José Antonio Encinar
Bello Perez M, Falco A, Galiano V, Coll J, Perez L, Encinar J. Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV). Drug Des Devel Ther. 2018;12:2337-2359 pubmed publisher
..Two non-toxic compounds have been tested in vitro with antiviral capacity against IPNV Sp and LWVRT60 strains in the low µM range with different activity depending on the IPNV strain used. ..
Cuyàs E, Verdura S, Lozano Sánchez J, Viciano I, Llorach Pares L, Nonell Canals A, et al
. The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase. Food Chem Toxicol. 2019;128:35-45 pubmed publisher
..Our study provides a theoretical determination of how EVOO dihydroxy-phenols can be metabolized via COMT. The ability of oleacein to inhibit COMT adds a new dimension to the physiological and therapeutic utility of EVOO secoiridoids. ..
Falco A, Medina Gali R, Poveda J, Bello Perez M, Novoa B, Encinar J. Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion. Mar Drugs. 2019;17: pubmed publisher
..Consequently, Nkl71⁻100 is shown as a promising broad-spectrum antiviral candidate. ..
Ruiz Torres V, Losada Echeberría M, Herranz López M, Barrajón Catalán E, Galiano V, Micol V, et al
. New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques. Mar Drugs. 2018;16: pubmed publisher
..The results have been discussed concerning the necessity to identify new molecules for therapeutic use, especially against aging, and with fewer side effects. ..
Medina Gali R, Bello Perez M, Martinez Lopez A, Falco A, Ortega Villaizan M, Encinar J, et al
. Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response. Fish Shellfish Immunol. 2018;82:514-521 pubmed publisher
..This study emphasizes the importance of epigenetic control in the response of zebrafish to SVCV infection. ..
Ruiz Torres V, Encinar J, Herranz López M, Pérez Sánchez A, Galiano V, Barrajón Catalán E, et al
. An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs. Molecules. 2017;22: pubmed publisher
..Finally, we introduce a novel and publically accessible chemical library of MNPs for virtual screening purposes. ..
Herranz López M, Olivares Vicente M, Encinar J, Barrajón Catalán E, Segura Carretero A, Joven J, et al
. Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity. Nutrients. 2017;9: pubmed publisher