A Estelles

Summary

Country: Spain

Publications

  1. ncbi request reprint Role of microRNAs in gynecological pathology
    J Gilabert-Estelles
    Gynecology Service, Hospital Universitario Dr Peset, Valencia, Spain
    Curr Med Chem 19:2406-13. 2012
  2. pmc Peritoneal fluid reduces angiogenesis-related microRNA expression in cell cultures of endometrial and endometriotic tissues from women with endometriosis
    Aitana Braza-Boïls
    Grupo de Hemostasia, Trombosis, Arteriosclerosis y Biología Vascular, Instituto Investigación Sanitaria Hospital La Fe, Valencia, Spain
    PLoS ONE 8:e62370. 2013
  3. ncbi request reprint Fibrinolysis: the key to new pathogenetic mechanisms
    Esther Zorio
    Hospital Universitario La Fe, Centro de Investigacion, Servicio de Cardiología y Servicio de Ginecología Valencia, Spain
    Curr Med Chem 15:923-9. 2008
  4. ncbi request reprint Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis
    J Gilabert-Estelles
    Maternal Hospital, Hospital Universitario La Fe, Valencia, Spain
    Hum Reprod 18:1516-22. 2003
  5. ncbi request reprint mRNA analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using a real-time quantitative RT-PCR assay
    L Ramon
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    Hum Reprod 20:272-8. 2005
  6. ncbi request reprint Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems
    J Gilabert-Estelles
    Gynecology Service, Hospital Arnau de Vilanova, Valencia, Spain
    Hum Reprod 22:2120-7. 2007
  7. ncbi request reprint Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis
    R Cosín
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    Hum Reprod 25:398-405. 2010
  8. ncbi request reprint Factor V Leiden and antibodies against phospholipids and protein S in a young woman with recurrent thromboses and abortion
    F Espana
    Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain
    Haematologica 84:80-4. 1999
  9. ncbi request reprint Risk of venous thrombosis in carriers of the prothrombin G20210A variant and factor V Leiden and their interaction with oral contraceptives
    J Aznar
    Department of Clinical Pathology, La Fe University Hospital, Avda Campanar 21, 46009 Valencia, Spain
    Haematologica 85:1271-6. 2000
  10. doi request reprint Functional analysis of two haplotypes of the human endothelial protein C receptor gene
    P Medina
    From the Grupo de Investigación en Hemostasia, Trombosis, Arteriosclerosis y Biología Vascular, Centro de Investigación P M, S N, E B, L M, A E, F E and Servicio de Análisis Clínicos E B, Hospital Universitario y Politécnico La Fe, Valencia, Spain and Department of Thrombosis and Haemostasis, Einthoven Laboratory, Leiden University Medical Centre, Leiden, The Netherlands R M B, H L V
    Arterioscler Thromb Vasc Biol 34:684-90. 2014

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Role of microRNAs in gynecological pathology
    J Gilabert-Estelles
    Gynecology Service, Hospital Universitario Dr Peset, Valencia, Spain
    Curr Med Chem 19:2406-13. 2012
    ..The development of therapies that might block the expression or mimic the functions of miRNAs could represent new therapeutic strategies for any of the aforementioned gynecological disorders...
  2. pmc Peritoneal fluid reduces angiogenesis-related microRNA expression in cell cultures of endometrial and endometriotic tissues from women with endometriosis
    Aitana Braza-Boïls
    Grupo de Hemostasia, Trombosis, Arteriosclerosis y Biología Vascular, Instituto Investigación Sanitaria Hospital La Fe, Valencia, Spain
    PLoS ONE 8:e62370. 2013
    ....
  3. ncbi request reprint Fibrinolysis: the key to new pathogenetic mechanisms
    Esther Zorio
    Hospital Universitario La Fe, Centro de Investigacion, Servicio de Cardiología y Servicio de Ginecología Valencia, Spain
    Curr Med Chem 15:923-9. 2008
    ....
  4. ncbi request reprint Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis
    J Gilabert-Estelles
    Maternal Hospital, Hospital Universitario La Fe, Valencia, Spain
    Hum Reprod 18:1516-22. 2003
    ....
  5. ncbi request reprint mRNA analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using a real-time quantitative RT-PCR assay
    L Ramon
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    Hum Reprod 20:272-8. 2005
    ..The aim of this study was to analyse mRNA and protein levels of several components of the PA and MMP systems in endometriotic tissue and endometrium from women with and without endometriosis. METHODS and..
  6. ncbi request reprint Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems
    J Gilabert-Estelles
    Gynecology Service, Hospital Arnau de Vilanova, Valencia, Spain
    Hum Reprod 22:2120-7. 2007
    ....
  7. ncbi request reprint Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis
    R Cosín
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    Hum Reprod 25:398-405. 2010
    ..The aim of this study was to evaluate the influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with and without endometriosis...
  8. ncbi request reprint Factor V Leiden and antibodies against phospholipids and protein S in a young woman with recurrent thromboses and abortion
    F Espana
    Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain
    Haematologica 84:80-4. 1999
    ..The impairment of the protein C pathway at various points could well explain the recurrent thromboses in the patient and supports the role of a disturbed protein C system in the pathophysiology of thrombosis in patients with APAs...
  9. ncbi request reprint Risk of venous thrombosis in carriers of the prothrombin G20210A variant and factor V Leiden and their interaction with oral contraceptives
    J Aznar
    Department of Clinical Pathology, La Fe University Hospital, Avda Campanar 21, 46009 Valencia, Spain
    Haematologica 85:1271-6. 2000
    ..Moreover, the influence of oral contraceptives (OC) on thrombotic events in patients with the prothrombin G20210A variant has not been well established. In this study we evaluate both circumstances...
  10. doi request reprint Functional analysis of two haplotypes of the human endothelial protein C receptor gene
    P Medina
    From the Grupo de Investigación en Hemostasia, Trombosis, Arteriosclerosis y Biología Vascular, Centro de Investigación P M, S N, E B, L M, A E, F E and Servicio de Análisis Clínicos E B, Hospital Universitario y Politécnico La Fe, Valencia, Spain and Department of Thrombosis and Haemostasis, Einthoven Laboratory, Leiden University Medical Centre, Leiden, The Netherlands R M B, H L V
    Arterioscler Thromb Vasc Biol 34:684-90. 2014
    ....
  11. ncbi request reprint Expression of the fibrinolytic components in endometriosis
    J Gilabert-Estelles
    Department of Gynecology, Hospital Arnau de Vilanova, Valencia, Spain
    Pathophysiol Haemost Thromb 35:136-40. 2006
    ..The aim of the present study is to review the expression of the plasminogen activator system in endometriosis, and to consider the clinical implications and the possible further research efforts in this disease...
  12. ncbi request reprint [PSA:alpha 1-antichymotrypsin ratio/total PSA in the diagnosis of prostatic cancer in the range of total PSA from 4 to 10 ng/ml]
    M Martínez Sarmiento
    Servicio de Urologia, Hospital Universitario La Fe, Valencia
    Actas Urol Esp 25:269-77. 2001
    ..To evaluate the usefulness of the ratio PSA:alpha-1-antichymotrypsin/total PSA (C/T) in the diagnosis of prostate cancer in the range of total PSA between 4 and 10 ng/mL...
  13. ncbi request reprint Plasma PAI-1 levels in obese children--effect of weight loss and influence of PAI-1 promoter 4G/5G genotype
    A Estelles
    Research Center, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 86:647-52. 2001
    ..In conclusion, a decrease in BMI in obese children shows a favourable effect on the fibrinolytic system due to a decrease in PAI-1 levels. However, no influence of 4G/5G genotype on PAI-1 levels was observed...
  14. ncbi request reprint Circulating activated protein C is reduced in young survivors of myocardial infarction and inversely correlates with the severity of coronary lesions
    E Zorio
    Department of Cardiology, Hospital Universitario La Fe, Centro de Investigacion, Av Campanar 21, 46009 Valencia, Spain
    J Thromb Haemost 4:1530-6. 2006
    ..As activated protein C (APC) provides systemic anticoagulant and anti-inflammatory protection, a low plasma APC level may be an arterial thrombotic risk factor...
  15. ncbi request reprint Low level of circulating activated protein C is a risk factor for venous thromboembolism
    F Espana
    Research Center, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 86:1368-73. 2001
    ..We conclude that a low level of circulating APC in individuals without any of the most recognized thrombophilic defects is a prevalent, independent risk factor for VTE, and that it predisposes to recurrent VTE...
  16. ncbi request reprint Congenital and acquired thrombotic risk factors in women using oral contraceptives: clinical aspects
    Y Mira
    Department of Clinical Pathology, Hospital La Fe, Valencia, Spain
    Clin Appl Thromb Hemost 6:162-8. 2000
    ..Moreover, if a patient develops a thrombotic complication while taking OC, an evaluation to search for a thrombophilic defect is warranted, and at the same time, alternative methods of contraception should be considered...
  17. ncbi request reprint The multifunctional protein C system
    F Espana
    Hospital Universitario La Fe, Centro de Investigacion, Av Campanar 21, 46009 Valencia, Spain
    Curr Med Chem Cardiovasc Hematol Agents 3:119-31. 2005
    ..This review will summarize the mechanisms that contribute to these biological activities of the protein C pathway...
  18. ncbi request reprint [Factors affecting the PSA:alpha 1 antichymotrypsin/total PSA ratio]
    M Martínez Sarmiento
    Servicio de Urologia, Hospital Universitario La Fe, Valencia, Espana
    Actas Urol Esp 25:350-6. 2001
    ..To evaluate the influence of several factors, including age, prostate volume, total PSA (PSA-T), clinical stage and Gleason on the PSA:alpha 1ACT/PSA-T (C/T) ratio...
  19. ncbi request reprint Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen
    F Espana
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    Thromb Res 64:309-20. 1991
    ..They also suggest a physiological role of PCI in reproduction, and show that PCI is present in various biological fluids...
  20. ncbi request reprint PAI-1 promoter 4G/5G genotype as an additional risk factor for venous thrombosis in subjects with genetic thrombophilic defects
    R Segui
    The Research Centre, La Fe University Hospital, Valencia, Spain
    Br J Haematol 111:122-8. 2000
    ..In conclusion, the PAI-1 promoter polymorphism was found to have an influence on PAI-1 levels in DVT patients and on the risk of venous thrombosis in subjects with other genetic thrombophilic defects...
  21. ncbi request reprint Factor V Leiden and prothrombin G20210A in relation to arterial and/or vein rethrombosis: two cases
    Y Mira
    Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Appl Thromb Hemost 7:234-7. 2001
    ....
  22. ncbi request reprint Complexes of tissue kallikrein with protein C inhibitor in human semen and urine
    F Espana
    Research Center, La Fe University Hospital, Valencia, Spain
    Eur J Biochem 234:641-9. 1995
    ..Formation of tKK:PCI complex in urine and semen was also demonstrated by immunoblotting. These results suggest that PCI is a physiological inhibitor of tKK and provide additional evidence of the involvement of PCI in human reproduction...
  23. ncbi request reprint Fibrinolysis and lipoprotein(a) in women with coronary artery disease. Influence of hormone replacement therapy
    C Falco
    Research Center, La Fe University Hospital, Valencia, Spain
    Haematologica 86:92-8. 2001
    ..HRT could modify the cardiovascular risk via several mechanisms, including modifications in the fibrinolytic system and lipoprotein (a) levels. Our study was aimed at investigating some of these modifications...
  24. ncbi request reprint Functional and immunologic protein S in normal pregnant women and in full-term newborns
    J A Fernandez
    Research Center, Hospital La Fe, Valencia, Spain
    Thromb Haemost 61:474-8. 1989
    ..84 +/- 0.31. C4bp values were 23.5 +/- 10.3% in the FTN group, and crossed immunoelectrophoresis showed that in this group the major protein S peak corresponded to free protein S.(ABSTRACT TRUNCATED AT 250 WORDS)..
  25. ncbi request reprint Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance
    E Sola
    Endocrinology Service, Doctor Peset University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 37:309-18. 2007
    ..050). Obese patients show increased fibrinogen levels, PV and cBV. These rheological disturbances seem to be associated with insulin resistance and the metabolic syndrome, and do not seem to improve with moderate weight loss...
  26. ncbi request reprint Insights into the role of microRNAs in cardiac diseases: from biological signalling to therapeutic targets
    E Zorio
    Cardiology Department, Hospital Universitario La Fe, Av Campanar 21, Valencia, Spain
    Cardiovasc Hematol Agents Med Chem 7:82-90. 2009
    ..However, the final effect of the blockage of microRNAs in vivo remains unclear, since each of them can target hundreds of genes with different intensity. The era of the microRNAs in cardiovascular diseases has just started...
  27. ncbi request reprint P62Role of microRNAs associated with non-alcoholic fatty liver disease in sudden cardiac death from coronary artery disease
    A Braza-Boïls
    Health Research Institute La Fe, Valencia, Spain
    Cardiovasc Res 103:S10. 2014
    ..05) between miR-34a and GGT was observed. Conclusions: The CAD-SCD is associated with NAFLD and NASH. The miRNAs studied appear to be associated with NAFLD severity...
  28. ncbi request reprint Complexes of activated protein C with alpha 1-antitrypsin in normal pregnancy and in severe preeclampsia
    F Espana
    Research Center Hospital La Fe, Valencia, Spain
    Am J Obstet Gynecol 164:1310-6. 1991
    ....
  29. ncbi request reprint Changes in molecular forms of prostate-specific antigen during treatment with finasteride
    F Espana
    Research Center and Department of Urology, La Fe University Hospital, Valencia, Spain
    BJU Int 90:672-7. 2002
    ..To study the influence of finasteride treatment on the molecular forms of prostate-specific antigen (PSA) in patients with benign prostatic hyperplasia (BPH)...