I Ferrer

Summary

Country: Spain

Publications

  1. ncbi [Pathology of paraneoplastic syndromes of the central and peripheral nervous systems and muscle ]
    I Ferrer
    Servicio de Anatomia Patologica, Hospital Princeps d Espanya, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Banco de Tejidos Neurológicos, Barcelona, Espana
    Rev Neurol 31:1228-36. 2000
  2. ncbi [Cell signaling in the epileptic hippocampus]
    I Ferrer
    Unidad de Neuropatologia, Servicio de Anatomia Pato Hospital Principes de España Bellvitge, L Hospitalet de Llobregat, 08907, Espana
    Rev Neurol 34:544-50. 2002
  3. ncbi Active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates are differentially expressed following systemic administration of kainic acid to the adult rat
    I Ferrer
    Departament de Biologia Cel lular i Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Spain
    Acta Neuropathol 103:391-407. 2002
  4. ncbi Synaptic pathology and cell death in the cerebellum in Creutzfeldt-Jakob disease
    I Ferrer
    Institut de Neuropatologia, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    Cerebellum 1:213-22. 2002
  5. ncbi Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neuron
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    J Neural Transm (Vienna) 108:1397-415. 2001
  6. ncbi Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    J Neural Transm (Vienna) 108:1383-96. 2001
  7. ncbi Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, i Departament de Biologia Cellular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 27:343-51. 2001
  8. ncbi Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya Bellvitge, c Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Brain Res Mol Brain Res 94:48-58. 2001
  9. ncbi Fas and Fas ligand expression in Alzheimer's disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Barcelona, Spain
    Acta Neuropathol 102:121-31. 2001
  10. ncbi [Alpha-synucleinopathies]
    I Ferrer
    Unidad de Neuropatologia, Servicio de Anatomia Patologica, Hospital Principes de Espana, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Spain
    Neurologia 16:163-70. 2001

Detail Information

Publications93

  1. ncbi [Pathology of paraneoplastic syndromes of the central and peripheral nervous systems and muscle ]
    I Ferrer
    Servicio de Anatomia Patologica, Hospital Princeps d Espanya, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Banco de Tejidos Neurológicos, Barcelona, Espana
    Rev Neurol 31:1228-36. 2000
    ..In this paper we describe the main paraneoplastic neurological pictures and known antibodies, including the molecular aspects and the neoplasias most frequently related to them...
  2. ncbi [Cell signaling in the epileptic hippocampus]
    I Ferrer
    Unidad de Neuropatologia, Servicio de Anatomia Pato Hospital Principes de España Bellvitge, L Hospitalet de Llobregat, 08907, Espana
    Rev Neurol 34:544-50. 2002
    ..This abnormal regeneration, in turn, facilitates seizure recruitment and the chronic maintenance of convulsions...
  3. ncbi Active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates are differentially expressed following systemic administration of kainic acid to the adult rat
    I Ferrer
    Departament de Biologia Cel lular i Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Spain
    Acta Neuropathol 103:391-407. 2002
    ..Furthermore, increased Ras activation, as seen with p21 Ras activation assay, indicates a crucial role for Ras in activating MAP kinases following excitotoxic insult...
  4. ncbi Synaptic pathology and cell death in the cerebellum in Creutzfeldt-Jakob disease
    I Ferrer
    Institut de Neuropatologia, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    Cerebellum 1:213-22. 2002
    ..Together, these data suggest activation of the caspase pathway of apoptosis in human and animal prion diseases...
  5. ncbi Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neuron
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    J Neural Transm (Vienna) 108:1397-415. 2001
    ....
  6. ncbi Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    J Neural Transm (Vienna) 108:1383-96. 2001
    ....
  7. ncbi Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, i Departament de Biologia Cellular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 27:343-51. 2001
    ..Therefore, it is not clear that the activation of the Ras/MAPK/c-Myc subprogramme leads to neuronal death in AD and other tauopathies...
  8. ncbi Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya Bellvitge, c Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Brain Res Mol Brain Res 94:48-58. 2001
    ..The present results demonstrate selective activation of specific MAPK signals which are involved either in cell death or cell survival triggered by excitotoxic insult...
  9. ncbi Fas and Fas ligand expression in Alzheimer's disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Barcelona, Spain
    Acta Neuropathol 102:121-31. 2001
    ....
  10. ncbi [Alpha-synucleinopathies]
    I Ferrer
    Unidad de Neuropatologia, Servicio de Anatomia Patologica, Hospital Principes de Espana, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Spain
    Neurologia 16:163-70. 2001
    ..Although studies in vitro and in vivo have shown toxic effects of alpha-synuclein, the consequence of alpha-synuclein deposition on cell survival in alpha-synucleinopathies is not known...
  11. ncbi Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Campus de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 101:229-38. 2001
    ..Thus, our results show that BDNF specifically up-regulates its full-length TrkB receptor in cortical neurons of the penumbra area and prevents their death in an in vivo model of focal ischemia...
  12. ncbi Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy an
    I Ferrer
    Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat
    Brain Pathol 11:144-58. 2001
    ....
  13. ncbi Prion protein expression in senile plaques in Alzheimer's disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
    Acta Neuropathol 101:49-56. 2001
    ....
  14. ncbi Methylazoximethanol acetate-induced cell death in the granule cell layer of the developing mouse cerebellum is associated with caspase-3 activation, but does not depend on the tissue-type plasminogen activator
    I Ferrer
    Unitat de Neuropatologia, Departament de Biologia, Cellular i Anatomia Patológica, Universitat de Barcelona, Campus de Bellvitge, carrer Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Neurosci Lett 299:77-80. 2001
    ..These results indicate that tPA is not involved in MAM-induced cell death in the developing brain...
  15. ncbi Fas and Fas-L expression in Huntington's disease and Parkinson's disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Barcelona, Spain
    Neuropathol Appl Neurobiol 26:424-33. 2000
    ..The meaning of increased Fas and Fas-L expression in astrocytes is still unclear. However, the present results suggest that Fas/Fas-L signals are minimized in sensitive neurones in HD and PD...
  16. ncbi N-myc and c-myc expression in Alzheimer disease, Huntington disease and Parkinson disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, i Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Hospitalet de Llobregat, Llobregat, Spain
    Brain Res Mol Brain Res 77:270-6. 2000
    ..Increased N-myc and c-myc expression in reactive astrocytes probably plays a role in reactive astrocytosis in human neurodegenerative disorders...
  17. ncbi Brain-derived neurotrophic factor in Huntington disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya Bellvitge, Barcelona, Spain
    Brain Res 866:257-61. 2000
    ..These data demonstrate selective BDNF decay in regions that are vulnerable to HD, and suggest, in combination with results in experimental models, that a BDNF surplus may have beneficial effects in the treatment of HD...
  18. ncbi Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzfeldt-Jakob disease
    I Ferrer
    Unidad de Neuropatologia, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Campus de Bellvitge, 08907, Hospitalet de Llobregat, Spain
    Neuroscience 97:715-26. 2000
    ..Therefore, it remains to be elucidated how abnormal PrP impacts on the metabolism of proteins linked to exocytosis and neurotransmission, and how abnormal PrP deposition results in eventual synaptic loss...
  19. ncbi Fra-1 immunoreactivity in the rat brain during normal postnatal development and after injury in adulthood
    E Pozas
    Servei d Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Spain
    Neurosci Res 33:137-45. 1999
    ....
  20. ncbi Brain-derived neurotrophic factor in patients with frontotemporal dementia
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
    Neurosci Lett 279:33-6. 2000
    ..These results show that FTD is not associated with a decay of BDNF in cortical neurons, and therefore, that BDNF is differentially regulated in diseases causing dementia...
  21. ncbi Differential c-Fos and caspase expression following kainic acid excitotoxicity
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya Bellvitge, carrer Feixa Llarga sn, E 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 99:245-56. 2000
    ..Although these results suggest caspase activation, further studies have to be performed to elucidate whether caspase activation plays a crucial role in KA excitotoxicity...
  22. ncbi Neurons and their dendrites in frontotemporal dementia
    I Ferrer
    Unidad de Neuropatologia, Servicio de Anatomia Patologica, Hospital Príncipes de España Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Spain
    Dement Geriatr Cogn Disord 10:55-60. 1999
    ....
  23. ncbi [Neuronal death mechanisms in cerebral ischemia]
    I Ferrer
    Unidad de Neuropatologia, Hospital Principes de Espana, Bellvitge, Espana
    Rev Neurol 29:515-21. 1999
    ..Morphological and biochemical studies have shown an apoptotic component in neurons following either focal or global ischemia in adults, or hypoxia-ischemia during development...
  24. ncbi Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP Tg2576 mice
    B Puig
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 30:491-502. 2004
    ....
  25. ncbi Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Campus de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 105:425-37. 2003
    ..Whether phosphorylated kinases and specific substrates participate in promoting cell death or survival in the penumbra probably depends on additional factors and on the interaction with other proteins...
  26. ncbi Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease
    M Barrachina
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 32:505-16. 2006
    ..These findings support the participation of lysosomes in betaA-amyloid and, probably, in hyperphosphorylated tau turnover in AD...
  27. ncbi Metabotropic glutamate receptor/phospholipase C pathway: a vulnerable target to Creutzfeldt-Jakob disease in the cerebral cortex
    A Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, c Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neuroscience 131:825-32. 2005
    ..These abnormalities are not the result of abnormal PLC solubility or interactions with PrP. Selective involvement of group I mGluRs may have functional effects on glutamatergic transmission modulation and processing in CJD...
  28. ncbi Glycolitic enzymes are targets of oxidation in aged human frontal cortex and oxidative damage of these proteins is increased in progressive supranuclear palsy
    A Martinez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    J Neural Transm (Vienna) 115:59-66. 2008
    ..These findings show that PGK-1 and aldolase A are targets of oxidation in the frontal cortex in the aged human cerebral cortex and that oxidative damage of these proteins is markedly increased in the frontal cortex in PSP...
  29. ncbi Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Bellvitge Hospitalet de Llobregat, Barcelona, Spain
    Neuropathol Appl Neurobiol 29:472-81. 2003
    ....
  30. ncbi Primary progressive aphasia as the initial manifestation of corticobasal degeneration and unusual tauopathies
    I Ferrer
    Banc de Teixits Neurològics, Universitat de Barcelona Hospital Clinic, Barcelona, Spain
    Acta Neuropathol 106:419-35. 2003
    ..Taken together, the present series further supports pure and combined CBD as causes of primary progressive aphasia, and they extend the hypothesis that primary progressive aphasia may be the initial symptom of distinct tauopathies...
  31. ncbi Tau phosphorylation and kinase activation in familial tauopathy linked to deln296 mutation
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 29:23-34. 2003
    ..These findings show, for the first time, activation of precise kinases that regulate tau phosphorylation at specific sites in familial tauopathy...
  32. ncbi Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    Brain Pathol 13:62-78. 2003
    ....
  33. ncbi Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 30:329-37. 2004
    ..Whether Dpl in neuritic plaques may attenuate amyloid-induced oxidative stress and participate in the glial response around amyloid cores is discussed in light of the few available data on Dpl functions...
  34. ncbi Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies
    G Santpere
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Larga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 397:30-4. 2006
    ....
  35. ncbi Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Curr Alzheimer Res 2:3-18. 2005
    ..These findings support the amyloid cascade hypothesis of tau phosphorylation mediated by stress kinases in dystrophic neurites of senile plaques but not that of neurofibrillary tangles and neuropil threads in AD...
  36. ncbi Low concentrations of 1-methyl-4-phenylpyridinium ion induce caspase-mediated apoptosis in human SH-SY5Y neuroblastoma cells
    C Gomez
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Universitat de Barcelona, Barcelona, Spain
    J Neurosci Res 63:421-8. 2001
    ....
  37. doi Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies
    G Muntane
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultat de Medicina, Universitat de Barcelona, CIBERNED, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neuroscience 152:913-23. 2008
    ..Tau phosphorylation at Ser396 has also been found in synaptic-enriched fractions in 12-month-old transgenic mice bearing the A53T alpha-synuclein mutation...
  38. ncbi Cell death signaling in the cerebellum in Creutzfeldt-Jakob disease
    B Puig
    , Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Acta Neuropathol 102:207-15. 2001
    ..These findings point to the likelihood that expression of these cell death proteins in neurodegeneration has functional roles differing from those related with apoptosis...
  39. doi α-synuclein phosphorylation and truncation are normal events in the adult human brain
    G Muntane
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, CIBERNED, Instituto Carlos III, Barcelona, Spain
    Neuroscience 200:106-19. 2012
    ..Although accumulation of truncated α-synuclein variants and phosphorylated α-synuclein occurs in Lewy bodies, α-synuclein phosphorylation and truncation can be considered constitutive in control and diseased brains...
  40. ncbi Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
    Acta Neuropathol 104:583-91. 2002
    ....
  41. ncbi Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultad de Medicina, Universitat de Barcelona, carrer Feixa Llarga s n, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 415:205-9. 2007
    ..These findings emphasize the presence of mitochondrial modifications before the appearance of histological hallmarks of PD, and point to the possibility of a more extended molecular pathology in PD than currently accepted...
  42. ncbi Juvenile neuroaxonal dystrophy in a Rottweiler: accumulation of synaptic proteins in dystrophic axons
    S Siso
    Unitat de Neuropatologia, Servei Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Spain
    Acta Neuropathol 102:501-4. 2001
    ....
  43. ncbi Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions
    E Dalfo
    Instituto de Neuropatologia, Servicio de Anatomia Patologica, IDIBELL Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain
    Brain Pathol 14:388-98. 2004
    ..Finally, these results emphasize the emergence of a functional neuropathology that has to be explored for a better understanding of the effects of abnormal protein interactions in degenerative diseases of the nervous system...
  44. ncbi Late-onset frontotemporal dementia associated with a novel PGRN mutation
    A Lladó
    Alzheimer s Disease and Cognitive Disorders Unit, Neurology Service, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neural Transm (Vienna) 114:1051-4. 2007
    ..The A303AfsX57 mutation is consistent with a nucleotide deletion in exon 8 (c908delC). This deletion causes a frameshift at codon 303 that introduces a premature termination codon (A303AfsX57)...
  45. ncbi Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease
    I Ferrer
    Departament de Biologia Cellular i Anatomia Patologica, Universitat de Barcelona, Neurològics, Universitat de Barcelona Hospital Clinic, Barcelona, Spain
    Neuropathol Appl Neurobiol 28:441-51. 2002
    ....
  46. ncbi Cell death and decreased synaptic protein expression in the ventral horn of Holstein-Friesian calves with spinal muscular atrophy
    S Siso
    Priocat Laboratory, CReSA Centre de Recerca en Sanitat Animal, and Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    J Comp Pathol 128:132-9. 2003
    ..Taken together, the present findings point to necrosis as a major cause of motor neuron death in the advanced stages of SMA in Holstein-Friesian calves...
  47. ncbi Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation
    T Valente
    Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 1a planta, E 08028, Spain
    Neuroscience 128:323-36. 2004
    ....
  48. ncbi Differential regulation of chromogranin A, chromogranin B and secretoneurin protein expression after transient forebrain ischemia in the gerbil
    E Marti
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, Spain
    Acta Neuropathol 101:159-66. 2001
    ..Furthermore, the present data suggest a possible implication of chromogranin A and secretoneurin in the pathophysiology of transient forebrain ischemia...
  49. ncbi Alpha-synuclein binding to rab3a in multiple system atrophy
    E Dalfo
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 380:170-5. 2005
    ....
  50. ncbi Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease
    E Dalfo
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    Neurobiol Dis 16:92-7. 2004
    ..Since, alpha-synuclein, rab3a and rabphilin participate in the docking and fusion of synaptic vesicles, it can be suggested that exocytosis of neurotransmitters may be impaired in LB diseases...
  51. ncbi Expression of transcription factors CREB and c-Fos in the brains of terminal Creutzfeldt-Jakob disease cases
    A Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 421:10-5. 2007
    ..These observations point to exhausted CREB and c-Fos brain responses, in spite of preserved up-stream signaling kinases, thus favoring cell death in terminal stages of CJD...
  52. ncbi CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat
    J Krupinski
    Unitat de Neuropatologia, Departament de Biologia Cellular i Anatomia Patologica, Universitat de Barcelona, Barcelona, Spain
    Neuropharmacology 42:846-54. 2002
    ..The expression of caspase-cleaved products of PARP (PARP 89 kDa) was reduced in citicoline-treated ischaemic rats. These results show that citicoline inhibits the expression of proteins involved in apoptosis following MCAO...
  53. ncbi Expression levels of adenosine receptors in hippocampus and frontal cortex in argyrophilic grain disease
    S Perez-Buira
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultad de Medicina, Universitat de Barcelona, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 423:194-9. 2007
    ..These findings indicate sensitization of A1/AC in the hippocampus in AGD, and support a putative activation of the A1/AC pathway that may facilitate protection of this preferentially involved region in AGD...
  54. ncbi Neuronopathic juvenile glucosylceramidosis due to sap-C deficiency: clinical course, neuropathology and brain lipid composition in this Gaucher disease variant
    T Pampols
    Institut de Bioquimica Clinica, Corporacio Sanitaria, Barcelona, Spain
    Acta Neuropathol 97:91-7. 1999
    ..Studying the phenotypic consequences of mutant sphingolipid activator proteins is critical to a better understanding of the physiological significance of these proteins...
  55. ncbi Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Neurotox Res 6:469-75. 2004
    ..These findings support the amyloid cascade hypothesis of tau phosphorylation mediated by stress kinases in dystrophic neurites of senile plaques but not that of neurofibrillary tangles and neuropil threads in AD...
  56. ncbi Bcl-2 and Bax expression following methylazoxymethanol acetate-induced apoptosis in the external granule cell layer of the developing rat cerebellum
    E Lopez
    Unitat de Neuropatologia, Hospital Princeps d Espanya Bellvitge, Barcelona, Spain
    Brain Res Dev Brain Res 112:149-53. 1999
    ..These data indicate that MAM-induced apoptosis is not associated with modifications in the expression of Bcl-2 and Bax...
  57. ncbi Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway
    E Lopez
    Unitat de Neuropatologia, Department de Biologia Cel lular i Anatomia Patologica, Universitat de Barcelona, Campus de Bellvitge, 08907 Hospitalet de Llobregat, Llobregat, Spain
    Brain Res Mol Brain Res 85:61-7. 2000
    ..These findings indicate that the Fas/Fas-L-caspase-8 pathway of cell death signaling is not involved in staurosporine- and H-7-induced apoptosis in SH-SY5Y neuroblastoma cells...
  58. ncbi Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease
    G Muntane
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    J Neurochem 99:177-85. 2006
    ..The present results demonstrate that glial acidic protein is a target of oxidative damage in the frontal cortex in Pick's disease...
  59. ncbi Anti-tau phospho-specific Ser262 antibody recognizes a variety of abnormal hyper-phosphorylated tau deposits in tauopathies including Pick bodies and argyrophilic grains
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
    Acta Neuropathol 104:658-64. 2002
    ....
  60. ncbi Early induction of secretoneurin expression following kainic acid administration at convulsant doses in the rat and gerbil hippocampus
    E Marti
    Laboratori de Neurobiologia Cellular i Molecular, Biologia Cellular i Anatomia Patològica Department, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, Spain
    Hippocampus 12:174-85. 2002
    ..However, no increased cell damage was observed under these conditions. The present data provide evidence of a species-differential reactive response to KA that might be based, in part, on distinct inhibitory intrahippocampal circuitry...
  61. ncbi Familial Alzheimer disease associated with A713T mutation in APP
    J Armstrong
    Institut de Neuropatologia, Servei d Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 370:241-3. 2004
    ..Since the immunohistochemical study indicates that A713T mutation is not likely to relate with Abeta-amyloid processing, the causative role of this rare mutation remains to be warranted...
  62. ncbi Caspase-3-associated apoptotic cell death in excitotoxic necrosis of the entorhinal cortex following intraperitoneal injection of kainic acid in the rat
    B Puig
    Unitat Neuropatología, Departament Biologia Cel lular i Anatomia Patològica, Universitat de Barcelona, Campus de Bellvitge, Spain
    Neurosci Lett 321:182-6. 2002
    ....
  63. ncbi Intranuclear inclusions, neuronal loss and CAG mosaicism in two patients with Machado-Joseph disease
    E Munoz
    Neurology Service, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Neurol Sci 200:19-25. 2002
    ..The presence of neuronal intranuclear inclusions (NIIs) and neuronal mosaicism has been described in some autosomal dominant spinocerebellar ataxias (SCA), but their implication in neurodegenerative mechanisms still remains unclear...
  64. ncbi Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy
    G Santpere
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultat de Medicina, Universitat de Barcelona, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Llobregat, Spain
    Neuroscience 146:1640-51. 2007
    ..These findings demonstrate that 14-3-3 glyco- and lipoxidation occurs in AD and CAA, probably as a direct consequence of Abeta deposition...
  65. ncbi Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies
    K Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Neuropathol Appl Neurobiol 30:601-7. 2004
    ..These results show differential overexpression of alpha-synuclein 112 in DLB, a finding that could be of importance in DLB pathogenesis...
  66. ncbi Expression of mutant ubiquitin (UBB+1) and p62 in myotilinopathies and desminopathies
    M Olive
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Barcelona, Spain
    Neuropathol Appl Neurobiol 34:76-87. 2008
    ..Furthermore, these observations suggest a relationship between the presence of p62 and the formation of inclusions in different subtypes of myofibrillar myopathies...
  67. doi Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia i Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Neuroscience 154:1388-97. 2008
    ..SIRT1 expression decreased dramatically in HD, but there were no significant changes in Parkinson-related illnesses. In conclusion, SIRT1 expression may be a good sensor of toxic neuronal processes...
  68. ncbi A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart
    J J Fuentes
    Molecular Genetics Department, Hospital Duran i Reynals, L Hospitalet de Liobregat, Barcelona, Spain
    Hum Mol Genet 4:1935-44. 1995
    ....
  69. ncbi Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis
    F Graus
    Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain
    Neurosci Lett 112:14-8. 1990
    ..Although the Hu is also expressed by neural cells other than neurons, the strongest staining of mature neurons could indicate that Hu plays a role in the process of neuronal differentiation...
  70. ncbi Role of caspases in ionizing radiation-induced apoptosis in the developing cerebellum
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, i Departament de Biologia Cel lular i Anatomia Patològica, Universitat de Barcelona Campus de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat
    J Neurobiol 41:549-58. 1999
    ..Taken together, these observations suggest that the caspases examined are not essential for radiation-induced apoptosis in the developing cerebellum...
  71. ncbi Overexpression of semicarbazide sensitive amine oxidase in the cerebral blood vessels in patients with Alzheimer's disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    I Ferrer
    Institut de Neuropatologia, Hospital Princeps d Espanya, L Hospitalet de Llobregat 08907, Barcelona, Spain
    Neurosci Lett 321:21-4. 2002
    ..Therefore, it is suggested that increased SSAO expression is a source of oxidative stress in the blood vessel wall in AD and CADASIL...
  72. doi Involvement of Dab1 in APP processing and beta-amyloid deposition in sporadic Creutzfeldt-Jakob patients
    R Gavin
    Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia and Department of Cell Biology, University of Barcelona, Baldiri Reixac 15 21, Barcelona, Spain
    Neurobiol Dis 37:324-9. 2010
    ..Thus, the present observations suggest a correlation between Dab1 phosphorylation, Abeta deposition and PrP(sc) type in sCJD...
  73. ncbi Clusterin solubility and aggregation in Creutzfeldt-Jakob disease
    M Freixes
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 108:295-301. 2004
    ..The implications of this property are not known, but it can be suggested that clusterin participates in PrP clustering and sequestration, thus modifying PrP toxicity in CJD...
  74. ncbi BetaII-tubulin and phospho-tau aggregates in Alzheimer's disease and Pick's disease
    B Puig
    Instituto de Neuropatologia, IDIBELL Hospital Universitario de Bellvitge, Spain
    J Alzheimers Dis 7:213-20; discussion 255-62. 2005
    ..Taken together, these findings support the view that high betaII-tubulin content is a contributing factor in the formation of abnormal hyper-phosphorylated tau aggregates...
  75. ncbi Abnormal synaptic protein expression and cell death in murine scrapie
    S Siso
    Priocat Laboratory, Centre of Animal Health Research CReSA, Department of Medicine and Animal Surgery, Autonomous University of Barcelona, Bellaterra, Spain
    Acta Neuropathol 103:615-26. 2002
    ....
  76. ncbi GluR2/3, NMDAepsilon1 and GABAA receptors in Creutzfeldt-Jakob disease
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Acta Neuropathol 106:311-8. 2003
    ..These findings stress selective vulnerability of glutamate receptors versus GABA receptors in CJD...
  77. ncbi [L-2 hydroxyglutaric aciduria in a patient with Klinefelter syndrome]
    I Pascual-Castroviejo
    Servicio de Neurología Pediátrica, Hospital Universitario La Paz, Madrid
    Neurologia 20:90-3. 2005
    ..Blood and urine were analyzed and showed great elevation of L-2-hydroxyglutaric acid (L-2-HGA) and more discrete elevation of its metabolites and lysine. The parents of the patient are first cousins...
  78. ncbi A novel spongiform degeneration of the grey matter in the brain of a kitten
    E Vidal
    Departament de Medicina i Cirurgia Animals, Institut de Neurociències and Laboratori, Centre de Recerca en Sanitat Animal, Facultad de Veterinaria, Bellaterra, Barcelona, Spain
    J Comp Pathol 131:98-103. 2004
    ..The age of the animal and histological changes suggested a novel, possibly congenital, spongiform degeneration of the brain and cervical spinal cord...
  79. ncbi Abnormal synaptic protein expression in two Arabian horses with equine degenerative myeloencephalopathy
    S Siso
    Priocat Laboratory, Centre de Recerca en Sanitat Animal, Bellaterra Campus, Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet J 166:238-43. 2003
    ....
  80. ncbi Gene symbol: NOTCH3. Disease: CADASIL
    I Rojas-Marcos
    Servicio de Neurologia, Hospital Universitario Virgen del Rocio, Sevilla, Spain
    Hum Genet 115:175. 2004
  81. ncbi Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas
    B Puig
    Unitat de Neuropatologia, , Universitat de Barcelona, Campus de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Barcelona, Spain
    Neurosci Lett 306:85-8. 2001
    ..These findings indicate that effector caspase-3 and -7 may act in association, although caspase-7 may be exceptionally dominant in selected tumors...
  82. ncbi [Man aged 49 years suffering from progressive clinical picture with palatal tremor, segmental myoclonus, ataxia, parkinsonism, amyotrophy, pyramidal signs, supranuclear ophthalmoplegia and cognitive decline]
    J Berciano
    Servicio de Neurología Hospital Universitario Marqués de Valdecilla UC Santander Spain
    Neurologia 17:237-43. 2002
    ..This case illustrates the great clinicopathological complexity of OPCA and that not all forms of sporadic OPCA may be included within MSA...
  83. ncbi NMDA receptors mediate heat shock protein induction in the mouse brain following administration of the ibotenic acid analogue AMAA
    A M Planas
    Departament de Farmacologia i Toxicologia, CID, CSIC, Jordi Girona, Barcelona, Spain
    Brain Res 700:289-94. 1995
    ..AMAA-induced hsp-70 mRNA expression was prevented by pre-treatment with the non-competitive NMDA antagonist MK-801. These results suggest that NMDA receptors are involved in the stress response induced by AMAA...
  84. ncbi Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation
    M Perez
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Neuroscience 130:339-47. 2005
    ..Also, they suggest that different types of tau filamentous polymers can occur in different mouse models for tauopathies, like those used for Alzheimer's disease or FTDP-17...
  85. ncbi Oxidation, glycoxidation, lipoxidation, nitration, and responses to oxidative stress in the cerebral cortex in Creutzfeldt-Jakob disease
    M Freixes
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurobiol Aging 27:1807-15. 2006
    ..These results provide support for the concept that oxidative stress may have important implications in the pathogenesis of prion diseases...
  86. ncbi A novel mutation (K317M) in the MAPT gene causes FTDP and motor neuron disease
    J J Zarranz
    Neurology Service, Department of Neurosciences, Hospital Cruces, University of the Basque Country, Baracaldo, Vizcaya, Spain
    Neurology 64:1578-85. 2005
    ..In some families the genetic basis is still unknown. The authors report two pedigrees with FTDP-17 harboring a novel mutation (K317M) in exon 11 in the MAPT gene...
  87. ncbi Protein 14.3.3 in pellagra encephalopathy
    A Pellisé
    Neurologia 17:655-6. 2002
  88. pmc Familial Creutzfeldt-Jakob disease with E200K mutation presenting with neurosensorial hypoacusis
    R Rene
    J Neurol Neurosurg Psychiatry 78:103-4. 2007
  89. ncbi Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis
    I Ferrer
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    Brain Pathol 15:101-8. 2005
    ....
  90. ncbi [Molecular factors of cerebral hypoxia-ischemia]
    A Macaya
    , Hospital Vall d Hebron, Barcelona
    Rev Neurol 24:855-64. 1996
    ..High-dose dexamethasone prevented c-fos induction in cerebral regions sensitive to HI. This effect may be due to a functional antagonism, at the transcriptional level, between Fos and the glucocorticoid receptor...
  91. ncbi NARP-MILS syndrome caused by 8993 T>G mitochondrial DNA mutation: a clinical, genetic and neuropathological study
    A Rojo
    Neurology Services, Hospital Mutua de Terrassa, and University of Barcelona, Spain
    Acta Neuropathol 111:610-6. 2006
    ..These observations illustrate the continuum of clinical and neuropathological manifestations associated with the 8993 T>G mutation of the mtDNA...
  92. ncbi Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice
    E Dalfo
    Unitat de Neuropatologia Experimental, Departament de Biologia Cel lular i Anatomia Patològica, Universitat de Barcelona, Barcelona, Spain
    J Neuropathol Exp Neurol 63:302-13. 2004
    ..This rationale is consistent with previous data showing that short-term hippocampal synaptic plasticity is altered and that alpha-synuclein accumulates in the cytoplasm of neurons in Tg mice...
  93. ncbi Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level
    C Quintana
    IMM CNM, CSIC, Madrid, Spain
    J Struct Biol 153:42-54. 2006
    ..2004. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease. Neurobiol. Aging 25, 5-18)...