Hector F Escobar-Morreale

Summary

Country: Spain

Publications

  1. ncbi request reprint Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Hum Reprod 21:2257-65. 2006
  2. pmc Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women
    Francisco Alvarez-Blasco
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    PLoS ONE 4:e5606. 2009
  3. doi request reprint Iron metabolism and the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, University of Alcalá and Hospital Universitario Ramón y Cajal and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    Trends Endocrinol Metab 23:509-15. 2012
  4. doi request reprint Metabolic heterogeneity in polycystic ovary syndrome is determined by obesity: plasma metabolomic approach using GC-MS
    Hector F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Clin Chem 58:999-1009. 2012
  5. doi request reprint Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society
    H F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcalá and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS and CIBER Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, 28034 Madrid, Spain
    Hum Reprod Update 18:146-70. 2012
  6. doi request reprint Surgical management of metabolic dysfunction in PCOS
    Hector F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcalá and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, E 28034 Madrid, Spain
    Steroids 77:312-6. 2012
  7. ncbi request reprint Body iron stores are increased in overweight and obese women with polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, Madrid E 28034, Spain
    Diabetes Care 28:2042-4. 2005
  8. ncbi request reprint The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid E 28034, Spain
    J Clin Endocrinol Metab 90:6364-9. 2005
  9. ncbi request reprint Polycystic ovary syndrome: treatment strategies and management
    Hector F Escobar-Morreale
    University of Alcala, Hospital Universitario Ramon y Cajal, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Department of Endocrinology, Madrid, Spain
    Expert Opin Pharmacother 9:2995-3008. 2008
  10. ncbi request reprint The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, Madrid E 28034, Spain
    Endocr Rev 26:251-82. 2005

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study
    H F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Hum Reprod 21:2257-65. 2006
    ..We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary syndrome (PCOS)...
  2. pmc Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women
    Francisco Alvarez-Blasco
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    PLoS ONE 4:e5606. 2009
    ....
  3. doi request reprint Iron metabolism and the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, University of Alcalá and Hospital Universitario Ramón y Cajal and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    Trends Endocrinol Metab 23:509-15. 2012
    ..Future venues of research should address the long-term effects of PCOS treatment on iron overload and, conversely, the possible effects of iron lowering strategies on the glucose tolerance of patients with PCOS...
  4. doi request reprint Metabolic heterogeneity in polycystic ovary syndrome is determined by obesity: plasma metabolomic approach using GC-MS
    Hector F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Clin Chem 58:999-1009. 2012
    ..Abdominal adiposity and obesity influence the association of polycystic ovary syndrome (PCOS) with insulin resistance and diabetes. We aimed to characterize the intermediate metabolism phenotypes associated with PCOS and obesity...
  5. doi request reprint Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society
    H F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcalá and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS and CIBER Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, 28034 Madrid, Spain
    Hum Reprod Update 18:146-70. 2012
    ..Hirsutism, defined by the presence of excessive terminal hair in androgen-sensitive areas of the female body, is one of the most common disorders in women during reproductive age...
  6. doi request reprint Surgical management of metabolic dysfunction in PCOS
    Hector F Escobar-Morreale
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcalá and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, E 28034 Madrid, Spain
    Steroids 77:312-6. 2012
    ..Finally, avoidance of the risks associated with morbid obesity compensate for the possible residual risks for pregnancy derived from the previous bariatric procedure itself...
  7. ncbi request reprint Body iron stores are increased in overweight and obese women with polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, Madrid E 28034, Spain
    Diabetes Care 28:2042-4. 2005
  8. ncbi request reprint The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid E 28034, Spain
    J Clin Endocrinol Metab 90:6364-9. 2005
    ..The polycystic ovary syndrome (PCOS) is frequently associated with obesity. However, there are very few data about PCOS in morbid obesity, especially with regard to its evolution after bariatric surgery...
  9. ncbi request reprint Polycystic ovary syndrome: treatment strategies and management
    Hector F Escobar-Morreale
    University of Alcala, Hospital Universitario Ramon y Cajal, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Department of Endocrinology, Madrid, Spain
    Expert Opin Pharmacother 9:2995-3008. 2008
    ..These pathophysiological mechanisms must be considered when deciding the optimal therapy for PCOS patients...
  10. ncbi request reprint The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, Madrid E 28034, Spain
    Endocr Rev 26:251-82. 2005
    ....
  11. ncbi request reprint A prospective study of the prevalence of nonclassical congenital adrenal hyperplasia among women presenting with hyperandrogenic symptoms and signs
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1 E 28034 Madrid, Spain
    J Clin Endocrinol Metab 93:527-33. 2008
    ..The diagnosis of the polycystic ovary syndrome requires the exclusion of nonclassical congenital adrenal hyperplasia (NCAH)...
  12. ncbi request reprint Abdominal adiposity and the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    Trends Endocrinol Metab 18:266-72. 2007
    ..Here we review the existing evidence for a vicious circle whereby androgen excess favoring the abdominal deposition of fat further facilitates androgen secretion by the ovaries and adrenals in PCOS patients...
  13. doi request reprint Diagnosis and management of hirsutism
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid and Centro de Investigaciones Biomédicas en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain
    Ann N Y Acad Sci 1205:166-74. 2010
    ..For nonfunctional disorders, treatment should focus on solving the underlying etiology as hirsutism is usually responsive to the elimination of the source of androgen excess...
  14. doi request reprint Proteomics and genomics: A hypothesis-free approach to the study of the role of visceral adiposity in the pathogenesis of the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal and University of Alcala, Madrid, Spain
    Proteomics Clin Appl 2:444-55. 2008
    ....
  15. pmc Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Fertil Steril 95:1048-58.e1-2. 2011
    ..To perform a review and metaanalysis of the studies evaluating the status of serum inflammatory markers in women with polycystic ovary syndrome (PCOS)...
  16. ncbi request reprint Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Ann Intern Med 142:412-24. 2005
    ..Substituting part of the dose of l-thyroxine with small but supraphysiologic doses of liothyronine in hypothyroid patients has yielded conflicting results...
  17. ncbi request reprint Macroprolactinemia in women presenting with hyperandrogenic symptoms: Implications for the management of polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 82:1697-9. 2004
    ....
  18. doi request reprint Role of androgen-mediated enhancement of erythropoiesis in the increased body iron stores of patients with polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Fertil Steril 95:1730-5.e1. 2011
    ....
  19. ncbi request reprint Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses
    Manuel Luque-Ramírez
    Department of Endocrinology and Molecular Genetics, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Diabetes Care 30:2309-13. 2007
    ....
  20. ncbi request reprint Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women
    Rosa M Calvo
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 77:666-8. 2002
    ..To determine if the insulin gene variable number of tandem repeats (VNTR) regulatory polymorphism is associated with hyperandrogenism in a population of Spanish women...
  21. ncbi request reprint Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity
    Jose L San Millan
    Department of Molecular Genetics, Hospital Ramon y Cajal, 28034 Madrid, Spain
    J Clin Endocrinol Metab 89:2640-6. 2004
    ....
  22. ncbi request reprint Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1 28034 Madrid, Spain
    J Clin Endocrinol Metab 92:2453-61. 2007
    ..Oral contraceptives may worsen the metabolic profile of patients with polycystic ovary syndrome (PCOS), favoring the use of insulin sensitizers in these patients...
  23. doi request reprint Prevalence of hyperprolactinaemia in female premenopausal blood donors
    Macarena Alpañés
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Madrid, Spain
    Clin Endocrinol (Oxf) 79:545-9. 2013
    ....
  24. ncbi request reprint Common single nucleotide polymorphisms in intron 3 of the calpain-10 gene influence hirsutism
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Fertil Steril 77:581-7. 2002
    ..To study three common polymorphisms in intron 3 of the calpain-10 gene (CAPN10) in hyperandrogenic patients...
  25. doi request reprint Office blood pressure, ambulatory blood pressure monitoring, and echocardiographic abnormalities in women with polycystic ovary syndrome: role of obesity and androgen excess
    Manuel Luque-Ramírez
    Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    Hypertension 63:624-9. 2014
    ..In summary, our results show that patients with classic PCOS and weight excess frequently have undiagnosed BP abnormalities, leading to target organ damage. ..
  26. ncbi request reprint Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls
    Gemma Villuendas
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Hum Reprod 20:3184-91. 2005
    ....
  27. doi request reprint Global adiposity and thickness of intraperitoneal and mesenteric adipose tissue depots are increased in women with polycystic ovary syndrome (PCOS)
    Susana Borruel
    Diabetes, Obesity, and Human Reproduction Research Group, Universidad de Alcalá and Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Clin Endocrinol Metab 98:1254-63. 2013
    ..Sexual dimorphism suggests a role for androgens in body fat distribution. Women with polycystic ovary syndrome (PCOS), a mainly androgen excess disorder, often present with abdominal obesity and visceral adiposity...
  28. ncbi request reprint Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 89:806-11. 2004
    ..23; P < 0.03). In conclusion, PCOS and obesity induce an increase in serum IL-18 levels, which are also associated with several indexes of global and visceral adiposity and with insulin resistance...
  29. ncbi request reprint Obesity is the major determinant of the abnormalities in blood pressure found in young women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    J Clin Endocrinol Metab 92:2141-8. 2007
    ..Obesity and insulin resistance predispose patients with the polycystic ovary syndrome (PCOS) to abnormalities in blood pressure regulation...
  30. doi request reprint Serum osteoprotegerin concentrations are decreased in women with the polycystic ovary syndrome
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramón y Cajal and Universidad de Alcalá, Madrid, Spain
    Eur J Endocrinol 159:225-32. 2008
    ..Both low-grade chronic inflammation and cardiovascular risk are increased in women with the polycystic ovary syndrome (PCOS). We aimed to study serum OPG concentrations in PCOS patients...
  31. doi request reprint Sexual dimorphism in adipose tissue function as evidenced by circulating adipokine concentrations in the fasting state and after an oral glucose challenge
    Manuel Luque-Ramírez
    Diabetes, Obesity and Human Reproduction Research Group, Universidad de Alcalá and Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain
    Hum Reprod 28:1908-18. 2013
    ..Do the circulating levels of a panel of adipokines involved in glucose metabolism exhibit sexual dimorphism in the fasting state and after an oral glucose load?..
  32. pmc Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism
    M Ángeles Martínez-García
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Diabetes Care 32:1525-30. 2009
    ....
  33. ncbi request reprint Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism
    Hector F Escobar-Morreale
    Department of Endocrinology and Department of Molecular Genetics, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 100, 28034 Madrid, Spain
    Obes Res 11:987-96. 2003
    ..Genetic variability at these loci might contribute to explain the development of obesity and hyperandrogenism...
  34. doi request reprint Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal, Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1, 28034 Madrid, Spain
    Hum Reprod 23:1594-601. 2008
    ..Serum uric acid levels have emerged as a cardiovascular risk factor, and interventions aimed to decrease its level have been related with an improvement in clinical and non-clinical cardiovascular outcomes...
  35. ncbi request reprint Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with undesirable cardiovascular effects in patients with differentiated thyroid carcinoma
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Endocr Relat Cancer 11:345-56. 2004
    ....
  36. doi request reprint Role of decreased circulating hepcidin concentrations in the iron excess of women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 96:846-52. 2011
    ..Hepcidin inhibits the intestinal absorption of iron and its deficiency causes juvenile hemochromatosis...
  37. doi request reprint Proteomic analysis of plasma in the polycystic ovary syndrome identifies novel markers involved in iron metabolism, acute-phase response, and inflammation
    María Insenser
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1 Madrid E 28034, Spain
    J Clin Endocrinol Metab 95:3863-70. 2010
    ..Hypothesis-free approaches such as proteomic analysis may identify novel biomarkers for disease...
  38. ncbi request reprint Mediators of low-grade chronic inflammation in polycystic ovary syndrome (PCOS)
    Miriam Ojeda-Ojeda
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcalá and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, E 28034 Madrid, Spain
    Curr Pharm Des 19:5775-91. 2013
    ..In the future, strategies ameliorating inflammation may prove useful for the management of PCOS and associated conditions. ..
  39. doi request reprint The determinants of insulin sensitivity, β-cell function, and glucose tolerance are different in patients with polycystic ovary syndrome than in women who do not have hyperandrogenism
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Madrid, Spain
    Fertil Steril 94:2214-21. 2010
    ..To evaluate the pathogenetic mechanisms underlying abnormal glucose tolerance in polycystic ovary syndrome (PCOS)...
  40. doi request reprint A nontargeted proteomic study of the influence of androgen excess on human visceral and subcutaneous adipose tissue proteomes
    Rafael Montes-Nieto
    Diabetes, Obesity, and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Madrid, Spain
    J Clin Endocrinol Metab 98:E576-85. 2013
    ..Sex hormones, particularly androgens, may influence not only adipose tissue distribution but also its functions...
  41. doi request reprint Proteomic and metabolomic approaches to the study of polycystic ovary syndrome
    María Insenser
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala, E 28034 Madrid, Spain
    Mol Cell Endocrinol 370:65-77. 2013
    ..The biomolecules identified by nontargeted proteomic and metabolomic approaches should be considered as candidates in future studies aiming to define specific molecular phenotypes of PCOS...
  42. ncbi request reprint The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism
    Gemma Villuendas
    Department of Endocrinology, Hospital Ramon y Cajal, 28034 Madrid, Spain
    J Clin Endocrinol Metab 87:1134-41. 2002
    ..In conclusion, our present results suggest that the -597G-->A and -174G-->C polymorphisms in IL-6 are involved in the pathogenesis of hyperandrogenic disorders...
  43. ncbi request reprint Effects of thyroid hormones on serum levels of adipokines as studied in patients with differentiated thyroid carcinoma during thyroxine withdrawal
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Thyroid 16:397-402. 2006
    ..We aimed to study the impact of short-term overt hypothyroidism on serum leptin, resistin, and adiponectin levels in an in vivo human model...
  44. ncbi request reprint Androgen excess is associated with the increased carotid intima-media thickness observed in young women with polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal, Universidad de Alcala, Carretera de Colmenar Viejo Km 9, 1 E 28034 Madrid, Spain
    Hum Reprod 22:3197-203. 2007
    ..We evaluated carotid intima-media thickness (CIMT) as an early marker of atherosclerosis, as well as its main determinants among androgen excess, obesity and insulin resistance, in patients with polycystic ovary syndrome (PCOS)...
  45. ncbi request reprint A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome
    Jose L San Millan
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 90:4157-62. 2005
    ....
  46. ncbi request reprint The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women
    Jose L San Millan
    Department of Molecular Genetics, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Hum Reprod 21:3157-61. 2006
    ..Because serum paraoxonase activity is influenced by the -108C/T polymorphism in the PON1 gene, we studied its involvement in the decreased paraoxonase activity recently described in the polycystic ovary syndrome (PCOS)...
  47. doi request reprint Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: influence of obesity and smoking
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Eur J Endocrinol 160:469-80. 2009
    ..To study the blood clotting tests and endothelial function of polycystic ovary syndrome (PCOS) patients and non-hyperandrogenic women, and their changes during PCOS treatment, as a function of the presence of obesity and smoking...
  48. doi request reprint Proteomic analysis of visceral adipose tissue in pre-obese patients with type 2 diabetes
    Mora Murri
    Diabetes, Obesity and Human Reproduction Group, Hospital Universitario Ramon y Cajal, Universidad de Alcala, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain
    Mol Cell Endocrinol 376:99-106. 2013
    ..Hence, the proteins identified here could be considered candidate molecules in future studies addressing the role that VAT dysfunction plays in the development of type 2 diabetes. ..
  49. doi request reprint Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 expression
    Mora Murri
    or Héctor F Escobar Morreale, Department of Endocrinology and Nutrition, Hospital Universitario Ramon y Cajal, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 98:E1835-44. 2013
    ..miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 have been associated with metabolic disorders such as obesity and diabetes, which are also associated with polycystic ovary syndrome (PCOS)...
  50. doi request reprint Evidence for masculinization of adipokine gene expression in visceral and subcutaneous adipose tissue of obese women with polycystic ovary syndrome (PCOS)
    M Ángeles Martínez-García
    Diabetes, Obesity and Human Reproduction Research Group, Universidad de Alcala, Madrid, Spain
    J Clin Endocrinol Metab 98:E388-96. 2013
    ..Sex hormones, particularly androgens, may influence not only adipose tissue distribution but also its functions. Objective: We explored the possibility of sexual dimorphism in adipose tissue and skeletal muscle function...
  51. ncbi request reprint Improved resolution of the human adipose tissue proteome at alkaline and wide range pH by the addition of hydroxyethyl disulfide
    Marta Corton
    Instituto de Investigaciones Biomedicas, CSIC UAM, Madrid, Spain
    Proteomics 4:438-41. 2004
    ..This information will aid studies on metabolic diseases such as polycystic ovary syndrome, obesity, hypertension and type 2 diabetes...
  52. ncbi request reprint Thyroid hormone deficiency and postmenopausal status independently increase serum osteoprotegerin concentrations in women
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramon y Cajal and University of Alcala, Madrid, Spain
    Eur J Endocrinol 156:539-45. 2007
    ..Serum thyroid hormones, urinary bone markers and serum osteoprotegerin concentrations were measured. Statistical methods included repeated measures analysis of variance and one-way analysis of variance...
  53. ncbi request reprint Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women
    Francisco Alvarez-Blasco
    Departments of Endocrinology, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Arch Intern Med 166:2081-6. 2006
    ..We conducted the present study to obtain an unbiased estimate of the prevalence of PCOS in unselected overweight and obese premenopausal women from Spain...
  54. ncbi request reprint The effects of thyroid hormones on circulating markers of cell-mediated immune response, as studied in patients with differentiated thyroid carcinoma before and during thyroxine withdrawal
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Endocrinol 153:223-30. 2005
    ..To address the influence of thyroid hormones on circulating markers of cell-mediated immune response in an in vivo human model...
  55. doi request reprint Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women
    M Ángeles Martínez-García
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Madrid E 28034, Spain
    Hum Reprod 27:3569-76. 2012
    ..Is there an association between polycystic ovary syndrome (PCOS) and the sex hormone-binding globulin (SHBG) rs1799941, rs6257, rs6259 and rs727428 variants in a large series of Mediterranean women?..
  56. doi request reprint Prevalence of functional disorders of androgen excess in unselected premenopausal women: a study in blood donors
    Raul Sanchón
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Madrid E 28034, Spain
    Hum Reprod 27:1209-16. 2012
    ..We aimed to obtain an unbiased estimate of the prevalence in premenopausal women of (i) signs of androgen excess and (ii) PCOS, idiopathic hyperandrogenism and idiopathic hirsutism...
  57. doi request reprint Antiandrogenic contraceptives increase serum adiponectin in obese polycystic ovary syndrome patients
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Obesity (Silver Spring) 17:3-9. 2009
    ....
  58. doi request reprint Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease
    José I Botella-Carretero
    Unit of Obesity Surgery, Department of Endocrinology and Nutrition, Hospital Universitario Ramon y Cajal, Carretera de Colmenar Km 9 1, 28034 Madrid, Spain
    Obes Surg 20:69-76. 2010
    ....
  59. doi request reprint Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis
    Mora Murri
    Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Hum Reprod Update 19:268-88. 2013
    ..CONCLUSIONS Circulating markers of oxidative stress are abnormal in women with PCOS independent of weight excess. This finding suggests that oxidative stress may participate in the pathophysiology of this common disorder...
  60. doi request reprint The increase in serum visfatin after bariatric surgery in morbidly obese women is modulated by weight loss, waist circumference, and presence or absence of diabetes before surgery
    José I Botella-Carretero
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Km 9 1, Madrid, Spain
    Obes Surg 18:1000-6. 2008
    ..Previous studies addressing the changes in serum visfatin levels after bariatric surgery yielded conflicting results...
  61. ncbi request reprint Genetic basis of metabolic abnormalities in polycystic ovary syndrome: implications for therapy
    Belen Roldan
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Am J Pharmacogenomics 4:93-107. 2004
    ..In the future, new therapeutic approaches to PCOS will rely on knowing the genes, environmental influences, and etiologic mechanisms associated with the disorder...
  62. ncbi request reprint Genomic variants in polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    Clin Chim Acta 366:14-26. 2006
    ....
  63. ncbi request reprint Hyperandrogenism, insulin resistance and hyperinsulinemia as cardiovascular risk factors in diabetes mellitus
    Gema García-Romero
    Department of Endocrinology, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Curr Diabetes Rev 2:39-49. 2006
    ....
  64. ncbi request reprint The decrease in serum IL-18 levels after bariatric surgery in morbidly obese women is a time-dependent event
    José I Botella-Carretero
    Department of Endocrinology, Hospital Ramón y Cajal and Universidad de Alcalá, Madrid, Spain
    Obes Surg 17:1199-208. 2007
    ....
  65. ncbi request reprint Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity
    José I Botella-Carretero
    Department of Clinical Nutrition, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Clin Nutr 26:573-80. 2007
    ..However, it is not known whether this possible association of vitamin D deficiency with the metabolic syndrome is still present at very high degrees of obesity, as in morbidly obese patients...
  66. ncbi request reprint REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Clin Endocrinol Metab 90:4946-54. 2005
    ....
  67. doi request reprint A nontargeted proteomic approach to the study of visceral and subcutaneous adipose tissue in human obesity
    María Insenser
    Diabetes, Obesity and Human Reproduction Group, Universidad de Alcalá and Hospital Universitario Ramon y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain
    Mol Cell Endocrinol 363:10-9. 2012
    ..Our nontargeted proteomic approach identified novel protein species that may be involved in the development of obesity in humans...
  68. ncbi request reprint The ACAA-insertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance
    Gemma Villuendas
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Km 9 1, Madrid E 28034, Spain
    Eur J Endocrinol 155:331-6. 2006
    ..In the present study conducted in Spaniards, we tested a common polymorphism in IGFIIR for association with type 2 diabetes and insulin-resistant traits...
  69. doi request reprint Obesity impairs general health-related quality of life (HR-QoL) in premenopausal women to a greater extent than polycystic ovary syndrome (PCOS)
    Francisco Alvarez-Blasco
    Department of Endocrinology, Hospital Universitario Ramon y Cajal, Universidad de Alcala, and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, E 28034, Madrid, Spain
    Clin Endocrinol (Oxf) 73:595-601. 2010
    ..We aimed to estimate the relative impact of obesity and PCOS on the general HR-QoL of premenopausal women...
  70. ncbi request reprint Impact of the storage temperature on human plasma proteomic analysis: implications for the use of human plasma collections in research
    María Insenser
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Spain
    Proteomics Clin Appl 4:739-44. 2010
    ..To analyze the impact of storage temperature on the 2D-DIGE profile of human plasma...
  71. doi request reprint Management of postmenopausal virilization
    Macarena Alpañés
    University of Alcalá and Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 97:2584-8. 2012
    ....
  72. doi request reprint Diet composition and physical activity in overweight and obese premenopausal women with or without polycystic ovary syndrome
    Francisco Alvarez-Blasco
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Madrid, E 28034, Spain
    Gynecol Endocrinol 27:978-81. 2011
    ..In conclusion, diet composition and physical activity were apparently not decisive for the development of PCOS among overweight and obese premenopausal women...
  73. doi request reprint The role of genetic variation in peroxisome proliferator-activated receptors in the polycystic ovary syndrome (PCOS): an original case-control study followed by systematic review and meta-analysis of existing evidence
    Jose L San-Millan
    Department of Molecular Genetics, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Clin Endocrinol (Oxf) 72:383-92. 2010
    ..To study the association of polymorphisms in the genes encoding peroxisome proliferator-activated receptors (PPARs) with the polycystic ovary syndrome (PCOS)...
  74. doi request reprint Effects of metformin versus ethinyl-estradiol plus cyproterone acetate on ambulatory blood pressure monitoring and carotid intima media thickness in women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Madrid, Spain
    Fertil Steril 91:2527-36. 2009
    ..To compare the effects of metformin versus an antiandrogenic contraceptive pill on ambulatory blood pressure monitoring (ABPM) and carotid intima media thickness (CIMT) in women with polycystic ovary syndrome (PCOS)...