J M Fernández-Real Lemos

Summary

Affiliation: Endocrinology and Nutrition
Country: Spain

Publications

  1. ncbi G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Hypertension 41:124-9. 2003
  2. ncbi The fat-free mass compartment influences serum leptin in men
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Girona, Hormonal Laboratory, University Hospital Clinic, Barcelona, Spain
    Eur J Endocrinol 142:25-9. 2000
  3. ncbi [Ponderal evolution in the Girona population, 1989-1999]
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, Hospital Universitari de Girona, Dr Josep Trueta, Girona, Spain
    Rev Clin Esp 203:57-63. 2003
  4. ncbi Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes Care 25:2249-55. 2002
  5. ncbi Cross-talk between iron metabolism and diabetes
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes 51:2348-54. 2002
  6. ncbi [Insulin resistance and evolution]
    J M Fernández-Real Lemos
    Unidad de Diabetes, Endocrinología y Nutrición UDEN, Hospital Universitario de Girona Dr Josep Trueta, Girona, Espana
    Nutr Hosp 17:60-6. 2002
  7. ncbi Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes 51:1000-4. 2002
  8. ncbi Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
    Am J Physiol Endocrinol Metab 282:E952-9. 2002
  9. ncbi [Body mass index (BMI) and percent fat mass. A BMI > 27.5 kg/m2 could be indicative of obesity in the Spanish population]
    J M Fernandez-Real
    Unidad de Diabetes, Endocrinología y Nutrición, Hospital Universitario de Girona, Laboratori Hormonal, Hospital Clinic i Provincial, Barcelona, Spain
    Med Clin (Barc) 117:681-4. 2001
  10. ncbi Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    J Clin Endocrinol Metab 85:1334-9. 2000

Collaborators

Detail Information

Publications19

  1. ncbi G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Hypertension 41:124-9. 2003
    ..The GNB3 gene polymorphism might be an example of pharmacogenetics, with the underlying etiological genetic defect altering the response to treatment...
  2. ncbi The fat-free mass compartment influences serum leptin in men
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Girona, Hormonal Laboratory, University Hospital Clinic, Barcelona, Spain
    Eur J Endocrinol 142:25-9. 2000
    ..As this latter tissue is the main target for insulin-estimulated glucose disposal, we hypothesized that the muscular and fat-free mass (FFM) compartments might influence serum leptin levels in humans through increased insulin resistance...
  3. ncbi [Ponderal evolution in the Girona population, 1989-1999]
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, Hospital Universitari de Girona, Dr Josep Trueta, Girona, Spain
    Rev Clin Esp 203:57-63. 2003
    ..The objective of the present paper was to determine the modifications in the different degrees of body adiposity in a population in Catalunya...
  4. ncbi Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes Care 25:2249-55. 2002
    ..We tested the hypothesis that decreasing circulating iron stores might improve vascular dysfunction in patients with type 2 diabetes and increased serum ferritin concentration...
  5. ncbi Cross-talk between iron metabolism and diabetes
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes 51:2348-54. 2002
    ..The study of individual susceptibility and of the mechanisms that influence tissue iron deposition and damage are proposed to be valuable in anticipating and treating diabetes complications...
  6. ncbi [Insulin resistance and evolution]
    J M Fernández-Real Lemos
    Unidad de Diabetes, Endocrinología y Nutrición UDEN, Hospital Universitario de Girona Dr Josep Trueta, Girona, Espana
    Nutr Hosp 17:60-6. 2002
    ..It is contended that these changes constitute examples of good adaptation to the environment or poor concordance between our current lifestyle and our genome...
  7. ncbi Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes 51:1000-4. 2002
    ..The mechanisms for improvement in peripheral insulin sensitivity after blood letting should be investigated further...
  8. ncbi Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
    Am J Physiol Endocrinol Metab 282:E952-9. 2002
    ..Our findings suggest that insulin resistance and blood pressure are linked to altered shedding of TNF-alpha receptors in DM-2. The latter seems reversible and is not genetically determined...
  9. ncbi [Body mass index (BMI) and percent fat mass. A BMI > 27.5 kg/m2 could be indicative of obesity in the Spanish population]
    J M Fernandez-Real
    Unidad de Diabetes, Endocrinología y Nutrición, Hospital Universitario de Girona, Laboratori Hormonal, Hospital Clinic i Provincial, Barcelona, Spain
    Med Clin (Barc) 117:681-4. 2001
    ..However, the relation between BMI and PFM is not uniform among populations. It is important to define in each population the threshold of BMI which corresponds to the definition of obesity...
  10. ncbi Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    J Clin Endocrinol Metab 85:1334-9. 2000
    ..Whether this polymorphism contributes to lipid alterations associated with other metabolic disorders awaits additional studies...
  11. ncbi Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients
    J M Fernandez-Real
    Diabetes Unit, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Barcelona, Spain
    Diabetes Care 23:831-7. 2000
    ..The purpose of this study was to evaluate a polymorphism in the 3' untranslated region of the TNFR2 gene on chromosome 1 in relation to BMI, leptin levels, and insulin resistance...
  12. ncbi Interleukin-6 gene polymorphism and insulin sensitivity
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    Diabetes 49:517-20. 2000
    ..6+/-2.9 vs. 37.6+/-4.6 mg/l, P = 0.03). In summary, a polymorphism of the IL-6 gene influences the relationship among insulin sensitivity, postload glucose levels, and peripheral white blood cell count...
  13. ncbi Plasma soluble tumor necrosis factor-alpha receptors circulate in proportion to leptin levels during the menstrual cycle in lean but not in obese women
    J M Fernandez-Real
    Unitat de Diabetes, Endocrinologia i Nutricio, Hospital Universitario de Girona Dr Josep Trueta, Girona, Spain
    Eur J Endocrinol 143:235-41. 2000
    ..As TNF-alpha appears to regulate leptin secretion, we speculated that TNF-alpha might be involved in leptin variations during the menstrual cycle...
  14. ncbi [Analysis of mutations A3243G, C3256T and mitochondrial deletions in 41 diabetic patients]
    J Biarnésa
    Departamento de Genética Médica y Molecular IRO Hospital Duran i Reynals Barcelona
    Med Clin (Barc) 116:292-3. 2001
    ..Mutations or deletions of mitochondrial DNA (mtDNA) define a new diabetes subtype...
  15. ncbi No decrease in free IGF-I with increasing insulin in obesity-related insulin resistance
    W Ricart
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona, Spain
    Obes Res 9:631-6. 2001
    ..This study was undertaken to evaluate the effects of acute changes in plasma glucose and insulin levels on free IGF-I and IGFBP-1 in obese and non-obese subjects...
  16. ncbi CD14 monocyte receptor, involved in the inflammatory cascade, and insulin sensitivity
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 88:1780-4. 2003
    ..To our knowledge, this is the first study to suggest an effect of a genetic polymorphism on both SI (healthy subjects and type 2 diabetic patients) and endothelial dysfunction (sICAM-1 levels) in type 2 diabetes mellitus...
  17. ncbi Circulating soluble CD14 monocyte receptor is associated with increased alanine aminotransferase
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Chem 50:1456-8. 2004
  18. ncbi Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome
    Eduardo Esteve
    Department of Endocrinology, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Endocrinol (Oxf) 65:88-91. 2006
    ....