Hector F Escobar-Morreale

Summary

Country: Spain

Publications

  1. ncbi Abnormalities in the serum insulin-like growth factor-1 axis in women with hyperandrogenism
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 70:1090-100. 1998
  2. ncbi Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism
    Hector F Escobar-Morreale
    Department of Endocrinology and Department of Molecular Genetics, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 100, 28034 Madrid, Spain
    Obes Res 11:987-96. 2003
  3. ncbi Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, Madrid, Spain
    Diabetologia 46:625-33. 2003
  4. ncbi Common single nucleotide polymorphisms in intron 3 of the calpain-10 gene influence hirsutism
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 77:581-7. 2002
  5. ncbi Receiver operating characteristic analysis of the performance of basal serum hormone profiles for the diagnosis of polycystic ovary syndrome in epidemiological studies
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 100, 28034 Madrid, Spain
    Eur J Endocrinol 145:619-24. 2001
  6. ncbi TNF-alpha and hyperandrogenism: a clinical, biochemical, and molecular genetic study
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, 28034 Madrid, Spain
    J Clin Endocrinol Metab 86:3761-7. 2001
  7. ncbi High prevalence of the polycystic ovary syndrome and hirsutism in women with type 1 diabetes mellitus
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Clin Endocrinol Metab 85:4182-7. 2000
  8. ncbi Treatment of hirsutism with ethinyl estradiol-desogestrel contraceptive pills has beneficial effects on the lipid profile and improves insulin sensitivity
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 74:816-9. 2000
  9. ncbi Serum prostate-specific antigen concentrations are not useful for monitoring the treatment of hirsutism with oral contraceptive pills
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Clin Endocrinol Metab 85:2488-92. 2000
  10. ncbi The presence of the 21-hydroxylase deficiency carrier status in hirsute women: phenotype-genotype correlations
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 72:629-38. 1999

Collaborators

Detail Information

Publications73

  1. ncbi Abnormalities in the serum insulin-like growth factor-1 axis in women with hyperandrogenism
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 70:1090-100. 1998
    ..To study the insulin-like growth factor-1 (IGF-1) axis in hirsute women...
  2. ncbi Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism
    Hector F Escobar-Morreale
    Department of Endocrinology and Department of Molecular Genetics, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 100, 28034 Madrid, Spain
    Obes Res 11:987-96. 2003
    ..Genetic variability at these loci might contribute to explain the development of obesity and hyperandrogenism...
  3. ncbi Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, Madrid, Spain
    Diabetologia 46:625-33. 2003
    ..We evaluated whether obesity, insulin resistance, or both, are related to the increased concentrations of inflammatory markers in pre-menopausal women...
  4. ncbi Common single nucleotide polymorphisms in intron 3 of the calpain-10 gene influence hirsutism
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 77:581-7. 2002
    ..To study three common polymorphisms in intron 3 of the calpain-10 gene (CAPN10) in hyperandrogenic patients...
  5. ncbi Receiver operating characteristic analysis of the performance of basal serum hormone profiles for the diagnosis of polycystic ovary syndrome in epidemiological studies
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 100, 28034 Madrid, Spain
    Eur J Endocrinol 145:619-24. 2001
    ....
  6. ncbi TNF-alpha and hyperandrogenism: a clinical, biochemical, and molecular genetic study
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, 28034 Madrid, Spain
    J Clin Endocrinol Metab 86:3761-7. 2001
    ....
  7. ncbi High prevalence of the polycystic ovary syndrome and hirsutism in women with type 1 diabetes mellitus
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Clin Endocrinol Metab 85:4182-7. 2000
    ..In conclusion, women with type 1 diabetes mellitus have a high prevalence of hyperandrogenic disorders, including PCOS and hirsutism...
  8. ncbi Treatment of hirsutism with ethinyl estradiol-desogestrel contraceptive pills has beneficial effects on the lipid profile and improves insulin sensitivity
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 74:816-9. 2000
    ..To evaluate the effects on the lipid pattern and insulin sensitivity of hirsute women of an oral contraceptive pill containing 30 microg of ethinyl estradiol and 150 microg of desogestrel...
  9. ncbi Serum prostate-specific antigen concentrations are not useful for monitoring the treatment of hirsutism with oral contraceptive pills
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Clin Endocrinol Metab 85:2488-92. 2000
    ..Thus, serum PSA measurements have no apparent role in the management of hirsute patients on oral contraceptive treatment, at least with the ultrasensitive assays currently available...
  10. ncbi The presence of the 21-hydroxylase deficiency carrier status in hirsute women: phenotype-genotype correlations
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 72:629-38. 1999
    ..To determine the role of heterozygosity for mutations in the 21-hydroxylase gene (CYP21) in the pathogenesis of hyperandrogenism...
  11. ncbi Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women
    Rosa M Calvo
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 77:666-8. 2002
    ..To determine if the insulin gene variable number of tandem repeats (VNTR) regulatory polymorphism is associated with hyperandrogenism in a population of Spanish women...
  12. ncbi Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity
    Jose L San Millan
    Department of Molecular Genetics, Hospital Ramon y Cajal, 28034 Madrid, Spain
    J Clin Endocrinol Metab 89:2640-6. 2004
    ....
  13. ncbi Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses
    Manuel Luque-Ramírez
    Department of Endocrinology and Molecular Genetics, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Diabetes Care 30:2309-13. 2007
    ....
  14. ncbi Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1 28034 Madrid, Spain
    J Clin Endocrinol Metab 92:2453-61. 2007
    ..Oral contraceptives may worsen the metabolic profile of patients with polycystic ovary syndrome (PCOS), favoring the use of insulin sensitizers in these patients...
  15. pmc Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism
    M Ángeles Martínez-García
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Diabetes Care 32:1525-30. 2009
    ....
  16. ncbi Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls
    Gemma Villuendas
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Hum Reprod 20:3184-91. 2005
    ....
  17. doi Serum osteoprotegerin concentrations are decreased in women with the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramón y Cajal and Universidad de Alcalá, Madrid, Spain
    Eur J Endocrinol 159:225-32. 2008
    ..Both low-grade chronic inflammation and cardiovascular risk are increased in women with the polycystic ovary syndrome (PCOS). We aimed to study serum OPG concentrations in PCOS patients...
  18. ncbi Obesity is the major determinant of the abnormalities in blood pressure found in young women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    J Clin Endocrinol Metab 92:2141-8. 2007
    ..Obesity and insulin resistance predispose patients with the polycystic ovary syndrome (PCOS) to abnormalities in blood pressure regulation...
  19. ncbi Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 89:806-11. 2004
    ..23; P < 0.03). In conclusion, PCOS and obesity induce an increase in serum IL-18 levels, which are also associated with several indexes of global and visceral adiposity and with insulin resistance...
  20. doi Global adiposity and thickness of intraperitoneal and mesenteric adipose tissue depots are increased in women with polycystic ovary syndrome (PCOS)
    Susana Borruel
    Diabetes, Obesity, and Human Reproduction Research Group, Universidad de Alcalá and Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Clin Endocrinol Metab 98:1254-63. 2013
    ..Sexual dimorphism suggests a role for androgens in body fat distribution. Women with polycystic ovary syndrome (PCOS), a mainly androgen excess disorder, often present with abdominal obesity and visceral adiposity...
  21. doi Role of decreased circulating hepcidin concentrations in the iron excess of women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 96:846-52. 2011
    ..Hepcidin inhibits the intestinal absorption of iron and its deficiency causes juvenile hemochromatosis...
  22. ncbi Body iron stores are increased in overweight and obese women with polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, Madrid E 28034, Spain
    Diabetes Care 28:2042-4. 2005
  23. ncbi A prospective study of the prevalence of nonclassical congenital adrenal hyperplasia among women presenting with hyperandrogenic symptoms and signs
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1 E 28034 Madrid, Spain
    J Clin Endocrinol Metab 93:527-33. 2008
    ..The diagnosis of the polycystic ovary syndrome requires the exclusion of nonclassical congenital adrenal hyperplasia (NCAH)...
  24. ncbi Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with undesirable cardiovascular effects in patients with differentiated thyroid carcinoma
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Endocr Relat Cancer 11:345-56. 2004
    ....
  25. doi Proteomic analysis of plasma in the polycystic ovary syndrome identifies novel markers involved in iron metabolism, acute-phase response, and inflammation
    María Insenser
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1 Madrid E 28034, Spain
    J Clin Endocrinol Metab 95:3863-70. 2010
    ..Hypothesis-free approaches such as proteomic analysis may identify novel biomarkers for disease...
  26. ncbi A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome
    Jose L San Millan
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 90:4157-62. 2005
    ....
  27. ncbi The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism
    Gemma Villuendas
    Department of Endocrinology, Hospital Ramon y Cajal, 28034 Madrid, Spain
    J Clin Endocrinol Metab 87:1134-41. 2002
    ..In conclusion, our present results suggest that the -597G-->A and -174G-->C polymorphisms in IL-6 are involved in the pathogenesis of hyperandrogenic disorders...
  28. ncbi Androgen excess is associated with the increased carotid intima-media thickness observed in young women with polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal, Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1 E 28034 Madrid, Spain
    Hum Reprod 22:3197-203. 2007
    ..We evaluated carotid intima-media thickness (CIMT) as an early marker of atherosclerosis, as well as its main determinants among androgen excess, obesity and insulin resistance, in patients with polycystic ovary syndrome (PCOS)...
  29. doi Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal, Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1, 28034 Madrid, Spain
    Hum Reprod 23:1594-601. 2008
    ..Serum uric acid levels have emerged as a cardiovascular risk factor, and interventions aimed to decrease its level have been related with an improvement in clinical and non-clinical cardiovascular outcomes...
  30. ncbi The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women
    Jose L San Millan
    Department of Molecular Genetics, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Hum Reprod 21:3157-61. 2006
    ..Because serum paraoxonase activity is influenced by the -108C/T polymorphism in the PON1 gene, we studied its involvement in the decreased paraoxonase activity recently described in the polycystic ovary syndrome (PCOS)...
  31. ncbi Effects of thyroid hormones on serum levels of adipokines as studied in patients with differentiated thyroid carcinoma during thyroxine withdrawal
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Thyroid 16:397-402. 2006
    ..We aimed to study the impact of short-term overt hypothyroidism on serum leptin, resistin, and adiponectin levels in an in vivo human model...
  32. doi Metabolic heterogeneity in polycystic ovary syndrome is determined by obesity: plasma metabolomic approach using GC-MS
    Hector F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Clin Chem 58:999-1009. 2012
    ..Abdominal adiposity and obesity influence the association of polycystic ovary syndrome (PCOS) with insulin resistance and diabetes. We aimed to characterize the intermediate metabolism phenotypes associated with PCOS and obesity...
  33. doi A nontargeted proteomic study of the influence of androgen excess on human visceral and subcutaneous adipose tissue proteomes
    Rafael Montes-Nieto
    Diabetes, Obesity, and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Madrid, Spain
    J Clin Endocrinol Metab 98:E576-85. 2013
    ..Sex hormones, particularly androgens, may influence not only adipose tissue distribution but also its functions...
  34. doi Antiandrogenic contraceptives increase serum adiponectin in obese polycystic ovary syndrome patients
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Obesity (Silver Spring) 17:3-9. 2009
    ....
  35. doi Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: influence of obesity and smoking
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Eur J Endocrinol 160:469-80. 2009
    ..To study the blood clotting tests and endothelial function of polycystic ovary syndrome (PCOS) patients and non-hyperandrogenic women, and their changes during PCOS treatment, as a function of the presence of obesity and smoking...
  36. doi The determinants of insulin sensitivity, β-cell function, and glucose tolerance are different in patients with polycystic ovary syndrome than in women who do not have hyperandrogenism
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Madrid, Spain
    Fertil Steril 94:2214-21. 2010
    ..To evaluate the pathogenetic mechanisms underlying abnormal glucose tolerance in polycystic ovary syndrome (PCOS)...
  37. doi Role of androgen-mediated enhancement of erythropoiesis in the increased body iron stores of patients with polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Fertil Steril 95:1730-5.e1. 2011
    ....
  38. doi Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 expression
    Mora Murri
    or Héctor F Escobar Morreale, Department of Endocrinology and Nutrition, Hospital Universitario Ramon y Cajal, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 98:E1835-44. 2013
    ..miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 have been associated with metabolic disorders such as obesity and diabetes, which are also associated with polycystic ovary syndrome (PCOS)...
  39. ncbi The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid E 28034, Spain
    J Clin Endocrinol Metab 90:6364-9. 2005
    ..The polycystic ovary syndrome (PCOS) is frequently associated with obesity. However, there are very few data about PCOS in morbid obesity, especially with regard to its evolution after bariatric surgery...
  40. ncbi The effects of thyroid hormones on circulating markers of cell-mediated immune response, as studied in patients with differentiated thyroid carcinoma before and during thyroxine withdrawal
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Endocrinol 153:223-30. 2005
    ..To address the influence of thyroid hormones on circulating markers of cell-mediated immune response in an in vivo human model...
  41. ncbi Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women
    Francisco Alvarez-Blasco
    Departments of Endocrinology, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Arch Intern Med 166:2081-6. 2006
    ..We conducted the present study to obtain an unbiased estimate of the prevalence of PCOS in unselected overweight and obese premenopausal women from Spain...
  42. ncbi Improved resolution of the human adipose tissue proteome at alkaline and wide range pH by the addition of hydroxyethyl disulfide
    Marta Corton
    Instituto de Investigaciones Biomedicas, CSIC UAM, Madrid, Spain
    Proteomics 4:438-41. 2004
    ..This information will aid studies on metabolic diseases such as polycystic ovary syndrome, obesity, hypertension and type 2 diabetes...
  43. doi Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis
    Mora Murri
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Hum Reprod Update 19:268-88. 2013
    ..CONCLUSIONS Circulating markers of oxidative stress are abnormal in women with PCOS independent of weight excess. This finding suggests that oxidative stress may participate in the pathophysiology of this common disorder...
  44. ncbi Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Ann Intern Med 142:412-24. 2005
    ..Substituting part of the dose of l-thyroxine with small but supraphysiologic doses of liothyronine in hypothyroid patients has yielded conflicting results...
  45. ncbi Genomic variants in polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    Clin Chim Acta 366:14-26. 2006
    ....
  46. ncbi Hyperandrogenism, insulin resistance and hyperinsulinemia as cardiovascular risk factors in diabetes mellitus
    Gema García-Romero
    Department of Endocrinology, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Curr Diabetes Rev 2:39-49. 2006
    ....
  47. ncbi Genetic basis of metabolic abnormalities in polycystic ovary syndrome: implications for therapy
    Belen Roldan
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Am J Pharmacogenomics 4:93-107. 2004
    ..In the future, new therapeutic approaches to PCOS will rely on knowing the genes, environmental influences, and etiologic mechanisms associated with the disorder...
  48. doi Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease
    José I Botella-Carretero
    Unit of Obesity Surgery, Department of Endocrinology and Nutrition, Hospital Universitario Ramon y Cajal, Carretera de Colmenar Km 9 1, 28034 Madrid, Spain
    Obes Surg 20:69-76. 2010
    ....
  49. doi Evidence for masculinization of adipokine gene expression in visceral and subcutaneous adipose tissue of obese women with polycystic ovary syndrome (PCOS)
    M Ángeles Martínez-García
    Diabetes, Obesity and Human Reproduction Research Group, Universidad de Alcala, Madrid, Spain
    J Clin Endocrinol Metab 98:E388-96. 2013
    ..Sex hormones, particularly androgens, may influence not only adipose tissue distribution but also its functions. Objective: We explored the possibility of sexual dimorphism in adipose tissue and skeletal muscle function...
  50. ncbi The decrease in serum IL-18 levels after bariatric surgery in morbidly obese women is a time-dependent event
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramón y Cajal and Universidad de Alcalá, Madrid, Spain
    Obes Surg 17:1199-208. 2007
    ....
  51. ncbi The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, Madrid E 28034, Spain
    Endocr Rev 26:251-82. 2005
    ....
  52. doi Sexual dimorphism in adipose tissue function as evidenced by circulating adipokine concentrations in the fasting state and after an oral glucose challenge
    Manuel Luque-Ramírez
    Diabetes, Obesity and Human Reproduction Research Group, Universidad de Alcalá and Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain
    Hum Reprod 28:1908-18. 2013
    ..Do the circulating levels of a panel of adipokines involved in glucose metabolism exhibit sexual dimorphism in the fasting state and after an oral glucose load?..
  53. pmc Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Fertil Steril 95:1048-58.e1-2. 2011
    ..To perform a review and metaanalysis of the studies evaluating the status of serum inflammatory markers in women with polycystic ovary syndrome (PCOS)...
  54. ncbi The ACAA-insertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance
    Gemma Villuendas
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Km 9 1, Madrid E 28034, Spain
    Eur J Endocrinol 155:331-6. 2006
    ..In the present study conducted in Spaniards, we tested a common polymorphism in IGFIIR for association with type 2 diabetes and insulin-resistant traits...
  55. pmc Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women
    Francisco Alvarez-Blasco
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    PLoS ONE 4:e5606. 2009
    ....
  56. ncbi Abdominal adiposity and the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    Trends Endocrinol Metab 18:266-72. 2007
    ..Here we review the existing evidence for a vicious circle whereby androgen excess favoring the abdominal deposition of fat further facilitates androgen secretion by the ovaries and adrenals in PCOS patients...
  57. ncbi Clinical review: Hyperandrogenism and polycystic ovary syndrome in women with type 1 diabetes mellitus
    Ethel Codner
    Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile, and Department of Endocrinology, Hospital Ramón y Cajal and Universidad de Alcalá, Carretera de Colmenar Km 9 100, Madrid, E 28034 Spain
    J Clin Endocrinol Metab 92:1209-16. 2007
    ..As will be seen in the present review, androgen excess and PCOS are very frequent complaints in women with DM1, yet nowadays hyperandrogenism is seldom diagnosed in these patients...
  58. ncbi REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Clin Endocrinol Metab 90:4946-54. 2005
    ....
  59. ncbi Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity
    José I Botella-Carretero
    Department of Clinical Nutrition, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Clin Nutr 26:573-80. 2007
    ..However, it is not known whether this possible association of vitamin D deficiency with the metabolic syndrome is still present at very high degrees of obesity, as in morbidly obese patients...
  60. doi Obesity impairs general health-related quality of life (HR-QoL) in premenopausal women to a greater extent than polycystic ovary syndrome (PCOS)
    Francisco Alvarez-Blasco
    Department of Endocrinology, Hospital Universitario Ramon y Cajal, Universidad de Alcala, and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, E 28034, Madrid, Spain
    Clin Endocrinol (Oxf) 73:595-601. 2010
    ..We aimed to estimate the relative impact of obesity and PCOS on the general HR-QoL of premenopausal women...
  61. doi The role of genetic variation in peroxisome proliferator-activated receptors in the polycystic ovary syndrome (PCOS): an original case-control study followed by systematic review and meta-analysis of existing evidence
    Jose L San-Millan
    Department of Molecular Genetics, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Clin Endocrinol (Oxf) 72:383-92. 2010
    ..To study the association of polymorphisms in the genes encoding peroxisome proliferator-activated receptors (PPARs) with the polycystic ovary syndrome (PCOS)...
  62. doi The increase in serum visfatin after bariatric surgery in morbidly obese women is modulated by weight loss, waist circumference, and presence or absence of diabetes before surgery
    José I Botella-Carretero
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Km 9 1, Madrid, Spain
    Obes Surg 18:1000-6. 2008
    ..Previous studies addressing the changes in serum visfatin levels after bariatric surgery yielded conflicting results...
  63. ncbi Macroprolactinemia in women presenting with hyperandrogenic symptoms: Implications for the management of polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 82:1697-9. 2004
    ....
  64. doi Iron metabolism and the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, University of Alcalá and Hospital Universitario Ramón y Cajal and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    Trends Endocrinol Metab 23:509-15. 2012
    ..Future venues of research should address the long-term effects of PCOS treatment on iron overload and, conversely, the possible effects of iron lowering strategies on the glucose tolerance of patients with PCOS...
  65. doi Diet composition and physical activity in overweight and obese premenopausal women with or without polycystic ovary syndrome
    Francisco Alvarez-Blasco
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Madrid, E 28034, Spain
    Gynecol Endocrinol 27:978-81. 2011
    ..In conclusion, diet composition and physical activity were apparently not decisive for the development of PCOS among overweight and obese premenopausal women...
  66. doi Prevalence of hyperprolactinaemia in female premenopausal blood donors
    Macarena Alpañés
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Madrid, Spain
    Clin Endocrinol (Oxf) 79:545-9. 2013
    ....
  67. doi A nontargeted proteomic approach to the study of visceral and subcutaneous adipose tissue in human obesity
    María Insenser
    Diabetes, Obesity and Human Reproduction Group, Universidad de Alcalá and Hospital Universitario Ramon y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain
    Mol Cell Endocrinol 363:10-9. 2012
    ..Our nontargeted proteomic approach identified novel protein species that may be involved in the development of obesity in humans...
  68. ncbi Polycystic ovary syndrome: treatment strategies and management
    Hector F Escobar-Morreale
    University of Alcala, Hospital Universitario Ramon y Cajal, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Department of Endocrinology, Madrid, Spain
    Expert Opin Pharmacother 9:2995-3008. 2008
    ..These pathophysiological mechanisms must be considered when deciding the optimal therapy for PCOS patients...
  69. doi Proteomics and genomics: A hypothesis-free approach to the study of the role of visceral adiposity in the pathogenesis of the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal and University of Alcala, Madrid, Spain
    Proteomics Clin Appl 2:444-55. 2008
    ....
  70. doi Proteomic analysis of visceral adipose tissue in pre-obese patients with type 2 diabetes
    Mora Murri
    Diabetes, Obesity and Human Reproduction Group, Hospital Universitario Ramon y Cajal, Universidad de Alcala, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain
    Mol Cell Endocrinol 376:99-106. 2013
    ..Hence, the proteins identified here could be considered candidate molecules in future studies addressing the role that VAT dysfunction plays in the development of type 2 diabetes. ..
  71. ncbi Impact of the storage temperature on human plasma proteomic analysis: implications for the use of human plasma collections in research
    María Insenser
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Spain
    Proteomics Clin Appl 4:739-44. 2010
    ..To analyze the impact of storage temperature on the 2D-DIGE profile of human plasma...
  72. doi Diagnosis and management of hirsutism
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid and Centro de Investigaciones Biomédicas en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain
    Ann N Y Acad Sci 1205:166-74. 2010
    ..For nonfunctional disorders, treatment should focus on solving the underlying etiology as hirsutism is usually responsive to the elimination of the source of androgen excess...
  73. doi Effects of metformin versus ethinyl-estradiol plus cyproterone acetate on ambulatory blood pressure monitoring and carotid intima media thickness in women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Fertil Steril 91:2527-36. 2009
    ..To compare the effects of metformin versus an antiandrogenic contraceptive pill on ambulatory blood pressure monitoring (ABPM) and carotid intima media thickness (CIMT) in women with polycystic ovary syndrome (PCOS)...