Ramon Estruch

Summary

Country: Spain

Publications

  1. ncbi request reprint Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
    Ramon Estruch
    Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
    Ann Intern Med 145:1-11. 2006
  2. doi request reprint Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study
    Ramon Estruch
    Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Proc Nutr Soc 69:333-40. 2010
  3. doi request reprint "Towards an even healthier Mediterranean diet"
    R Estruch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigació, August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain CIBER OBN, Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Government of Spain, Santiago de Compostela, Spain Electronic address
    Nutr Metab Cardiovasc Dis 23:1163-6. 2013
  4. pmc Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk
    Martí Juanola-Falgarona
    Universitat Rovira i Virgili, C Sant Llorenç 21, Reus, Spain
    Cardiovasc Diabetol 12:7. 2013
  5. pmc Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
    Carolina Ortega-Azorín
    Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain
    Cardiovasc Diabetol 11:137. 2012
  6. pmc Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial
    Marta Guasch-Ferré
    Human Nutrition Unit, Hospital Universitari de Sant Joan de Reus, Faculty of Medicine and Health Sciences, IISPV Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain
    BMC Med 11:164. 2013
  7. ncbi request reprint Primary prevention of cardiovascular disease with a Mediterranean diet
    Ramon Estruch
    Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
    N Engl J Med 368:1279-90. 2013
  8. doi request reprint Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
    R Estruch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain
    J Epidemiol Community Health 63:582-8. 2009
  9. doi request reprint Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trial
    R Estruch
    Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Nutr Metab Cardiovasc Dis 21:46-53. 2011
  10. doi request reprint Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial
    Gemma Chiva-Blanch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Nutr 32:200-6. 2013

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
    Ramon Estruch
    Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
    Ann Intern Med 145:1-11. 2006
    ..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...
  2. doi request reprint Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study
    Ramon Estruch
    Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Proc Nutr Soc 69:333-40. 2010
    ..These results support the recommendation of the Med-Diet as a useful tool against CVD...
  3. doi request reprint "Towards an even healthier Mediterranean diet"
    R Estruch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigació, August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain CIBER OBN, Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Government of Spain, Santiago de Compostela, Spain Electronic address
    Nutr Metab Cardiovasc Dis 23:1163-6. 2013
    ....
  4. pmc Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk
    Martí Juanola-Falgarona
    Universitat Rovira i Virgili, C Sant Llorenç 21, Reus, Spain
    Cardiovasc Diabetol 12:7. 2013
    ..The purpose of the study was to assess the associations between dietary intake of vitamin K and peripheral adipokines and other metabolic risk markers related to insulin resistance and type 2 diabetes mellitus...
  5. pmc Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
    Carolina Ortega-Azorín
    Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain
    Cardiovasc Diabetol 11:137. 2012
    ..However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet)...
  6. pmc Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial
    Marta Guasch-Ferré
    Human Nutrition Unit, Hospital Universitari de Sant Joan de Reus, Faculty of Medicine and Health Sciences, IISPV Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain
    BMC Med 11:164. 2013
    ..To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person...
  7. ncbi request reprint Primary prevention of cardiovascular disease with a Mediterranean diet
    Ramon Estruch
    Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
    N Engl J Med 368:1279-90. 2013
    ..We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events...
  8. doi request reprint Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
    R Estruch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain
    J Epidemiol Community Health 63:582-8. 2009
    ..Thus, the effects of changes in dietary fibre intake on cardiovascular risk factors were assessed over 3 months in free-living high-risk subjects...
  9. doi request reprint Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trial
    R Estruch
    Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Nutr Metab Cardiovasc Dis 21:46-53. 2011
    ....
  10. doi request reprint Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial
    Gemma Chiva-Blanch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Nutr 32:200-6. 2013
    ..The aim of the present study was to compare the effects of moderate consumption of red wine, dealcoholized red wine, and gin on glucose metabolism and the lipid profile...
  11. ncbi request reprint Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial
    Emilio Sacanella
    Department of Internal Medicine, Hospital Clinic, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Am J Clin Nutr 86:1463-9. 2007
    ..The mechanism for this beneficial effect might be reduced inflammatory responses, as suggested by prospective studies and small clinical trials in men. No studies have evaluated the antiinflammatory effects of wine in women...
  12. doi request reprint High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients
    Raul Zamora-Ros
    Nutrition and Food Science Department, XaRTA INSA, Pharmacy School, University of Barcelona, Spain
    Pharmacol Res 65:615-20. 2012
    ....
  13. ncbi request reprint Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease
    Maria Monagas
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Clin Nutr 90:1144-50. 2009
    ..Because atherosclerosis is considered a low-grade inflammatory disease, some feeding trials have analyzed the effects of cocoa (an important source of flavonoids) on inflammatory biomarkers, but the results have been controversial...
  14. ncbi request reprint Myocardial antioxidant status in chronic alcoholism
    Francesc Fatjó
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Alcohol Clin Exp Res 29:864-70. 2005
    ..The pathogenesis is multifactorial, with the antioxidant imbalance of cardiac muscle being a potential factor. The current study evaluates myocardial antioxidant status in ethanol consumers and its relation to cardiac damage...
  15. doi request reprint Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet
    Mari Pau Mena
    Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Instituto de Salud Carlos III, Spain
    Am J Clin Nutr 89:248-56. 2009
    ..Adherence to the Mediterranean diet (Med-Diet) is associated with a reduced risk of cardiovascular disease (CVD). However, the molecular mechanisms involved are not fully understood...
  16. doi request reprint Hypertensive status and lipoprotein oxidation in an elderly population at high cardiovascular risk
    Monica Guxens
    Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Am J Hypertens 22:68-73. 2009
    ..Our aim was to assess the relationship between the degree of in vivo low-density lipoprotein (oxLDL) oxidation and the hypertensive status in a elderly population at high cardiovascular risk...
  17. ncbi request reprint Decreased tumor necrosis factor-induced adhesion of human monocytes to endothelial cells after moderate alcohol consumption
    Eva Badia
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, Spain
    Am J Clin Nutr 80:225-30. 2004
    ..Moderate alcohol consumption protects against ischemic heart disease, possibly through an antiinflammatory effect. However, little is known about the mechanisms by which alcohol may interfere in the development of atherosclerosis...
  18. doi request reprint The Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease
    Mireia Urpi-Sarda
    Department of Internal Medicine, University of Barcelona, Barcelona, Spain
    J Nutr 142:1019-25. 2012
    ..01). This study suggests that a MD reduces TNFR concentrations in patients at high cardiovascular risk...
  19. ncbi request reprint Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption
    Raul Zamora-Ros
    Nutrition and Food Science Department CeRTA, Pharmacy School, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Clin Chem 52:1373-80. 2006
    ..We evaluated resveratrol metabolites, potential biomarkers of wine consumption, in humans after moderate consumption of sparkling, white, or red wines...
  20. ncbi request reprint Alcohol consumption is associated with high concentrations of urinary hydroxytyrosol
    Helmut Schroder
    CIBER Fisiopatología Obesidad y Nutrición and Biochemistry and Molecular Biology, Instituto de Salud Carlos III, Santiago de Compostela, Spain
    Am J Clin Nutr 90:1329-35. 2009
    ..We hypothesized that the alcohol present in wine could promote endogenous hydroxytyrosol generation...
  21. doi request reprint Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosis
    Mireia Urpi-Sarda
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, University of Barcelona, C Villarroel, 170, 08036 Barcelona, Spain
    Pharmacol Res 65:577-83. 2012
    ..02). In conclusion, Med-Diet exerts an anti-inflammatory effect on cardiovascular system since it down-regulates cellular and circulating inflammatory biomarkers related to atherogenesis in subjects at high cardiovascular risk...
  22. ncbi request reprint Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: short communication
    Gemma Chiva-Blanch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Circ Res 111:1065-8. 2012
    ..Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear...
  23. ncbi request reprint Urinary isoxanthohumol is a specific and accurate biomarker of beer consumption
    Paola Quifer-Rada
    Department of Nutrition and Food Science XARTA INSA, School of Pharmacy, University of Barcelona, Barcelona, Spain
    J Nutr 144:484-8. 2014
    ..IX in urine samples was found to be a specific and accurate biomarker of beer consumption and may be a powerful tool in epidemiologic studies...
  24. ncbi request reprint Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects at high cardiovascular risk
    Nágila R T Damasceno
    Lipid Clinic, Endocrinology and Nutrition Service, Biomedical Research Institute August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
    Atherosclerosis 230:347-53. 2013
    ..We investigated changes in adiposity and lipoprotein subfractions after consumption of the PREDIMED diets...
  25. doi request reprint Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: evidences from human studies
    Gemma Chiva-Blanch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, 08036 Barcelona, Spain
    Alcohol Alcohol 48:270-7. 2013
    ..The aim of this review was to focus on the knowledge of the cardiovascular benefits of moderate alcohol consumption, as well as to analyze the effects of the different types of alcoholic beverages...
  26. doi request reprint Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study
    Raul Zamora-Ros
    Nutrition and Food Science Department XaRTA, INSA, Pharmacy School, University of Barcelona, 08028 Barcelona, Spain
    Free Radic Biol Med 46:1562-6. 2009
    ..This biomarker would provide an additional tool for investigating more precisely the relationship between wine consumption and health benefits...
  27. ncbi request reprint Evidence of apoptosis in chronic alcoholic skeletal myopathy
    Joaquim Fernández-Solà
    Department of Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Hum Pathol 34:1247-52. 2003
    ..However, the specific pathogenic mechanism of apoptosis in chronic skeletal myopathy in alcoholics remains to be elucidated...
  28. ncbi request reprint Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk
    Mónica Vázquez-Agell
    Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona 08036, Spain
    J Nutr 137:2279-84. 2007
    ..05). In conclusion, both cava and gin showed antiinflammatory properties; however, cava had a greater protective effect, probably due its polyphenol content...
  29. doi request reprint The effects of milk as a food matrix for polyphenols on the excretion profile of cocoa (-)-epicatechin metabolites in healthy human subjects
    Elena Roura
    Department of Nutrition and Food Science CeRTA, University of Barcelona, Av Joan XXIII s n, Barcelona 08028, Spain
    Br J Nutr 100:846-51. 2008
    ..Thus, more studies are needed to evaluate the effect of these different metabolite profiles on the body...
  30. doi request reprint The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial
    Maria Teresa Mitjavila
    Department of Physiology, INSA, University of Barcelona, Spain
    Clin Nutr 32:172-8. 2013
    ..However, the effect of the MedDiet on biomarkers for oxidative damage has not been assessed in MetS individuals. We have investigated the effect of the MedDiet on systemic oxidative biomarkers in MetS individuals...
  31. doi request reprint Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography-tandem mass spectrometry
    Mireia Urpi-Sarda
    Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, 08028 Barcelona, Spain
    J Chromatogr A 1216:7258-67. 2009
    ..The results found herein indicate that 5-(3',4'-dihydroxyphenyl)-gamma-valerolactone and hydroxyphenylacetic acids could be good biomarkers of the regular consumption of cocoa and therefore, of flavanol-rich foods...
  32. doi request reprint Cardioprotective effects of cocoa: clinical evidence from randomized clinical intervention trials in humans
    Sara Arranz
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Mol Nutr Food Res 57:936-47. 2013
    ..However, larger randomized trials are required to definitively establish the impact of cocoa and cocoa products consumption on hard cardiovascular outcomes...
  33. pmc A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial
    Miguel Angel Martinez-Gonzalez
    Prevención con Dieta Mediterránea Network RD 06 0045, Instituto de Salud Carlos III, Spanish Government, Madrid, Spain
    PLoS ONE 7:e43134. 2012
    ..We examined these associations using a 14-item tool of adherence to the Mediterranean diet as exposure and body mass index, waist circumference and waist-to-height ratio (WHtR) as outcomes...
  34. doi request reprint Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk
    Vicenta Llorente-Cortes
    Cardiovascular Research Center, CSIC ICCC, Hospital Sant Pau, Barcelona, Spain
    Atherosclerosis 208:442-50. 2010
    ..Dietary intervention can thus actively modulate the expression of pro-atherothrombotic genes even in a high-risk population...
  35. pmc Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer
    Sara Arranz
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, Barcelona, 08036, Spain
    Nutrients 4:759-81. 2012
    ..This review summarizes the main protective effects on the cardiovascular system and cancer resulting from moderate wine and beer intake due mainly to their common components, alcohol and polyphenols...
  36. doi request reprint (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
    Rosa Vázquez-Fresno
    Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, Barcelona, Spain
    Electrophoresis 33:2345-54. 2012
    ..The results show the capacity of this approach to obtain a comprehensive metabolome picture including food metabolome and endogenous biomarkers of moderate wine intake...
  37. doi request reprint Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk
    Cinta Valls-Pedret
    Lipid Clinic, Endocrinology and Nutrition Service, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    J Alzheimers Dis 29:773-82. 2012
    ..The results reinforce the notion that Mediterranean diet components might counteract age-related cognitive decline...
  38. ncbi request reprint Microbial metabolomic fingerprinting in urine after regular dealcoholized red wine consumption in humans
    María Boto-Ordóñez
    Biomarkers and Nutritional and Food Metabolomics Research Group, Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, Avenida Joan XXIII s n, 08028 Barcelona, Spain
    J Agric Food Chem 61:9166-75. 2013
    ..These findings provide the most complete metabolic fingerprinting after wine consumption, amplifying the spectrum of microbial derived metabolites and their potential bioactivity related with health benefits. ..
  39. doi request reprint Changes in ultrasound-assessed carotid intima-media thickness and plaque with a Mediterranean diet: a substudy of the PREDIMED trial
    Aleix Sala-Vila
    From the Lipid Clinic, Endocrinology and Nutrition Service, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain A S V, E R Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Instituto de Salud Carlos III ISCIII, Madrid, Spain A S V, E S R M, I N, R d l T, D C, V R G, M C L S, X P, J R, M Á M G, R E, E R Department of Internal Medicine, IDIBAPS, Hospital Clinic, Barcelona, Spain E S R M, R E Diagnostic Imaging Centre, IDIBAPS, Hospital Clinic, Barcelona, Spain R G, I N Human Pharmacology and Clinical Neurosciences Research Group, Institut de Investigacions Mèdiques Hospital del Mar, Barcelona, Spain R d l T Department of Preventive Medicine, University of Valencia, Valencia, Spain D C Instituto de la Grasa
    Arterioscler Thromb Vasc Biol 34:439-45. 2014
    ..We assessed the effect of both supplemented MedDiets on internal carotid intima-media thickness (ICA-IMT) and plaque height, the ultrasound features that best predict future cardiovascular events, in subjects at high cardiovascular risk...
  40. doi request reprint Gut and microbial resveratrol metabolite profiling after moderate long-term consumption of red wine versus dealcoholized red wine in humans by an optimized ultra-high-pressure liquid chromatography tandem mass spectrometry method
    Maria Rotchés-Ribalta
    Nutrition and Food Science Department, XaRTA INSA, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, S N, 08028 Barcelona, Spain
    J Chromatogr A 1265:105-13. 2012
    ..In this sense, having a more precise concentration value of all the resveratrol metabolites in target tissues would finally lead to a better interpretation of the obtained results...
  41. ncbi request reprint Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers
    Ramon Estruch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Atherosclerosis 175:117-23. 2004
    ..We embarked on a randomized, crossover, single-blinded trial to evaluate the effects of wine and gin on inflammatory biomarkers of atherosclerosis...
  42. doi request reprint Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial
    Gemma Chiva-Blanch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, Barcelona, Spain
    Am J Clin Nutr 95:326-34. 2012
    ..Few clinical studies have focused on the alcohol-independent cardiovascular effects of the phenolic compounds of red wine (RW)...
  43. ncbi request reprint Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression
    Meritxell Lluis
    Alcohol Research Unit, Department of Internal Medicine, Institut d Investigació August Pi i Sunyer, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Alcohol Alcohol 46:534-41. 2011
    ..We evaluated myocyte proliferation response in the heart of chronic alcoholic donors with telomerase activity (telomerase reverse transcriptase (TERT)) compared with Ki-67 nuclear expression...
  44. pmc The effects of the mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial
    Rosa Casas
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain CIBER 06 03 Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 9:e100084. 2014
    ..Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known...
  45. ncbi request reprint The effect of polyphenol consumption on blood pressure
    Alexander Medina-Remón
    Nutrition and Food Science Department, XaRTA, INSA Pharmacy School, University of Barcelona, Spain
    Mini Rev Med Chem 13:1137-49. 2013
    ....
  46. doi request reprint Light gazpachos contain higher phytochemical levels than conventional gazpachos
    Anna Vallverdú-Queralt
    Nutrition and Food Science Department, University of Barcelona, Barcelona, Spain
    Food Sci Technol Int 19:377-85. 2013
    ..Higher consumption levels of phenolic compounds, which are greater in light products, along with caloric restriction and physical activity may be helpful in preventing obesity. ..
  47. doi request reprint Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells
    Maria Monagas
    Department of Internal Medicine, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Hospital Clinic, Universitat de Barcelona, 08036 Barcelona, Spain
    Br J Nutr 102:201-6. 2009
    ....
  48. ncbi request reprint Milk does not affect the bioavailability of cocoa powder flavonoid in healthy human
    Elena Roura
    Department of Nutrition and Food Science CeRTA, University of Barcelona, Barcelona, Spain
    Ann Nutr Metab 51:493-8. 2007
    ..The food matrix is one the factors than can affect their bioavailability, but previous studies have concluded rather contradictory results about the effect of milk on the bioavailability of polyphenols...
  49. doi request reprint Serum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet
    Veronica Escurriol
    Lipid Clinic, Endocrinology and Nutrition Service, Institut d Investigacions Biomèdiques Ausgust Pi Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Eur J Nutr 48:373-82. 2009
    ..Phytosterols in natural foods are thought to inhibit cholesterol absorption. The Mediterranean diet is rich in phytosterol-containing plant foods...
  50. ncbi request reprint Novel Multimetabolite Prediction of Walnut Consumption by a Urinary Biomarker Model in a Free-Living Population: the PREDIMED Study
    Mar Garcia-Aloy
    Biomarkers and Nutrimetabolomic Lab, Nutrition and Food Science Department, XaRTA, INSA, Campus Torribera, Pharmacy Faculty, University of Barcelona, Barcelona 08028, Spain
    J Proteome Res 13:3476-83. 2014
    ....
  51. doi request reprint Determination of resveratrol and piceid in beer matrices by solid-phase extraction and liquid chromatography-tandem mass spectrometry
    Gemma Chiva-Blanch
    Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    J Chromatogr A 1218:698-705. 2011
    ..Overall, beer is one of the products with the lowest levels of total resveratrol (μg/L), and despite its high consumption it should not be considered as a representative source of resveratrol...
  52. doi request reprint Effect of milk on the urinary excretion of microbial phenolic acids after cocoa powder consumption in humans
    Mireia Urpi-Sarda
    Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, Barcelona, Spain
    J Agric Food Chem 58:4706-11. 2010
    ..In conclusion, milk partially affects the formation of microbial phenolic acids derived from the colonic degradation of procyanidins and other compounds present in cocoa powder...
  53. ncbi request reprint Evidence of apoptosis in alcoholic cardiomyopathy
    Joaquim Fernández-Solà
    Department of Internal Medicine, Hospital Clinic, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain
    Hum Pathol 37:1100-10. 2006
    ..Proapoptotic mechanisms are activated in alcoholic patients without heart damage...
  54. doi request reprint Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD
    Aleix Sala-Vila
    Lipid Clinic, Endocrinology and Nutrition Service, Institut d Investigacions Biomèdiques August Pi Sunyer, Unitat de Lípids, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Br J Nutr 106:425-31. 2011
    ..Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors...
  55. doi request reprint Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets
    Maria Rotchés-Ribalta
    Nutrition and Food Science Department, XaRTA INSA, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, S N, Barcelona, Spain
    Pharmacol Res 66:375-82. 2012
    ..1-3.6-fold higher urinary concentrations of microbial metabolites were observed after GE intervention at 12-24h urinary fraction. Therefore, supplement intake could be also a way to bring resveratrol benefits to human health...
  56. ncbi request reprint Total polyphenol intake estimated by a modified Folin-Ciocalteu assay of urine
    Elena Roura
    Department of Nutrition, Institut d Investigacio Biomedica August Pi i Sunyer, IDIBAPS, University of Barcelona, Barcelona, Spain
    Clin Chem 52:749-52. 2006
    ..Measurement of polyphenol content excreted in urine as an indicator of polyphenol consumption may offer a routine screening method that could be used for these pathologies...
  57. doi request reprint Rapid Folin-Ciocalteu method using microtiter 96-well plate cartridges for solid phase extraction to assess urinary total phenolic compounds, as a biomarker of total polyphenols intake
    Alexander Medina-Remón
    Nutrition and Food Science Department, XaRTA, INSA Pharmacy School, University of Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Anal Chim Acta 634:54-60. 2009
    ..The method is fast and simple and it allows analysis of a large number of samples at the same time...
  58. ncbi request reprint Socioeconomic status and health inequalities for cardiovascular prevention among elderly Spaniards
    Cília Mejía-Lancheros
    Departamento de Pediatria, Obstetricia, Ginecología y Medicina Preventiva, Universitat Autonoma de Barcelona, Barcelona, Spain
    Rev Esp Cardiol (Engl Ed) 66:803-11. 2013
    ....
  59. ncbi request reprint Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
    Anna Tresserra-Rimbau
    Nutrition and Food Science Department, XaRTA, INSA, Pharmacy School, University of Barcelona, Barcelona, Spain
    BMC Med 12:77. 2014
    ..Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk...
  60. pmc Mediterranean dietary pattern and depression: the PREDIMED randomized trial
    Almudena Sanchez-Villegas
    Biomedical Research Center Network on Obesity and Nutrition CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain
    BMC Med 11:208. 2013
    ..The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention...
  61. doi request reprint Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy
    Joaquim Fernández-Solà
    Alcohol Research Unit, Hospital Clinic, Institut d Investigació August Pi i Sunyer, Department of Medicine, University of Barcelona, Barcelona, Spain
    Alcohol Clin Exp Res 35:1220-9. 2011
    ..Myostatin is upregulated after cardiac damage and by alcohol consumption thereby decreasing myocyte renewal. We assess the potential role of alcohol in inducing myocyte apoptosis as well as in inhibiting myocyte proliferation...
  62. ncbi request reprint Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial
    Montserrat Fito
    Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica, IMIM Hospital del Mar, Barcelona, Spain
    Arch Intern Med 167:1195-203. 2007
    ..Despite the richness in antioxidants of the Mediterranean diet, to our knowledge, no randomized controlled trials have assessed its effect on in vivo lipoprotein oxidation...
  63. doi request reprint Cross-sectional associations between macronutrient intake and chronic kidney disease in a population at high cardiovascular risk
    Andrés Díaz-López
    Human Nutrition Unit, IISPV, Universitat Rovira i Virgili, Reus, Spain
    Clin Nutr 32:606-12. 2013
    ..The aim was to examine the associations between macronutrient intake and the prevalence of chronic kidney disease (CKD) or microalbuminuria (MiA) in individuals at high cardiovascular risk...
  64. doi request reprint Polyphenols excreted in urine as biomarkers of total polyphenol intake
    Alexander Medina-Remón
    Nutrition and Food Science Department, XaRTA, Instituto de Investigaciónen Nutrición y Seguridad Alimentaria, Pharmacy School, University of Barcelona, Barcelona, Spain
    Bioanalysis 4:2705-13. 2012
    ..A precise estimation of polyphenol consumption requires blood or urine sample biomarkers, although their association is usually highly complex...
  65. ncbi request reprint Effects of alcohol withdrawal on 24 hour ambulatory blood pressure among alcohol-dependent patients
    Ramon Estruch
    Alcohol Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut de Investigacions Biomediques August Pi i Sunyer, Spain
    Alcohol Clin Exp Res 27:2002-8. 2003
    ..We embarked on a study to determine whether different subgroups of alcohol-dependent patients may be identified in relation to the effect of alcohol on BP...
  66. doi request reprint The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: a randomized clinical trial
    Gemma Chiva-Blanch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain CIBER CB06 03 Fisiopatología de la Obesidad y la Nutrición, CIBERobn and RETIC RD06 0045, Spain
    Atherosclerosis 233:518-24. 2014
    ..Nevertheless, no study has been carried out on the effects of moderate beer consumption on the number of circulating EPC in high cardiovascular risk patients...
  67. pmc Effects of 1-year intervention with a mediterranean diet on plasma Fatty acid composition and metabolic syndrome in a population at high cardiovascular risk
    Jordi Mayneris-Perxachs
    Department of Nutrition and Food Science XARTA INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    PLoS ONE 9:e85202. 2014
    ..The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention...
  68. ncbi request reprint Up-regulation of myocardial L-type Ca2+ channel in chronic alcoholic subjects without cardiomyopathy
    Francesc Fatjó
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Alcohol Clin Exp Res 31:1099-105. 2007
    ..This study was designed to evaluate the density and function of myocardial L-type Ca(2+) channel receptors in organ donors with chronic alcoholism and controls...
  69. ncbi request reprint Human urine: epicatechin metabolites and antioxidant activity after cocoa beverage intake
    Elena Roura
    Department of Nutrition and Food Science, University of Barcelona, Barcelona, Spain
    Free Radic Res 41:943-9. 2007
    ..Significance of TAC increase was found in urine samples excreted during 0-6 and 6-12 h (66.6 and 72.67%, respectively, with respect to the 0 h)...
  70. doi request reprint Analytical condition setting a crucial step in the quantification of unstable polyphenols in acidic conditions: analyzing prenylflavanoids in biological samples by liquid chromatography-electrospray ionization triple quadruple mass spectrometry
    Paola Quifer-Rada
    Department of Nutrition and Food Science XARTA INSA, School of Pharmacy, University of Barcelona, Barcelona, Spain
    Anal Chem 85:5547-54. 2013
    ..The method was applied to quantify 10 human samples of urine and was able to quantify prenylflavanoids in urine after the consumption of a single dose of beer (330 mL)...
  71. ncbi request reprint Influence of nutritional status on alcoholic myopathy
    José M Nicolás
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Am J Clin Nutr 78:326-33. 2003
    ..Muscle weakness and structural changes in striated skeletal muscle are common in persons with chronic alcoholism...
  72. pmc Cross-sectional assessment of nut consumption and obesity, metabolic syndrome and other cardiometabolic risk factors: the PREDIMED study
    Núria Ibarrola-Jurado
    Human Nutrition Unit, Hospital Universitari de Sant Joan de Reus, Institut d Investigació Sanitària Pere Virgili IISPV, Universitat Rovira i Virgili, Reus, Spain
    PLoS ONE 8:e57367. 2013
    ..Limited data are available on the epidemiological associations between nut intake and cardiometabolic risk factors...
  73. doi request reprint Validation of a new LC-MS/MS method for the detection and quantification of phenolic metabolites from tomato sauce in biological samples
    Miriam Martínez-Huelamo
    Department of Nutrition and Food Science XARTA INSA, School of Pharmacy, University of Barcelona, Barcelona, Spain
    J Agric Food Chem 60:4542-9. 2012
    ..The method allowed detection and quantification limits of 0.5-29 and 2.0-90 ng mL⁻¹ in urine, respectively, and 0.5-30 and 2.0-105 ng mL⁻¹ in plasma, respectively, for the same phenolic compounds...
  74. ncbi request reprint Molecular and cellular events in alcohol-induced muscle disease
    Joaquim Fernández-Solà
    Alcohol Unit, Hospital Clinic, University of Barcelona, Spain
    Alcohol Clin Exp Res 31:1953-62. 2007
    ..Finally, ethanol induces skeletal muscle apoptosis and increases both pro- and antiapoptotic regulatory mechanisms...
  75. ncbi request reprint HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans
    Mireia Urpi-Sarda
    Nutrition and Food Science Department, CeRTA, Pharmacy School, University of Barcelona, Barcelona, Spain
    Clin Chem 53:292-9. 2007
    ..We sought to develop a method for nutritional analysis of resveratrol, a phenolic compound with purported health-promoting properties, and to determine all resveratrol metabolites...
  76. doi request reprint Attenuated total reflection infrared microspectroscopy combined with multivariate analysis: a novel tool to study the presence of cocoa polyphenol metabolites in urine samples
    Claudia Sánchez-González
    Department of Nutrition and Food Science XARTA INSA, University of Barcelona, Barcelona, Spain
    Analyst 137:3565-70. 2012
    ..Moreover, it could be a valuable tool in studies aimed to identify biomarkers of consumption of polyphenol-rich diets...
  77. ncbi request reprint High blood pressure, alcohol and cardiovascular risk
    Ramon Estruch
    Department of Medicine, Hospital Clinic, Institut d Investgació Biomèdica August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    J Hypertens 23:226-9. 2005
  78. doi request reprint Bioactive compounds present in the Mediterranean sofrito
    Anna Vallverdú-Queralt
    Nutrition and Food Science Department, XaRTA, INSA Pharmacy University of Barcelona, Spain
    Food Chem 141:3365-72. 2013
    ..The quantification levels of phenolic and carotenoid compounds led to the distinction of features among different Mediterranean sofritos according to the type of vegetables (garlic and onions) or olive oil added for their production...
  79. ncbi request reprint Rapid liquid chromatography tandem mass spectrometry assay to quantify plasma (-)-epicatechin metabolites after ingestion of a standard portion of cocoa beverage in humans
    Elena Roura
    Department of Nutrition and Food Science CeRTA, University of Barcelona, Spain
    J Agric Food Chem 53:6190-4. 2005
    ..7 +/- 198.3 nmol/L at 2 h after consumption of a cocoa beverage containing 54.4 mg of (-)-Ec...
  80. ncbi request reprint Muscle antioxidant status in chronic alcoholism
    Joaquim Fernández-Solà
    Department of Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Alcohol Clin Exp Res 26:1858-62. 2002
    ..Its pathogenesis is multi-factorial, only partially clarified, and antioxidant imbalance has been suggested to influence its development, being a type II glucolytic, fast-twitch fiber subset more sensitive to this effect...
  81. ncbi request reprint The effect of controlled drinking in alcoholic cardiomyopathy
    Josep Maria Nicolas
    Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Ann Intern Med 136:192-200. 2002
    ..In alcoholic persons who develop cardiac dysfunction, abstinence is thought to be essential to halt further deterioration of cardiac contractility. Some evidence indicates that reducing alcohol intake may also be beneficial...