I Ferrer

Summary

Country: Spain

Publications

  1. ncbi Neurochemistry and the non-motor aspects of PD
    I Ferrer
    Institute of Neuropathology, Service of Pathology, University Hospital of Bellvitge, Spain
    Neurobiol Dis 46:508-26. 2012
  2. ncbi Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Bellvitge Hospitalet de Llobregat, Barcelona, Spain
    Neuropathol Appl Neurobiol 29:472-81. 2003
  3. ncbi Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models
    Isidro Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurobiol Dis 20:392-400. 2005
  4. ncbi Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    Brain Pathol 13:62-78. 2003
  5. ncbi Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease
    I Ferrer
    Departament de Biologia Cellular i Anatomia Patologica, Universitat de Barcelona, Neurològics, Universitat de Barcelona Hospital Clinic, Barcelona, Spain
    Neuropathol Appl Neurobiol 28:441-51. 2002
  6. ncbi Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 30:329-37. 2004
  7. ncbi Anti-tau phospho-specific Ser262 antibody recognizes a variety of abnormal hyper-phosphorylated tau deposits in tauopathies including Pick bodies and argyrophilic grains
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
    Acta Neuropathol 104:658-64. 2002
  8. ncbi Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
    Acta Neuropathol 104:583-91. 2002
  9. doi Delineation of early changes in cases with progressive supranuclear palsy-like pathology. Astrocytes in striatum are primary targets of tau phosphorylation and GFAP oxidation
    Gabriel Santpere
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Llarga s n, Hospitalet de Llobregat, Spain
    Brain Pathol 19:177-87. 2009
  10. ncbi Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis
    I Ferrer
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    Brain Pathol 15:101-8. 2005

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi Neurochemistry and the non-motor aspects of PD
    I Ferrer
    Institute of Neuropathology, Service of Pathology, University Hospital of Bellvitge, Spain
    Neurobiol Dis 46:508-26. 2012
    ..These observations have important implications in the design of therapeutic approaches geared to prevention and treatment of PD...
  2. ncbi Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Bellvitge Hospitalet de Llobregat, Barcelona, Spain
    Neuropathol Appl Neurobiol 29:472-81. 2003
    ....
  3. ncbi Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models
    Isidro Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurobiol Dis 20:392-400. 2005
    ..The present observations indicate modifications in the expression of constitutive Dyrk1A in the cytoplasm and nuclei of neurons in various neurodegenerative diseases associated with tau phosphorylation...
  4. ncbi Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    Brain Pathol 13:62-78. 2003
    ....
  5. ncbi Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease
    I Ferrer
    Departament de Biologia Cellular i Anatomia Patologica, Universitat de Barcelona, Neurològics, Universitat de Barcelona Hospital Clinic, Barcelona, Spain
    Neuropathol Appl Neurobiol 28:441-51. 2002
    ....
  6. ncbi Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 30:329-37. 2004
    ..Whether Dpl in neuritic plaques may attenuate amyloid-induced oxidative stress and participate in the glial response around amyloid cores is discussed in light of the few available data on Dpl functions...
  7. ncbi Anti-tau phospho-specific Ser262 antibody recognizes a variety of abnormal hyper-phosphorylated tau deposits in tauopathies including Pick bodies and argyrophilic grains
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
    Acta Neuropathol 104:658-64. 2002
    ....
  8. ncbi Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
    Acta Neuropathol 104:583-91. 2002
    ....
  9. doi Delineation of early changes in cases with progressive supranuclear palsy-like pathology. Astrocytes in striatum are primary targets of tau phosphorylation and GFAP oxidation
    Gabriel Santpere
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Llarga s n, Hospitalet de Llobregat, Spain
    Brain Pathol 19:177-87. 2009
    ....
  10. ncbi Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis
    I Ferrer
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    Brain Pathol 15:101-8. 2005
    ....
  11. ncbi Tau phosphorylation and kinase activation in familial tauopathy linked to deln296 mutation
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 29:23-34. 2003
    ..These findings show, for the first time, activation of precise kinases that regulate tau phosphorylation at specific sites in familial tauopathy...
  12. ncbi Proteasomal expression, induction of immunoproteasome subunits, and local MHC class I presentation in myofibrillar myopathy and inclusion body myositis
    Isidro Ferrer
    Instituto de Neuropatologia, Servicio de Anatomia Patologica, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain
    J Neuropathol Exp Neurol 63:484-98. 2004
    ..The present findings provide a link between abnormal protein accumulation and altered proteasomal expression in IBM and MM...
  13. ncbi Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
    Isidre Ferrer
    Servei Anatomia Patològica, Institut de Neuropatologia, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain
    Brain Pathol 14:11-20. 2004
    ..Release of antigenic peptides derived from beta-amyloid processing may enhance T-cell inflammatory responses accounting for the meningoencephalitis following amyloid-beta peptide immunization...
  14. ncbi Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultad de Medicina, Universitat de Barcelona, carrer Feixa Llarga s n, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 415:205-9. 2007
    ..These findings emphasize the presence of mitochondrial modifications before the appearance of histological hallmarks of PD, and point to the possibility of a more extended molecular pathology in PD than currently accepted...
  15. ncbi Effects of formalin fixation, paraffin embedding, and time of storage on DNA preservation in brain tissue: a BrainNet Europe study
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
    Brain Pathol 17:297-303. 2007
    ..Genomiphi and TaKaRa Ex Taq methods were also assayed in paraffin blocks and in formalin-fixed samples with limited success...
  16. ncbi Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe Study
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona IF, 08907 Hospitalet de Llobregat, Barcelona, Spain
    J Neuropathol Exp Neurol 66:35-46. 2007
    ..These results emphasize the necessity of reducing the body temperature after death to minimize protein degradation...
  17. ncbi Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra
    Isidro Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    J Neuropathol Exp Neurol 62:329-39. 2003
    ....
  18. ncbi Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Curr Alzheimer Res 2:3-18. 2005
    ..These findings support the amyloid cascade hypothesis of tau phosphorylation mediated by stress kinases in dystrophic neurites of senile plaques but not that of neurofibrillary tangles and neuropil threads in AD...
  19. ncbi Primary progressive aphasia as the initial manifestation of corticobasal degeneration and unusual tauopathies
    I Ferrer
    Banc de Teixits Neurològics, Universitat de Barcelona Hospital Clinic, Barcelona, Spain
    Acta Neuropathol 106:419-35. 2003
    ..Taken together, the present series further supports pure and combined CBD as causes of primary progressive aphasia, and they extend the hypothesis that primary progressive aphasia may be the initial symptom of distinct tauopathies...
  20. ncbi GluR2/3, NMDAepsilon1 and GABAA receptors in Creutzfeldt-Jakob disease
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Acta Neuropathol 106:311-8. 2003
    ..These findings stress selective vulnerability of glutamate receptors versus GABA receptors in CJD...
  21. ncbi Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Campus de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 105:425-37. 2003
    ..Whether phosphorylated kinases and specific substrates participate in promoting cell death or survival in the penumbra probably depends on additional factors and on the interaction with other proteins...
  22. ncbi Apoptosis: future targets for neuroprotective strategies
    Isidro Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Cerebrovasc Dis 21:9-20. 2006
    ....
  23. ncbi Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy an
    I Ferrer
    Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat
    Brain Pathol 11:144-58. 2001
    ....
  24. ncbi Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya Bellvitge, c Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Brain Res Mol Brain Res 94:48-58. 2001
    ..The present results demonstrate selective activation of specific MAPK signals which are involved either in cell death or cell survival triggered by excitotoxic insult...
  25. ncbi Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    J Neural Transm 108:1383-96. 2001
    ....
  26. ncbi Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease
    M Barrachina
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 32:505-16. 2006
    ..These findings support the participation of lysosomes in betaA-amyloid and, probably, in hyperphosphorylated tau turnover in AD...
  27. ncbi Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neuron
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Spain
    J Neural Transm 108:1397-415. 2001
    ....
  28. ncbi Fas and Fas ligand expression in Alzheimer's disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Hospitalet de Llobregat, Barcelona, Spain
    Acta Neuropathol 102:121-31. 2001
    ....
  29. ncbi Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP Tg2576 mice
    B Puig
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 30:491-502. 2004
    ....
  30. ncbi Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Campus de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 101:229-38. 2001
    ..Thus, our results show that BDNF specifically up-regulates its full-length TrkB receptor in cortical neurons of the penumbra area and prevents their death in an in vivo model of focal ischemia...
  31. ncbi Active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates are differentially expressed following systemic administration of kainic acid to the adult rat
    I Ferrer
    Departament de Biologia Cel lular i Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Spain
    Acta Neuropathol 103:391-407. 2002
    ..Furthermore, increased Ras activation, as seen with p21 Ras activation assay, indicates a crucial role for Ras in activating MAP kinases following excitotoxic insult...
  32. ncbi Metabotropic glutamate receptor/phospholipase C pathway: a vulnerable target to Creutzfeldt-Jakob disease in the cerebral cortex
    A Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, c Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neuroscience 131:825-32. 2005
    ..These abnormalities are not the result of abnormal PLC solubility or interactions with PrP. Selective involvement of group I mGluRs may have functional effects on glutamatergic transmission modulation and processing in CJD...
  33. ncbi Glycolitic enzymes are targets of oxidation in aged human frontal cortex and oxidative damage of these proteins is increased in progressive supranuclear palsy
    A Martinez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    J Neural Transm 115:59-66. 2008
    ..These findings show that PGK-1 and aldolase A are targets of oxidation in the frontal cortex in the aged human cerebral cortex and that oxidative damage of these proteins is markedly increased in the frontal cortex in PSP...
  34. ncbi BetaII-tubulin and phospho-tau aggregates in Alzheimer's disease and Pick's disease
    B Puig
    Instituto de Neuropatologia, IDIBELL Hospital Universitario de Bellvitge, Spain
    J Alzheimers Dis 7:213-20; discussion 255-62. 2005
    ..Taken together, these findings support the view that high betaII-tubulin content is a contributing factor in the formation of abnormal hyper-phosphorylated tau aggregates...
  35. ncbi N-myc and c-myc expression in Alzheimer disease, Huntington disease and Parkinson disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, i Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Hospitalet de Llobregat, Llobregat, Spain
    Brain Res Mol Brain Res 77:270-6. 2000
    ..Increased N-myc and c-myc expression in reactive astrocytes probably plays a role in reactive astrocytosis in human neurodegenerative disorders...
  36. ncbi Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies
    G Santpere
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Larga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 397:30-4. 2006
    ....
  37. ncbi Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, i Departament de Biologia Cellular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Neuropathol Appl Neurobiol 27:343-51. 2001
    ..Therefore, it is not clear that the activation of the Ras/MAPK/c-Myc subprogramme leads to neuronal death in AD and other tauopathies...
  38. doi Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies
    G Muntane
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultat de Medicina, Universitat de Barcelona, CIBERNED, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neuroscience 152:913-23. 2008
    ..Tau phosphorylation at Ser396 has also been found in synaptic-enriched fractions in 12-month-old transgenic mice bearing the A53T alpha-synuclein mutation...
  39. ncbi Cell death signaling in the cerebellum in Creutzfeldt-Jakob disease
    B Puig
    , Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Acta Neuropathol 102:207-15. 2001
    ..These findings point to the likelihood that expression of these cell death proteins in neurodegeneration has functional roles differing from those related with apoptosis...
  40. ncbi Prion protein expression in senile plaques in Alzheimer's disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
    Acta Neuropathol 101:49-56. 2001
    ....
  41. ncbi Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions
    E Dalfo
    Instituto de Neuropatologia, Servicio de Anatomia Patologica, IDIBELL Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain
    Brain Pathol 14:388-98. 2004
    ..Finally, these results emphasize the emergence of a functional neuropathology that has to be explored for a better understanding of the effects of abnormal protein interactions in degenerative diseases of the nervous system...
  42. doi α-synuclein phosphorylation and truncation are normal events in the adult human brain
    G Muntane
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, CIBERNED, Instituto Carlos III, Barcelona, Spain
    Neuroscience 200:106-19. 2012
    ..Although accumulation of truncated α-synuclein variants and phosphorylated α-synuclein occurs in Lewy bodies, α-synuclein phosphorylation and truncation can be considered constitutive in control and diseased brains...
  43. ncbi Juvenile neuroaxonal dystrophy in a Rottweiler: accumulation of synaptic proteins in dystrophic axons
    S Siso
    Unitat de Neuropatologia, Servei Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Spain
    Acta Neuropathol 102:501-4. 2001
    ....
  44. ncbi Late-onset frontotemporal dementia associated with a novel PGRN mutation
    A Lladó
    Alzheimer s Disease and Cognitive Disorders Unit, Neurology Service, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neural Transm 114:1051-4. 2007
    ..The A303AfsX57 mutation is consistent with a nucleotide deletion in exon 8 (c908delC). This deletion causes a frameshift at codon 303 that introduces a premature termination codon (A303AfsX57)...
  45. ncbi Clusterin solubility and aggregation in Creutzfeldt-Jakob disease
    M Freixes
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 108:295-301. 2004
    ..The implications of this property are not known, but it can be suggested that clusterin participates in PrP clustering and sequestration, thus modifying PrP toxicity in CJD...
  46. ncbi Low concentrations of 1-methyl-4-phenylpyridinium ion induce caspase-mediated apoptosis in human SH-SY5Y neuroblastoma cells
    C Gomez
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Universitat de Barcelona, Barcelona, Spain
    J Neurosci Res 63:421-8. 2001
    ....
  47. ncbi [Alpha-synucleinopathies]
    I Ferrer
    Unidad de Neuropatologia, Servicio de Anatomia Patologica, Hospital Principes de Espana, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Spain
    Neurologia 16:163-70. 2001
    ..Although studies in vitro and in vivo have shown toxic effects of alpha-synuclein, the consequence of alpha-synuclein deposition on cell survival in alpha-synucleinopathies is not known...
  48. ncbi Differential c-Fos and caspase expression following kainic acid excitotoxicity
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya Bellvitge, carrer Feixa Llarga sn, E 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 99:245-56. 2000
    ..Although these results suggest caspase activation, further studies have to be performed to elucidate whether caspase activation plays a crucial role in KA excitotoxicity...
  49. ncbi Expression of mutant ubiquitin (UBB+1) and p62 in myotilinopathies and desminopathies
    M Olive
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Barcelona, Spain
    Neuropathol Appl Neurobiol 34:76-87. 2008
    ..Furthermore, these observations suggest a relationship between the presence of p62 and the formation of inclusions in different subtypes of myofibrillar myopathies...
  50. ncbi Intranuclear inclusions, neuronal loss and CAG mosaicism in two patients with Machado-Joseph disease
    E Munoz
    Neurology Service, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Neurol Sci 200:19-25. 2002
    ..The presence of neuronal intranuclear inclusions (NIIs) and neuronal mosaicism has been described in some autosomal dominant spinocerebellar ataxias (SCA), but their implication in neurodegenerative mechanisms still remains unclear...
  51. ncbi Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease
    G Muntane
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    J Neurochem 99:177-85. 2006
    ..The present results demonstrate that glial acidic protein is a target of oxidative damage in the frontal cortex in Pick's disease...
  52. ncbi Expression levels of adenosine receptors in hippocampus and frontal cortex in argyrophilic grain disease
    S Perez-Buira
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultad de Medicina, Universitat de Barcelona, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 423:194-9. 2007
    ..These findings indicate sensitization of A1/AC in the hippocampus in AGD, and support a putative activation of the A1/AC pathway that may facilitate protection of this preferentially involved region in AGD...
  53. ncbi Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation
    T Valente
    Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 1a planta, E 08028, Spain
    Neuroscience 128:323-36. 2004
    ....
  54. ncbi Differential regulation of chromogranin A, chromogranin B and secretoneurin protein expression after transient forebrain ischemia in the gerbil
    E Marti
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, Spain
    Acta Neuropathol 101:159-66. 2001
    ..Furthermore, the present data suggest a possible implication of chromogranin A and secretoneurin in the pathophysiology of transient forebrain ischemia...
  55. ncbi Methylazoximethanol acetate-induced cell death in the granule cell layer of the developing mouse cerebellum is associated with caspase-3 activation, but does not depend on the tissue-type plasminogen activator
    I Ferrer
    Unitat de Neuropatologia, Departament de Biologia, Cellular i Anatomia Patológica, Universitat de Barcelona, Campus de Bellvitge, carrer Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Neurosci Lett 299:77-80. 2001
    ..These results indicate that tPA is not involved in MAM-induced cell death in the developing brain...
  56. ncbi Caspase-3-associated apoptotic cell death in excitotoxic necrosis of the entorhinal cortex following intraperitoneal injection of kainic acid in the rat
    B Puig
    Unitat Neuropatología, Departament Biologia Cel lular i Anatomia Patològica, Universitat de Barcelona, Campus de Bellvitge, Spain
    Neurosci Lett 321:182-6. 2002
    ....
  57. ncbi Alpha-synuclein binding to rab3a in multiple system atrophy
    E Dalfo
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 380:170-5. 2005
    ....
  58. ncbi Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease
    E Dalfo
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    Neurobiol Dis 16:92-7. 2004
    ..Since, alpha-synuclein, rab3a and rabphilin participate in the docking and fusion of synaptic vesicles, it can be suggested that exocytosis of neurotransmitters may be impaired in LB diseases...
  59. ncbi Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway
    E Lopez
    Unitat de Neuropatologia, Department de Biologia Cel lular i Anatomia Patologica, Universitat de Barcelona, Campus de Bellvitge, 08907 Hospitalet de Llobregat, Llobregat, Spain
    Brain Res Mol Brain Res 85:61-7. 2000
    ..These findings indicate that the Fas/Fas-L-caspase-8 pathway of cell death signaling is not involved in staurosporine- and H-7-induced apoptosis in SH-SY5Y neuroblastoma cells...
  60. ncbi Expression of transcription factors CREB and c-Fos in the brains of terminal Creutzfeldt-Jakob disease cases
    A Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 421:10-5. 2007
    ..These observations point to exhausted CREB and c-Fos brain responses, in spite of preserved up-stream signaling kinases, thus favoring cell death in terminal stages of CJD...
  61. ncbi Cell death and decreased synaptic protein expression in the ventral horn of Holstein-Friesian calves with spinal muscular atrophy
    S Siso
    Priocat Laboratory, CReSA Centre de Recerca en Sanitat Animal, and Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    J Comp Pathol 128:132-9. 2003
    ..Taken together, the present findings point to necrosis as a major cause of motor neuron death in the advanced stages of SMA in Holstein-Friesian calves...
  62. ncbi Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice
    I Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Neurotox Res 6:469-75. 2004
    ..These findings support the amyloid cascade hypothesis of tau phosphorylation mediated by stress kinases in dystrophic neurites of senile plaques but not that of neurofibrillary tangles and neuropil threads in AD...
  63. ncbi Familial Alzheimer disease associated with A713T mutation in APP
    J Armstrong
    Institut de Neuropatologia, Servei d Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 370:241-3. 2004
    ..Since the immunohistochemical study indicates that A713T mutation is not likely to relate with Abeta-amyloid processing, the causative role of this rare mutation remains to be warranted...
  64. ncbi Neuronopathic juvenile glucosylceramidosis due to sap-C deficiency: clinical course, neuropathology and brain lipid composition in this Gaucher disease variant
    T Pampols
    Institut de Bioquimica Clinica, Corporacio Sanitaria, Barcelona, Spain
    Acta Neuropathol 97:91-7. 1999
    ..Studying the phenotypic consequences of mutant sphingolipid activator proteins is critical to a better understanding of the physiological significance of these proteins...
  65. ncbi Fra-1 immunoreactivity in the rat brain during normal postnatal development and after injury in adulthood
    E Pozas
    Servei d Anatomia Patològica, Hospital Princeps d Espanya, Universitat de Barcelona, Spain
    Neurosci Res 33:137-45. 1999
    ....
  66. doi Involvement of Dab1 in APP processing and beta-amyloid deposition in sporadic Creutzfeldt-Jakob patients
    R Gavin
    Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia and Department of Cell Biology, University of Barcelona, Baldiri Reixac 15 21, Barcelona, Spain
    Neurobiol Dis 37:324-9. 2010
    ..Thus, the present observations suggest a correlation between Dab1 phosphorylation, Abeta deposition and PrP(sc) type in sCJD...
  67. ncbi Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzfeldt-Jakob disease
    I Ferrer
    Unidad de Neuropatologia, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Campus de Bellvitge, 08907, Hospitalet de Llobregat, Spain
    Neuroscience 97:715-26. 2000
    ..Therefore, it remains to be elucidated how abnormal PrP impacts on the metabolism of proteins linked to exocytosis and neurotransmission, and how abnormal PrP deposition results in eventual synaptic loss...
  68. ncbi Oxidation, glycoxidation, lipoxidation, nitration, and responses to oxidative stress in the cerebral cortex in Creutzfeldt-Jakob disease
    M Freixes
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurobiol Aging 27:1807-15. 2006
    ..These results provide support for the concept that oxidative stress may have important implications in the pathogenesis of prion diseases...
  69. ncbi Clinicopathological and genetic correlates of frontotemporal lobar degeneration and corticobasal degeneration
    Albert Lladó
    Service of Neurology, Hospital Clínic and Institut d Investigació, Biomedica August Pi i Sunyer, Barcelona, Spain
    J Neurol 255:488-94. 2008
    ..To correlate clinical diagnosis and genetic features with different pathological substrates in patients with frontotemporal lobar degeneration (FTLD) and corticobasal degeneration (CBD)...
  70. ncbi Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy
    Isidro Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    J Alzheimers Dis 5:445-54. 2003
    ..Yet the P310L mutation has particular phospho-tau inclusions that are not tag with ubiquitin and appear to be rather soluble when compared with AD...
  71. ncbi Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies
    Marta Barrachina
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Spain
    Neurobiol Dis 22:265-73. 2006
    ..Together, these observations show reduced UCHL-1 expression as a contributory factor in the abnormal protein aggregation in DLB, and points UCHL-1 as a putative therapeutic target in the treatment of DLB...
  72. ncbi Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits
    Marco Pugliese
    Unitat de Bioquimica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Acta Neuropathol 112:175-83. 2006
    ....
  73. ncbi Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseases
    Montse Olive
    Institut de Neuropatologia, Ciutat Sanitaria i Universitaria de Bellvitge, C Feixa Llarga s n masculine, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 106:1-7. 2003
    ....
  74. doi Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology
    Beatrice Terni
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL, Hospital Universitari de Bellvitge, Universitat de Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain
    Brain Pathol 20:222-33. 2010
    ..This is the first study showing oxidative damage in the first stage, and clinically silent period, of AD-related pathology characterized by entorhinal and transentorhinal tauopathy...
  75. ncbi Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system
    Eulalia Marti
    Program in Genes and Disease, Centre de Regulacio Genomica CRG, Passeig Maritim 37 49, 08003, Barcelona, Spain
    Brain Res 964:250-63. 2003
    ....
  76. ncbi Desmin-related myopathy: clinical, electrophysiological, radiological, neuropathological and genetic studies
    Montse Olive
    Institut de Neuropatologia, Hospital de Bellvitge, C Feixa Llarga s n degrees, 08907 Hospitalet de Llobregat, Barcelona, Spain
    J Neurol Sci 219:125-37. 2004
    ..Analysis of 10 Spanish DRM cases illustrates a wide clinical, myopathological and genetic spectrum of DRM, reinforcing the need for further exploration of genetic causes for this group of disorders...
  77. ncbi Oxidative stress damage and oxidative stress responses in the choroid plexus in Alzheimer's disease
    Ester Perez-Gracia
    Servei Anatomia Patològica, Institut Neuropatologia, CIBERNED, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Universitat de Barcelona, carrer Feixa Llarga sn, Barcelona, Spain
    Acta Neuropathol 118:497-504. 2009
    ....
  78. pmc Transcription-terminating mutation in telethonin causing autosomal recessive muscular dystrophy type 2G in a European patient
    Montse Olive
    Institut de Neuropatologia, IDIBELL Hospital de Bellvitge, and Universitat Autonoma de Barcelona, Barcelona, Spain
    Neuromuscul Disord 18:929-33. 2008
    ..With this current identification of a case outside the Brazilian population, telethonin mutation-associated LGMD should be considered worldwide...
  79. ncbi Overexpression of semicarbazide-sensitive amine oxidase in human myopathies
    Montse Olive
    Institut de Neuropatologia, Hospital Universitari de Bellvitge, 08907 Hospitalet de Llobregat, Barcelona, Spain
    Muscle Nerve 29:261-6. 2004
    ..Alternatively, the expression of SSAO in muscle fibers may be a consequence of muscle fiber injury...
  80. ncbi Myotilinopathy: refining the clinical and myopathological phenotype
    Montse Olive
    Institut de Neuropatologia, IDIBELL Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
    Brain 128:2315-26. 2005
    ....
  81. ncbi Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies
    K Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Neuropathol Appl Neurobiol 30:601-7. 2004
    ..These results show differential overexpression of alpha-synuclein 112 in DLB, a finding that could be of importance in DLB pathogenesis...
  82. ncbi Neurons and their dendrites in frontotemporal dementia
    I Ferrer
    Unidad de Neuropatologia, Servicio de Anatomia Patologica, Hospital Príncipes de España Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Spain
    Dement Geriatr Cogn Disord 10:55-60. 1999
    ....
  83. ncbi Overexpression of semicarbazide sensitive amine oxidase in the cerebral blood vessels in patients with Alzheimer's disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    I Ferrer
    Institut de Neuropatologia, Hospital Princeps d Espanya, L Hospitalet de Llobregat 08907, Barcelona, Spain
    Neurosci Lett 321:21-4. 2002
    ..Therefore, it is suggested that increased SSAO expression is a source of oxidative stress in the blood vessel wall in AD and CADASIL...
  84. ncbi CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat
    J Krupinski
    Unitat de Neuropatologia, Departament de Biologia Cellular i Anatomia Patologica, Universitat de Barcelona, Barcelona, Spain
    Neuropharmacology 42:846-54. 2002
    ..The expression of caspase-cleaved products of PARP (PARP 89 kDa) was reduced in citicoline-treated ischaemic rats. These results show that citicoline inhibits the expression of proteins involved in apoptosis following MCAO...
  85. ncbi Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy
    G Santpere
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultat de Medicina, Universitat de Barcelona, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Llobregat, Spain
    Neuroscience 146:1640-51. 2007
    ..These findings demonstrate that 14-3-3 glyco- and lipoxidation occurs in AD and CAA, probably as a direct consequence of Abeta deposition...
  86. ncbi Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease
    Esther Dalfo
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain
    J Neuropathol Exp Neurol 64:638-47. 2005
    ..These results demontrate for the first time abnormal mGluR signaling in the cerebral cortex in PiD and selective vulnerability of phospholipases and PKC to PiD...
  87. ncbi Desmin is oxidized and nitrated in affected muscles in myotilinopathies and desminopathies
    Anna Janué
    Institut de Neuropatologia, Servei Anatomia Patològica, Institut d Investigacio de Bellvitge Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Plataforma de Proteómica, Barcelona Spain
    J Neuropathol Exp Neurol 66:711-23. 2007
    ..In addition to desmin, pyruvate kinase muscle splice form M1 is oxidized, thus supporting complemental mitochondrial damage, at least in some cases of myotilinopathy...
  88. ncbi A novel mutation in the caveolin-3 gene causing familial isolated hyperCKaemia
    Laura Alias
    Servei de Genètica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Neuromuscul Disord 14:321-4. 2004
    ..This is the second mutation in the CAV-3 gene associated with familial isolated hyperCKaemia...
  89. ncbi Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice
    E Dalfo
    Unitat de Neuropatologia Experimental, Departament de Biologia Cel lular i Anatomia Patològica, Universitat de Barcelona, Barcelona, Spain
    J Neuropathol Exp Neurol 63:302-13. 2004
    ..This rationale is consistent with previous data showing that short-term hippocampal synaptic plasticity is altered and that alpha-synuclein accumulates in the cytoplasm of neurons in Tg mice...
  90. doi Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia i Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Neuroscience 154:1388-97. 2008
    ..SIRT1 expression decreased dramatically in HD, but there were no significant changes in Parkinson-related illnesses. In conclusion, SIRT1 expression may be a good sensor of toxic neuronal processes...
  91. ncbi Brain-derived neurotrophic factor in patients with frontotemporal dementia
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
    Neurosci Lett 279:33-6. 2000
    ..These results show that FTD is not associated with a decay of BDNF in cortical neurons, and therefore, that BDNF is differentially regulated in diseases causing dementia...
  92. ncbi Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice
    Agustin Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    Acta Neuropathol 112:573-85. 2006
    ..These modifications may have implications in the regulation of water transport in astrocytes and may account for an imbalance in water and ion homeostasis in prion diseases...
  93. ncbi Adenosine A1 receptor protein levels and activity is increased in the cerebral cortex in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP mice
    Agustin Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
    J Neuropathol Exp Neurol 65:964-75. 2006
    ..These results show, for the first time, sensitization of A1Rs in prion diseases...
  94. doi Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease
    Katrin Beyer
    Department of Pathology, Hospital Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Neurogenetics 9:163-72. 2008
    ..In conclusion, isoform-expression profiles in LB diseases represent additional evidence for the direct involvement of isoform-expression deregulation in the development of neurodegenerative disorders...
  95. ncbi Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells
    Marta Barrachina
    Departament de Biologia Cellular i Anatomia Patologica, Universitat de Barcelona, Campus de Bellvitge, carrer Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Brain Res 957:84-90. 2002
    ..These findings demonstrate that citicoline affects the staurosporine-induced apoptosis cell-signalling pathway by interacting with the glutathione system and by inhibiting caspase-3 in SH-SY5Y human neuroblastoma cells...
  96. ncbi Amyloid-beta deposition in the cerebral cortex in Dementia with Lewy bodies is accompanied by a relative increase in AbetaPP mRNA isoforms containing the Kunitz protease inhibitor
    Marta Barrachina
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 L Hospitalet de Llobregat, Spain
    Neurochem Int 46:253-60. 2005
    ..No modifications in the ratio were found in PD, AD stage I-IIA and PSP. These findings suggest that alternative splicing of the AbetaPP mRNA may play a role in betaA4 amyloidogenesis in DLBp, DLBc, AD stage VC and Amyloid angiopathy...
  97. ncbi Downregulation of Bcl-2 proteins in type I spinal muscular atrophy motor neurons during fetal development
    Carolina Soler-Botija
    Servei de Genètica, Institut de Recerca, Hospital de Sant Pau, Barcelona, Spain
    J Neuropathol Exp Neurol 62:420-6. 2003
    ..The difference in the pattern and degree of expression is consistent with a role for both proteins in the aberrant programmed cell death observed in type I SMA...
  98. ncbi [Pathology of paraneoplastic syndromes of the central and peripheral nervous systems and muscle ]
    I Ferrer
    Servicio de Anatomia Patologica, Hospital Princeps d Espanya, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Banco de Tejidos Neurológicos, Barcelona, Espana
    Rev Neurol 31:1228-36. 2000
    ..In this paper we describe the main paraneoplastic neurological pictures and known antibodies, including the molecular aspects and the neoplasias most frequently related to them...
  99. pmc A novel mutation (V89L) in the presenilin 1 gene in a family with early onset Alzheimer's disease and marked behavioural disturbances
    R Queralt
    Genetics Service, Hospital Clinic, Universitat de Barcelona, Spain
    J Neurol Neurosurg Psychiatry 72:266-9. 2002
    ..The mutation is located on the same side of the helix as other described mutations in the first transmembrane domain and its relation to other mutations in this helix suggests that they share a common pathogenic mechanism...
  100. ncbi Role of caspases in ionizing radiation-induced apoptosis in the developing cerebellum
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, i Departament de Biologia Cel lular i Anatomia Patològica, Universitat de Barcelona Campus de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat
    J Neurobiol 41:549-58. 1999
    ..Taken together, these observations suggest that the caspases examined are not essential for radiation-induced apoptosis in the developing cerebellum...
  101. ncbi Abnormal synaptic protein expression in two Arabian horses with equine degenerative myeloencephalopathy
    S Siso
    Priocat Laboratory, Centre de Recerca en Sanitat Animal, Bellaterra Campus, Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet J 166:238-43. 2003
    ....