Jose Manuel Fernandez-Real

Summary

Affiliation: Endocrinology and Nutrition
Country: Spain

Publications

  1. ncbi request reprint Burden of infection and fat mass in healthy middle-aged men
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Avinguda de França s n, 17007 Girona, Spain
    Obesity (Silver Spring) 15:245-52. 2007
  2. pmc Back to past leeches: repeated phlebotomies and cardiovascular risk
    Melania Manco
    Bambino Gesu Children s Hospital and Research Institute, Research Unit for Multifactorial Disease, Rome, Italy
    BMC Med 10:53. 2012
  3. ncbi request reprint Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology and Nutrition Research Unit, Dr Josep Trueta University Hospital of Girona, Carretera de Francia s n, 17007 Girona, Spain
    Metabolism 54:584-9. 2005
  4. ncbi request reprint Circulating soluble transferrin receptor according to glucose tolerance status and insulin sensitivity
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Girona, Spain
    Diabetes Care 30:604-8. 2007
  5. ncbi request reprint Iron stores, blood donation, and insulin sensitivity and secretion
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Chem 51:1201-5. 2005
  6. ncbi request reprint Opposite relationship between circulating soluble CD14 concentration and endothelial function in diabetic and nondiabetic subjects
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio and Servei de Medicina Interna, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Thromb Haemost 94:615-9. 2005
  7. pmc Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology, and Nutrition Unit, Dr Josep Trueta Hospital, Girona Institute for Biomedical Research, Girona, Spain
    Diabetes 57:1918-25. 2008
  8. ncbi request reprint Genetic predispositions to low-grade inflammation and type 2 diabetes
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes Technol Ther 8:55-66. 2006
  9. ncbi request reprint Burden of infection and insulin resistance in healthy middle-aged men
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Avinguda de França s n, 17007 Girona, Spain
    Diabetes Care 29:1058-64. 2006
  10. ncbi request reprint An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    Eur J Endocrinol 154:723-30. 2006

Detail Information

Publications79

  1. ncbi request reprint Burden of infection and fat mass in healthy middle-aged men
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Avinguda de França s n, 17007 Girona, Spain
    Obesity (Silver Spring) 15:245-52. 2007
    ..Our aim was to study the effect of exposure to four infections on fat mass...
  2. pmc Back to past leeches: repeated phlebotomies and cardiovascular risk
    Melania Manco
    Bambino Gesu Children s Hospital and Research Institute, Research Unit for Multifactorial Disease, Rome, Italy
    BMC Med 10:53. 2012
    ..Please see related article: http://www.biomedcentral.com/1741-7015/10/54...
  3. ncbi request reprint Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology and Nutrition Research Unit, Dr Josep Trueta University Hospital of Girona, Carretera de Francia s n, 17007 Girona, Spain
    Metabolism 54:584-9. 2005
    ..In summary, circulating adiponectin, CBG concentration, and fasting cortisol were significantly interrelated in healthy subjects. A significant sexual dimorphism exists in this association...
  4. ncbi request reprint Circulating soluble transferrin receptor according to glucose tolerance status and insulin sensitivity
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Girona, Spain
    Diabetes Care 30:604-8. 2007
    ..The mechanisms of these interactions depend on poorly known factors. We aimed to study the contribution of the serum soluble transferrin receptor (sTfR)...
  5. ncbi request reprint Iron stores, blood donation, and insulin sensitivity and secretion
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Chem 51:1201-5. 2005
    ..Epidemiologists have observed that blood donation is associated with decreased risk of type 2 diabetes and cardiovascular disease...
  6. ncbi request reprint Opposite relationship between circulating soluble CD14 concentration and endothelial function in diabetic and nondiabetic subjects
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio and Servei de Medicina Interna, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Thromb Haemost 94:615-9. 2005
    ..While in non-diabetic subjects sCD14 behaves as an acute phase reactant, its role in type 2 diabetic patients should be further clarified. These findings need to be confirmed in further studies with larger number of patients...
  7. pmc Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology, and Nutrition Unit, Dr Josep Trueta Hospital, Girona Institute for Biomedical Research, Girona, Spain
    Diabetes 57:1918-25. 2008
    ..An interaction between iron and vitamin A status, of which RBP4 is a surrogate, has long been recognized. We hypothesized that iron-associated insulin resistance could be behind the impaired insulin action caused by RBP4...
  8. ncbi request reprint Genetic predispositions to low-grade inflammation and type 2 diabetes
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes Technol Ther 8:55-66. 2006
    ..would lead in westernized countries to chronic inflammation conditions, such as obesity and type 2 diabetes, resulting in cardiovascular disease...
  9. ncbi request reprint Burden of infection and insulin resistance in healthy middle-aged men
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Avinguda de França s n, 17007 Girona, Spain
    Diabetes Care 29:1058-64. 2006
    ..We aimed to study the effect of exposure to four infections on insulin sensitivity in apparently healthy middle-aged men (n = 124)...
  10. ncbi request reprint An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    Eur J Endocrinol 154:723-30. 2006
    ..We aimed to evaluate whether this circulating DS-TNFR2 is associated with insulin action in humans...
  11. ncbi request reprint Thyroid function is intrinsically linked to insulin sensitivity and endothelium-dependent vasodilation in healthy euthyroid subjects
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology, and Nutrition, Hospital de Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    J Clin Endocrinol Metab 91:3337-43. 2006
    ..Levels of TSH respond to fluctuations in serum free T(4) (fT(4)) but remain in a very narrow individual range. There exists current controversy regarding the upper limit of normal serum TSH values above which treatment should be indicated...
  12. doi request reprint Circulating surfactant protein A (SP-A), a marker of lung injury, is associated with insulin resistance
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona and CIBER Fisiopatología de la Obesidad y Nutrición, Girona, Spain
    Diabetes Care 31:958-63. 2008
    ..We hypothesized that circulating levels of surfactant protein (SP)-A, which reflects interstitial lung injury, could be associated with altered glucose tolerance and insulin resistance...
  13. ncbi request reprint Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin
    J M Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Carretera de França s n, 17007, Girona, Spain
    Diabetologia 49:2402-11. 2006
    ..Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance...
  14. ncbi request reprint An alternatively spliced soluble TNF-alpha receptor is associated with metabolic disorders: a replication study
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    Clin Immunol 121:236-41. 2006
    ..96+/-2.2 versus 1.7+/-3.2, p=0.033). In summary, the circulating concentration of DS-TNFR2 seems to be inversely linked to metabolic disorders, hinting at a possible anti-inflammatory role...
  15. ncbi request reprint Innate immunity, insulin resistance and type 2 diabetes
    Jose Manuel Fernandez-Real
    University Hospital of Girona Dr Josep Trueta and CIBER Fisiopatología de la Obesidad CB06 03 010 17007 Girona, Spain
    Trends Endocrinol Metab 19:10-6. 2008
    ..The common characteristics shared among innate immunity activation, obesity and insulin resistance are summarized...
  16. ncbi request reprint Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    Diabetes Care 30:616-21. 2007
    ..Despite the coincidence of visfatin expression in iron-rich tissues, no study has investigated the possible interaction of visfatin with parameters of iron metabolism...
  17. doi request reprint Salicylates increase insulin secretion in healthy obese subjects
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona, Avinguda de França s n, Girona, Spain
    J Clin Endocrinol Metab 93:2523-30. 2008
    ..Conflicting results on the effects of salicylates on glucose tolerance in subjects with normal glucose tolerance or type 2 diabetes have been reported...
  18. ncbi request reprint Circulating adiponectin and plasma fatty acid profile
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Chem 51:603-9. 2005
    ..Knowledge of the possible influence of dietary habits on circulating adiponectin, a molecule with putative antiinflammatory properties, may be helpful in preventing atherosclerosis and type 2 diabetes...
  19. ncbi request reprint CD14 monocyte receptor, involved in the inflammatory cascade, and insulin sensitivity
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 88:1780-4. 2003
    ..To our knowledge, this is the first study to suggest an effect of a genetic polymorphism on both SI (healthy subjects and type 2 diabetic patients) and endothelial dysfunction (sICAM-1 levels) in type 2 diabetes mellitus...
  20. ncbi request reprint Insulin resistance, inflammation, and serum fatty acid composition
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    Diabetes Care 26:1362-8. 2003
    ..However, the relation among insulin resistance, obesity, inflammatory activity (circulating interleukin [IL]-6) and dietary FAs has been scarcely studied in otherwise healthy subjects...
  21. ncbi request reprint Insulin resistance and chronic cardiovascular inflammatory syndrome
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, 17007 Girona, Spain
    Endocr Rev 24:278-301. 2003
    ..The effective administration of antiinflammatory agents in the treatment of insulin resistance and atherosclerosis is only the beginning of a promising approach in the management of these syndromes...
  22. ncbi request reprint Novel interactions of adiponectin with the endocrine system and inflammatory parameters
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, Department of Internal Medicine, University Hospital of Girona Dr Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 88:2714-8. 2003
    ....
  23. ncbi request reprint Adiponectin is independently associated with glycosylated haemoglobin
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Eur J Endocrinol 150:201-5. 2004
    ..In humans, adiponectin has been demonstrated to circulate in inverse proportion to the degree of insulin resistance...
  24. ncbi request reprint Adiponectin is associated with vascular function independent of insulin sensitivity
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio and Servei de Medicina Interna, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes Care 27:739-45. 2004
    ..Because adiponectin appears to influence both insulin sensitivity and vessel wall physiology, we examined insulin sensitivity and vascular function in relation with circulating adiponectin...
  25. doi request reprint Circulating soluble CD36 is a novel marker of liver injury in subjects with altered glucose tolerance
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, Hospital of Girona Dr Josep Trueta, Girona, Spain
    J Nutr Biochem 20:477-84. 2009
    ..The correlation between ALT activity and sCD36 was confirmed in an independent, replication study. In summary, circulating sCD36 could represent a novel marker of liver injury in subjects with altered glucose tolerance...
  26. doi request reprint The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training
    Jose Manuel Fernandez-Real
    Department of Diabetes, Institut d Investigació Biomédica de Girona, CIBER Fisiopatología de la Obesidad y Nutrición CB06 03 010, 17007 Girona, Catalonia, Spain
    J Clin Endocrinol Metab 94:237-45. 2009
    ..Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models...
  27. ncbi request reprint Circulating soluble CD14 monocyte receptor is associated with increased alanine aminotransferase
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Chem 50:1456-8. 2004
  28. doi request reprint Circulating omentin as a novel biomarker of endothelial dysfunction
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition Institut d Investigació Biomédica de Girona, CIBER Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Spain
    Obesity (Silver Spring) 19:1552-9. 2011
    ..In NGT subjects, only circulating omentin concentration (P = 0.01) was significantly associated with EDV. In conclusion, circulating omentin concentration could be a useful marker of endothelial function...
  29. ncbi request reprint Serum corticosteroid-binding globulin concentration and insulin resistance syndrome: a population study
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, Dr Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 87:4686-90. 2002
    ....
  30. ncbi request reprint Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
    Am J Physiol Endocrinol Metab 282:E952-9. 2002
    ..Our findings suggest that insulin resistance and blood pressure are linked to altered shedding of TNF-alpha receptors in DM-2. The latter seems reversible and is not genetically determined...
  31. ncbi request reprint Potential role of interleukin-18 in liver disease associated with insulin resistance
    Abel Lopez-Bermejo
    Unit of Diabetes, Endocrinology, and Nutrition, Dr Josep Trueta Hospital, Av Francia s n, 17007 Girona, Spain
    Obes Res 13:1925-31. 2005
    ..We hypothesized that circulating IL-18 would be related to serum concentrations of liver chemistry tests (LCTs) in apparently healthy subjects and wished to study whether this correlation was dependent on insulin sensitivity (S(I))...
  32. doi request reprint Circulating bactericidal/permeability-increasing protein (BPI) is associated with serum lipids and endothelial function
    Eduardo Esteve
    Section of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Girona, Spain
    Thromb Haemost 103:780-7. 2010
    ..In conclusion, circulating BPI could constitute a biomarker of lipid metabolism in subjects with normal glucose tolerance and could help to identify those subjects with preserved endothelial function...
  33. ncbi request reprint Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status
    José María Moreno-Navarrete
    Unit of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, and CIBER Fisiopatologia Obesidad y Nutricion CB06 03 010, Instituto de Salud Carlos III, Girona, Spain
    Clin Chem 54:301-9. 2008
    ..We investigated the relationship between circulating lactoferrin, lactoferrin gene (LTF, lactotransferrin) polymorphisms, dyslipidemia, and vascular reactivity in the context of glucose-tolerance status in men...
  34. ncbi request reprint Adiponectin, hepatocellular dysfunction and insulin sensitivity
    Abel Lopez-Bermejo
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Endocrinol (Oxf) 60:256-63. 2004
    ....
  35. pmc Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institutd Investigació Biomédica de Girona, CIBERobn Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Catalonia, Spain
    Diabetes 59:1506-11. 2010
    ..The aim of this study was to determine whether circulating FASN could be a biomarker of overnutrition-induced metabolic stress and insulin resistance in common metabolic disorders...
  36. ncbi request reprint Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity
    Eduardo Esteve
    Unit of Diabetes, Endocrinology, and Nutrition, Department of Internal Medicine, Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes Care 30:939-45. 2007
    ..We aimed to evaluate whether increased serum IL-6 concentrations associated with endothelial dysfunction are independent of insulin sensitivity in apparently healthy men...
  37. doi request reprint Study of lactoferrin gene expression in human and mouse adipose tissue, human preadipocytes and mouse 3T3-L1 fibroblasts. Association with adipogenic and inflammatory markers
    José María Moreno-Navarrete
    Service of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBEROBN, CB06 03 010 and Instituto de Salud Carlos III, 17007 Girona, Spain
    J Nutr Biochem 24:1266-75. 2013
    ....
  38. ncbi request reprint Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes 51:1000-4. 2002
    ..The mechanisms for improvement in peripheral insulin sensitivity after blood letting should be investigated further...
  39. ncbi request reprint Sex-specific, independent associations of insulin resistance with erythrocyte sedimentation rate in apparently healthy subjects
    Abel Lopez-Bermejo
    Unit of Diabetes, Endocrinology and Nutrition, Dr Josep Trueta Hospital, Av Francia s n, 17007 Girona, Spain
    Thromb Haemost 97:240-4. 2007
    ..In conclusion, ESR is independently associated with either insulin resistance or obesity in a sex-specific manner. These findings contribute to explain the known relationship of this inflammatory marker with cardiovascular disease...
  40. pmc Complement factor H is expressed in adipose tissue in association with insulin resistance
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, and CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Girona, Spain
    Diabetes 59:200-9. 2010
    ..Our objective was to study the associations between circulating and adipose tissue gene expressions of CFH and complement factor B (fB; CFB) with obesity and insulin resistance...
  41. ncbi request reprint G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Hypertension 41:124-9. 2003
    ..The GNB3 gene polymorphism might be an example of pharmacogenetics, with the underlying etiological genetic defect altering the response to treatment...
  42. ncbi request reprint Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome
    Eduardo Esteve
    Department of Endocrinology, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Endocrinol (Oxf) 65:88-91. 2006
    ....
  43. pmc Surfactant protein d, a marker of lung innate immunity, is positively associated with insulin sensitivity
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomèdica deGirona, Girona, Spain
    Diabetes Care 33:847-53. 2010
    ..We aimed to evaluate whether surfactant protein D (SP-D), a lung-derived innate immune protein, was behind these associations...
  44. pmc Real-time glucose estimation algorithm for continuous glucose monitoring using autoregressive models
    Yenny Leal
    Institute of Informatics and Applications, University of Girona, Girona, Spain
    J Diabetes Sci Technol 4:391-403. 2010
    ..A new algorithm is presented here aimed at improving the measurement accuracy and hypoglycemia detection. Its core is the estimation of blood glucose (BG) in real time (RT) from CGM intensity readings using autoregressive (AR) models...
  45. ncbi request reprint A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigacio Biomedica de Girona IdIBGi, Hospital Universitari Dr Josep Trueta, Carretera de França s n, 17007, Girona, Spain
    Diabetologia 56:2524-37. 2013
    ..Circulating lipopolysaccharide-binding protein (LBP) is an acute-phase reactant known to be increased in obesity. We hypothesised that LBP is produced by adipose tissue (AT) in association with obesity...
  46. ncbi request reprint Soluble TNF-alpha receptor 2 produced by alternative splicing is paradoxically associated with markers of liver injury
    Eduardo Esteve
    Unit of Diabetes, Endocrinology and Nutrition, Hospital de Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    Clin Immunol 123:89-94. 2007
    ..These results suggest potential anti-inflammatory properties of this TNF-alpha receptor 2 isoform at the hepatic level...
  47. doi request reprint Serum and urinary concentrations of calprotectin as markers of insulin resistance and type 2 diabetes
    Francisco J Ortega
    Department of Diabetes, Endocrinology and Nutrition UDEN, Institut d Investigacio Biomedica de Girona IdIBGi, CIBER de la Fisiopatología de la Obesidad y la Nutrición CIBERobn, CB06 03 0010 and Instituto de Salud Carlos III ISCIII, Girona, Spain
    Eur J Endocrinol 167:569-78. 2012
    ..The main aim of this study was to determine whether calprotectins in plasma and urine are associated with insulin resistance...
  48. doi request reprint Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss
    Monica Sabater
    Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona, Instituto de Salud Carlos III, Girona, Spain
    J Clin Endocrinol Metab 95:4720-8. 2010
    ..We aimed to study circulating pigment epithelium-derived factor (PEDF) in vivo in association with insulin resistance and in vitro in human adipocytes...
  49. ncbi request reprint Both intrauterine growth restriction and postnatal growth influence childhood serum concentrations of adiponectin
    Abel Lopez-Bermejo
    Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital of Girona, Girona, Spain
    Clin Endocrinol (Oxf) 61:339-46. 2004
    ..We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA)...
  50. ncbi request reprint Serum visfatin increases with progressive beta-cell deterioration
    Abel Lopez-Bermejo
    Diabetes, Endocrinology and Nutrition, Dr Josep Trueta Hospital, Av Francia s n, 17007 Girona, Spain
    Diabetes 55:2871-5. 2006
    ..In summary, circulating visfatin is increased with progressive beta-cell deterioration. The study of the regulation and role of visfatin in diabetes merits further consideration...
  51. ncbi request reprint Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability-increasing protein
    Carme Gubern
    Unit of Diabetes, Endocrinology and Nutrition, Hospital de Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    Diabetes 55:216-24. 2006
    ..These findings suggest that this component of the innate immune system is associated with metabolic pathways...
  52. ncbi request reprint Insulin resistance is associated with increased serum concentration of IGF-binding protein-related protein 1 (IGFBP-rP1/MAC25)
    Abel Lopez-Bermejo
    Unit of Diabetes, Endocrinology and Nutrition, Dr Josep Trueta Hospital, Av Francia s n, 17007 Girona, Spain
    Diabetes 55:2333-9. 2006
    ..These findings show for the first time that circulating IGFBP-rP1 is increased with insulin resistance, and they also suggest novel interactions between IGFBP-rP1 and the IGF system in humans...
  53. doi request reprint Phosphorylated S6K1 (Thr389) is a molecular adipose tissue marker of altered glucose tolerance
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigacio Biomedica de Girona IdIBGi, CIBEROBN Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III ISCIII, 17007, Girona, Spain
    J Nutr Biochem 24:32-8. 2013
    ..In conclusion, in human and rat adipose tissue, phosphorylated S6K1 is a marker for increased glucose levels...
  54. doi request reprint Decreased STAMP2 expression in association with visceral adipose tissue dysfunction
    José María Moreno-Navarrete
    Service of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona, CIBEROBN and Instituto de Salud Carlos III, 17007 Girona, Spain
    J Clin Endocrinol Metab 96:E1816-25. 2011
    ..Six-transmembrane protein of prostate 2 (STAMP2) is a counter-regulator of inflammation and insulin resistance according to findings in mice. However, there have been contradictory reports in humans...
  55. pmc OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBER Fisiopatologia de la Obesidad y Nutricion, Spain
    Diabetes 60:168-76. 2011
    ..We investigated the gene expression and protein levels of OCT-1 and OCT-2 in adipose tissue and during adipogenesis and evaluated their possible role in metformin action on adipocytes...
  56. ncbi request reprint Alpha defensins 1, 2, and 3: potential roles in dyslipidemia and vascular dysfunction in humans
    Abel Lopez-Bermejo
    Unit of Diabetes, Endocrinology, and Nutrition, Dr Josep Trueta Hospital, Av Francia s n, 17007 Girona, Spain
    Arterioscler Thromb Vasc Biol 27:1166-71. 2007
    ..We hypothesized that alpha-defensins 1 to 3 (DEFA1-3) are associated with serum lipids and vascular reactivity in humans...
  57. ncbi request reprint Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1/MAC25) is linked to endothelial-dependent vasodilation in high-ferritin type 2 diabetes
    Abel Lopez-Bermejo
    Department of Endocrinology, Dr Josep Trueta Hospital, Girona, Spain
    Diabetes Care 30:1615-7. 2007
  58. ncbi request reprint Differential regulation of insulin action and tumor necrosis factor alpha system activity by metformin
    Josefina Biarnes
    Diabetes, Endocrinology and Nutrition Unit, Hospital University Dr Josep Trueta de Girona, 17007 Girona, Spain
    Metabolism 54:235-9. 2005
    ..Tumor necrosis factor alpha has a key role in insulin resistance. We study the effects of metformin on glucose tolerance, insulin resistance, beta cell function, and soluble tumor necrosis factor receptor (sTNFR) levels...
  59. doi request reprint Proadipogenic effects of lactoferrin in human subcutaneous and visceral preadipocytes
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, CIBEROBN Fisiopatología de la Obesidad y Nutrición CB06 03 010 and Girona Biomedical Research Institute, Girona, Spain
    J Nutr Biochem 22:1143-9. 2011
    ..In conclusion, these results suggest that lactoferrin promotes adipogenesis in human adipocytes by enhancing insulin signaling and inhibiting RB1 and AMPK activities...
  60. pmc Iron and obesity status-associated insulin resistance influence circulating fibroblast-growth factor-23 concentrations
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBERobn Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Spain
    PLoS ONE 8:e58961. 2013
    ..In summary, the associations of circulating FGF-23 concentration with parameters of glucose metabolism, bone density and atherosclerosis are dependent on iron and obesity status-associated insulin resistance...
  61. ncbi request reprint Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes Care 25:2249-55. 2002
    ..We tested the hypothesis that decreasing circulating iron stores might improve vascular dysfunction in patients with type 2 diabetes and increased serum ferritin concentration...
  62. ncbi request reprint An inflammation score is better associated with basal than stimulated surrogate indexes of insulin resistance
    Mònica Recasens
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Spain
    J Clin Endocrinol Metab 90:112-6. 2005
    ..Basal rather than stimulated indexes should be used in the evaluation of therapeutic measures aimed at modifying IR-associated inflammatory activity...
  63. doi request reprint Targeting the circulating microRNA signature of obesity
    Francisco Jose Ortega
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Girona, Spain
    Clin Chem 59:781-92. 2013
    ..Circulating microRNAs (miRNAs) are valuable biomarkers of systemic diseases and potential therapeutic targets. We sought to define the circulating pattern of miRNAs in obesity and examine changes after weight loss...
  64. doi request reprint Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology, and Nutrition, Hospital of Girona Dr Josep Trueta, Girona, Spain
    J Clin Endocrinol Metab 98:E769-78. 2013
    ..Recently irisin (encoded by Fndc5 gene) has been reported to stimulate browning and uncoupling protein 1 expression in sc adipose tissue of mice...
  65. pmc CD14 modulates inflammation-driven insulin resistance
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona, Biomedical Research Institute Dr Josep Trueta and CIBERobn Fisiopatología de la Obesidad y Nutrición, Girona, Spain
    Diabetes 60:2179-86. 2011
    ..The study objective was to evaluate the possible role of the macrophage molecule CD14 in insulin resistance...
  66. pmc Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigacio Biomedica de Girona IdIBGi, CIBEROBN CB06 03 010, Girona, Spain
    PLoS ONE 7:e37160. 2012
    ..01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase...
  67. pmc The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona Catalonia, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Girona, Spain
    Diabetes 61:281-91. 2012
    ..These findings indicate that the LPI/GPR55 system is positively associated with obesity in humans...
  68. ncbi request reprint Study of circulating prohepcidin in association with insulin sensitivity and changing iron stores
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta and CIBER Fisiopatología de Obesidad y Nutrición CB06 03 010, 17007 Girona, Spain
    J Clin Endocrinol Metab 94:982-8. 2009
    ..The pathophysiology of type 2 diabetes is associated with increased iron stores. We aimed to study circulating prohepcidin in association with insulin sensitivity and parameters of glucose and iron metabolism...
  69. pmc A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology, and Nutrition Unit, Hospital Dr Josep Trueta, Carretera de França s n, 17007 Girona, Spain
    J Clin Endocrinol Metab 97:3792-8. 2012
    ..The intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans...
  70. ncbi request reprint Cross-talk between iron metabolism and diabetes
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes 51:2348-54. 2002
    ..The study of individual susceptibility and of the mechanisms that influence tissue iron deposition and damage are proposed to be valuable in anticipating and treating diabetes complications...
  71. doi request reprint The alarm secretory leukocyte protease inhibitor increases with progressive metabolic dysfunction
    Abel Lopez-Bermejo
    Pediatric Endocrinology, Dr Josep Trueta Hospital, 17007 Girona, Spain
    Clin Chim Acta 412:1122-6. 2011
    ..We hypothesized that SLPI is related to chronic low-grade inflammatory diseases, such as metabolic syndrome (MS) or type-2 diabetes (T2DM)...
  72. ncbi request reprint Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients
    Alejandro Vazquez-Martin
    Catalan Institute of Oncology, Health Services Division of Catalonia, Catalonia, Spain
    Int J Oncol 35:1369-76. 2009
    ....
  73. doi request reprint Transferrin receptor-1 gene polymorphisms are associated with type 2 diabetes
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona and CIBER Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Spain
    Eur J Clin Invest 40:600-7. 2010
    ..Transferrin receptor (TFRC) constitutes the major receptor by which most cells take up iron. The aim of this study was to evaluate whether TFRC gene polymorphisms are associated with T2D...
  74. pmc Circulating omentin concentration increases after weight loss
    José María Moreno-Navarrete
    Service of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomèdica de Girona IdIBGi Hospital Dr Josep Trueta, Girona, 17007, CIBEROBN CB06 03 010, Spain
    Nutr Metab (Lond) 7:27. 2010
    ..We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations...
  75. doi request reprint The tyrosine kinase receptor HER2 (erbB-2): from oncogenesis to adipogenesis
    Alejandro Vazquez-Martin
    Catalan Institute of Oncology ICO, Girona Biomedical Research Institute IdIBGi, Hospital Universitari de Girona Dr Josep Trueta, Girona, Catalonia, Spain
    J Cell Biochem 105:1147-52. 2008
    ..Our findings not only confirm a non-oncogenic role for HER2 in the process of adipose differentiation but further suggest that HER2 might represent a previously unrecognized target to manage obesity via the lipogenic enzyme FASN...
  76. pmc Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, CIBERobn Fisiopatología de la Obesidad y Nutrición CB06 03 010, Instituto de Salud Carlos III, 28029 Madrid, Spain
    Nutr Metab (Lond) 7:14. 2010
    ..We aimed to evaluate circulating HER-2 concentrations in association with insulin resistance in healthy and obese subjects...
  77. ncbi request reprint Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer
    Javier A Menendez
    Catalan Institute of Oncology, Girona Biomedical Research Institute, Hospital Universitari de Girona Josep Trueta, Girona, Catalonia, Spain
    Clin Chem 55:425-38. 2009
    ..An emerging paradigm supports the notion that deregulation of fatty acid synthase (FASN)-catalyzed de novo FA biogenesis could play a central role in the pathogenesis of metabolic diseases sharing the hallmark of insulin-resistance...
  78. ncbi request reprint Enhanced algorithm for glucose estimation using the continuous glucose monitoring system
    Yenny Leal
    Institute of Informatics and Applications, University of Girona, Girona, Spain
    Med Sci Monit 16:MT51-8. 2010
    ..A new calibration algorithm was developed and implemented using CGMS Gold intensity readings and capillary glucose...
  79. ncbi request reprint Study of the proinflammatory role of human differentiated omental adipocytes
    Judit Bassols
    Department of Diabetes, Endocrinology and Nutrition, Hospital of Girona Dr Josep Trueta, Biomedical Research Institute and CIBEROBN Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Spain
    J Cell Biochem 107:1107-17. 2009
    ....