D Garcia-Olmo

Summary

Country: Spain

Publications

  1. ncbi request reprint Expanded adipose-derived stem cells for the treatment of complex perianal fistula including Crohn's disease
    Damian Garcia-Olmo
    Hospital Universitario La Paz, Servicio de Cirugia General, Paseo de la Castellana 261, 28046 Madrid, Spain
    Expert Opin Biol Ther 8:1417-23. 2008
  2. doi request reprint Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation
    M D Herreros
    Department of Surgery and Cell Therapy, La Paz University Hospital, Universidad Autonoma de Madrid, Hospital La Paz IdiPaz, Madrid, Spain
    Dis Colon Rectum 55:762-72. 2012
  3. pmc Quantitation of cell-free DNA and RNA in plasma during tumor progression in rats
    Dolores C García-Olmo
    Experimental Research Unit, General University Hospital of Albacete, C Hermanos Falcó 37, 02006, Albacete, Spain
    Mol Cancer 12:8. 2013
  4. doi request reprint Oncogenic transformation induced by cell-free nucleic acids circulating in plasma (genometastasis) remains after the surgical resection of the primary tumor: a pilot study
    Damian Garcia-Olmo
    Servicio de Cirugia General, Hospital Universitario La Paz, Paseo Castellana 261, 28046 Madrid, Spain
    Expert Opin Biol Ther 12:S61-8. 2012
  5. doi request reprint Treatment of enterocutaneous fistula in Crohn's Disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion
    Damian Garcia-Olmo
    Department of Surgery, La Paz University Hospital, Madrid, Spain
    Int J Colorectal Dis 24:27-30. 2009
  6. doi request reprint Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial
    Damian Garcia-Olmo
    Department of Surgery and Cell Therapy, La Paz University Hospital, Universidad Autonoma de Madrid, Madrid, Spain
    Dis Colon Rectum 52:79-86. 2009
  7. ncbi request reprint A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation
    Damian Garcia-Olmo
    Department of General Surgery, La Paz University Hospital, Madrid, Spain
    Dis Colon Rectum 48:1416-23. 2005
  8. doi request reprint Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells
    Dolores C García-Olmo
    Experimental Research Unit, General University Hospital of Albacete, Albacete, Spain
    Cancer Res 70:560-7. 2010
  9. ncbi request reprint Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy
    Damian Garcia-Olmo
    Department of General Surgery, La Paz University Hospital, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain
    Int J Colorectal Dis 18:451-4. 2003
  10. ncbi request reprint Functionality of circulating DNA: the hypothesis of genometastasis
    D Garcia-Olmo
    Autonomous University of Madrid, Spain
    Ann N Y Acad Sci 945:265-75. 2001

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Expanded adipose-derived stem cells for the treatment of complex perianal fistula including Crohn's disease
    Damian Garcia-Olmo
    Hospital Universitario La Paz, Servicio de Cirugia General, Paseo de la Castellana 261, 28046 Madrid, Spain
    Expert Opin Biol Ther 8:1417-23. 2008
    ..In patients without Crohn's disease, surgery is the mainstay treatment but faecal incontinence and recurrence are high. Infliximab is used in Crohn's patients but not all respond to therapy...
  2. doi request reprint Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation
    M D Herreros
    Department of Surgery and Cell Therapy, La Paz University Hospital, Universidad Autonoma de Madrid, Hospital La Paz IdiPaz, Madrid, Spain
    Dis Colon Rectum 55:762-72. 2012
    ..Autologous adipose-derived stem cells may represent a novel approach for the management of complex fistula-in-ano. After successful phase I and II clinical trials, a phase III trial was performed to investigate the safety and efficacy...
  3. pmc Quantitation of cell-free DNA and RNA in plasma during tumor progression in rats
    Dolores C García-Olmo
    Experimental Research Unit, General University Hospital of Albacete, C Hermanos Falcó 37, 02006, Albacete, Spain
    Mol Cancer 12:8. 2013
    ..To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation...
  4. doi request reprint Oncogenic transformation induced by cell-free nucleic acids circulating in plasma (genometastasis) remains after the surgical resection of the primary tumor: a pilot study
    Damian Garcia-Olmo
    Servicio de Cirugia General, Hospital Universitario La Paz, Paseo Castellana 261, 28046 Madrid, Spain
    Expert Opin Biol Ther 12:S61-8. 2012
    ....
  5. doi request reprint Treatment of enterocutaneous fistula in Crohn's Disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion
    Damian Garcia-Olmo
    Department of Surgery, La Paz University Hospital, Madrid, Spain
    Int J Colorectal Dis 24:27-30. 2009
    ..It is possible that unexpanded cells corresponding to the stromal vascular fraction (SVF) may also be effective...
  6. doi request reprint Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial
    Damian Garcia-Olmo
    Department of Surgery and Cell Therapy, La Paz University Hospital, Universidad Autonoma de Madrid, Madrid, Spain
    Dis Colon Rectum 52:79-86. 2009
    ..The present study was designed as a phase II multicenter, randomized controlled trial to further investigate the effectiveness and safety of ASCs in the treatment of complex perianal fistulas...
  7. ncbi request reprint A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation
    Damian Garcia-Olmo
    Department of General Surgery, La Paz University Hospital, Madrid, Spain
    Dis Colon Rectum 48:1416-23. 2005
    ..Mesenchymal adult stem cells extracted from certain tissues, such as adipose tissue, can differentiate into various cell types. Therefore, we have tried to use such cells to stimulate healing of Crohn's fistulas...
  8. doi request reprint Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells
    Dolores C García-Olmo
    Experimental Research Unit, General University Hospital of Albacete, Albacete, Spain
    Cancer Res 70:560-7. 2010
    ..4 mum. Our results indicate that plasma from cancer patients is able to transform cultured cells oncogenically, supporting the previously proposed hypothesis of genometastasis...
  9. ncbi request reprint Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy
    Damian Garcia-Olmo
    Department of General Surgery, La Paz University Hospital, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain
    Int J Colorectal Dis 18:451-4. 2003
    ..Recent studies have shown that adult stem cells extracted from certain tissues, such as adipose tissue, can develop into different tissues, such as muscle...
  10. ncbi request reprint Functionality of circulating DNA: the hypothesis of genometastasis
    D Garcia-Olmo
    Autonomous University of Madrid, Spain
    Ann N Y Acad Sci 945:265-75. 2001
    ....
  11. ncbi request reprint Circulating nucleic acids in plasma and serum (CNAPS) and its relation to stem cells and cancer metastasis: state of the issue
    D C García-Olmo
    Experimental Research Unit, Albacete General Hospital, Albacete, Spain
    Histol Histopathol 19:575-83. 2004
    ..In this review we intend to expound and integrate two theories about metastatization: the "genometastasis hypothesis" and the idea of stem cells as cancer stem cells...
  12. ncbi request reprint Tumor DNA circulating in the plasma might play a role in metastasis. The hypothesis of the genometastasis
    D Garcia-Olmo
    Experimental Research Unit, Albacete General Hospital, Spain
    Histol Histopathol 14:1159-64. 1999
    ..We also investigated whether plasma of tumor-bearing rats had any effect on cultured cells and healthy animals...
  13. ncbi request reprint Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat
    D C García-Olmo
    Experimental Research Unit, Albacete General Hospital, Spain
    Nutr Cancer 35:120-6. 1999
    ..In conclusion, long-term treatment with crocin enhances survival selectively in female rats with colon cancer without major toxic effects. The effects of crocin might be related to its strong cytotoxic effect on cultured tumor cells...
  14. doi request reprint A new bronchoscopic treatment of tracheomediastinal fistula using autologous adipose-derived stem cells
    P Díaz Agero Alvarez
    Thoracic Surgery Unit, Residencia General, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
    Thorax 63:374-6. 2008
    ..To our knowledge, this is the first report of treatment of tracheal fistula by autologous cell therapy. Further studies are needed to confirm whether this new method should become routine practice...
  15. doi request reprint Adipose-derived mesenchymal stem cells in biosutures do not improve healing of experimental colonic anastomoses
    I Pascual
    Department of General Surgery, La Paz University Hospital, Madrid, Spain
    Br J Surg 95:1180-4. 2008
    ..The feasibility of producing 'biosutures' coated with adipose-derived mesenchymal stem cells (ASCs) was assessed and their effect on colonic anastomoses evaluated...
  16. ncbi request reprint Development of a simple and sensitive technique for detection of point mutations in the K-ras oncogene
    C Fernandez-Vega
    Experimental Research Unit, Albacete General Hospital, Spain
    Mol Biotechnol 22:115-21. 2002
    ..Our methods should allow the detection of small amounts of mutant k-ras DNA in tissue, serum, and plasma, combining speed with efficiency and specificity...
  17. ncbi request reprint Loss of a reporter gene for green fluorescent protein during tumor progression suggests the recruitment of host cells in rats with experimentally induced colon cancer
    D C García-Olmo
    Experimental Research Unit, General University Hospital of Albacete, Albacete, Spain
    Histol Histopathol 23:1205-11. 2008
    ..To explain these findings, we present a brief review of the literature and postulate that tumor growth did not occur exclusively as a result of the division of the injected cells, but also involved recruitment of host cells...
  18. pmc Adipose-derived stem cells in Crohn's rectovaginal fistula
    D Garcia-Olmo
    Department of Surgery, La Paz University Hospital IdiPAZ, 28046 Madrid, Spain
    Case Report Med 2010:961758. 2010
    ....
  19. ncbi request reprint Is routine endoanal ultrasound useful in anal fistulas?
    I Pascual Miguelañez
    Department of Surgery, Universidad Autonoma, Madrid, Spain
    Rev Esp Enferm Dig 97:323-7. 2005
    ....
  20. ncbi request reprint Absence of a relationship between the increased survival of skin grafts provoked by additional spleen transplantation and the detection of donor chimeric cells in rats
    Dolores C García-Olmo
    Experimental Research Unit, Albacete General Hospital, Albacete, Spain
    Eur Surg Res 35:425-9. 2003
    ..To conclude, the beneficial effect of spleen auxiliary transplantation on allograft survival was not related to the detection of long-term chimerism in the recipient's tissues...