E Domingo

Summary

Country: Spain

Publications

  1. ncbi request reprint RNA virus mutations and fitness for survival
    E Domingo
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Annu Rev Microbiol 51:151-78. 1997
  2. pmc Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites
    M G Mateu
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    J Virol 68:1407-17. 1994
  3. pmc Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus
    M G Mateu
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 86:5883-7. 1989
  4. ncbi request reprint A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C
    M G Mateu
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    J Gen Virol 71:629-37. 1990
  5. ncbi request reprint Two mechanisms of antigenic diversification of foot-and-mouth disease virus
    M A Martinez
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    Virology 184:695-706. 1991
  6. ncbi request reprint Antigenic properties and population stability of a foot-and-mouth disease virus with an altered Arg-Gly-Asp receptor-recognition motif
    C M Ruiz-Jarabo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Gen Virol 80:1899-909. 1999
  7. pmc Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage
    E Baranowski
    Centro de Biolog ia Molecular Severo Ochoa, Universidad Aut onoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 74:1641-7. 2000
  8. ncbi request reprint Molecular evolution of aphthoviruses
    E Domingo
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    Virus Genes 11:197-207. 1995
  9. pmc Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity
    S Sierra
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 74:8316-23. 2000
  10. pmc Rapid selection in modified BHK-21 cells of a foot-and-mouth disease virus variant showing alterations in cell tropism
    C Escarmis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Virol 72:10171-9. 1998

Collaborators

Detail Information

Publications57

  1. ncbi request reprint RNA virus mutations and fitness for survival
    E Domingo
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Annu Rev Microbiol 51:151-78. 1997
    ..Viruses occupy only a tiny portion of their potential sequence space. Such limited tolerance to mutations may open new avenues for combating viral infections...
  2. pmc Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites
    M G Mateu
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    J Virol 68:1407-17. 1994
    ..The results suggest that within a serotype of FMDV, antigenically highly divergent viruses can arise in the field by very limited sequence variation at exposed key residues of each of several antigenic sites...
  3. pmc Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus
    M G Mateu
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 86:5883-7. 1989
    ..The results implicate the extreme heterogeneity of foot-and-mouth disease virus as an important element of viral pathogenesis...
  4. ncbi request reprint A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C
    M G Mateu
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    J Gen Virol 71:629-37. 1990
    ..This indicates that a minimum genetic change can result in a highly amplified phenotypic effect, as regards the antigenicity of FMDV...
  5. ncbi request reprint Two mechanisms of antigenic diversification of foot-and-mouth disease virus
    M A Martinez
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    Virology 184:695-706. 1991
    ..However, the screening of isolates from six decades suggests that the virus, even within the confines of a single serotype, has exploited a minimum of its potential for antigenic variation...
  6. ncbi request reprint Antigenic properties and population stability of a foot-and-mouth disease virus with an altered Arg-Gly-Asp receptor-recognition motif
    C M Ruiz-Jarabo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Gen Virol 80:1899-909. 1999
    ..These critical replacements may yield viruses whose stability allows them to replicate efficiently and to expand the sequence repertoire of an antigenic site...
  7. pmc Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage
    E Baranowski
    Centro de Biolog ia Molecular Severo Ochoa, Universidad Aut onoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 74:1641-7. 2000
    ..These results indicate at least three different mechanisms for cell recognition by FMDV and suggest a potential for this virus to use multiple, alternative receptors for entry even into the same cell type...
  8. ncbi request reprint Molecular evolution of aphthoviruses
    E Domingo
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    Virus Genes 11:197-207. 1995
    ..We review recent evidence to support this proposal, and we suggest that similar concepts may apply to other RNA viruses as well...
  9. pmc Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity
    S Sierra
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 74:8316-23. 2000
    ..The results suggest that strategies to combine reductions of viral load and viral fitness could be effectively associated with extinction mutagenesis as a potential new antiviral strategy...
  10. pmc Rapid selection in modified BHK-21 cells of a foot-and-mouth disease virus variant showing alterations in cell tropism
    C Escarmis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Virol 72:10171-9. 1998
    ..These results prove that infection of partially permissive cells can promote the rapid selection of virus variants that show alterations in cell tropism and are highly virulent for the same cells...
  11. pmc Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades
    M A Martinez
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    J Virol 66:3557-65. 1992
    ..Thus, the antigenic variation attained by FMDV type C over 6 decades was due to fluctuations among limited combinations of amino acid residues without net accumulation of amino acid replacements over time...
  12. pmc Unique amino acid substitutions in the capsid proteins of foot-and-mouth disease virus from a persistent infection in cell culture
    J Diez
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    J Virol 64:5519-28. 1990
    ....
  13. pmc A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig
    J I Núñez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Virol 75:3977-83. 2001
    ....
  14. pmc Memory in viral quasispecies
    C M Ruiz-Jarabo
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 74:3543-7. 2000
    ..The molecular memory of the viral quasispecies influenced both the nature and the intensity of the response of the virus to a selective constraint...
  15. pmc Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle
    F Gebauer
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    J Virol 62:2041-9. 1988
    ..We suggest that persistent, inapparent infections of ruminants, in addition to being a reservoir of virus, may promote the rapid selection of antigenically variant FMDVs...
  16. ncbi request reprint Antibodies raised in a natural host and monoclonal antibodies recognize similar antigenic features of foot-and-mouth disease virus
    M G Mateu
    Centro de Biologia Molecular, Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Spain
    Virology 210:120-7. 1995
    ..In addition, the results encourage the use of extended panels of well-characterized MAbs for a precise molecular analysis of the antigenic variation of FMDV, and of other viruses, in the field...
  17. ncbi request reprint Direct evaluation of the immunodominance of a major antigenic site of foot-and-mouth disease virus in a natural host
    M G Mateu
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    Virology 206:298-306. 1995
    ..Thus, the major antigenic site of FMDV shows heterogeneous dominance in a natural host. Possible implications for evolution of viral quasispecies are discussed...
  18. ncbi request reprint [Variability and development of viral populations: assessment and implications]
    E Baranowski
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Espana
    Med Trop (Mars) 59:430-4. 1999
    ..Finally the quasi-species concept provides the basis for defining the selective factors that could influence the evolution of RNA virus and promote the emergence or reemergence of viral diseases...
  19. ncbi request reprint Extensive antigenic heterogeneity of foot-and-mouth disease virus of serotype C
    M G Mateu
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    Virology 167:113-24. 1988
    ..It is concluded that variation of epitopes involved in neutralization of FMDV is extensive among subtypes of serotype C and also among individual isolates of one subtype...
  20. pmc Unprocessed foot-and-mouth disease virus capsid precursor displays discontinuous epitopes involved in viral neutralization
    J C Saiz
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Virol 68:4557-64. 1994
    ....
  21. ncbi request reprint Biochemical and structural studies with neutralizing antibodies raised against foot-and-mouth disease virus
    E Domingo
    Centro de Biologá Molecular Servero Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Virus Res 62:169-75. 1999
    ..Essential residues at one stage of virus evolution may become dispensable at another not very distant point in the evolutionary landscape. Implications for FMDV evolution and vaccine design are discussed...
  22. ncbi request reprint Mutational analysis of discontinuous epitopes of foot-and-mouth disease virus using an unprocessed capsid protomer precursor
    M G Mateu
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Cantoblanco, Madrid, Spain
    Virus Res 53:27-37. 1998
    ..The results validate site-directed mutagenesis of constructs encoding capsid precursors as an approach to probe the structure of viral discontinuous epitopes not amenable to analysis with synthetic peptides...
  23. ncbi request reprint Non-additive effects of multiple amino acid substitutions on antigen-antibody recognition
    M G Mateu
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Eur J Immunol 22:1385-9. 1992
    ..The non-additive effects of multiple replacements may modulate the extent of antigenic diversification of highly variable RNA viruses, and keep viruses confined within antigenic groups by precluding linear antigenic divergence...
  24. ncbi request reprint Antibody and host cell recognition of foot-and-mouth disease virus (serotype C) cleaved at the Arg-Gly-Asp (RGD) motif: a structural interpretation
    J Hernandez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    J Gen Virol 77:257-64. 1996
    ....
  25. ncbi request reprint Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype
    J Hernandez
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    J Gen Virol 73:213-6. 1992
    ....
  26. pmc Coevolution of cells and viruses in a persistent infection of foot-and-mouth disease virus in cell culture
    J C de La Torre
    Centro de Biología Molecular Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Spain
    J Virol 62:2050-8. 1988
    ..The results suggest that coevolution of BHK-21 cells and FMDV contributes to the maintenance of persistence in cell culture...
  27. ncbi request reprint Molecular intermediates of fitness gain of an RNA virus: characterization of a mutant spectrum by biological and molecular cloning
    A Arias
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Gen Virol 82:1049-60. 2001
    ..The results underline the observation that greater insight into evolutionary processes of viruses may be gained from detailed clonal analyses of the mutant swarms at the sequence level...
  28. ncbi request reprint Long-term, large-population passage of aphthovirus can generate and amplify defective noninterfering particles deleted in the leader protease gene
    N Charpentier
    Centro de Biologia Molecular, Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Virology 223:10-8. 1996
    ..This is the first description of naturally occurring, defective particles of FMDV...
  29. ncbi request reprint Foot-and-mouth disease virus lacking the VP1 G-H loop: the mutant spectrum uncovers interactions among antigenic sites for fitness gain
    E Baranowski
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Virology 288:192-202. 2001
    ..The possibility of producing viable viruses lacking antigenic site A may find application in the design of new anti-FMD vaccines...
  30. ncbi request reprint Systematic replacement of amino acid residues within an Arg-Gly-Asp-containing loop of foot-and-mouth disease virus and effect on cell recognition
    M G Mateu
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 271:12814-9. 1996
    ..The results support the proposal that, in spite of their involvement in antibody recognition, RGD and other FMDV loop residues are remarkably conserved because of their essential role in cell recognition...
  31. pmc A single nucleotide substitution in the internal ribosome entry site of foot-and-mouth disease virus leads to enhanced cap-independent translation in vivo
    E Martinez-Salas
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    J Virol 67:3748-55. 1993
    ..The results show that a single point mutation in an IRES element of a picornavirus can cause an increase in translation efficiency...
  32. ncbi request reprint Large deletions in the 5'-untranslated region of foot-and-mouth disease virus of serotype C
    C Escarmis
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Spain
    Virus Res 35:155-67. 1995
    ..Implications for FMDV evolution are discussed...
  33. ncbi request reprint An RNA virus can adapt to the multiplicity of infection
    N Sevilla
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Gen Virol 79:2971-80. 1998
    ..Therefore, different viral mutants from quasispecies replicating in vivo may be selected depending on the number of variant viruses relative to the number of susceptible cells...
  34. pmc Rapid cell variation can determine the establishment of a persistent viral infection
    A M Martin Hernandez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas UAM, Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 91:3705-9. 1994
    ..The possible relevance of this mechanism to viral persistence in vivo is discussed...
  35. ncbi request reprint Genomic nucleotide sequence of a foot-and-mouth disease virus clone and its persistent derivatives. Implications for the evolution of viral quasispecies during a persistent infection
    M Toja
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid, Spain
    Virus Res 64:161-71. 1999
    ....
  36. pmc Virulence as a positive trait in viral persistence
    J C Saiz
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Spain
    J Virol 70:6410-3. 1996
    ..A model based on the selection of virus-resistant cell variants during persistence is proposed to interpret these observations. Implications about the persistence of viruses in their host cells and organisms are discussed...
  37. pmc Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus
    M A Martinez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid, Spain
    Proc Natl Acad Sci U S A 94:6798-802. 1997
    ..Thus, variability of highly conserved motifs, even those that viruses have adapted from functional cellular motifs, can contribute to phenotypic flexibility of RNA viruses in nature...
  38. pmc Efficient virus extinction by combinations of a mutagen and antiviral inhibitors
    N Pariente
    , , Cantoblanco, 28049 Madrid, Spain
    J Virol 75:9723-30. 2001
    ..The results suggest that combinations of mutagenic agents and antiviral inhibitors can effectively drive high-fitness virus into extinction...
  39. pmc Evolution of a persistent aphthovirus in cytolytic infections: partial reversion of phenotypic traits accompanied by genetic diversification
    N Sevilla
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    J Virol 70:6617-24. 1996
    ..Implications for the evolution of RNA viruses are discussed...
  40. pmc Quasispecies structure and persistence of RNA viruses
    E Domingo
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Emerg Infect Dis 4:521-7. 1998
    ....
  41. ncbi request reprint Evolution of cell recognition by viruses
    E Baranowski
    , , Cantoblanco, 28049 Madrid, Spain
    Science 292:1102-5. 2001
    ..A capacity to exploit alternative entry pathways may reflect the ancient evolutionary origins of viruses and a possible role as agents of horizontal gene transfers among cells...
  42. ncbi request reprint Effect of expression of the aphthovirus protease 3C on viral infection and gene expression
    E Martinez-Salas
    Centro de Biología Molecular Severo Ochoa CSIC, UAM, Universidad Autonoma de Madrid, Spain
    Virology 212:111-20. 1995
    ..The results show that cells with a low level of expression of the aphthoviral 3C can be stably maintained and can provide a useful tool to study polyprotein processing...
  43. ncbi request reprint Coxsackieviruses and quasispecies theory: evolution of enteroviruses
    E Domingo
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Curr Top Microbiol Immunol 323:3-32. 2008
    ....
  44. ncbi request reprint Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet
    C Escarmis
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Cantoblanco, Universidad Autonoma de Madrid, 28049, Spain
    J Mol Biol 285:495-505. 1999
    ..The results document that an RNA virus can find multiple pathways to reach alternative high fitness peaks on the fitness landscape...
  45. ncbi request reprint Antigenically profound amino acid substitutions occur during large population passages of foot-and-mouth disease virus
    N Sevilla
    Centro de Biologia Molecular Severo Ochoa Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Virology 225:400-5. 1996
    ..In addition to documenting profound antigenic variation without immune selection, the results suggest that the repertoire of antigenic variants evolving in viral quasispecies may be greatly influenced by the population size of the virus...
  46. ncbi request reprint Genetic lesions associated with Muller's ratchet in an RNA virus
    C Escarmis
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Mol Biol 264:255-67. 1996
    ..The results provide an account of the molecular basis of Muller's ratchet for an RNA virus, and insight into the types of genetic variants which populate the mutant spectra of FMDV quasispecies...
  47. ncbi request reprint Differential restrictions on antigenic variation among antigenic sites of foot-and-mouth disease virus in the absence of antibody selection
    A Holguin
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    J Gen Virol 78:601-9. 1997
    ..It is proposed that the degree of tolerance to acceptance of amino acid replacements may modulate the variation at different antigenic epitopes of the same virus...
  48. ncbi request reprint Virus population dynamics, fitness variations and the control of viral disease: an update
    E Domingo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Prog Drug Res 57:77-115. 2001
    ..Future trends in multiple target antiviral therapy and new approaches based on virus entry into error catastrophe (extinction mutagenesis) are discussed...
  49. ncbi request reprint RNA virus evolution, population dynamics, and nutritional status
    E Domingo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Biol Trace Elem Res 56:23-30. 1997
    ..Recent results suggest links between nutritional deficiencies and the generation of variant viruses, a possibility that is addressed in the present article...
  50. ncbi request reprint Viruses as quasispecies: biological implications
    E Domingo
    Centro de Biologia Molecular, Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Curr Top Microbiol Immunol 299:51-82. 2006
    ..Also, mutant spectra are the target on which selection and random drift act to shape the long-term evolution of viruses. The biological relevance of mutant spectra is the central topic of this chapter...
  51. ncbi request reprint Quasispecies and the implications for virus persistence and escape
    E Domingo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Clin Diagn Virol 10:97-101. 1998
    ..In striking similarity with the proposals for such early replicons, present-day RNA viruses consist of complex distributions of nonidentical but closely related genomes termed quasispecies...
  52. ncbi request reprint Minimum number of cells required for reconstitution of a foot-and-mouth disease virus-carrier cell culture
    J C de La Torre
    Centro de Biología Molecular Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Spain
    Microbiologia 4:161-6. 1988
    ..The results suggest, instead, that the behaviour of C1-BHK-Rc1 cultures is the result of complex interactions acting at the population level. Implications for viral persistence are discussed...
  53. ncbi request reprint Viruses at the edge of adaptation
    E Domingo
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM Universidad Autonoma de Madrid, Cantoblanco, Madrid, 28049, Spain
    Virology 270:251-3. 2000
    ..New information has been recently obtained on the two sides of the survival line: the edge of adaptation and the edge of extinction...
  54. ncbi request reprint Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction
    E Domingo
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Curr Top Microbiol Immunol 288:149-73. 2005
    ..Such a comparison is contributing to the development of new antiviral strategies based on the transition of viral replication into error catastrophe...
  55. pmc Multiple virulence determinants of foot-and-mouth disease virus in cell culture
    E Baranowski
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Virol 72:6362-72. 1998
    ....
  56. ncbi request reprint Contribution of LCMV towards deciphering biology of quasispecies in vivo
    N Sevilla
    Department of Neuropharmacology, Scripps Research Institute, 10550 North Torrey Pines Road, IMM 6, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 263:197-220. 2002
  57. pmc Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity
    A Grande-Pérez
    Molecular Medicine and Gene Therapy Unit, Department of Medicine, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 99:12938-43. 2002
    ....