33:8891-7. 2013
    ..These findings suggest that TSPO is a promising target for the development of pleiotropic treatment strategies for the management of AD...
  59. ncbi request reprint Estrogen-induced hypothalamic synaptic plasticity and pituitary sensitization in the control of the estrogen-induced gonadotrophin surge
    Frederick Naftolin
    Reproductive Neuroscience Unit, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Reprod Sci 14:101-16. 2007
    ..This enhanced understanding of the mechanics of gonadotrophin control clarifies elements of the involved feedback loops and opens the way to a better understanding of the neurobiology of reproduction...
  60. ncbi request reprint Synergistic interaction of estradiol and insulin-like growth factor-I in the activation of PI3K/Akt signaling in the adult rat hypothalamus
    Gloria Patricia Cardona-Gomez
    Instituto Cajal, C S I C, Av Dr Arce 37, 28002 Madrid, Spain
    Brain Res Mol Brain Res 107:80-8. 2002
    ..These findings suggest that estrogen effects in the hypothalamus may be mediated in part by the activation of the signaling pathways of the IGF-I receptor...
  61. ncbi request reprint Dehydroepiandrosterone regulates astroglia reaction to denervation of olfactory glomeruli
    Zsofia Hoyk
    Institute of Biophysics, Biological Research Center, Szeged, Hungary
    Glia 48:207-16. 2004
    ..These effects are likely to be mediated at least in part by the conversion of DHEA to estradiol...
  62. ncbi request reprint Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats
    Emanuela Leonelli
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, via G Balzaretti 9, 20133 Milano, Italy
    Mech Ageing Dev 126:1159-63. 2005
    ..These findings support the potential role of PBR ligands to prevent aging-associated peripheral nerve degeneration...
  63. ncbi request reprint The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Michael A Cowley
    The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Neuron 37:649-61. 2003
    ..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis...
  64. ncbi request reprint Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain
    M Morissette
    Molecular Endocrinology and Oncology Research Center, Medical Center and Faculty of Pharmacy, Laval University, 2705 Laurier Boulevard, Sainte Foy, Quebec, Canada
    J Steroid Biochem Mol Biol 108:327-38. 2008
    ..ERKOalpha mice are more susceptible to MPTP toxicity and not protected by estradiol; differences in ERKObeta mice are subtler. These results suggest therapeutic potential for the brain of ER specific agonists...
  65. ncbi request reprint Interdependence of oestrogen and insulin-like growth factor-I in the brain: potential for analysing neuroprotective mechanisms
    Pablo Mendez
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    J Endocrinol 185:11-7. 2005
    ..In addition, Akt and glycogen synthase kinase 3beta are key molecular targets to explain the interaction of oestrogen and IGF-I receptor signalling in the promotion of neuroprotection...
  66. ncbi request reprint Dehydroepiandrosterone regulates insulin-like growth factor-1 system in adult rat hypothalamus
    Maria Flavia Ribeiro
    Departamento de Fisiologia, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Endocrine 17:129-34. 2002
    ..The effects of DHEA on the hypothalamic IGF-1 system may be highly relevant to the control and maintenance of hypothalamic neuroendocrine function...
  67. ncbi request reprint Early motherhood in rats is associated with a modification of hippocampal function
    Muriel Darnaudéry
    Neurosciences and Adaptive Physiology Department, UPRES EA 4052 Perinatal Stress Team, University of Lille 1, Bat SN4 1, 59655 Villeneuve d Ascq cedex, France
    Psychoneuroendocrinology 32:803-12. 2007
    ..In summary, our findings suggest that early postpartum period is associated with a modification of hippocampal function. This may reflect a homeostatic form of hippocampal plasticity in response to the onset of the maternal experience...
  68. ncbi request reprint Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells
    Pablo Mendez
    Instituto Cajal, Cajero Superior de Investigaciones, E 28002 Madrid, Spain
    Endocrinology 147:3027-39. 2006
    ..In summary, our findings suggest that ER-dependent gene expression in N2a cells is controlled by the PI3K/Akt/GSK3 signaling pathway...
  69. pmc Classical androgen receptors in non-classical sites in the brain
    Sara Sarkey
    Neuroscience Graduate Program and Neuroscience Institute, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, Illinois 60153, USA
    Horm Behav 53:753-64. 2008
    ..Androgen receptors in axons located in the cerebral cortex and amygdala and originating in the hippocampus may play an important role in the rapid behavioral effects of androgens...
  70. ncbi request reprint Estrogen dissociates Tau and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit in postischemic hippocampus
    Gloria Patricia Cardona-Gomez
    Group of Neuroscience, School of Medicine, University of Antioquia, Cali, Colombia
    Neuroreport 17:1337-41. 2006
    ....
  71. ncbi request reprint Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats
    Muriel Darnaudéry
    Laboratory of Perinatal Stress, University of Lille 1, JE2365, Bat SN4 1, 59655 Villeneuve d Ascq, France
    Neurobiol Aging 27:119-27. 2006
    ..These findings support the hypothesis of an early programming of the vulnerability to some neurological diseases during senescence and reinforce the potential therapeutic interest of IGF-1 during brain aging...
  72. ncbi request reprint Antisense oligodeoxynucleotides for estrogen receptor-beta and alpha attenuate estradiol's modulation of affective and sexual behavior, respectively
    Alicia A Walf
    Department of Psychology, Research The University at Albany Suny, Albany, NY 12222, USA
    Neuropsychopharmacology 33:431-40. 2008
    ..Thus, ERbeta and ERalpha may be required for E(2)'s modulation of affective and sexual behavior, respectively...
  73. ncbi request reprint Cellular phenotype of androgen receptor-immunoreactive nuclei in the developing and adult rat brain
    Betty Lorenz
    Neuroscience Program, Loyola University Chicago, Maywood, IL 60153, USA
    J Comp Neurol 492:456-68. 2005
    ..Thus, both neurons and astrocytes in the male rat forebrain contain ARs, suggesting that androgens, via ARs, may exert effects on both cell types in an age- and region-dependent manner...
  74. ncbi request reprint Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice
    Myreille D'Astous
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    Mol Pharmacol 69:1492-8. 2006
    ..Delta5-Diol increased GSK3beta phosphorylation less than the PPT treatment. These results suggest that a pretreatment with estradiol promoted dopamine neuron survival by activating ERalpha and increasing Akt and GSK3beta phosphorylation...
  75. ncbi request reprint Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat
    Lydia L Doncarlos
    Department of Cell Biology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA
    Endocrinology 144:3632-8. 2003
    ..The observation that ARs are present in axons and dendrites highlights the possibility that androgens play an important and novel extra-nuclear role in neuronal function...
  76. ncbi request reprint Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes
    Donatella Caruso
    Department of Pharmacological Sciences, University of Milan, Milano, Italy
    Neurochem Int 52:560-8. 2008
    ....