Amadeo R Fernandez Alba


Country: Spain


  1. Cutillas V, Murcia Morales M, Gómez Ramos M, Taha S, Fernandez Alba A. Supercritical fluid chromatography coupled to tandem mass spectrometry for the analysis of pesticide residues in dried spices. Benefits and drawbacks. Anal Chim Acta. 2019;1059:124-135 pubmed publisher
    ..A high number of these samples presented one or more pesticides (81%). Some of these detected pesticides are not approved in the European Union and, in many cases, the positive findings exposed concentrations that exceed the EU MRLs. ..
  2. Lozano A, Ferrer C, Fernandez Alba A. Selectivity enhancement using sequential mass isolation window acquisition with hybrid quadrupole time-of-flight mass spectrometry for pesticide residues. J Chromatogr A. 2019;1591:99-109 pubmed publisher
    ..Finally, to verify the efficiency of the optimum parameters proposed, two proficiency samples were analysed, obtaining good results. This proved the benefits in terms of identification and quantification purposes. ..
  3. Gomez Ramos M, Lozano A, Fernandez Alba A. High-resolution mass spectrometry with data independent acquisition for the comprehensive non-targeted analysis of migrating chemicals coming from multilayer plastic packaging materials used for fruit purée and juice. Talanta. 2019;191:180-192 pubmed publisher
    ..This study shows the high potential of non-targeted approaches using high resolution accurate mass spectrometry (HRAMS) with SWATH acquisition for the characterization of food packaging materials aimed at food safety evaluation. ..
  4. Hakme E, Lozano A, Uclés S, Gómez Ramos M, Fernandez Alba A. High-throughput gas chromatography-mass spectrometry analysis of pesticide residues in spices by using the enhanced matrix removal-lipid and the sample dilution approach. J Chromatogr A. 2018;1573:28-41 pubmed publisher
    ..To demonstrate the applicability of the proposed method, 50 real dried and non-dried spice samples were analyzed. The most detected pesticides were metalaxyl, chlorpyrifos, tebuconazole, ethion, and chinomethionate. ..
  5. Uclés S, Hakme E, Ferrer C, Fernandez Alba A. Analysis of thermally labile pesticides by on-column injection gas chromatography in fruit and vegetables. Anal Bioanal Chem. 2018;410:6861-6871 pubmed publisher
    ..010 mg/kg in fruit and vegetable samples. The OCI grants evident differentiation between metabolites naturally occurring in food and thermal degradation products created during the analysis. Graphical abstract ?. ..
  6. Gil Garcia M, Martinez Galera M, Uclés S, Lozano A, Fernandez Alba A. Ultrasound-assisted extraction based on QuEChERS of pesticide residues in honeybees and determination by LC-MS/MS and GC-MS/MS. Anal Bioanal Chem. 2018;410:5195-5210 pubmed publisher
    ..Permethrin, thiabendazole, carbendazim, and coumaphos were the most frequently detected pesticide residues in the selected samples. ..
  7. Vázquez P, Lozano A, Uclés S, Ramos M, Fernández Alba A. A sensitive and efficient method for routine pesticide multiresidue analysis in bee pollen samples using gas and liquid chromatography coupled to tandem mass spectrometry. J Chromatogr A. 2015;1426:161-73 pubmed publisher
    ..Pesticides considered potentially toxic to bees (DL50<2μg/bee) were detected in some samples with concentrations up to 72.7μgkg(-1), which could negatively affect honeybee health. ..
  8. Uclés A, Herrera López S, Dolores Hernando M, Rosal R, Ferrer C, Fernández Alba A. Application of zirconium dioxide nanoparticle sorbent for the clean-up step in post-harvest pesticide residue analysis. Talanta. 2015;144:51-61 pubmed publisher
    ..The most frequently-detected pesticide residues were: carbendazim, thiabendazole and imazalil-all were below the MRL. The highest concentration found was imazalil at 1175 µg kg(-1) in a pear sample. ..
  9. Martínez Bueno M, Díaz Galiano F, Rajski Ł, Cutillas V, Fernandez Alba A. A non-targeted metabolomic approach to identify food markers to support discrimination between organic and conventional tomato crops. J Chromatogr A. 2018;1546:66-76 pubmed publisher

More Information


  1. Cutillas V, Galera M, Rajski Ł, Fernandez Alba A. Evaluation of supercritical fluid chromatography coupled to tandem mass spectrometry for pesticide residues in food. J Chromatogr A. 2018;1545:67-74 pubmed publisher
    ..Carbon dioxide as mobile phase with methanol as modifier can represent a good alternative to LC-MS/MS with reduction of matrix effects and shorter run times. ..
  2. Reichert B, Pizzutti I, Costabeber I, Uclés A, Herrera S, Fernández Alba A. Validation and application of micro flow liquid chromatography-tandem mass spectrometry for the determination of pesticide residues in fruit jams. Talanta. 2015;134:415-24 pubmed publisher
  3. Uclés S, Ucles A, Lozano A, Martínez Bueno M, Fernandez Alba A. Shifting the paradigm in gas chromatography mass spectrometry pesticide analysis using high resolution accurate mass spectrometry. J Chromatogr A. 2017;1501:107-116 pubmed publisher
    ..The performance of the GC-EI-full scan Orbitrap HRAMS developed method was confirmed with the analysis of 102 real samples providing good results. ..
  4. Rajski Å, Del Mar Gómez Ramos M, Fernández Alba A. Evaluation of MS2 workflows in LC-Q-Orbitrap for pesticide multi-residue methods in fruits and vegetables. Anal Bioanal Chem. 2017;409:5389-5400 pubmed publisher
    ..Graphical abstract LC-Q-Orbitrap was used for pesticide residues analysis in fruit and vegetables. Three approaches to MS2 identificaton were evaluated. ..
  5. Garcia M, Duque S, Fernández A, Sosa A, Fernandez Alba A. Multiresidue method for trace pesticide analysis in honeybee wax comb by GC-QqQ-MS. Talanta. 2017;163:54-64 pubmed publisher
  6. Parrilla Vázquez P, Hakme E, Uclés S, Cutillas V, Martinez Galera M, Mughari A, et al. Large multiresidue analysis of pesticides in edible vegetable oils by using efficient solid-phase extraction sorbents based on quick, easy, cheap, effective, rugged and safe methodology followed by gas chromatography-tandem mass spectrometry. J Chromatogr A. 2016;1463:20-31 pubmed publisher
    ..The modified methodology was applied for the analysis of different 17 oil samples. Fourteen pesticides were detected with values lower than MRLs and their concentration ranged between 10.2 and 156.0?gkg(-1). ..
  7. Herrera López S, Lozano A, Sosa A, Hernando M, Fernandez Alba A. Screening of pesticide residues in honeybee wax comb by LC-ESI-MS/MS. A pilot study. Chemosphere. 2016;163:44-53 pubmed publisher
    ..The number of positive detections due to herbicides was lower as expected and at a lower level of concentration, from 1 to 5.9 μg kg(-1). ..
  8. Dias J, Cutillas V, Lozano A, Pizzutti I, Fernandez Alba A. Determination of pesticides in edible oils by liquid chromatography-tandem mass spectrometry employing new generation materials for dispersive solid phase extraction clean-up. J Chromatogr A. 2016;1462:8-18 pubmed publisher
    ..In order to evaluate the performance of the method, this same procedure was employed to other oils such as soya and sunflower with very good results. ..
  9. Moreno González D, Pérez Ortega P, Gilbert López B, Molina Diaz A, Garcia Reyes J, Fernandez Alba A. Evaluation of nanoflow liquid chromatography high resolution mass spectrometry for pesticide residue analysis in food. J Chromatogr A. 2017;1512:78-87 pubmed publisher
  10. Uclés S, Lozano A, Sosa A, Parrilla Vázquez P, Valverde A, Fernández Alba A. Matrix interference evaluation employing GC and LC coupled to triple quadrupole tandem mass spectrometry. Talanta. 2017;174:72-81 pubmed publisher
    ..In a third study, the "matrix effect" was evaluated for each commodity/extraction method. Results showed 44% of cases with suppression/enhancement for LC and 93% of cases with enhancement for GC. ..
  11. Hakme E, Lozano A, Uclés S, Fernandez Alba A. Further improvements in pesticide residue analysis in food by applying gas chromatography triple quadrupole mass spectrometry (GC-QqQ-MS/MS) technologies. Anal Bioanal Chem. 2018;410:5491-5506 pubmed publisher
    ..It is also very useful for risk assessment studies, where the needs of low reporting limits and very wide analytical scope are necessary. ..
  12. Hakme E, Lozano A, Gómez Ramos M, Hernando M, Fernandez Alba A. Non-target evaluation of contaminants in honey bees and pollen samples by gas chromatography time-of-flight mass spectrometry. Chemosphere. 2017;184:1310-1319 pubmed publisher
    ..The proposed method presents important advantages as it can avoid the use of an unachievable number of analytical standards considered target compounds "a priori" but not present in the analyzed samples. ..