Ortega Villaizan M, Chico V, Martinez Lopez A, Garcia Valtanen P, Coll J, Estepa A. Development of new therapeutical/adjuvant molecules by pepscan mapping of autophagy and IFN inducing determinants of rhabdoviral G proteins. Mol Immunol. 2016;70:118-24 pubmed publisher
..In addition, these results have also contributed to improve our knowledge on how to stimulate the fish immune system. ..
Encinas P, Rodriguez Milla M, Novoa B, Estepa A, Figueras A, Coll J. Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. BMC Genomics. 2010;11:518 pubmed publisher
Estepa A, Coll J. Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish. Fish Shellfish Immunol. 2015;47:264-70 pubmed publisher
..These studies are an example of how the identification of host genes targeted by viral infections using microarrays might facilitate the identification of novel prevention drugs in aquaculture and illuminate viral infection mechanisms. ..
Falco A, Ortega Villaizan M, Chico V, Brocal I, Perez L, Coll J, et al
. Antimicrobial peptides as model molecules for the development of novel antiviral agents in aquaculture. Mini Rev Med Chem. 2009;9:1159-64 pubmed
..In addition, because fish rely more heavily on their innate immune defences than mammals, they might constitute a potential rich source of antiviral compounds for fighting against mammalian viral infections. ..
Garcia Valtanen P, Martinez Lopez A, Ortega Villaizan M, Perez L, Coll J, Estepa A. In addition to its antiviral and immunomodulatory properties, the zebrafish ?-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Res. 2014;101:136-47 pubmed publisher
..To note that psoriasis can be induced in zebrafish and the over-expression of ?-defensin 2 is implicated in the inflammatory response associated with this human skin disorder. ..
Martinez Lopez A, Garcia Valtanen P, Ortega Villaizan M, Chico V, Gomez Casado E, Coll J, et al
. VHSV G glycoprotein major determinants implicated in triggering the host type I IFN antiviral response as DNA vaccine molecular adjuvants. Vaccine. 2014;32:6012-9 pubmed publisher